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Lyn McDivitt Duncan, MD


  • Gerami P, Busam K, Cochran A, Cook MG, Duncan LM, Elder DE, Fullen DR, Guitart J, Leboit PE, Mihm MC, Prieto VG, Rabkin MS, Scolyer RA, Xu X, Yun SJ, Obregon R, Yazdan P, Cooper C, Weitner BB, Rademaker A, Barnhill RL.Histomorphologic Assessment and Interobserver Diagnostic Reproducibility of Atypical Spitzoid Melanocytic Neoplasms With Long-term Follow-up.Am J Surg Pathol. 2014 Mar 10.
  • Nazarian RM, Primiani A, Doyle LA, Linskey KR, Duncan LM, Odze RD, Zukerberg LR.Cytokeratin 17: an adjunctive marker of invasion in squamous neoplastic lesions of the anus.Am J Surg Pathol. 2014 Jan;38(1):78-85.
  • Aboutalebi A, Korman JB, Sohani AR, Hasserjian RP, Louissaint A, Le L, Kraft S, Duncan LM, Nazarian RM.Aleukemic cutaneous myeloid sarcoma.J Cutan Pathol. 2013 Dec;40(12):996-1005.
  • Dekker J, Duncan LM.Lack of standards for the detection of melanoma in sentinel lymph nodes: a survey and recommendations.Arch Pathol Lab Med. 2013 Nov;137(11):1603-9.
  • Linskey KR, Gimbel DC, Zukerberg LR, Duncan LM, Sadow PM, Nazarian RM.BerEp4, cytokeratin 14, and cytokeratin 17 immunohistochemical staining aid in differentiation of basaloid squamous cell carcinoma from basal cell carcinoma with squamous metaplasia.Arch Pathol Lab Med. 2013 Nov;137(11):1591-8.
  • Nemlich Y, Greenberg E, Ortenberg R, Besser MJ, Barshack I, Jacob-Hirsch J, Jacoby E, Eyal E, Rivkin L, Prieto VG, Chakravarti N, Duncan LM, Kallenberg DM, Galun E, Bennett DC, Amariglio N, Bar-Eli M, Schachter J, Rechavi G, Markel G.MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.J Clin Invest. 2013 Jun 3;123(6):2703-18.
  • Hanna SC, Krishnan B, Bailey ST, Moschos SJ, Kuan PF, Shimamura T, Osborne LD, Siegel MB, Duncan LM, O'Brien ET, Superfine R, Miller CR, Simon MC, Wong KK, Kim WY.HIF1α and HIF2α independently activate SRC to promote melanoma metastases.J Clin Invest. 2013 May 1;123(5):2078-93.
  • Schlegel J, Sambade MJ, Sather S, Moschos SJ, Tan AC, Winges A, DeRyckere D, Carson CC, Trembath DG, Tentler JJ, Eckhardt SG, Kuan PF, Hamilton RL, Duncan LM, Miller CR, Nikolaishvili-Feinberg N, Midkiff BR, Liu J, Zhang W, Yang C, Wang X, Frye SV, Earp HS, Shields JM, Graham DK.MERTK receptor tyrosine kinase is a therapeutic target in melanoma.J Clin Invest. 2013 May 1;123(5):2257-67.
  • Chan MP, Duncan LM, Nazarian RM.Subcutaneous Sweet syndrome in the setting of myeloid disorders: A case series and review of the literature.J Am Acad Dermatol. 2013 Feb 8.
  • Lobo AZ, Tanabe KK, Luo S, Muzikansky A, Sober AJ, Tsao H, Cosimi AB, Duncan LM.The distribution of microscopic melanoma metastases in sentinel lymph nodes: implications for pathology protocols.Am J Surg Pathol. 2012 Dec;36(12):1841-8.
  • Le LP, Garibyan L, Lara D, Finberg KE, Iafrate AJ, Duncan LM, Kay J, Nazarian RM.Fibrosis-Associated Single-Nucleotide Polymorphisms in TGFΒ1 and CAV1 Are Not Associated With the Development of Nephrogenic Systemic Fibrosis.Am J Dermatopathol. 2012 Oct 9.
  • Ho J, Barbi de Moura M, Lin Y, Vincent G, Thorne S, Duncan LM, Lin HM, Kirkwood JM, Becker D, van Houten B, Moschos S.Importance of glycolysis and oxidative phosphorylation in advanced melanoma.Mol Cancer. 2012 Oct 9;11(1):76.
  • Piris A, Lobo AC, Duncan LM.Melanoma staging: where are we now?.Dermatol Clin. 2012 Oct;30(4):581-92.
  • Hawryluk EB, Sober AJ, Piris A, Nazarian RM, Hoang MP, Tsao H, Mihm MC, Duncan LM.Histologically challenging melanocytic tumors referred to a tertiary care pigmented lesion clinic.J Am Acad Dermatol. 2012 Oct;67(4):727-35.
  • Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q, Lee CW, Hu D, Lian BQ, Kleffel S, Yang Y, Neiswender J, Khorasani AJ, Fang R, Lezcano C, Duncan LM, Scolyer RA, Thompson JF, Kakavand H, Houvras Y, Zon LI, Mihm MC, Kaiser UB, Schatton T, Woda BA, Murphy GF, Shi YG.Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma.Cell. 2012 Sep 14;150(6):1135-46.
  • Hung T, Piris A, Lobo A, Mihm MC, Sober AJ, Tsao H, Tanabe KK, Duncan LM.Sentinel lymph node metastasis is not predictive of poor outcome in patients with problematic spitzoid melanocytic tumors.Hum Pathol. 2012 Aug 30.
  • Piris A, Mihm MC, Duncan LM.AJCC melanoma staging update: impact on dermatopathology practice and patient management.J Cutan Pathol. 2011 May;38(5):394-400.
  • Luo S, Chaplin AC, Langley RG, Njauw CN, Duncan LM, Miller RA, Tsao H.Agminated segmental nevi demonstrating intranevic concordance of BRAF status.J Invest Dermatol. 2011 Mar;131(3):788-90.
  • Kolman O, Hoang MP, Piris A, Mihm MC, Duncan LM.Histologic processing and reporting of cutaneous pigmented lesions: recommendations based on a survey of 94 dermatopathologists.J Am Acad Dermatol. 2010 Oct;63(4):661-7.
  • Pless ML, Kroshinsky D, LaRocque RC, Buchbinder BR, Duncan LM.Case records of the Massachusetts General Hospital. Case 26-2010. A 54-year-old man with loss of vision and a rash.N Engl J Med. 2010 Aug 26;363(9):865-74.
  • Kabbarah O, Nogueira C, Feng B, Nazarian RM, Bosenberg M, Wu M, Scott KL, Kwong LN, Xiao Y, Cordon-Cardo C, Granter SR, Ramaswamy S, Golub T, Duncan LM, Wagner SN, Brennan C, Chin L.Integrative genome comparison of primary and metastatic melanomas.PLoS ONE. 2010;5(5):e10770.
  • Nazarian RM, Prieto VG, Elder DE, Duncan LM.Melanoma biomarker expression in melanocytic tumor progression: a tissue microarray study.J Cutan Pathol. 2010 Apr;37 Suppl 1:41-7.
  • Jané-Valbuena J, Widlund HR, Perner S, Johnson LA, Dibner AC, Lin WM, Baker AC, Nazarian RM, Vijayendran KG, Sellers WR, Hahn WC, Duncan LM, Rubin MA, Fisher DE, Garraway LA.An oncogenic role for ETV1 in melanoma.Cancer Res. 2010 Mar 1;70(5):2075-84.
  • Koreishi AF, Nazarian RM, Saenz AJ, Klepeis VE, McDonald AG, Farris AB, Colvin RB, Duncan LM, Mandal RV, Kay J.Nephrogenic systemic fibrosis: a pathologic study of autopsy cases.Arch Pathol Lab Med. 2009 Dec;133(12):1943-8.
  • Wilbur DC, Madi K, Colvin RB, Duncan LM, Faquin WC, Ferry JA, Frosch MP, Houser SL, Kradin RL, Lauwers GY, Louis DN, Mark EJ, Mino-Kenudson M, Misdraji J, Nielsen GP, Pitman MB, Rosenberg AE, Smith RN, Sohani AR, Stone JR, Tambouret RH, Wu CL, Young RH, Zembowicz A, Klietmann W.Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations.Arch Pathol Lab Med. 2009 Dec;133(12):1949-53.
  • Mandal RV,Duncan LM,Austen WG Jr,Nielsen GP.Infiltrating intramuscular spindle cell lipoma of the face.J Cutan Pathol. 2009 Oct;36 Suppl 1:70-3.
  • Nazarian RM, Van Cott EM, Zembowicz A, Duncan LM.Warfarin-induced skin necrosis.J Am Acad Dermatol. 2009 Aug;61(2):325-32. Review.
  • Shah SM, Konnikov N, Duncan LM, Tannous ZS.The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas.Lasers Surg Med. 2009 Aug;41(6):417-22.
  • Erickson LA,Letts GA,Shah SM,Shackelton JB,Duncan LM.TRPM1 (Melastatin-1/MLSN1) mRNA expression in Spitz nevi and nodular melanomas.Mod Pathol. 2009 Jul;22(7):969-76.
  • Rothberg BE, Moeder CB, Kluger H, Halaban R, Elder DE, Murphy GF, Lazar A, Prieto V, Duncan LM, Rimm DL.Nuclear to non-nuclear Pmel17/gp100 expression (HMB45 staining) as a discriminator between benign and malignant melanocytic lesions.Mod Pathol. 2008 Sep;21(9):1121-9.
  • Robertson GT, Bonventre EJ, Doyle TB, Du Q, Duncan L, Morris TW, Roche ED, Yan D, Lynch AS.In Vitro Evaluation of CBR-2092, a Novel Rifamycin-Quinolone Hybrid Antibiotic: Studies of the Mode of Action in Staphylococcus aureus.Antimicrob Agents Chemother. 2008 Jul;52(7):2313-23.
  • Robertson GT, Bonventre EJ, Doyle TB, Du Q, Duncan L, Morris TW, Roche ED, Yan D, Lynch AS.In Vitro Evaluation of CBR-2092, a Novel Rifamycin-Quinolone Hybrid Antibiotic: Microbiology Profiling Studies Undertaken in Staphylococci and Streptococci.Antimicrob Agents Chemother. 2008 Jul;52(7):2324-34.
  • Mittal S, Marshall NA, Duncan L, Culligan DJ, Barker RN, Vickers MA.Local and systemic induction of CD4+CD25+ regulatory T cell population by non-Hodgkin's lymphoma.Blood. 2008 Jun 1;111(11):5359-70.
  • Duncan LK, Jinschek JR, Vikesland PJ.C60 colloid formation in aqueous systems: effects of preparation method on size, structure, and surface charge.Environ Sci Technol. 2008 Jan 1;42(1):173-8.
  • Walsh K, Moss C, Lawless J, McKelvie R, Duncan L.Puzzling practice: a strategy for working with clinical practice issues.Int J Nurs Pract. 2008 Apr;14(2):94-100.
  • Kuffova L, Netukova M, Duncan L, Porter A, Stockinger B, Forrester JV.Cross presentation of antigen on MHC class II via the draining lymph node after corneal transplantation in mice.J Immunol. 2008 Feb 1;180(3):1353-61.
  • Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH.Identification of cells initiating human melanomas.Nature. 2008 Jan 17;451(7176):345-9.
  • Duncan L, Jacob S, Hubbard E.Evaluation of p16INK4a as a diagnostic tool in the triage of Pap smears demonstrating atypical squamous cells of undetermined significance.Cancer. 2008 Feb 25;114(1):34-48.
  • Duncan L, Shelmerdine H, Hughes MP, Coley HM, Hubner Y, Labeed FH.Dielectrophoretic analysis of changes in cytoplasmic ion levels due to ion channel blocker action reveals underlying differences between drug-sensitive and multidrug-resistant leukaemic cells.Phys Med Biol. 2008 Jan 21;53(2):N1-7.
  • Nahmias C, Carlson ER, Duncan LD, Blodgett TM, Kennedy J, Long MJ, Carr C, Hubner KF, Townsend DW.Positron emission tomography/computerized tomography (PET/CT) scanning for preoperative staging of patients with oral/head and neck cancer.J Oral Maxillofac Surg. 2007 Dec;65(12):2524-35.
  • Kim M, Gans JD, Nogueira C, Wang A, Paik JH, Feng B, Brennan C, Hahn WC, Cordon-Cardo C, Wagner SN, Flotte TJ, Duncan LM, Granter SR, Chin L.Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene.Cell. 2006 Jun 30;125(7):1269-81.
  • Koehler JE, Duncan LM.Case records of the Massachusetts General Hospital. Case 30-2005. A 56-year-old man with fever and axillary lymphadenopathy.N Engl J Med. 2005 Sep 29;353(13):1387-94.
  • Polisson RP, Crocker JT, Mueller PR, Harris NL, Duncan LM.Case records of the Massachusetts General Hospital. Case 29-2005. A 68-year-old man with periorbital swelling, rash, and weakness.N Engl J Med. 2005 Sep 22;353(12):1275-84.
  • Quinn TR, Duncan LM, Zembowicz A, Faquin WC.Cutaneous metastases of follicular thyroid carcinoma: a report of four cases and a review of the literature.Am J Dermatopathol. 2005 Aug;27(4):306-12.
  • Tannous ZS, Mihm MC, Sober AJ, Duncan LM.Congenital melanocytic nevi: clinical and histopathologic features, risk of melanoma, and clinical management.J Am Acad Dermatol. 2005 Feb;52(2):197-203.
  • Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, Ralfkiaer E, Chimenti S, Diaz-Perez JL, Duncan LM, Grange F, Harris NL, Kempf W, Kerl H, Kurrer M, Knobler R, Pimpinelli N, Sander C, Santucci M, Sterry W, Vermeer MH, Wechsler J, Whittaker S, Meijer CJ.WHO-EORTC classification for cutaneous lymphomas.Blood. 2005 May 15;105(10):3768-85.
  • Zand S, Lio PA, Mackool BT, Duncan LM.A slightly erythematous, firm papule on the upper arm--quiz case.Arch Dermatol. 2005 Jan;141(1):93-8.
  • Zubovits J, Buzney E, Yu L, Duncan LM.HMB-45, S-100, NK1/C3, and MART-1 in metastatic melanoma.Hum Pathol. 2004 Feb;35(2):217-23.
  • Ahmed AR, Avram MM, Duncan LM.Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 23-2003. A 79-year-old woman with gastric lymphoma and erosive mucosal and cutaneous lesions.N Engl J Med. 2003 Jul 24;349(4):382-91.
  • Santucci M, Pimpinelli N, Massi D, Kadin ME, Meijer CJ, Muller-Hermelink HK, Paulli M, Wechsler J, Willemze R, Audring H, Bernengo MG, Cerroni L, Chimenti S, Chott A, Diaz-Perez JL, Dippel E, Duncan LM, Feller AC, Geerts ML, Hallermann C, Kempf W, Russell-Jones R, Sander C, Berti E.Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force Workshop.Cancer. 2003 Feb 1;97(3):610-27.
  • de Leval L, Harris NL, Longtine J, Ferry JA, Duncan LM.Cutaneous b-cell lymphomas of follicular and marginal zone types: use of Bcl-6, CD10, Bcl-2, and CD21 in differential diagnosis and classification.Am J Surg Pathol. 2001 Jun;25(6):732-41.
  • Wrone DA, Duncan LM, Sober AJ.Melanoma and pregnancy: eight questions with discussion.J Gend Specif Med. 1999 Jul-Aug;2(4):52-4.
  • Duncan LM, Deeds J, Cronin FE, Donovan M, Sober AJ, Kauffman M, McCarthy JJ.Melastatin expression and prognosis in cutaneous malignant melanoma.J Clin Oncol. 2001 Jan 15;19(2):568-76.
  • Deeds J, Cronin F, Duncan LM.Patterns of melastatin mRNA expression in melanocytic tumors.Hum Pathol. 2000 Nov;31(11):1346-56.
  • Tannous ZS, Lerner LH, Duncan LM, Mihm MC, Flotte TJ.Progression to invasive melanoma from malignant melanoma in situ, lentigo maligna type.Hum Pathol. 2000 Jun;31(6):705-8.
  • Su LD, Duncan LM.Lymphoma- and leukemia-associated cutaneous atypical CD30+ T-cell reactions.J Cutan Pathol. 2000 May;27(5):249-54.
  • Yu LL, Flotte TJ, Tanabe KK, Gadd MA, Cosimi AB, Sober AJ, Mihm MC, Duncan LM.Detection of microscopic melanoma metastases in sentinel lymph nodes.Cancer. 1999 Aug 15;86(4):617-27.
  • Tannous Z, Baldassano MF, Li VW, Kvedar J, Duncan LM.Syringolymphoid hyperplasia and follicular mucinosis in a patient with cutaneous T-cell lymphoma.J Am Acad Dermatol. 1999 Aug;41(2 Pt 2):303-8.
  • Duncan LM.Cutaneous lymphoma. Understanding the new classification schemes.Dermatol Clin. 1999 Jul;17(3):569-92.
  • Gadd MA, Cosimi AB, Yu J, Duncan LM, Yu L, Flotte TJ, Souba WW, Ott MJ, Wong LS, Sober AJ, Mihm MC, Haluska FG, Tanabe KK.Outcome of patients with melanoma and histologically negative sentinel lymph nodes.Arch Surg. 1999 Apr;134(4):381-7.
  • Baldassano MF, Bailey EM, Ferry JA, Harris NL, Duncan LM.Cutaneous lymphoid hyperplasia and cutaneous marginal zone lymphoma: comparison of morphologic and immunophenotypic features.Am J Surg Pathol. 1999 Jan;23(1):88-96.
  • Duncan LM.Prognostic Indicators in Melanoma.Harrison's Principles of Internal Medicine. 1999;15:489-518.
  • Duncan LM, Deeds J, Hunter J, Shao J, Holmgren LM, Woolf EA, Tepper RI, Shyjan AW.Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis.Cancer Res. 1998 Apr 1;58(7):1515-20.
  • Duncan LM, Richards LA, Mihm MC.Increased mast cell density in invasive melanoma.J Cutan Pathol. 1998 Jan;25(1):11-5.
  • Duncan LM, Bouffard D, Howard C, Mihm MC, Byers HR.In situ distribution of integrin alpha 2 beta 1 and alpha-actinin in melanocytic proliferations.Mod Pathol. 1996 Sep;9(9):938-43.
  • Bailey EM, Ferry JA, Harris NL, Mihm MC, Jacobson JO, Duncan LM.Marginal zone lymphoma (low-grade B-cell lymphoma of mucosa-associated lymphoid tissue type) of skin and subcutaneous tissue: a study of 15 patients.Am J Surg Pathol. 1996 Aug;20(8):1011-23.