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John W. Chen, MD, PhD


  • Niers JM, Chen JW, Weissleder R, Tannous BA.Enhanced in vivo imaging of metabolically biotinylated cell surface reporters.Anal Chem. 2011 Feb 1;83(3):994-9.
  • Rodríguez E, Nilges M, Weissleder R, Chen JW.Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity.J Am Chem Soc. 2010 Jan 13;132(1):168-77.
  • Ronald JA, Chen JW, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, Rutt BK.Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques.Circulation. 2009 Aug 18;120(7):592-9.
  • Rajendran R, Ronald JA, Ye T, Minqin R, Chen JW, Weissleder R, Rutt BK, Halliwell B, Watt F.Nuclear microscopy: a novel technique for quantitative imaging of gadolinium distribution within tissue sections.Microsc. Microanal. 2009 Aug;15(4):338-44.
  • Zhu H,Acquaviva J,Ramachandran P,Boskovitz A,Woolfenden S,Pfannl R,Bronson RT,Chen JW,Weissleder R,Housman DE,Charest A.Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2712-6.
  • McCann CM,Waterman P,Figueiredo JL,Aikawa E,Weissleder R,Chen JW.Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.Neuroimage. 2009 Apr 1;45(2):360-9.
  • Brass SD,Durand ML,Stone JH,Chen JW,Stone JR.Case records of the Massachusetts General Hospital. Case 36-2008. A 59-year-old man with chronic daily headache.N Engl J Med. 2008 Nov 20;359(21):2267-78.
  • Breckwoldt MO,Chen JW,Stangenberg L,Aikawa E,Rodriguez E,Qiu S,Moskowitz MA,Weissleder R.Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase.Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18584-9.
  • Nahrendorf M,Sosnovik D,Chen JW,Panizzi P,Figueiredo JL,Aikawa E,Libby P,Swirski FK,Weissleder R.Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury.Circulation. 2008 Mar 4;117(9):1153-60.
  • Chen JW,Breckwoldt MO,Aikawa E,Chiang G,Weissleder R.Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.Brain. 2008 Apr;131(Pt 4):1123-33.
  • Wu S, Chen JJ, Kudelka A, Lu J, Zhu X.Incidence and risk of hypertension with sorafenib in patients with cancer: a systematic review and meta-analysis.Lancet Oncol. 2008 Feb;9(2):117-23. Review.
  • Kawamata N, Chen J, Koeffler HP.Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells.Blood. 2007 Oct 1;110(7):2667-73.
  • Chen J, Ouyang ZG, Zhang SH, Zhen YS.Down-regulation of the nuclear factor-kappaB by lidamycin in association with inducing apoptosis in human pancreatic cancer cells and inhibiting xenograft growth.Oncol Rep. 2007 Jun;17(6):1445-51.
  • Zhang Y, Chen J, Zhang Y, Hu Z, Hu D, Pan Y, Ou S, Liu G, Yin X, Zhao J, Ren L, Wang J.Panning and identification of a colon tumor binding peptide from a phage display peptide library.J Biomol Screen. 2007 Apr;12(3):429-35.
  • Chen J, Jette C, Kanki JP, Aster JC, Look AT, Griffin JD.NOTCH1-induced T-cell leukemia in transgenic zebrafish.Leukemia. 2007 Mar;21(3):462-71.
  • Chen JW, Querol Sans M, Bogdanov A, Weissleder R.Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates.Radiology. 2006 Aug;240(2):473-81.
  • Querol M, Chen JW, Bogdanov AA.A paramagnetic contrast agent with myeloperoxidase-sensing properties.Org Biomol Chem. 2006 May 21;4(10):1887-95.
  • Tannous BA, Grimm J, Perry KF, Chen JW, Weissleder R, Breakefield XO.Metabolic biotinylation of cell surface receptors for in vivo imaging.Nat Methods. 2006 May;3(5):391-6.
  • Chen JW, Wasserman BA.Vulnerable plaque imaging.Neuroimaging Clin N Am. 2005 Aug;15(3):609-21, xi.
  • Querol Sans M, Chen JW, Weissleder R, Bogdanov AA.Myeloperoxidase activity imaging using (67)Ga labeled substrate.Mol Imaging Biol. 2005 Nov-Dec;7(6):403-10.
  • Chen JW, Pham W, Weissleder R, Bogdanov A.Human myeloperoxidase: a potential target for molecular MR imaging in atherosclerosis.Magn Reson Med. 2004 Nov;52(5):1021-8.