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Nicholas J. Dyson, PhD


  • Manning AL, Yazinski SA, Nicolay B, Bryll A, Zou L, Dyson NJ.Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion.Mol Cell. 2014 Mar 20;53(6):993-1004.
  • Evertts AG, Manning AL, Wang X, Dyson NJ, Garcia BA, Coller HA.H4K20 methylation regulates quiescence and chromatin compaction.Mol Biol Cell. 2013 Oct;24(19):3025-37.
  • Black JC, Manning AL, Van Rechem C, Kim J, Ladd B, Cho J, Pineda CM, Murphy N, Daniels DL, Montagna C, Lewis PW, Glass K, Allis CD, Dyson NJ, Getz G, Whetstine JR.KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors.Cell. 2013 Aug 1;154(3):541-55.
  • Nicolay BN, Gameiro PA, Tschöp K, Korenjak M, Heilmann AM, Asara JM, Stephanopoulos G, Iliopoulos O, Dyson NJ.Loss of RBF1 changes glutamine catabolism.Genes Dev. 2013 Jan 15;27(2):182-96.
  • Ji JY, Miles WO, Korenjak M, Zheng Y, Dyson NJ.In vivo regulation of E2F1 by Polycomb group genes in Drosophila.G3 (Bethesda, Md.). 2012 Dec;2(12):1651-60.
  • Herr A, Longworth M, Ji JY, Korenjak M, Macalpine DM, Dyson NJ.Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation.Dev Dyn. 2012 Nov;241(11):1695-707.
  • Korenjak M, Anderssen E, Ramaswamy S, Whetstine JR, Dyson NJ.RBF Binding to both Canonical E2F Targets and Noncanonical Targets Depends on Functional dE2F/dDP Complexes.Mol Cell Biol. 2012 Nov;32(21):4375-87.
  • Nicolay BN, Dyson NJ.It's all in the timing: too much E2F is a bad thing.PLoS Genet. 2012 Aug;8(8):e1002909.
  • Heilmann AM, Dyson NJ.Phosphorylation puts the pRb tumor suppressor into shape.Genes Dev. 2012 Jun 1;26(11):1128-30.
  • Di Stefano L, Walker JA, Burgio G, Corona DF, Mulligan P, Näär AM, Dyson NJ.Functional antagonism between histone H3K4 demethylases in vivo.Genes Dev. 2011 Jan 1;25(1):17-28.
  • Black JC, Allen A, Van Rechem C, Forbes E, Longworth M, Tschöp K, Rinehart C, Quiton J, Walsh R, Smallwood A, Dyson NJ, Whetstine JR.Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression.Mol Cell. 2010 Dec 10;40(5):736-48.
  • Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L.CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.Mol Cell. 2010 Oct 8;40(1):22-33.
  • Manning AL, Longworth MS, Dyson NJ.Loss of pRB causes centromere dysfunction and chromosomal instability.Genes Dev. 2010 Jul 1;24(13):1364-76.
  • Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM.Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.Genes Dev. 2010 Jul 1;24(13):1403-17.
  • Longworth MS, Dyson NJ.pRb, a local chromatin organizer with global possibilities.Chromosoma. 2010 Feb;119(1):1-11. Review.
  • Zhang J, Ji JY, Yu M, Overholtzer M, Smolen GA, Wang R, Brugge JS, Dyson NJ, Haber DA.YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway.Nat Cell Biol. 2009 Dec;11(12):1444-50.
  • Morris EJ,Ji JY,Yang F,Di Stefano L,Herr A,Moon NS,Kwon EJ,Haigis KM,Naar AM,Dyson NJ.E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8.Nature. 2008 Sep 25;455(7212):552-6.
  • van den Heuvel S,Dyson NJ.Conserved functions of the pRB and E2F families.Nat Rev Mol Cell Biol. 2008 Sep;9(9):713-24. Review.
  • Moon NS,Di Stefano L,Morris EJ,Patel R,White K,Dyson NJ.E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage.PLoS Genet. 2008;4(8):e1000153.
  • Wu X, Yamada-Mabuchi M, Morris EJ, Tanwar PS, Dobens L, Gluderer S, Khan S, Cao J, Stocker H, Hafen E, Dyson NJ, Raftery LA.The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival.Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5414-9.
  • Longworth MS, Herr A, Ji JY, Dyson NJ.RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3.Genes Dev. 2008 Apr 15;22(8):1011-24.
  • Moon NS, Dyson N.E2F7 and E2F8 keep the E2F family in balance.Dev Cell. 2008 Jan;14(1):1-3.
  • Isaac CE, Francis SM, Martens AL, Julian LM, Seifried LA, Erdmann N, Binn UK, Harrington L, Sicinski P, Brub NG, Dyson NJ, Dick FA.The retinoblastoma protein regulates pericentric heterochromatin.Mol Cell Biol. 2006 May;26(9):3659-71.
  • Moon NS, Frolov MV, Kwon EJ, Di Stefano L, Dimova DK, Morris EJ, Taylor-Harding B, White K, Dyson NJ.Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development.Dev Cell. 2005 Oct;9(4):463-75.
  • Stevaux O, Dimova DK, Ji JY, Moon NS, Frolov MV, Dyson NJ.Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes.Cell Cycle. 2005 Sep;4(9):1272-80.
  • Frolov MV, Moon NS, Dyson NJ.dDP is needed for normal cell proliferation.Mol Cell Biol. 2005 Apr;25(8):3027-39.
  • Korenjak M, Taylor-Harding B, Binn UK, Satterlee JS, Stevaux O, Aasland R, White-Cooper H, Dyson N, Brehm A.Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes.Cell. 2004 Oct 15;119(2):181-93.
  • Taylor-Harding B, Binn UK, Korenjak M, Brehm A, Dyson NJ.p55, the Drosophila ortholog of RbAp46/RbAp48, is required for the repression of dE2F2/RBF-regulated genes.Mol Cell Biol. 2004 Oct;24(20):9124-36.
  • Dick FA, Dyson N.pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities.Mol Cell. 2003 Sep;12(3):639-49.
  • Dimova DK, Stevaux O, Frolov MV, Dyson NJ.Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway.Genes Dev. 2003 Sep 15;17(18):2308-20.
  • Chakravarti A, Noll E, Black PM, Finkelstein DF, Finkelstein DM, Dyson NJ, Loeffler JS.Quantitatively determined survivin expression levels are of prognostic value in human gliomas.J Clin Oncol. 2002 Feb 15;20(4):1063-8.
  • Chakravarti A, Loeffler JS, Dyson NJ.Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling.Cancer Res. 2002 Jan 1;62(1):200-7.
  • Boulton SJ, Gartner A, Reboul J, Vaglio P, Dyson N, Hill DE, Vidal M.Combined functional genomic maps of the C. elegans DNA damage response.Science. 2002 Jan 4;295(5552):127-31.
  • Geng Y, Yu Q, Whoriskey W, Dick F, Tsai KY, Ford HL, Biswas DK, Pardee AB, Amati B, Jacks T, Richardson A, Dyson N, Sicinski P.Expression of cyclins E1 and E2 during mouse development and in neoplasia.Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13138-43.
  • Frolov MV, Huen DS, Stevaux O, Dimova D, Balczarek-Strang K, Elsdon M, Dyson NJ.Functional antagonism between E2F family members.Genes Dev. 2001 Aug 15;15(16):2146-60.
  • Chakravarti A, Delaney MA, Noll E, Black PM, Loeffler JS, Muzikansky A, Dyson NJ.Prognostic and pathologic significance of quantitative protein expression profiling in human gliomas.Clin Cancer Res. 2001 Aug;7(8):2387-95.
  • Kennedy BK, Liu OW, Dick FA, Dyson N, Harlow E, Vidal M.Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft.Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8720-5.
  • Dick FA, Sailhamer E, Dyson NJ.Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins.Mol Cell Biol. 2000 May;20(10):3715-27.
  • McCaffrey J, Yamasaki L, Dyson NJ, Harlow E, Griep AE.Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1.Mol Cell Biol. 1999 Sep;19(9):6458-68.
  • Pan H, Yin C, Dyson NJ, Harlow E, Yamasaki L, Van Dyke T.Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors.Mol Cell. 1998 Sep;2(3):283-92.
  • Dyson N.The regulation of E2F by pRB-family proteins.Genes Dev. 1998 Aug 1;12(15):2245-62.
  • Hurford RK, Cobrinik D, Lee MH, Dyson N.pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.Genes Dev. 1997 Jun 1;11(11):1447-63.
  • Zukerberg LR, Benedict WF, Arnold A, Dyson N, Harlow E, Harris NL.Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1.Blood. 1996 Jul 1;88(1):268-76.
  • Yamasaki L, Jacks T, Bronson R, Goillot E, Harlow E, Dyson NJ.Tumor induction and tissue atrophy in mice lacking E2F-1.Cell. 1996 May 17;85(4):537-48.
  • Du W, Vidal M, Xie JE, Dyson N.RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila.Genes Dev. 1996 May 15;10(10):1206-18.
  • Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K.The retinoblastoma protein binds to a family of E2F transcription factors.Mol Cell Biol. 1993 Dec;13(12):7813-25.
  • Dyson N, Guida P, Mnger K, Harlow E.Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins.J Virol. 1992 Dec;66(12):6893-902.
  • Helin K, Lees JA, Vidal M, Dyson N, Harlow E, Fattaey A.A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F.Cell. 1992 Jul 24;70(2):337-50.
  • Cao L, Faha B, Dembski M, Tsai LH, Harlow E, Dyson N.Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F.Nature. 1992 Jan 9;355(6356):176-9.
  • Mnger K, Werness BA, Dyson N, Phelps WC, Harlow E, Howley PM.Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.EMBO J. 1989 Dec 20;8(13):4099-105.
  • Dyson NJ, Brown TA, Ray JA, Waring RB, Scazzocchio C, Davies RW.Processing of mitochondrial RNA in Aspergillus nidulans.J Mol Biol. 1989 Aug 20;208(4):587-99.
  • Dyson N, Howley PM, Mnger K, Harlow E.The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product.Science. 1989 Feb 17;243(4893):934-7.
  • Dyson NJ, Brown TA, Waring RB, Davies RW.The mitochondrial ribosomal RNA molecules of Aspergillus nidulans.Gene. 1989 Jan 30;75(1):109-18.