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Gordon J. Freeman, PhD

Publications

  • Duraiswamy J, Kaluza KM, Freeman GJ, Coukos G.Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors.Cancer Res. 2013 Jun 15;73(12):3591-603.
    23633484
  • Wei F, Zhong S, Ma Z, Kong H, Medvec A, Ahmed R, Freeman GJ, Krogsgaard M, Riley JL.Strength of PD-1 signaling differentially affects T-cell effector functions.Proc Natl Acad Sci U S A. 2013 Apr 22.
    23610399
  • D'Addio F, Ueno T, Clarkson M, Zhu B, Vergani A, Freeman GJ, Sayegh MH, Ansari MJ, Fiorina P, Habicht A.CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft Survival.PLoS ONE. 2013;8(4):e60391.
    23593209
  • Chou CK, Schietinger A, Liggitt HD, Tan X, Funk S, Freeman GJ, Ratliff TL, Greenberg NM, Greenberg PD.Cell-Intrinsic Abrogation of TGF-β Signaling Delays but Does Not Prevent Dysfunction of Self/Tumor-Specific CD8 T Cells in a Murine Model of Autochthonous Prostate Cancer.J Immunol. 2012 Oct 15;189(8):3936-46.
    22984076
  • Naito M, Hainz U, Burkhardt UE, Fu B, Ahove D, Stevenson KE, Rajasagi M, Zhu B, Alonso A, Witten E, Matsuoka KI, Neuberg D, Duke-Cohan JS, Wu CJ, Freeman GJ.CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells.Cancer Immunol Immunother. 2012 Aug 25.
    22926059
  • Bu DX, Tarrio M, Maganto-Garcia E, Stavrakis G, Tajima G, Lederer J, Jarolim P, Freeman GJ, Sharpe AH, Lichtman AH.Impairment of the Programmed Cell Death-1 Pathway Increases Atherosclerotic Lesion Development and Inflammation.Arterioscler Thromb Vasc Biol. 2011 Mar 10.
    21393583
  • Allen SJ, Hamrah P, Gate DM, Mott KR, Mantopoulos D, Zheng L, Town T, Jones C, von Andrian UH, Freeman GJ, Sharpe AH, Benmohamed L, Ahmed R, Wechsler SL, Ghiasi H.The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus type 1.J Virol. 2011 Feb 9.
    21307196
  • Albacker LA, Karisola P, Chang YJ, Umetsu SE, Zhou M, Akbari O, Kobayashi N, Baumgarth N, Freeman GJ, Umetsu DT, DeKruyff RH.TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells.J Immunol. 2010 Dec 1;185(11):6839-49.
    21037090
  • Flutter B, Edwards N, Fallah-Arani F, Henderson S, Chai JG, Sivakumaran S, Ghorashian S, Bennett CL, Freeman GJ, Sykes M, Chakraverty R.Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.J Clin Invest. 2010 Nov 1;120(11):3855-68.
    20978352
  • Dorfman DM, Hornick JL, Shahsafaei A, Freeman GJ.The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms.Hum Pathol. 2010 Oct;41(10):1486-94.
    20656318
  • Peña-Cruz V, McDonough SM, Diaz-Griffero F, Crum CP, Carrasco RD, Freeman GJ.PD-1 on Immature and PD-1 Ligands on Migratory Human Langerhans Cells Regulate Antigen-Presenting Cell Activity.J Invest Dermatol. 2010 Sep;130(9):2222-30.
    20445553
  • El Annan J, Goyal S, Zhang Q, Freeman GJ, Sharpe AH, Dana R.Regulation of T-cell chemotaxis by programmed death-ligand 1 (PD-L1) in dry eye-associated corneal inflammation.Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3418-23.
    20019373
  • Brown KE, Freeman GJ, Wherry EJ, Sharpe AH.Role of PD-1 in regulating acute infections.Curr Opin Immunol. 2010 Jun;22(3):397-401. Review.
    20427170
  • Freeman GJ, Casasnovas JM, Umetsu DT, DeKruyff RH.TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.Immunol Rev. 2010 May;235(1):172-89. Review.
    20536563
  • DeKruyff RH, Bu X, Ballesteros A, Santiago C, Chim YL, Lee HH, Karisola P, Pichavant M, Kaplan GG, Umetsu DT, Freeman GJ, Casasnovas JM.T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells.J Immunol. 2010 Feb 15;184(4):1918-30.
    20083673
  • Blackburn SD, Crawford A, Shin H, Polley A, Freeman GJ, Wherry EJ.Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion.J Virol. 2010 Feb;84(4):2078-89.
    19955307
  • Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH.PD-L1 regulates the development, maintenance, and function of induced regulatory T cells.J Exp Med. 2009 Dec 21;206(13):3015-29.
    20008522
  • Currie AJ, Prosser A, McDonnell A, Cleaver AL, Robinson BW, Freeman GJ, van der Most RG.Dual control of antitumor CD8 T cells through the programmed death-1/programmed death-ligand 1 pathway and immunosuppressive CD4 T cells: regulation and counterregulation.J Immunol. 2009 Dec 15;183(12):7898-908.
    20007574
  • Chen L,Sham CW,Chan AM,Francisco LM,Wu Y,Mareninov S,Sharpe AH,Freeman G,Yang XJ,Braun J,Gordon LK.Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells.Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4941-8.
    19420345
  • Sauce D, Larsen M, Abbott RJ, Hislop AD, Leese AM, Khan N, Papagno L, Freeman GJ, Rickinson AB.Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infection.J Virol. 2009 Sep;83(18):9068-78.
    19605492
  • Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, Glimcher LH, Sayegh MH.Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10734-9.
    19528638
  • Brainard DM,Seung E,Frahm N,Cariappa A,Bailey CC,Hart WK,Shin HS,Brooks SF,Knight HL,Eichbaum Q,Yang YG,Sykes M,Walker BD,Freeman GJ,Pillai S,Westmoreland SV,Brander C,Luster AD,Tager AM.Induction of robust cellular and humoral virus-specific adaptive immune responses in HIV-infected humanized BLT mice.J Virol. 2009 Jul;83(14):7305-21.
    19420076
  • Cai G,Freeman GJ.The CD160, BTLA, LIGHT/HVEM pathway: a bidirectional switch regulating T-cell activation.Immunol Rev. 2009 May;229(1):244-58. Review.
    19426226
  • Chen L,Pai V,Levinson R,Sharpe AH,Freeman GJ,Braun J,Gordon LK.Constitutive neuronal expression of the immune regulator, programmed death 1 (PD-1), identified during experimental autoimmune uveitis.Ocul Immunol Inflamm. 2009 Jan-Feb;17(1):47-55.
    19294574
  • Nakamoto N,Cho H,Shaked A,Olthoff K,Valiga ME,Kaminski M,Gostick E,Price DA,Freeman GJ,Wherry EJ,Chang KM.Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade.PLoS Pathog. 2009 Feb;5(2):e1000313.
    19247441
  • Reynoso ED,Elpek KG,Francisco L,Bronson R,Bellemare-Pelletier A,Sharpe AH,Freeman GJ,Turley SJ.Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade.J Immunol. 2009 Feb 15;182(4):2102-12.
    19201863
  • Brooks DG,Ha SJ,Elsaesser H,Sharpe AH,Freeman GJ,Oldstone MB.IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection.Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20428-33.
    19075244
  • Velu V,Titanji K,Zhu B,Husain S,Pladevega A,Lai L,Vanderford TH,Chennareddi L,Silvestri G,Freeman GJ,Ahmed R,Amara RR.Enhancing SIV-specific immunity in vivo by PD-1 blockade.Nature. 2009 Mar 12;458(7235):206-10.
    19078956
  • Blackburn SD,Shin H,Haining WN,Zou T,Workman CJ,Polley A,Betts MR,Freeman GJ,Vignali DA,Wherry EJ.Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.Nat Immunol. 2009 Jan;10(1):29-37.
    19043418
  • Zahn RC,Rett MD,Korioth-Schmitz B,Sun Y,Buzby AP,Goldstein S,Brown CR,Byrum RA,Freeman GJ,Letvin NL,Hirsch VM,Schmitz JE.Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm.J Virol. 2008 Dec;82(23):11577-88.
    18829748
  • Blackburn SD,Shin H,Freeman GJ,Wherry EJ.Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade.Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15016-21.
    18809920
  • Lichterfeld M,Mou D,Cung TD,Williams KL,Waring MT,Huang J,Pereyra F,Trocha A,Freeman GJ,Rosenberg ES,Walker BD,Yu XG.Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors.Blood. 2008 Nov 1;112(9):3679-87.
    18728248
  • Radziewicz H,Ibegbu CC,Hon H,Osborn MK,Obideen K,Wehbi M,Freeman GJ,Lennox JL,Workowski KA,Hanson HL,Grakoui A.Impaired hepatitis C virus (HCV)-specific effector CD8+ T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection.J Virol. 2008 Oct;82(20):9808-22.
    18667503
  • Freeman GJ.Structures of PD-1 with its ligands: sideways and dancing cheek to cheek.Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10275-6.
    18650389
  • Butte MJ,Pena-Cruz V,Kim MJ,Freeman GJ,Sharpe AH.Interaction of human PD-L1 and B7-1.Mol Immunol. 2008 Aug;45(13):3567-72.
    18585785
  • Haspot F,Fehr T,Gibbons C,Zhao G,Hogan T,Honjo T,Freeman GJ,Sykes M.Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway.Blood. 2008 Sep 1;112(5):2149-55.
    18577709
  • Nakamoto N,Kaplan DE,Coleclough J,Li Y,Valiga ME,Kaminski M,Shaked A,Olthoff K,Gostick E,Price DA,Freeman GJ,Wherry EJ,Chang KM.Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization.Gastroenterology. 2008 Jun;134(7):1927-37, 1937.e1-2.
    18549878
  • Cai G, Anumanthan A, Brown JA, Greenfield EA, Zhu B, Freeman GJ.Corrigendum: CD160 inhibits activation of human CD4(+) T cells through interaction with herpesvirus entry mediator.Nat Immunol. 2008 May;9(5):567.
    18425109
  • Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH.ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival.J Immunol. 2008 Apr 15;180(8):5448-56.
    18390727
  • Bowen DG, Shoukry NH, Grakoui A, Fuller MJ, Cawthon AG, Dong C, Hasselschwert DL, Brasky KM, Freeman GJ, Seth NP, Wucherpfennig KW, Houghton M, Walker CM.Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection.J Virol. 2008 May;82(10):5109-14.
    18337576
  • Ha SJ, Mueller SN, Wherry EJ, Barber DL, Aubert RD, Sharpe AH, Freeman GJ, Ahmed R.Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection.J Exp Med. 2008 Mar 17;205(3):543-55.
    18332181
  • Lazar-Molnar E, Gacser A, Freeman GJ, Almo SC, Nathenson SG, Nosanchuk JD.The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum.Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2658-63.
    18268348
  • Cai G, Anumanthan A, Brown JA, Greenfield EA, Zhu B, Freeman GJ.CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator.Nat Immunol. 2008 Feb;9(2):176-85.
    18193050
  • Keir ME, Butte MJ, Freeman GJ, Sharpe AH.PD-1 and Its Ligands in Tolerance and Immunity.Annu Rev Immunol. 2008 Apr;26:677-704. Review.
    18173375
  • Kobayashi N, Karisola P, Pea-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, Umetsu DT, Dekruyff RH, Freeman GJ.TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells.Immunity. 2007 Dec;27(6):927-40.
    18082433
  • Keir ME, Freeman GJ, Sharpe AH.PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues.J Immunol. 2007 Oct 15;179(8):5064-70.
    17911591
  • Kaufmann DE, Kavanagh DG, Pereyra F, Zaunders JJ, Mackey EW, Miura T, Palmer S, Brockman M, Rathod A, Piechocka-Trocha A, Baker B, Zhu B, Le Gall S, Waring MT, Ahern R, Moss K, Kelleher AD, Coffin JM, Freeman GJ, Rosenberg ES, Walker BD.Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.Nat Immunol. 2007 Nov;8(11):1246-54.
    17906628
  • Ansari MJ, Fiorina P, Dada S, Guleria I, Ueno T, Yuan X, Trikudanathan S, Smith RN, Freeman G, Sayegh MH.Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice.Clin Immunol. 2008 Feb;126(2):140-7.
    17889619
  • Sauce D, Almeida JR, Larsen M, Haro L, Autran B, Freeman GJ, Appay V.PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status.AIDS. 2007 Oct 1;21(15):2005-13.
    17885290
  • Mueller SN, Matloubian M, Clemens DM, Sharpe AH, Freeman GJ, Gangappa S, Larsen CP, Ahmed R.Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection.Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15430-5.
    17878315
  • Shen L, Jin Y, Freeman GJ, Sharpe AH, Dana MR.The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival.J Immunol. 2007 Sep 15;179(6):3672-9.
    17785803
  • Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ.Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.Immunity. 2007 Jul;27(1):111-22.
    17629517
  • Izawa A, Yamaura K, Albin MJ, Jurewicz M, Tanaka K, Clarkson MR, Ueno T, Habicht A, Freeman GJ, Yagita H, Abdi R, Pearson T, Greiner DL, Sayegh MH, Najafian N.A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo.J Immunol. 2007 Jul 15;179(2):786-96.
    17617568
  • Velu V, Kannanganat S, Ibegbu C, Chennareddi L, Villinger F, Freeman GJ, Ahmed R, Amara RR.Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination.J Virol. 2007 Jun;81(11):5819-28.
    17376899
  • Dorfman DM, Brown JA, Shahsafaei A, Freeman GJ.Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma.Am J Surg Pathol. 2006 Jul;30(7):802-10.
    16819321
  • Keir ME, Liang SC, Guleria I, Latchman YE, Qipo A, Albacker LA, Koulmanda M, Freeman GJ, Sayegh MH, Sharpe AH.Tissue expression of PD-L1 mediates peripheral T cell tolerance.J Exp Med. 2006 Apr 17;203(4):883-95.
    16606670
  • Qian X, Agematsu K, Freeman GJ, Tagawa Y, Sugane K, Hayashi T.The ICOS-ligand B7-H2, expressed on human type II alveolar epithelial cells, plays a role in the pulmonary host defense system.Eur J Immunol. 2006 Apr;36(4):906-18.
    16552709
  • Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, Freeman GJ, Ahmed R.Restoring function in exhausted CD8 T cells during chronic viral infection.Nature. 2006 Feb 9;439(7077):682-7.
    16382236
  • Liang SC, Greenwald RJ, Latchman YE, Rosas L, Satoskar A, Freeman GJ, Sharpe AH.PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis.Eur J Immunol. 2006 Jan;36(1):58-64.
    16358363
  • Hirano N, Butler MO, Xia Z, Ansn S, von Bergwelt-Baildon MS, Neuberg D, Freeman GJ, Nadler LM.Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity.Blood. 2006 Feb 15;107(4):1528-36.
    16239433
  • Taylor PA, Panoskaltsis-Mortari A, Freeman GJ, Sharpe AH, Noelle RJ, Rudensky AY, Mak TW, Serody JS, Blazar BR.Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM).Blood. 2005 Apr 15;105(8):3372-80.
    15618467
  • Latchman YE, Liang SC, Wu Y, Chernova T, Sobel RA, Klemm M, Kuchroo VK, Freeman GJ, Sharpe AH.PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells.Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10691-6.
    15249675
  • Herman AE, Freeman GJ, Mathis D, Benoist C.CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion.J Exp Med. 2004 Jun 7;199(11):1479-89.
    15184501
  • Vijayakrishnan L, Slavik JM, Ills Z, Greenwald RJ, Rainbow D, Greve B, Peterson LB, Hafler DA, Freeman GJ, Sharpe AH, Wicker LS, Kuchroo VK.An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells.Immunity. 2004 May;20(5):563-75.
    15142525
  • Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA.CD4+CD25+ regulatory cells from human peripheral blood express very high levels of CD25 ex vivo.Novartis Found Symp. 2003;252:67-88; discussion 88-91,.
    14609213
  • Rodig N, Ryan T, Allen JA, Pang H, Grabie N, Chernova T, Greenfield EA, Liang SC, Sharpe AH, Lichtman AH, Freeman GJ.Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis.Eur J Immunol. 2003 Nov;33(11):3117-26.
    14579280
  • Sabatos CA, Chakravarti S, Cha E, Schubart A, Snchez-Fueyo A, Zheng XX, Coyle AJ, Strom TB, Freeman GJ, Kuchroo VK.Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance.Nat Immunol. 2003 Nov;4(11):1102-10.
    14556006
  • Liang SC, Latchman YE, Buhlmann JE, Tomczak MF, Horwitz BH, Freeman GJ, Sharpe AH.Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses.Eur J Immunol. 2003 Oct;33(10):2706-16.
    14515254
  • Harada H, Salama AD, Sho M, Izawa A, Sandner SE, Ito T, Akiba H, Yagita H, Sharpe AH, Freeman GJ, Sayegh MH.The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity.J Clin Invest. 2003 Jul;112(2):234-43.
    12865411
  • Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA.The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.J Biol Chem. 2003 Jun 13;278(24):21930-7.
    12670957
  • Meyers JH, Ryu A, Monney L, Nguyen K, Greenfield EA, Freeman GJ, Kuchroo VK.Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions.J Immunol. 2002 Nov 15;169(10):5382-6.
    12421909
  • Freeman GJ, Sharpe AH, Kuchroo VK.Protect the killer: CTLs need defenses against the tumor.Nat Med. 2002 Aug;8(8):787-9.
    12152031
  • Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT.Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity.Nat Med. 2002 Sep;8(9):1024-32.
    12145647
  • Sharpe AH, Freeman GJ.The B7-CD28 superfamily.Nat Rev Immunol. 2002 Feb;2(2):116-26.
    11910893
  • Gaglia JL, Mattoo A, Greenfield EA, Freeman GJ, Kuchroo VK.Characterization of endogenous Chinese hamster ovary cell surface molecules that mediate T cell costimulation.Cell Immunol. 2001 Nov 1;213(2):83-93.
    11831870
  • Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, Manning S, Greenfield EA, Coyle AJ, Sobel RA, Freeman GJ, Kuchroo VK.Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease.Nature. 2002 Jan 31;415(6871):536-41.
    11823861
  • McIntire JJ, Umetsu SE, Akbari O, Potter M, Kuchroo VK, Barsh GS, Freeman GJ, Umetsu DT, DeKruyff RH.Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family.Nat Immunol. 2001 Dec;2(12):1109-16.
    11725301
  • Tzachanis D, Freeman GJ, Hirano N, van Puijenbroek AA, Delfs MW, Berezovskaya A, Nadler LM, Boussiotis VA.Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells.Nat Immunol. 2001 Dec;2(12):1174-82.
    11694881
  • Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA.CD4+CD25high regulatory cells in human peripheral blood.J Immunol. 2001 Aug 1;167(3):1245-53.
    11466340
  • Datta MW, Shahsafaei A, Nadler LM, Freeman GJ, Dorfman DM.Expression of MHC class II-associated invariant chain (Ii;CD74) in thymic epithelial neoplasms.Appl Immunohistochem Mol Morphol. 2000 Sep;8(3):210-5.
    10981873
  • Boussiotis VA, Freeman GJ, Taylor PA, Berezovskaya A, Grass I, Blazar BR, Nadler LM.p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes.Nat Med. 2000 Mar;6(3):290-7.
    10700231
  • Aguiar RC, Yakushijin Y, Kharbanda S, Tiwari S, Freeman GJ, Shipp MA.PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest.Blood. 1999 Oct 1;94(7):2403-13.
    10498613
  • Stremmel C, Greenfield EA, Howard E, Freeman GJ, Kuchroo VK.B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an interleukin 4-dependent mechanism.J Exp Med. 1999 Mar 15;189(6):919-30.
    10075975
  • Agrawal S, Marquet J, Freeman GJ, Tawab A, Bouteiller PL, Roth P, Bolton W, Ogg G, Boumsell L, Bensussan A.Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells.J Immunol. 1999 Feb 1;162(3):1223-6.
    9973372
  • Anumanthan A, Bensussan A, Boumsell L, Christ AD, Blumberg RS, Voss SD, Patel AT, Robertson MJ, Nadler LM, Freeman GJ.Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes.J Immunol. 1998 Sep 15;161(6):2780-90.
    9743336
  • Freeman GJ, Cardoso AA, Boussiotis VA, Anumanthan A, Groves RW, Kupper TS, Clark EA, Nadler LM.The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor.J Immunol. 1998 Sep 15;161(6):2708-15.
    9743327
  • Duke-Cohan JS, Gu J, McLaughlin DF, Xu Y, Freeman GJ, Schlossman SF.Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions.Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11336-41.
    9736737
  • Dorfman DM, Shahsafaei A, Nadler LM, Freeman GJ.The leukocyte semaphorin CD100 is expressed in most T-cell, but few B-cell, non-Hodgkin's lymphomas.Am J Pathol. 1998 Jul;153(1):255-62.
    9665486
  • Scholz C, Patton KT, Anderson DE, Freeman GJ, Hafler DA.Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation.J Immunol. 1998 Feb 1;160(3):1532-8.
    9570577
  • Dorfman DM, Schultze JL, Shahsafaei A, Michalak S, Gribben JG, Freeman GJ, Pinkus GS, Nadler LM.In vivo expression of B7-1 and B7-2 by follicular lymphoma cells can prevent induction of T-cell anergy but is insufficient to induce significant T-cell proliferation.Blood. 1997 Dec 1;90(11):4297-306.
    9373240
  • Boussiotis VA, Freeman GJ, Berezovskaya A, Barber DL, Nadler LM.Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1.Science. 1997 Oct 3;278(5335):124-8.
    9311917
  • Anderson DE, Ausubel LJ, Krieger J, Hllsberg P, Freeman GJ, Hafler DA.Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones.J Immunol. 1997 Aug 15;159(4):1669-75.
    9257827
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