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Konrad Hochedlinger, PhD

Publications

  • Foudi A, Kramer DJ, Qin J, Ye D, Behlich AS, Mordecai S, Preffer FI, Amzallag A, Ramaswamy S, Hochedlinger K, Orkin SH, Hock H.Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation.J Exp Med. 2014 Apr 7.
    24711581
  • Schwarz BA, Bar-Nur O, Silva JC, Hochedlinger K.Nanog is dispensable for the generation of induced pluripotent stem cells.Curr Biol. 2014 Feb 3;24(3):347-50.
    24461999
  • Ferrari F, Apostolou E, Park PJ, Hochedlinger K.Rearranging the chromatin for pluripotency.Cell Cycle. 2014 Jan 15;13(2):167-8.
    24241209
  • Das PP, Shao Z, Beyaz S, Apostolou E, Pinello L, De Los Angeles A, O'Brien K, Atsma JM, Fujiwara Y, Nguyen M, Ljuboja D, Guo G, Woo A, Yuan GC, Onder T, Daley G, Hochedlinger K, Kim J, Orkin SH.Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity.Mol Cell. 2014 Jan 9;53(1):32-48.
    24361252
  • Wang L, Miao YL, Zheng X, Lackford B, Zhou B, Han L, Yao C, Ward JM, Burkholder A, Lipchina I, Fargo DC, Hochedlinger K, Shi Y, Williams CJ, Hu G.The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming.Cell Stem Cell. 2013 Dec 5;13(6):676-90.
    24315442
  • Brumbaugh J, Hochedlinger K.Removing reprogramming roadblocks: Mbd3 depletion allows deterministic iPSC generation.Cell Stem Cell. 2013 Oct 3;13(4):379-81.
    24094318
  • Walsh RM, Hochedlinger K.A variant CRISPR-Cas9 system adds versatility to genome engineering.Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15514-5.
    24014593
  • Apostolou E, Ferrari F, Walsh RM, Bar-Nur O, Stadtfeld M, Cheloufi S, Stuart HT, Polo JM, Ohsumi TK, Borowsky ML, Kharchenko PV, Park PJ, Hochedlinger K.Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming.Cell Stem Cell. 2013 Jun 6;12(6):699-712.
    23665121
  • Juuri E, Jussila M, Seidel K, Holmes S, Wu P, Richman J, Heikinheimo K, Chuong CM, Arnold K, Hochedlinger K, Klein O, Michon F, Thesleff I.Sox2 marks epithelial competence to generate teeth in mammals and reptiles.Development. 2013 Apr;140(7):1424-32.
    23462476
  • Wang S, Bates J, Li X, Schanz S, Chandler-Militello D, Levine C, Maherali N, Studer L, Hochedlinger K, Windrem M, Goldman SA.Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination.Cell Stem Cell. 2013 Feb 7;12(2):252-64.
    23395447
  • Sarkar A, Hochedlinger K.The sox family of transcription factors: versatile regulators of stem and progenitor cell fate.Cell Stem Cell. 2013 Jan 3;12(1):15-30.
    23290134
  • Hansson J, Rafiee MR, Reiland S, Polo JM, Gehring J, Okawa S, Huber W, Hochedlinger K, Krijgsveld J.Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency.Cell Rep. 2012 Dec 27;2(6):1579-92.
    23260666
  • Polo JM, Anderssen E, Walsh RM, Schwarz BA, Nefzger CM, Lim SM, Borkent M, Apostolou E, Alaei S, Cloutier J, Bar-Nur O, Cheloufi S, Stadtfeld M, Figueroa ME, Robinton D, Natesan S, Melnick A, Zhu J, Ramaswamy S, Hochedlinger K.A molecular roadmap of reprogramming somatic cells into iPS cells.Cell. 2012 Dec 21;151(7):1617-32.
    23260147
  • Hirata A, Utikal J, Yamashita S, Aoki H, Watanabe A, Yamamoto T, Okano H, Bardeesy N, Kunisada T, Ushijima T, Hara A, Jaenisch R, Hochedlinger K, Yamada Y.Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium.Development. 2013 Jan 1;140(1):66-75.
    23222438
  • Cheloufi S, Hochedlinger K.Reproductive biology: Stem cells bear eggs.Nature. 2012 Nov 21;491(7425):535-6.
    23172212
  • Buckley SM, Aranda-Orgilles B, Strikoudis A, Apostolou E, Loizou E, Moran-Crusio K, Farnsworth CL, Koller AA, Dasgupta R, Silva JC, Stadtfeld M, Hochedlinger K, Chen EI, Aifantis I.Regulation of Pluripotency and Cellular Reprogramming by the Ubiquitin-Proteasome System.Cell Stem Cell. 2012 Oct 24.
    23103054
  • Qin J, Whyte WA, Anderssen E, Apostolou E, Chen HH, Akbarian S, Bronson RT, Hochedlinger K, Ramaswamy S, Young RA, Hock H.The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.Cell Stem Cell. 2012 Sep 7;11(3):319-32.
    22770845
  • Juuri E, Saito K, Ahtiainen L, Seidel K, Tummers M, Hochedlinger K, Klein OD, Thesleff I, Michon F.Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors.Dev Cell. 2012 Aug 14;23(2):317-28.
    22819339
  • Blanpain C, Daley GQ, Hochedlinger K, Passegu√© E, Rossant J, Yamanaka S.Stem cells assessed.Nat Rev Mol Cell Biol. 2012 Jul;13(7):471-6.
    22678486
  • Hochedlinger K.From MYOD1 to iPS cells.Nat Rev Mol Cell Biol. 2010 Dec;11(12):817.
    21102604
  • Walsh RM, Hochedlinger K.Modeling Rett syndrome with stem cells.Cell. 2010 Nov 12;143(4):499-500.
    21074040
  • Serwold T, Hochedlinger K, Swindle J, Hedgpeth J, Jaenisch R, Weissman IL.T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18939-43.
    20956329
  • Stadtfeld M, Hochedlinger K.Induced pluripotency: history, mechanisms, and applications.Genes Dev. 2010 Oct 15;24(20):2239-63.
    20952534
  • Brady BL, Oropallo MA, Yang-Iott KS, Serwold T, Hochedlinger K, Jaenisch R, Weissman IL, Bassing CH.Position-dependent silencing of germline Vbeta segments on TCRbeta alleles containing preassembled VbetaDJbetaCbeta1 genes.J Immunol. 2010 Sep 15;185(6):3564-73.
    20709953
  • Polo JM, Liu S, Figueroa ME, Kulalert W, Eminli S, Tan KY, Apostolou E, Stadtfeld M, Li Y, Shioda T, Natesan S, Wagers AJ, Melnick A, Evans T, Hochedlinger K.Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells.Nat Biotechnol. 2010 Aug;28(8):848-55.
    20644536
  • Polo JM, Hochedlinger K.When fibroblasts MET iPSCs.Cell Stem Cell. 2010 Jul 2;7(1):5-6.
    20621040
  • Buecker C, Chen HH, Polo JM, Daheron L, Bu L, Barakat TS, Okwieka P, Porter A, Gribnau J, Hochedlinger K, Geijsen N.A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells.Cell Stem Cell. 2010 Jun 4;6(6):535-46.
    20569691
  • Stadtfeld M, Apostolou E, Akutsu H, Fukuda A, Follett P, Natesan S, Kono T, Shioda T, Hochedlinger K.Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells.Nature. 2010 May 13;465(7295):175-81.
    20418860
  • Hochedlinger K.Your inner healers.Sci Am. 2010 May;302(5):46-53.
    20443377
  • Yang-Iott KS, Carpenter AC, Rowh MA, Steinel N, Brady BL, Hochedlinger K, Jaenisch R, Bassing CH.TCR beta feedback signals inhibit the coupling of recombinationally accessible V beta 14 segments with DJ beta complexes.J Immunol. 2010 Feb 1;184(3):1369-78.
    20042591
  • Stadtfeld M, Maherali N, Borkent M, Hochedlinger K.A reprogrammable mouse strain from gene-targeted embryonic stem cells.Nat Methods. 2010 Jan;7(1):53-5.
    20010832
  • Belmonte JC, Ellis J, Hochedlinger K, Yamanaka S.Induced pluripotent stem cells and reprogramming: seeing the science through the hype.Nat Rev Genet. 2009 Dec;10(12):878-83.
    19859062
  • Maherali N, Hochedlinger K.Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc.Curr Biol. 2009 Nov 3;19(20):1718-23.
    19765992
  • Utikal J, Maherali N, Kulalert W, Hochedlinger K.Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells.J Cell Sci. 2009 Oct 1;122(Pt 19):3502-10.
    19723802
  • Chen L, Yabuuchi A, Eminli S, Takeuchi A, Lu CW, Hochedlinger K, Daley GQ.Cross-regulation of the Nanog and Cdx2 promoters.Cell Res. 2009 Sep;19(9):1052-61.
    19564890
  • Utikal J, Polo JM, Stadtfeld M, Maherali N, Kulalert W, Walsh RM, Khalil A, Rheinwald JG, Hochedlinger K.Immortalization eliminates a roadblock during cellular reprogramming into iPS cells.Nature. 2009 Aug 27;460(7259):1145-8.
    19668190
  • Eminli S, Foudi A, Stadtfeld M, Maherali N, Ahfeldt T, Mostoslavsky G, Hock H, Hochedlinger K.Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells.Nat Genet. 2009 Sep;41(9):968-76.
    19668214
  • Geijsen N, Hochedlinger K.gPS navigates germ cells to pluripotency.Cell Stem Cell. 2009 Jul 2;5(1):3-4.
    19570505
  • Stadtfeld M,Hochedlinger K.Without a trace? PiggyBac-ing toward pluripotency.Nat Methods. 2009 May;6(5):329-30.
    19404251
  • Deng J,Shoemaker R,Xie B,Gore A,LeProust EM,Antosiewicz-Bourget J,Egli D,Maherali N,Park IH,Yu J,Daley GQ,Eggan K,Hochedlinger K,Thomson J,Wang W,Gao Y,Zhang K.Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming.Nat Biotechnol. 2009 Apr;27(4):353-60.
    19330000
  • Hochedlinger K,Plath K.Epigenetic reprogramming and induced pluripotency.Development. 2009 Feb;136(4):509-23. Review.
    19168672
  • Sommer CA,Stadtfeld M,Murphy GJ,Hochedlinger K,Kotton DN,Mostoslavsky G.Induced pluripotent stem cell generation using a single lentiviral stem cell cassette.Stem Cells. 2009 Mar;27(3):543-9.
    19096035
  • Foudi A,Hochedlinger K,Van Buren D,Schindler JW,Jaenisch R,Carey V,Hock H.Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells.Nat Biotechnol. 2009 Jan;27(1):84-90.
    19060879
  • Maherali N,Hochedlinger K.Guidelines and techniques for the generation of induced pluripotent stem cells.Cell Stem Cell. 2008 Dec 4;3(6):595-605. Review.
    19041776
  • Varas F,Stadtfeld M,de Andres-Aguayo L,Maherali N,di Tullio A,Pantano L,Notredame C,Hochedlinger K,Graf T.Fibroblast-derived induced pluripotent stem cells show no common retroviral vector insertions.Stem Cells. 2009 Feb;27(2):300-6.
    19008347
  • Stadtfeld M,Nagaya M,Utikal J,Weir G,Hochedlinger K.Induced pluripotent stem cells generated without viral integration.Science. 2008 Nov 7;322(5903):945-9.
    18818365
  • Maherali N,Ahfeldt T,Rigamonti A,Utikal J,Cowan C,Hochedlinger K.A high-efficiency system for the generation and study of human induced pluripotent stem cells.Cell Stem Cell. 2008 Sep 11;3(3):340-5.
    18786420
  • Park IH,Arora N,Huo H,Maherali N,Ahfeldt T,Shimamura A,Lensch MW,Cowan C,Hochedlinger K,Daley GQ.Disease-specific induced pluripotent stem cells.Cell. 2008 Sep 5;134(5):877-86.
    18691744
  • Eminli S,Utikal J,Arnold K,Jaenisch R,Hochedlinger K.Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression.Stem Cells. 2008 Oct;26(10):2467-74.
    18635867
  • Stadtfeld M,Brennand K,Hochedlinger K.Reprogramming of pancreatic beta cells into induced pluripotent stem cells.Curr Biol. 2008 Jun 24;18(12):890-4.
    18501604
  • Stadtfeld M, Maherali N, Breault DT, Hochedlinger K.Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse.Cell Stem Cell. 2008 Mar 6;2(3):230-40.
    18371448
  • Hyun I, Hochedlinger K, Jaenisch R, Yamanaka S.New advances in iPS cell research do not obviate the need for human embryonic stem cells.Cell Stem Cell. 2007 Oct 11;1(4):367-8.
    18371375
  • Maherali N, Sridharan R, Xie W, Utikal J, Eminli S, Arnold K, Stadtfeld M, Yachechko R, Tchieu J, Jaenisch R, Plath K, Hochedlinger K.Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.Cell Stem Cell. 2007 Jun 7;1(1):55-70.
    18371336
  • Lengner CJ, Camargo FD, Hochedlinger K, Welstead GG, Zaidi S, Gokhale S, Scholer HR, Tomilin A, Jaenisch R.Oct4 expression is not required for mouse somatic stem cell self-renewal.Cell Stem Cell. 2007 Oct 11;1(4):403-15.
    18159219
  • Hochedlinger K.Konrad Hochedlinger: the new kid of nuclear reprogramming.J Cell Biol. 2007 Sep 24;178(7):1098-9.
    17893238
  • Serwold T, Hochedlinger K, Inlay MA, Jaenisch R, Weissman IL.Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes.J Immunol. 2007 Jul 15;179(2):928-38.
    17617584
  • Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, Bernstein BE, Jaenisch R.In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.Nature. 2007 Jul 19;448(7151):318-24.
    17554336
  • Hochedlinger K, Jaenisch R.On the cloning of animals from terminally differentiated cells.Nat Genet. 2007 Feb;39(2):136-7; author reply 137-8.
    17262020
  • Hochedlinger K, Jaenisch R.Nuclear reprogramming and pluripotency.Nature. 2006 Jun 29;441(7097):1061-7. Review.
    16810240
  • Brambrink T, Hochedlinger K, Bell G, Jaenisch R.ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable.Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):933-8.
    16418286
  • Beard C, Hochedlinger K, Plath K, Wutz A, Jaenisch R.Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells.Genesis. 2006 Jan;44(1):23-8.
    16400644
  • Hochedlinger K, Yamada Y, Beard C, Jaenisch R.Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues.Cell. 2005 May 6;121(3):465-77.
    15882627
  • Koralov SB, Novobrantseva TI, Hochedlinger K, Jaenisch R, Rajewsky K.Direct in vivo VH to JH rearrangement violating the 12/23 rule.J Exp Med. 2005 Feb 7;201(3):341-8.
    15699070
  • Gribnau J, Luikenhuis S, Hochedlinger K, Monkhorst K, Jaenisch R.X chromosome choice occurs independently of asynchronous replication timing.J Cell Biol. 2005 Jan 31;168(3):365-73.
    15668296
  • Blelloch RH, Hochedlinger K, Yamada Y, Brennan C, Kim M, Mintz B, Chin L, Jaenisch R.Nuclear cloning of embryonal carcinoma cells.Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):13985-90.
    15306687
  • Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, Wagner EF.Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation.Mol Cell. 2004 Sep 10;15(5):713-25.
    15350216
  • Hochedlinger K, Blelloch R, Brennan C, Yamada Y, Kim M, Chin L, Jaenisch R.Reprogramming of a melanoma genome by nuclear transplantation.Genes Dev. 2004 Aug 1;18(15):1875-85.
    15289459
  • Hochedlinger K, Jaenisch R.Nuclear transplantation, embryonic stem cells, and the potential for cell therapy.N Engl J Med. 2003 Jul 17;349(3):275-86.
    12867612
  • Gribnau J, Hochedlinger K, Hata K, Li E, Jaenisch R.Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization.Genes Dev. 2003 Mar 15;17(6):759-73.
    12651894
  • Hochedlinger K, Jaenisch R.Nuclear transplantation: lessons from frogs and mice.Curr Opin Cell Biol. 2002 Dec;14(6):741-8.
    12473349
  • Humpherys D, Eggan K, Akutsu H, Friedman A, Hochedlinger K, Yanagimachi R, Lander ES, Golub TR, Jaenisch R.Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei.Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12889-94.
    12235366
  • Rideout WM, Hochedlinger K, Kyba M, Daley GQ, Jaenisch R.Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy.Cell. 2002 Apr 5;109(1):17-27.
    11955443
  • Hochedlinger K, Wagner EF, Sabapathy K.Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis.Oncogene. 2002 Apr 4;21(15):2441-5.
    11948429
  • Hochedlinger K, Jaenisch R.Monoclonal mice generated by nuclear transfer from mature B and T donor cells.Nature. 2002 Feb 28;415(6875):1035-8.
    11875572
  • Humpherys D, Eggan K, Akutsu H, Hochedlinger K, Rideout WM, Biniszkiewicz D, Yanagimachi R, Jaenisch R.Epigenetic instability in ES cells and cloned mice.Science. 2001 Jul 6;293(5527):95-7.
    11441181
  • Eggan K, Akutsu H, Hochedlinger K, Rideout W, Yanagimachi R, Jaenisch R.X-Chromosome inactivation in cloned mouse embryos.Science. 2000 Nov 24;290(5496):1578-81.
    11090356
  • Sabapathy K, Jochum W, Hochedlinger K, Chang L, Karin M, Wagner EF.Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2.Mech Dev. 1999 Dec;89(1-2):115-24.
    10559486