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Laurie H. Glimcher, MD


  • Glimcher LH, Martinon F, Modlin RL.Editorial overview.Curr Opin Immunol. 2011 Feb;23(1):1-2.
  • Martinon F, Glimcher LH.Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum.Curr Opin Immunol. 2011 Feb;23(1):35-40. Review.
  • Hetz C, Glimcher LH.Protein homeostasis networks in physiology and disease.Curr Opin Cell Biol. 2011 Feb 7.
  • Zou W, Chen X, Shim JH, Huang Z, Brady N, Hu D, Drapp R, Sigrist K, Glimcher LH, Jones D.The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid.Nat Cell Biol. 2011 Jan;13(1):59-65.
  • Lazarevic V, Chen X, Shim JH, Hwang ES, Jang E, Bolm AN, Oukka M, Kuchroo VK, Glimcher LH.T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORĪ³t.Nat Immunol. 2011 Jan;12(1):96-104.
  • Huh WJ, Esen E, Geahlen JH, Bredemeyer AJ, Lee AH, Shi G, Konieczny SF, Glimcher LH, Mills JC.XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic Reticulum.Gastroenterology. 2010 Dec;139(6):2038-49.
  • Collins PL, Chang S, Henderson M, Soutto M, Davis GM, McLoed AG, Townsend MJ, Glimcher LH, Mortlock DP, Aune TM.Distal regions of the human IFNG locus direct cell type-specific expression.J Immunol. 2010 Aug 1;185(3):1492-501.
  • Greenblatt MB, Shim JH, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R, Park JM, Arthur S, Xie M, Schneider MD, Zhai B, Gygi S, Davis R, Glimcher LH.The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice.J Clin Invest. 2010 Jul 1;120(7):2457-73.
  • Martinon F, Chen X, Lee AH, Glimcher LH.TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.Nat Immunol. 2010 May;11(5):411-8.
  • Garrett WS, Gordon JI, Glimcher LH.Homeostasis and Inflammation in the Intestine.Cell. 2010 Mar 19;140(6):859-870. Review.
  • Anderson AC, Lord GM, Dardalhon V, Lee DH, Sabatos-Peyton CA, Glimcher LH, Kuchroo VK.T-bet, a Th1 transcription factor regulates the expression of Tim-3.Eur J Immunol. 2010 Mar;40(3):859-66.
  • Fathman JW, Gurish MF, Hemmers S, Bonham K, Friend DS, Grusby MJ, Glimcher LH, Mowen KA.NIP45 controls the magnitude of the type 2 T helper cell response.Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3663-8.
  • Riol-Blanco L, Lazarevic V, Awasthi A, Mitsdoerffer M, Wilson BS, Croxford A, Waisman A, Kuchroo VK, Glimcher LH, Oukka M.IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections.J Immunol. 2010 Feb 15;184(4):1710-20.
  • Glimcher LH.Reflections on health care.J Clin Invest. 2009 Oct;119(10):2858-9.
  • Matus S, Nassif M, Glimcher LH, Hetz C.XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy.Autophagy. 2009 Nov;5(8):1226-8.
  • Aliprantis AO, Glimcher LH.NFATc1 in Inflammatory and Musculoskeletal Conditions.Adv Exp Med Biol. 2010;658:69-75.
  • Jones DC, Glimcher LH.Regulation of bone formation and immune cell development by schnurri proteins.Adv Exp Med Biol. 2010;658:117-22.
  • Jenner RG, Townsend MJ, Jackson I, Sun K, Bouwman RD, Young RA, Glimcher LH, Lord GM.The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes.Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17876-81.
  • Todd DJ, McHeyzer-Williams LJ, Kowal C, Lee AH, Volpe BT, Diamond B, McHeyzer-Williams MG, Glimcher LH.XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development.J Exp Med. 2009 Sep 28;206(10):2151-9.
  • Hetz C, Thielen P, Matus S, Nassif M, Court F, Kiffin R, Martinez G, Cuervo AM, Brown RH, Glimcher LH.XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy.Genes Dev. 2009 Oct 1;23(19):2294-306.
  • Garrett WS, Glimcher LH.T-bet-/- RAG2-/- ulcerative colitis: the role of T-bet as a peacekeeper of host-commensal relationships.Cytokine.;48(1-2):144-7. Review.
  • Glimcher LH, Lee AH.From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis.Ann N Y Acad Sci. 2009 Sep;1173 Suppl 1:E2-9. Review.
  • Hetz C, Glimcher LH.Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome.Mol Cell. 2009 Sep 11;35(5):551-61. Review.
  • Garrett WS, Punit S, Gallini CA, Michaud M, Zhang D, Sigrist KS, Lord GM, Glickman JN, Glimcher LH.Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells.Cancer Cell. 2009 Sep 8;16(3):208-19.
  • Shim JH, Greenblatt MB, Xie M, Schneider MD, Zou W, Zhai B, Gygi S, Glimcher LH.TAK1 is an essential regulator of BMP signalling in cartilage.EMBO J. 2009 Jul 22;28(14):2028-41.
  • Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, Glimcher LH, Sayegh MH.Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10734-9.
  • Esensten JH, Lee MR, Glimcher LH, Bluestone JA.T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function.J Immunol. 2009 Jul 1;183(1):75-82.
  • Maldonado RA,Soriano MA,Perdomo LC,Sigrist K,Irvine DJ,Decker T,Glimcher LH.Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse.J Exp Med. 2009 Apr 13;206(4):877-92.
  • Lisbona F,Rojas-Rivera D,Thielen P,Zamorano S,Todd D,Martinon F,Glavic A,Kress C,Lin JH,Walter P,Reed JC,Glimcher LH,Hetz C.BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha.Mol Cell. 2009 Mar 27;33(6):679-91.
  • Lazarevic V,Zullo AJ,Schweitzer MN,Staton TL,Gallo EM,Crabtree GR,Glimcher LH.The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells.Nat Immunol. 2009 Mar;10(3):306-13.
  • Park JW,Min HJ,Sohn JH,Kim JY,Hong JH,Sigrist KS,Glimcher LH,Hwang ES.Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma.J Allergy Clin Immunol. 2009 Feb;123(2):479-85.
  • Yuan X,Paez-Cortez J,Schmitt-Knosalla I,D'Addio F,Mfarrej B,Donnarumma M,Habicht A,Clarkson MR,Iacomini J,Glimcher LH,Sayegh MH,Ansari MJ.A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy.J Exp Med. 2008 Dec 22;205(13):3133-44.
  • Wu J,Glimcher LH,Aliprantis AO.HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function.Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16934-9.
  • Aliprantis AO,Ueki Y,Sulyanto R,Park A,Sigrist KS,Sharma SM,Ostrowski MC,Olsen BR,Glimcher LH.NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism.J Clin Invest. 2008 Nov;118(11):3775-89.
  • Kaser A,Lee AH,Franke A,Glickman JN,Zeissig S,Tilg H,Nieuwenhuis EE,Higgins DE,Schreiber S,Glimcher LH,Blumberg RS.XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease.Cell. 2008 Sep 5;134(5):743-56.
  • Todd DJ,Lee AH,Glimcher LH.The endoplasmic reticulum stress response in immunity and autoimmunity.Nat Rev Immunol. 2008 Sep;8(9):663-74. Review.
  • Werneck MB,Lugo-Villarino G,Hwang ES,Cantor H,Glimcher LH.T-bet plays a key role in NK-mediated control of melanoma metastatic disease.J Immunol. 2008 Jun 15;180(12):8004-10.
  • Tzianabos AO,Holsti MA,Zheng XX,Stucchi AF,Kuchroo VK,Strom TB,Glimcher LH,Cruikshank WW.Functional Th1 cells are required for surgical adhesion formation in a murine model.J Immunol. 2008 May 15;180(10):6970-6.
  • Mukherjee S, Raje N, Schoonmaker JA, Liu JC, Hideshima T, Wein MN, Jones DC, Vallet S, Bouxsein ML, Pozzi S, Chhetri S, Seo YD, Aronson JP, Patel C, Fulciniti M, Purton LE, Glimcher LH, Lian JB, Stein G, Anderson KC, Scadden DT.Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice.J Clin Invest. 2008 Feb;118(2):491-504.
  • Erlebacher A, Vencato D, Price KA, Zhang D, Glimcher LH.Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus.J Clin Invest. 2007 May;117(5):1399-411.
  • Aliprantis AO, Wang J, Fathman JW, Lemaire R, Dorfman DM, Lafyatis R, Glimcher LH.Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13.Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2827-30.
  • Alcaide P, Jones TG, Lord GM, Glimcher LH, Hallgren J, Arinobu Y, Akashi K, Paterson AM, Gurish MA, Luscinskas FW.Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue.J Exp Med. 2007 Feb 19;204(2):431-9.
  • Taqueti VR, Grabie N, Colvin R, Pang H, Jarolim P, Luster AD, Glimcher LH, Lichtman AH.T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity.J Immunol. 2006 Nov 1;177(9):5890-901.
  • Rosas LE, Snider HM, Barbi J, Satoskar AA, Lugo-Villarino G, Keiser T, Papenfuss T, Durbin JE, Radzioch D, Glimcher LH, Satoskar AR.Cutting Edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani.J Immunol. 2006 Jul 1;177(1):22-5.
  • Jones DC, Wein MN, Oukka M, Hofstaetter JG, Glimcher MJ, Glimcher LH.Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3.Science. 2006 May 26;312(5777):1223-7.
  • Hetz C, Bernasconi P, Fisher J, Lee AH, Bassik MC, Antonsson B, Brandt GS, Iwakoshi NN, Schinzel A, Glimcher LH, Korsmeyer SJ.Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha.Science. 2006 Apr 28;312(5773):572-6.
  • Shinohara ML, Lu L, Bu J, Werneck MB, Kobayashi KS, Glimcher LH, Cantor H.Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells.Nat Immunol. 2006 May;7(5):498-506.
  • Wang J, Fathman JW, Lugo-Villarino G, Scimone L, von Andrian U, Dorfman DM, Glimcher LH.Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells.J Clin Invest. 2006 Feb;116(2):414-21.
  • Shinohara ML, Jansson M, Hwang ES, Werneck MB, Glimcher LH, Cantor H.T-bet-dependent expression of osteopontin contributes to T cell polarization.Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17101-6.
  • Sullivan BM, Jobe O, Lazarevic V, Vasquez K, Bronson R, Glimcher LH, Kramnik I.Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production.J Immunol. 2005 Oct 1;175(7):4593-602.
  • Dorfman DM, Hwang ES, Shahsafaei A, Glimcher LH.T-bet, a T cell-associated transcription factor, is expressed in Hodgkin's lymphoma.Hum Pathol. 2005 Jan;36(1):10-5.
  • Tirosh B, Iwakoshi NN, Lilley BN, Lee AH, Glimcher LH, Ploegh HL.Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products.J Virol. 2005 Mar;79(5):2768-79.
  • Buono C, Binder CJ, Stavrakis G, Witztum JL, Glimcher LH, Lichtman AH.T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses.Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1596-601.
  • Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH.T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.Science. 2005 Jan 21;307(5708):430-3.
  • Peng SL, Townsend MJ, Hecht JL, White IA, Glimcher LH.T-bet regulates metastasis rate in a murine model of primary prostate cancer.Cancer Res. 2004 Jan 15;64(2):452-5.
  • Lee AH, Iwakoshi NN, Glimcher LH.XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response.Mol Cell Biol. 2003 Nov;23(21):7448-59.
  • Lee AH, Iwakoshi NN, Anderson KC, Glimcher LH.Proteasome inhibitors disrupt the unfolded protein response in myeloma cells.Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9946-51.
  • Iwakoshi NN, Lee AH, Vallabhajosyula P, Otipoby KL, Rajewsky K, Glimcher LH.Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.Nat Immunol. 2003 Apr;4(4):321-9.
  • Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH.A novel transcription factor, T-bet, directs Th1 lineage commitment.Cell. 2000 Mar 17;100(6):655-69.
  • Ranger AM, Oukka M, Rengarajan J, Glimcher LH.Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.Immunity. 1998 Nov;9(5):627-35.
  • Ho IC, Hodge MR, Rooney JW, Glimcher LH.The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.Cell. 1996 Jun 28;85(7):973-83.
  • Crump AL, Grusby MJ, Glimcher LH, Cantor H.Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10739-43.