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John W. Chen, MD, PhD


  • Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, Rothstein TL, Nahrendorf M, Weissleder R, Swirski FK.Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis.J Exp Med. 2014 Jun 2;211(6):1243-56.
  • Lartey FM, Ahn GO, Ali R, Rosenblum S, Miao Z, Arksey N, Shen B, Colomer MV, Rafat M, Liu H, Alejandre-Alcazar MA, Chen JW, Palmer T, Chin FT, Guzman R, Loo BW, Graves E.The Relationship Between Serial [(18) F]PBR06 PET Imaging of Microglial Activation and Motor Function Following Stroke in Mice.Mol Imaging Biol. 2014 May 28.
  • Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL.Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors.Science. 2014 May 9;344(6184):630-4.
  • Ali M, Pulli B, Chen JW.Molecular imaging of macrophage enzyme activity in cardiac inflammation.Curr Cardiovasc Imaging Rep. 2014 Apr 1;7(4):9258.
  • Hsieh LC, Chen JW, Wang LY, Tsang YM, Shueng PW, Liao LJ, Lo WC, Lin YC, Tseng CF, Kuo YS, Jhuang JY, Tien HJ, Juan HF, Hsieh CH.Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging.PLoS ONE. 2014;9(3):e92561.
  • Lai CP, Mardini O, Ericsson M, Prabhakar S, Maguire CA, Chen JW, Tannous BA, Breakefield XO.Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter.ACS Nano. 2014 Jan 28;8(1):483-94.
  • Lartey FM, Ahn GO, Shen B, Cord KT, Smith T, Chua JY, Rosenblum S, Liu H, James ML, Chernikova S, Lee SW, Pisani LJ, Tirouvanziam R, Chen JW, Palmer TD, Chin FT, Guzman R, Graves EE, Loo BW.PET imaging of stroke-induced neuroinflammation in mice using [18F]PBR06.Mol Imaging Biol. 2014 Feb;16(1):109-17.
  • Prabhakar S, Goto J, Zhang X, Sena-Esteves M, Bronson R, Brockmann J, Gianni D, Wojtkiewicz GR, Chen JW, Stemmer-Rachamimov A, Kwiatkowski DJ, Breakefield XO.Correction: Stochastic Model of Tsc1 Lesions in Mouse Brain.PLoS ONE. 2013;8(11).
  • Oklu R, Deipolyi AR, Wicky S, Ergul E, Deik AA, Chen JW, Hirsch JA, Wojtkiewicz GR, Clish CB.Identification of small compound biomarkers of pituitary adenoma: a bilateral inferior petrosal sinus sampling study.Journal Of Neurointerventional Surgery. 2013 Sep 4.
  • Pulli B, Ali M, Forghani R, Schob S, Hsieh KL, Wojtkiewicz G, Linnoila JJ, Chen JW.Measuring myeloperoxidase activity in biological samples.PLoS ONE. 2013;8(7):e67976.
  • Prabhakar S, Goto J, Zuang X, Sena-Esteves M, Bronson R, Brockmann J, Gianni D, Wojtkiewicz GR, Chen JW, Stemmer-Rachamimov A, Kwiatkowski DJ, Breakefield XO.Stochastic model of Tsc1 lesions in mouse brain.PLoS ONE. 2013;8(5):e64224.
  • Majmudar MD, Keliher EJ, Heidt T, Leuschner F, Truelove J, Sena BF, Gorbatov R, Iwamoto Y, Dutta P, Wojtkiewicz G, Courties G, Sebas M, Borodovsky A, Fitzgerald K, Nolte MW, Dickneite G, Chen JW, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M.Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice.Circulation. 2013 Apr 24.
  • González RG, Copen WA, Schaefer PW, Lev MH, Pomerantz SR, Rapalino O, Chen JW, Hunter GJ, Romero JM, Buchbinder BR, Larvie M, Hirsch JA, Gupta R.The Massachusetts General Hospital acute stroke imaging algorithm: an experience and evidence based approach.Journal Of Neurointerventional Surgery. 2013 May;5 Suppl 1:i7-i12.
  • Cortez-Retamozo V, Etzrodt M, Newton A, Ryan R, Pucci F, Sio SW, Kuswanto W, Rauch PJ, Chudnovskiy A, Iwamoto Y, Kohler R, Marinelli B, Gorbatov R, Wojtkiewicz G, Panizzi P, Mino-Kenudson M, Forghani R, Figueiredo JL, Chen JW, Xavier R, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ.Angiotensin II drives the production of tumor-promoting macrophages.Immunity. 2013 Feb 21;38(2):296-308.
  • Chen JW, Figueiredo JL, Wojtkiewicz GR, Siegel C, Iwamoto Y, Kim DE, Nolte MW, Dickneite G, Weissleder R, Nahrendorf M.Selective Factor XIIa Inhibition Attenuates Silent Brain Ischemia: Application of Molecular Imaging Targeting Coagulation Pathway.JACC Cardiovasc Imaging. 2012 Nov;5(11):1127-38.
  • Atkinson W, Forghani R, Wojtkiewicz GR, Pulli B, Iwamoto Y, Ueno T, Waterman P, Truelove J, Oklu R, Chen JW.Ligation of the jugular veins does not result in brain inflammation or demyelination in mice.PLoS ONE. 2012;7(3):e33671.
  • Forghani R, Wojtkiewicz GR, Zhang Y, Seeburg D, Bautz BR, Pulli B, Milewski AR, Atkinson WL, Iwamoto Y, Zhang ER, Etzrodt M, Rodriguez E, Robbins CS, Swirski FK, Weissleder R, Chen JW.Demyelinating Diseases: Myeloperoxidase as an Imaging Biomarker and Therapeutic Target.Radiology. 2012 Mar 23.
  • Niers JM, Chen JW, Lewandrowski G, Kerami M, Garanger E, Wojtkiewicz G, Waterman P, Keliher E, Weissleder R, Tannous BA.Single reporter for targeted multimodal in vivo imaging.J Am Chem Soc. 2012 Mar 21;134(11):5149-56.
  • Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A, Berger C, Ryan RJ, Iwamoto Y, Marinelli B, Gorbatov R, Forghani R, Novobrantseva TI, Koteliansky V, Figueiredo JL, Chen JW, Anderson DG, Nahrendorf M, Swirski FK, Weissleder R, Pittet MJ.Origins of tumor-associated macrophages and neutrophils.Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2491-6.
  • Su HS, Nahrendorf M, Panizzi P, Breckwoldt MO, Rodriguez E, Iwamoto Y, Aikawa E, Weissleder R, Chen JW.Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase.Radiology. 2012 Jan;262(1):181-90.
  • Zhang W, Fulci G, Buhrman JS, Stemmer-Rachamimov AO, Chen JW, Wojtkiewicz GR, Weissleder R, Rabkin SD, Martuza RL.Bevacizumab With Angiostatin-armed oHSV Increases Antiangiogenesis and Decreases Bevacizumab-induced Invasion in U87 Glioma.Mol Ther. 2011 Sep 13.
  • Kleijn A, Chen JW, Buhrman JS, Wojtkiewicz GR, Iwamoto Y, Lamfers ML, Stemmer-Rachamimov AO, Rabkin SD, Weissleder R, Martuza RL, Fulci G.Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging.Clin Cancer Res. 2011 Jul 1;17(13):4484-93.
  • Niers JM, Chen JW, Weissleder R, Tannous BA.Enhanced in vivo imaging of metabolically biotinylated cell surface reporters.Anal Chem. 2011 Feb 1;83(3):994-9.
  • Swirski FK, Wildgruber M, Ueno T, Figueiredo JL, Panizzi P, Iwamoto Y, Zhang E, Stone JR, Rodriguez E, Chen JW, Pittet MJ, Weissleder R, Nahrendorf M.Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice.J Clin Invest. 2010 Jul 1;120(7):2627-34.
  • Rodríguez E, Nilges M, Weissleder R, Chen JW.Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity.J Am Chem Soc. 2010 Jan 13;132(1):168-77.
  • Ronald JA, Chen JW, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, Rutt BK.Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques.Circulation. 2009 Aug 18;120(7):592-9.
  • Rajendran R, Ronald JA, Ye T, Minqin R, Chen JW, Weissleder R, Rutt BK, Halliwell B, Watt F.Nuclear microscopy: a novel technique for quantitative imaging of gadolinium distribution within tissue sections.Microsc. Microanal. 2009 Aug;15(4):338-44.
  • Zhu H,Acquaviva J,Ramachandran P,Boskovitz A,Woolfenden S,Pfannl R,Bronson RT,Chen JW,Weissleder R,Housman DE,Charest A.Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2712-6.
  • McCann CM,Waterman P,Figueiredo JL,Aikawa E,Weissleder R,Chen JW.Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.Neuroimage. 2009 Apr 1;45(2):360-9.
  • Brass SD,Durand ML,Stone JH,Chen JW,Stone JR.Case records of the Massachusetts General Hospital. Case 36-2008. A 59-year-old man with chronic daily headache.N Engl J Med. 2008 Nov 20;359(21):2267-78.
  • Breckwoldt MO,Chen JW,Stangenberg L,Aikawa E,Rodriguez E,Qiu S,Moskowitz MA,Weissleder R.Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase.Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18584-9.
  • Nahrendorf M,Sosnovik D,Chen JW,Panizzi P,Figueiredo JL,Aikawa E,Libby P,Swirski FK,Weissleder R.Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury.Circulation. 2008 Mar 4;117(9):1153-60.
  • Chen JW,Breckwoldt MO,Aikawa E,Chiang G,Weissleder R.Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.Brain. 2008 Apr;131(Pt 4):1123-33.
  • Chen JW, Querol Sans M, Bogdanov A, Weissleder R.Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates.Radiology. 2006 Aug;240(2):473-81.
  • Querol M, Chen JW, Bogdanov AA.A paramagnetic contrast agent with myeloperoxidase-sensing properties.Org Biomol Chem. 2006 May 21;4(10):1887-95.
  • Tannous BA, Grimm J, Perry KF, Chen JW, Weissleder R, Breakefield XO.Metabolic biotinylation of cell surface receptors for in vivo imaging.Nat Methods. 2006 May;3(5):391-6.
  • Chen JW, Wasserman BA.Vulnerable plaque imaging.Neuroimaging Clin N Am. 2005 Aug;15(3):609-21, xi.
  • Querol Sans M, Chen JW, Weissleder R, Bogdanov AA.Myeloperoxidase activity imaging using (67)Ga labeled substrate.Mol Imaging Biol. 2005 Nov-Dec;7(6):403-10.
  • Querol M, Chen JW, Weissleder R, Bogdanov A.DTPA-bisamide-based MR sensor agents for peroxidase imaging.Org Lett. 2005 Apr 28;7(9):1719-22.
  • Chen JW, Pham W, Weissleder R, Bogdanov A.Human myeloperoxidase: a potential target for molecular MR imaging in atherosclerosis.Magn Reson Med. 2004 Nov;52(5):1021-8.