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Ralph Weissleder, MD, PhD

Publications

  • Heidt T, Sager HB, Courties G, Dutta P, Iwamoto Y, Zaltsman A, von Zur Muhlen C, Bode C, Fricchione GL, Denninger J, Lin CP, Vinegoni C, Libby P, Swirski FK, Weissleder R, Nahrendorf M.Chronic variable stress activates hematopoietic stem cells.Nat Med. 2014 Jul;20(7):754-8.
    24952646
  • Leuschner F, Courties G, Dutta P, Mortensen LJ, Gorbatov R, Sena B, Novobrantseva TI, Borodovsky A, Fitzgerald K, Koteliansky V, Iwamoto Y, Bohlender M, Meyer S, Lasitschka F, Meder B, Katus HA, Lin C, Libby P, Swirski FK, Anderson DG, Weissleder R, Nahrendorf M.Silencing of CCR2 in myocarditis.Eur Heart J. 2014 Jun 20.
    24950695
  • Meimetis LG, Carlson JC, Giedt RJ, Kohler RH, Weissleder R.Ultrafluorogenic Coumarin-Tetrazine Probes for Real-Time Biological Imaging.Angew Chem Int Ed Engl. 2014 Jun 10.
    24915832
  • Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, Rothstein TL, Nahrendorf M, Weissleder R, Swirski FK.Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis.J Exp Med. 2014 Jun 2;211(6):1243-56.
    24821911
  • Sprachman MM, Laughney AM, Kohler RH, Weissleder R.In Vivo Imaging of Multidrug Resistance Using a Third Generation MDR1 Inhibitor.Bioconjug Chem. 2014 May 14.
    24806886
  • Heidt T, Courties G, Dutta P, Sager H, Sebas M, Iwamoto Y, Sun Y, Da Silva N, Panizzi P, van der Laan AM, Swirski FK, Weissleder R, Nahrendorf M.Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction.Circ Res. 2014 May 1.
    24786973
  • Im H, Shao H, Park YI, Peterson VM, Castro CM, Weissleder R, Lee H.Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor.Nat Biotechnol. 2014 Apr 20.
    24752081
  • Turetsky A, Kim E, Kohler RH, Miller MA, Weissleder R.Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor.Sci Rep. 2014;4:4782.
    24759210
  • Thurber GM, Reiner T, Yang KS, Kohler RH, Weissleder R.Effect of Small-Molecule Modification on Single-Cell Pharmacokinetics of PARP Inhibitors.Mol Cancer Ther. 2014 Apr;13(4):986-95.
    24552776
  • Kim E, Yang KS, Giedt RJ, Weissleder R.Red Si-rhodamine drug conjugates enable imaging in GFP cells.Chem Commun (Camb). 2014 May 4;50(34):4504-7.
    24663433
  • Ghazani AA, Pectasides M, Sharma A, Castro CM, Mino-Kenudson M, Lee H, Shepard JA, Weissleder R.Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance.Nanomedicine : Nanotechnology, Biology, And Medicine. 2014 Apr;10(3):661-8.
    24200523
  • Miller MA, Askevold B, Yang KS, Kohler RH, Weissleder R.Platinum Compounds for High-Resolution In Vivo Cancer Imaging.ChemMedChem. 2014 Feb 6.
    24504646
  • Keliher EJ, Klubnick JA, Reiner T, Mazitschek R, Weissleder R.Efficient Acid-Catalyzed (18) F/(19) F Fluoride Exchange of BODIPY Dyes.ChemMedChem. 2014 Mar 5.
    24596307
  • Elman JS, Murray RM, Wang F, Shen K, Gao S, Conway KE, Yarmush ML, Tannous BA, Weissleder R, Parekkadan B.Pharmacokinetics of natural and engineered secreted factors delivered by mesenchymal stromal cells.PLoS ONE. 2014;9(2):e89882.
    24587097
  • Bronisz A, Wang Y, Nowicki MO, Peruzzi P, Ansari KI, Ogawa D, Balaj L, De Rienzo G, Mineo M, Nakano I, Ostrowski MC, Hochberg F, Weissleder R, Lawler SE, Chiocca EA, Godlewski J.Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1.Cancer Res. 2014 Feb 1;74(3):738-50.
    24310399
  • McDermott S, Thayer SP, Fernandez-Del Castillo C, Mino-Kenudson M, Weissleder R, Harisinghani MG.Accurate prediction of nodal status in preoperative patients with pancreatic ductal adenocarcinoma using next-gen nanoparticle.Transl Oncol. 2013 Dec 1;6(6):670-5.
    24466369
  • Ullal AV, Peterson V, Agasti SS, Tuang S, Juric D, Castro CM, Weissleder R.Cancer cell profiling by barcoding allows multiplexed protein analysis in fine-needle aspirates.Sci Transl Med. 2014 Jan 15;6(219):219ra9.
    24431113
  • Chung J, Issadore D, Ullal A, Lee K, Weissleder R, Lee H.Rare cell isolation and profiling on a hybrid magnetic/size-sorting chip.Biomicrofluidics. 2013;7(5):54107.
    24404070
  • Coffey SE, Giedt RJ, Weissleder R.Automated analysis of clonal cancer cells by intravital imaging.Intravital. 2013 7;2(3).
    24349895
  • Peterson VM, Castro CM, Chung J, Miller NC, Ullal AV, Castano MD, Penson RT, Lee H, Birrer MJ, Weissleder R.Ascites analysis by a microfluidic chip allows tumor-cell profiling.Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4978-86.
    24297935
  • Castro CM, Ghazani AA, Chung J, Shao H, Issadore D, Yoon TJ, Weissleder R, Lee H.Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells.Lab Chip. 2014 Jan 7;14(1):14-23.
    23835814
  • Kim E, Yang KS, Weissleder R.Bioorthogonal small molecule imaging agents allow single-cell imaging of MET.PLoS ONE. 2013;8(11):e81275.
    24265843
  • Tassa C, Liong M, Hilderbrand S, Sandler JE, Reiner T, Keliher EJ, Weissleder R, Shaw SY.Microfluidic on-chip capture-cycloaddition reaction to reversibly immobilize small molecules or multi-component structures for biosensor applications.Journal Of Visualized Experiments : Jo Ve. 2013(79):e50772.
    24084440
  • Yoon TJ, Shao H, Weissleder R, Lee H.Oxidation Kinetics and Magnetic Properties of Elemental Iron Nanoparticles.Part Part Syst Charact. 2013 Aug;30(8):667-671.
    24077230
  • Keliher EJ, Reiner T, Thurber GM, Upadhyay R, Weissleder R.Efficient (18)F-Labeling of Synthetic Exendin-4 Analogues for Imaging Beta Cells.ChemistryOpen. 2012 Aug;1(4):177-183.
    23997998
  • Zeglis BM, Sevak KK, Reiner T, Mohindra P, Carlin SD, Zanzonico P, Weissleder R, Lewis JS.A pretargeted PET imaging strategy based on bioorthogonal Diels-Alder click chemistry.J Nucl Med. 2013 Aug;54(8):1389-96.
    23708196
  • Keliher EJ, Reiner T, Earley S, Klubnick J, Tassa C, Lee AJ, Ramaswamy S, Bardeesy N, Hanahan D, Depinho RA, Castro CM, Weissleder R.Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection.Neoplasia. 2013 Jul;15(7):684-93.
    23814481
  • Chung HJ, Castro CM, Im H, Lee H, Weissleder R.A magneto-DNA nanoparticle system for rapid detection and phenotyping of bacteria.Nat Nanotechnol. 2013 May;8(5):369-75.
    23644570
  • Giedt RJ, Koch PD, Weissleder R.Single cell analysis of drug distribution by intravital imaging.PLoS ONE. 2013;8(4):e60988.
    23593370
  • Gounaris E, Martin J, Ishihara Y, Khan MW, Lee G, Sinh P, Chen EZ, Angarone M, Weissleder R, Khazaie K, Barrett TA.Fluorescence Endoscopy of Cathepsin Activity Discriminates Dysplasia from Colitis.Inflamm Bowel Dis. 2013 Apr 15.
    23591598
  • Ghazani AA, McDermott S, Pectasides M, Sebas M, Mino-Kenudson M, Lee H, Weissleder R, Castro CM.Comparison of select cancer biomarkers in human circulating and bulk tumor cells using magnetic nanoparticles and miniaturized micro-NMR system.Nanomedicine : Nanotechnology, Biology, And Medicine. 2013 Apr 6.
    23570873
  • Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R.Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.Nat Commun. 2013;4:1504.
    23422672
  • Novobrantseva TI, Borodovsky A, Wong J, Klebanov B, Zafari M, Yucius K, Querbes W, Ge P, Ruda VM, Milstein S, Speciner L, Duncan R, Barros S, Basha G, Cullis P, Akinc A, Donahoe JS, Narayanannair Jayaprakash K, Jayaraman M, Bogorad RL, Love K, Whitehead K, Levins C, Manoharan M, Swirski FK, Weissleder R, Langer R, Anderson DG, de Fougerolles A, Nahrendorf M, Koteliansky V.Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells.Mol Ther Nucleic Acids. 2012;1:e4.
    23344621
  • Shao H, Chung J, Balaj L, Charest A, Bigner DD, Carter BS, Hochberg FH, Breakefield XO, Weissleder R, Lee H.Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy.Nat Med. 2012 Dec;18(12):1835-40.
    23142818
  • Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R.The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.Cell. 2012 Dec 7;151(6):1185-99.
    23217706
  • Lee J, Li M, Milwid J, Dunham J, Vinegoni C, Gorbatov R, Iwamoto Y, Wang F, Shen K, Hatfield K, Enger M, Shafiee S, McCormack E, Ebert BL, Weissleder R, Yarmush ML, Parekkadan B.Implantable microenvironments to attract hematopoietic stem/cancer cells.Proc Natl Acad Sci U S A. 2012 Nov 12.
    23150542
  • Etzrodt M, Cortez-Retamozo V, Newton A, Zhao J, Ng A, Wildgruber M, Romero P, Wurdinger T, Xavier R, Geissmann F, Meylan E, Nahrendorf M, Swirski FK, Baltimore D, Weissleder R, Pittet MJ.Regulation of monocyte functional heterogeneity by miR-146a and Relb.Cell Rep. 2012 Apr 19;1(4):317-24.
    22545247
  • Waters JD, Sanchez C, Sahin A, Futalan D, Gonda DD, Scheer JK, Akers J, Palanichamy K, Waterman P, Chakravarti A, Weissleder R, Morse B, Marsh N, Furfine E, Chen CC, Carvajal I, Carter BS.CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy.J. Neurooncol. 2012 Oct;110(1):37-48.
    22875706
  • Liu X, Nielsen GP, Rosenberg AE, Waterman PR, Yang W, Choy E, Sassi S, Yang S, Harmon DC, Yang C, Schwab JH, Kobayashi E, Mankin HJ, Xavier R, Weissleder R, Duan Z, Hornicek FJ.Establishment and characterization of a novel chordoma cell line: CH22.J Orthop Res. 2012 Oct;30(10):1666-73.
    22504929
  • Feruglio PF, Vinegoni C, Fexon L, Thurber G, Sbarbati A, Weissleder R.Noise suppressed, multifocus image fusion for enhanced intraoperative navigation.J Biophotonics. 2012 Aug 6.
    22887724
  • Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M.Myocardial infarction accelerates atherosclerosis.Nature. 2012 Jul 19;487(7407):325-9.
    22763456
  • Issadore D, Chung J, Shao H, Liong M, Ghazani AA, Castro CM, Weissleder R, Lee H.Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector.Sci Transl Med. 2012 Jul 4;4(141):141ra92.
    22764208
  • Yang KS, Budin G, Reiner T, Vinegoni C, Weissleder R.Bioorthogonal imaging of aurora kinase A in live cells.Angew Chem Int Ed Engl. 2012 Jul 2;51(27):6598-603.
    22644700
  • Earley S, Vinegoni C, Dunham J, Gorbatov R, Feruglio PF, Weissleder R.In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single-cell resolution.Cancer Res. 2012 Jun 15;72(12):2949-56.
    22505651
  • Rauch PJ, Chudnovskiy A, Robbins CS, Weber GF, Etzrodt M, Hilgendorf I, Tiglao E, Figueiredo JL, Iwamoto Y, Theurl I, Gorbatov R, Waring MT, Chicoine AT, Mouded M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK.Innate response activator B cells protect against microbial sepsis.Science. 2012 Feb 3;335(6068):597-601.
    22245738
  • Haun JB, Yoon TJ, Lee H, Weissleder R.Molecular Detection of Biomarkers and Cells Using Magnetic Nanoparticles and Diagnostic Magnetic Resonance.Methods Mol Biol. 2011;726:33-49.
    21424441
  • Niers JM, Chen JW, Weissleder R, Tannous BA.Enhanced in vivo imaging of metabolically biotinylated cell surface reporters.Anal Chem. 2011 Feb 1;83(3):994-9.
    21214190
  • Haun JB, Devaraj NK, Marinelli BS, Lee H, Weissleder R.Probing Intracellular Biomarkers and Mediators of Cell Activation Using Nanosensors and Bioorthogonal Chemistry.ACS Nano. 2011 Mar 8.
    21351804
  • Keliher EJ, Reiner T, Turetsky A, Hilderbrand SA, Weissleder R.High-yielding, two-step 18F labeling strategy for 18F-PARP1 inhibitors.ChemMedChem. 2011 Mar 7;6(3):424-7.
    21360818
  • Haun JB, Castro CM, Wang R, Peterson VM, Marinelli BS, Lee H, Weissleder R.Micro-NMR for rapid molecular analysis of human tumor samples.Sci Transl Med. 2011 Feb 23;3(71):71ra16.
    21346169
  • Reiner T, Keliher EJ, Earley S, Marinelli B, Weissleder R.Synthesis and in vivo imaging of a 18F-labeled PARP1 inhibitor using a chemically orthogonal scavenger-assisted high-performance method.Angew Chem Int Ed Engl. 2011 Feb 18;50(8):1922-5.
    21328671
  • Xia Y, Cortez-Retamozo V, Niederkofler V, Salie R, Chen S, Samad TA, Hong CC, Arber S, Vyas JM, Weissleder R, Pittet MJ, Lin HY.Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages.J Immunol. 2011 Feb 1;186(3):1369-76.
    21187450
  • Keliher EJ, Reiner T, Turetsky A, Hilderbrand SA, Weissleder R.High-Yielding, Two-Step (18)F Labeling Strategy for (18)F-PARP1 Inhibitors.ChemMedChem. 2011 Jan 4.
    21207434
  • Parekkadan B, Upadhyay R, Dunham J, Iwamoto Y, Mizoguchi E, Mizoguchi A, Weissleder R, Yarmush ML.Bone Marrow Stromal Cell Transplants Prevent Experimental Enterocolitis and Require Host CD11b+ Splenocytes.Gastroenterology. 2010 Oct 16.
    20955701
  • Issadore D, Shao H, Chung J, Newton A, Pittet M, Weissleder R, Lee H.Self-assembled magnetic filter for highly efficient immunomagnetic separation.Lab Chip. 2011 Jan 7;11(1):147-51.
    20949198
  • Condeelis J, Weissleder R.In Vivo Imaging in Cancer.Cold Spring Harb Perspect Biol. 2010 Dec 1;2(12):a003848.
    20861158
  • Kraehenbuehl TP, Ferreira LS, Hayward AM, Nahrendorf M, van der Vlies AJ, Vasile E, Weissleder R, Langer R, Hubbell JA.Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction.Biomaterials. 2011 Feb;32(4):1102-9.
    21035182
  • Thurber GM, Figueiredo JL, Weissleder R.Detection limits of intraoperative near infrared imaging for tumor resection.J Surg Oncol. 2010 Dec 1;102(7):758-64.
    20872807
  • Gros J, Hu JK, Vinegoni C, Feruglio PF, Weissleder R, Tabin CJ.WNT5A/JNK and FGF/MAPK pathways regulate the cellular events shaping the vertebrate limb bud.Curr Biol. 2010 Nov 23;20(22):1993-2002.
    21055947
  • Reiner T, Earley S, Turetsky A, Weissleder R.Bioorthogonal Small-Molecule Ligands for PARP1 Imaging in Living Cells.Chembiochem. 2010 Nov 22;11(17):2374-7.
    20967817
  • McCarthy JR, Bhaumik J, Karver MR, Sibel Erdem S, Weissleder R.Targeted nanoagents for the detection of cancers.Mol Oncol. 2010 Dec;4(6):511-28.
    20851695
  • Haun JB, Devaraj NK, Hilderbrand SA, Lee H, Weissleder R.Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection.Nat Nanotechnol. 2010 Sep;5(9):660-5.
    20676091
  • Thurber GM, Weissleder R.Quantitating Antibody Uptake In Vivo: Conditional Dependence on Antigen Expression Levels.Mol Imaging Biol. 2010 Aug 31.
    20809210
  • Reiner T, Kohler RH, Liew CW, Hill JA, Gaglia J, Kulkarni RN, Weissleder R.Near-infrared fluorescent probe for imaging of pancreatic Beta cells.Bioconjug Chem. 2010 Jul 21;21(7):1362-8.
    20583828
  • Hjortnaes J, Gottlieb D, Figueiredo JL, Melero-Martin J, Kohler RH, Bischoff J, Weissleder R, Mayer J, Aikawa E.Intravital Molecular Imaging of Small-Diameter Tissue-Engineered Vascular Grafts: A Feasibility Study.Tissue Engineering. Part C, Methods. 2010 Aug;16(4):597-607.
    19751103
  • Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Alemán JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR.The Phosphoinositide 3-Kinase Regulatory Subunit p85{alpha} Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling.Cancer Res. 2010 Jul 1;70(13):5305-15.
    20530665
  • Bhaumik J, Weissleder R, McCarthy JR.Synthesis and Photophysical Properties of Sulfonamidophenyl Porphyrins as Models for Activatable Photosensitizers.J Org Chem. 2009 Aug 21;74(16):5894-901.
    19610602
  • Guimaraes AR, Ross R, Figuereido JL, Waterman P, Weissleder R.MRI with Magnetic Nanoparticles Monitors Downstream Anti-Angiogenic Effects of mTOR Inhibition.Mol Imaging Biol. 2010 Jun 18.
    20559742
  • Libby P, Nahrendorf M, Weissleder R.Molecular imaging of atherosclerosis: a progress report.Tex Heart Inst J. 2010;37(3):324-7.
    20548813
  • Han HS, Devaraj NK, Lee J, Hilderbrand SA, Weissleder R, Bawendi MG.Development of a bioorthogonal and highly efficient conjugation method for quantum dots using tetrazine-norbornene cycloaddition.J Am Chem Soc. 2010 Jun 16;132(23):7838-9.
    20481508
  • van Eekelen M, Sasportas LS, Kasmieh R, Yip S, Figueiredo JL, Louis DN, Weissleder R, Shah K.Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors.Oncogene. 2010 Jun 3;29(22):3185-95.
    20305695
  • Nahrendorf M, Keliher E, Marinelli B, Waterman P, Feruglio PF, Fexon L, Pivovarov M, Swirski FK, Pittet MJ, Vinegoni C, Weissleder R.Hybrid PET-optical imaging using targeted probes.Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7910-5.
    20385821
  • Hingtgen SD, Kasmieh R, van de Water J, Weissleder R, Shah K.Determining Multiple Aspects of Stem Cell-Based Therapies Using Novel Diagnostic and Therapeutic Multifunctional Molecules.Stem Cells. 2010 Apr;28(4):832-41.
    20127797
  • Haun JB, Yoon TJ, Lee H, Weissleder R.Magnetic nanoparticle biosensors.Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 May;2(3):291-304. Review.
    20336708
  • Bratlie KM, Dang TT, Lyle S, Nahrendorf M, Weissleder R, Langer R, Anderson DG.Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of mouse models.PLoS ONE. 2010;5(4):e10032.
    20386609
  • Vinegoni C, Fumene Feruglio P, Cortez-Retamozo V, Razansky D, Medoff BD, Ntziachristos V, Sbarbati A, Pittet M, Weissleder R.Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography.Opt Lett. 2010 Apr 1;35(7):1088-90.
    20364226
  • Martinez-Boubeta C, Balcells L, Cristòfol R, Sanfeliu C, Rodríguez E, Weissleder R, Lope-Piedrafita S, Simeonidis K, Angelakeris M, Sandiumenge F, Calleja A, Casas L, Monty C, Martínez B.Self-assembled multifunctional Fe/MgO nanospheres for magnetic resonance imaging and hyperthermia.Nanomedicine : Nanotechnology, Biology, And Medicine. 2010 Apr;6(2):362-70.
    19800988
  • Devaraj NK, Hilderbrand S, Upadhyay R, Mazitschek R, Weissleder R.Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells.Angew Chem Int Ed Engl. 2010 Mar 19;49(16):2869-2872.
    20306505
  • Vallet S, Mukherjee S, Vaghela N, Hideshima T, Fulciniti M, Pozzi S, Santo L, Cirstea D, Patel K, Sohani AR, Guimaraes A, Xie W, Chauhan D, Schoonmaker JA, Attar E, Churchill M, Weller E, Munshi N, Seehra JS, Weissleder R, Anderson KC, Scadden DT, Raje N.Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5124-9.
    20194748
  • Kirsch DG, Grimm J, Guimaraes AR, Wojtkiewicz GR, Perez BA, Santiago PM, Anthony NK, Forbes T, Doppke K, Weissleder R, Jacks T.Imaging primary lung cancers in mice to study radiation biology.Int J Radiat Oncol Biol Phys. 2010 Mar 15;76(4):973-7.
    20206017
  • Hilderbrand SA, Weissleder R.Near-infrared fluorescence: application to in vivo molecular imaging.Curr Opin Chem Biol. 2010 Feb;14(1):71-9. Review.
    19879798
  • Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R.The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.Cell. 2010 Jan 22;140(2):280-93.
    20141841
  • Hardcastle J, Kurozumi K, Dmitrieva N, Sayers MP, Ahmad S, Waterman P, Weissleder R, Chiocca EA, Kaur B.Enhanced antitumor efficacy of vasculostatin (Vstat120) expressing oncolytic HSV-1.Mol Ther. 2010 Feb;18(2):285-94.
    19844198
  • Figueiredo JL, Siegel C, Nahrendorf M, Weissleder R.Intraoperative near-infrared fluorescent cholangiography (NIRFC) in mouse models of bile duct injury.World J Surg. 2010 Feb;34(2):336-43.
    20033407
  • Tassa C, Duffner JL, Lewis TA, Weissleder R, Schreiber SL, Koehler AN, Shaw SY.Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles.Bioconjug Chem. 2010 Jan;21(1):14-9.
    20028085
  • Vinegoni C, Fexon L, Feruglio PF, Pivovarov M, Figueiredo JL, Nahrendorf M, Pozzo A, Sbarbati A, Weissleder R.High throughput transmission optical projection tomography using low cost graphics processing unit.Opt Express. 2009 Dec 7;17(25):22320-32.
    20052155
  • Rodríguez E, Nilges M, Weissleder R, Chen JW.Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity.J Am Chem Soc. 2010 Jan 13;132(1):168-77.
    19968300
  • Hamilton AM, Rogers KA, Belisle AJ, Ronald JA, Rutt BK, Weissleder R, Boughner DR.Early identification of aortic valve sclerosis using iron oxide enhanced MRI.J Magn Reson Imaging. 2010 Jan;31(1):110-6.
    20027578
  • Tsai CC, Vinegoni C, Weissleder R.Diffractionless beam in free space with adiabatic changing refractive index in a single mode tapered slab waveguide.Opt Express. 2009 Nov 23;17(24):21723-31.
    19997414
  • Thurber GM, Figueiredo JL, Weissleder R.Multicolor fluorescent intravital live microscopy (FILM) for surgical tumor resection in a mouse xenograft model.PLoS ONE. 2009;4(11):e8053.
    19956597
  • Smith RA, Yuan H, Weissleder R, Cantley LC, Josephson L.A wortmannin-cetuximab as a double drug.Bioconjug Chem. 2009 Nov;20(11):2185-9.
    19883074
  • Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L.Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia.Circ Cardiovasc Imaging. 2009 Nov;2(6):460-7.
    19920044
  • Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A.Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure.Circ Cardiovasc Imaging. 2009 Nov;2(6):468-75.
    19920045
  • Duchrow T, Shtatland T, Guettler D, Pivovarov M, Kramer S, Weissleder R.Enhancing navigation in biomedical databases by community voting and database-driven text classification.BMC Bioinformatics. 2009;10:317.
    19799796
  • Panizzi P, Nahrendorf M, Wildgruber M, Waterman P, Figueiredo JL, Aikawa E, McCarthy J, Weissleder R, Hilderbrand SA.Oxazine conjugated nanoparticle detects in vivo hypochlorous acid and peroxynitrite generation.J Am Chem Soc. 2009 Nov 4;131(43):15739-44.
    19817443
  • Nahrendorf M, Keliher E, Panizzi P, Zhang H, Hembrador S, Figueiredo JL, Aikawa E, Kelly K, Libby P, Weissleder R.18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis.JACC Cardiovasc Imaging. 2009 Oct;2(10):1213-22.
    19833312
  • Nahrendorf M, Waterman P, Thurber G, Groves K, Rajopadhye M, Panizzi P, Marinelli B, Aikawa E, Pittet MJ, Swirski FK, Weissleder R.Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors.Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1444-51.
    19608968
  • Swirski FK,Weissleder R,Pittet MJ.Heterogeneous In Vivo Behavior of Monocyte Subsets in Atherosclerosis.Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1424-32. Review.
    19372462
  • Vinegoni C, Razansky D, Hilderbrand SA, Shao F, Ntziachristos V, Weissleder R.Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticles.Opt Lett. 2009 Sep 1;34(17):2566-8.
    19724491
  • Bullain SS,Sahin A,Szentirmai O,Sanchez C,Lin N,Baratta E,Waterman P,Weissleder R,Mulligan RC,Carter BS.Genetically engineered T cells to target EGFRvIII expressing glioblastoma.J Neurooncol. 2009 Sep;94(3):373-82.
    19387557
  • Vinegoni C, Razansky D, Pitsouli C, Perrimon N, Ntziachristos V, Weissleder R.Mesoscopic fluorescence tomography for in-vivo imaging of developing Drosophila.Journal Of Visualized Experiments : Jo Ve. 2009(30).
    19696720
  • Ronald JA, Chen JW, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, Rutt BK.Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques.Circulation. 2009 Aug 18;120(7):592-9.
    19652086
  • McCarthy JR, Bhaumik J, Merbouh N, Weissleder R.High-yielding syntheses of hydrophilic conjugatable chlorins and bacteriochlorins.Org Biomol Chem. 2009 Sep 7;7(17):3430-6.
    19675897
  • Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U.Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function.Arthritis Rheum. 2009 Aug;60(8):2314-24.
    19644878
  • Lee H, Yoon TJ, Figueiredo JL, Swirski FK, Weissleder R.Rapid detection and profiling of cancer cells in fine-needle aspirates.Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12459-64.
    19620715
  • Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ.Identification of splenic reservoir monocytes and their deployment to inflammatory sites.Science. 2009 Jul 31;325(5940):612-6.
    19644120
  • Vonken EJ, Korosoglou G, Yu J, Schär M, Weissleder R, Stuber M.On the dual contrast enhancement mechanism in frequency-selective inversion-recovery magnetic resonance angiography (IRON-MRA).Magn Reson Med. 2009 Aug;62(2):314-24.
    19526511
  • Lee H, Yoon TJ, Weissleder R.Ultrasensitive detection of bacteria using core-shell nanoparticles and an NMR-filter system.Angew Chem Int Ed Engl. 2009;48(31):5657-60.
    19554581
  • Garanger E, Hilderbrand SA, Blois JT, Sosnovik DE, Weissleder R, Josephson L.A DNA-binding Gd chelate for the detection of cell death by MRI.Chem Commun (Camb). 2009 Aug 7(29):4444-6.
    19597620
  • Yuan H, Pupo MT, Blois J, Smith A, Weissleder R, Clardy J, Josephson L.A stabilized demethoxyviridin derivative inhibits PI3 kinase.Bioorg Med Chem Lett. 2009 Aug 1;19(15):4223-7.
    19523825
  • Hilderbrand SA, Shao F, Salthouse C, Mahmood U, Weissleder R.Upconverting luminescent nanomaterials: application to in vivo bioimaging.Chem Commun (Camb). 2009 Jul 28(28):4188-90.
    19585016
  • Vinegoni C, Razansky D, Figueiredo JL, Fexon L, Pivovarov M, Nahrendorf M, Ntziachristos V, Weissleder R.Born normalization for fluorescence optical projection tomography for whole heart imaging.Journal Of Visualized Experiments : Jo Ve. 2009(28).
    19578329
  • Rajendran R, Ronald JA, Ye T, Minqin R, Chen JW, Weissleder R, Rutt BK, Halliwell B, Watt F.Nuclear microscopy: a novel technique for quantitative imaging of gadolinium distribution within tissue sections.Microsc. Microanal. 2009 Aug;15(4):338-44.
    19575834
  • Ross RW, Zietman AL, Xie W, Coen JJ, Dahl DM, Shipley WU, Kaufman DS, Islam T, Guimaraes AR, Weissleder R, Harisinghani M.Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy.Clin Imaging.;33(4):301-5.
    19559353
  • Yoon SS, Stangenberg L, Lee YJ, Rothrock C, Dreyfuss JM, Baek KH, Waterman PR, Nielsen GP, Weissleder R, Mahmood U, Park PJ, Jacks T, Dodd RD, Fisher CJ, Ryeom S, Kirsch DG.Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma.Int J Radiat Oncol Biol Phys. 2009 Jul 15;74(4):1207-16.
    19545786
  • Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L.The antiproliferative cytostatic effects of a self-activating viridin prodrug.Mol Cancer Ther. 2009 Jun;8(6):1666-75.
    19509266
  • Daniel KD,Kim GY,Vassiliou CC,Galindo M,Guimaraes AR,Weissleder R,Charest A,Langer R,Cima MJ.Implantable diagnostic device for cancer monitoring.Biosens Bioelectron. 2009 Jul 15;24(11):3252-7.
    19442510
  • Leimgruber A,Berger C,Cortez-Retamozo V,Etzrodt M,Newton AP,Waterman P,Figueiredo JL,Kohler RH,Elpek N,Mempel TR,Swirski FK,Nahrendorf M,Weissleder R,Pittet MJ.Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle.Neoplasia. 2009 May;11(5):459-68, 2 p following 468.
    19412430
  • Christen T,Nahrendorf M,Wildgruber M,Swirski FK,Aikawa E,Waterman P,Shimizu K,Weissleder R,Libby P.Molecular imaging of innate immune cell function in transplant rejection.Circulation. 2009 Apr 14;119(14):1925-32.
    19332470
  • Koh I,Hong R,Weissleder R,Josephson L.Nanoparticle-target interactions parallel antibody-protein interactions.Anal Chem. 2009 May 1;81(9):3618-22.
    19323458
  • Sasportas LS,Kasmieh R,Wakimoto H,Hingtgen S,van de Water JA,Mohapatra G,Figueiredo JL,Martuza RL,Weissleder R,Shah K.Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy.Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4822-7.
    19264968
  • Tannous BA,Christensen AP,Pike L,Wurdinger T,Perry KF,Saydam O,Jacobs AH,Garcia-Anoveros J,Weissleder R,Sena-Esteves M,Corey DP,Breakefield XO.Mutant sodium channel for tumor therapy.Mol Ther. 2009 May;17(5):810-9.
    19259066
  • Zhu H,Acquaviva J,Ramachandran P,Boskovitz A,Woolfenden S,Pfannl R,Bronson RT,Chen JW,Weissleder R,Housman DE,Charest A.Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2712-6.
    19196966
  • Vinegoni C,Razansky D,Figueiredo JL,Nahrendorf M,Ntziachristos V,Weissleder R.Normalized Born ratio for fluorescence optical projection tomography.Opt Lett. 2009 Feb 1;34(3):319-21.
    19183644
  • McCann CM,Waterman P,Figueiredo JL,Aikawa E,Weissleder R,Chen JW.Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.Neuroimage. 2009 Apr 1;45(2):360-9.
    19154791
  • Devaraj NK,Keliher EJ,Thurber GM,Nahrendorf M,Weissleder R.18F labeled nanoparticles for in vivo PET-CT imaging.Bioconjug Chem. 2009 Feb;20(2):397-401.
    19138113
  • Sheth RA,Upadhyay R,Stangenberg L,Sheth R,Weissleder R,Mahmood U.Improved detection of ovarian cancer metastases by intraoperative quantitative fluorescence protease imaging in a pre-clinical model.Gynecol Oncol. 2009 Mar;112(3):616-22.
    19135233
  • Salthouse C,Hildebrand S,Weissleder R,Mahmood U.Design and demonstration of a small-animal up-conversion imager.Opt Express. 2008 Dec 22;16(26):21731-7.
    19104605
  • Jeong JH,Wang Z,Guimaraes AS,Ouyang X,Figueiredo JL,Ding Z,Jiang S,Guney I,Kang GH,Shin E,Hahn WC,Loda MF,Abate-Shen C,Weissleder R,Chin L.BRAF activation initiates but does not maintain invasive prostate adenocarcinoma.PLoS ONE. 2008;3(12):e3949.
    19079609
  • Garanger E,Weissleder R,Josephson L.A multifunctional single-attachment-point reagent for controlled protein biotinylation.Bioconjug Chem. 2009 Jan;20(1):170-3.
    19072220
  • Devaraj NK,Weissleder R,Hilderbrand SA.Tetrazine-based cycloadditions: application to pretargeted live cell imaging.Bioconjug Chem. 2008 Dec;19(12):2297-9.
    19053305
  • Shao F,Weissleder R,Hilderbrand SA.Monofunctional carbocyanine dyes for bio- and bioorthogonal conjugation.Bioconjug Chem. 2008 Dec;19(12):2487-91.
    19053316
  • Cortez-Retamozo V,Swirski FK,Waterman P,Yuan H,Figueiredo JL,Newton AP,Upadhyay R,Vinegoni C,Kohler R,Blois J,Smith A,Nahrendorf M,Josephson L,Weissleder R,Pittet MJ.Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation.J Clin Invest. 2008 Dec;118(12):4058-66.
    19033674
  • Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, Padera RF, Garca-Echeverra C, Weissleder R, Mahmood U, Cantley LC, Wong KK.Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.Nat Med. 2008 Dec;14(12):1351-6.
    19029981
  • Niedre MJ,de Kleine RH,Aikawa E,Kirsch DG,Weissleder R,Ntziachristos V.Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo.Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19126-31.
    19015534
  • Kozloff KM,Quinti L,Patntirapong S,Hauschka PV,Tung CH,Weissleder R,Mahmood U.Non-invasive optical detection of cathepsin K-mediated fluorescence reveals osteoclast activity in vitro and in vivo.Bone. 2009 Feb;44(2):190-8.
    19007918
  • Hingtgen S,Ren X,Terwilliger E,Classon M,Weissleder R,Shah K.Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide.Mol Cancer Ther. 2008 Nov;7(11):3575-85.
    19001440
  • Cortez-Retamozo V,Swirski FK,Waterman P,Yuan H,Figueiredo JL,Newton AP,Upadhyay R,Vinegoni C,Kohler R,Blois J,Smith A,Nahrendorf M,Josephson L,Weissleder R,Pittet MJ.Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation.J Clin Invest. 2008 Nov 6.
    18989378
  • Wurdinger T,Tannous BA,Saydam O,Skog J,Grau S,Soutschek J,Weissleder R,Breakefield XO,Krichevsky AM.miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells.Cancer Cell. 2008 Nov 4;14(5):382-93.
    18977327
  • Guimaraes AR,Rakhlin E,Weissleder R,Thayer SP.Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model.Pancreas. 2008 Nov;37(4):440-4.
    18953259
  • Girnun GD,Chen L,Silvaggi J,Drapkin R,Chirieac LR,Padera RF,Upadhyay R,Vafai SB,Weissleder R,Mahmood U,Naseri E,Buckley S,Li D,Force J,McNamara K,Demetri G,Spiegelman BM,Wong KK.Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.Clin Cancer Res. 2008 Oct 15;14(20):6478-86.
    18927287
  • Perez JM,Grimm J,Josephson L,Weissleder R.Integrated nanosensors to determine levels and functional activity of human telomerase.Neoplasia. 2008 Oct;10(10):1066-72.
    18813356
  • Korosoglou G,Shah S,Vonken EJ,Gilson WD,Schar M,Tang L,Kraitchman DL,Boston RC,Sosnovik DE,Weiss RG,Weissleder R,Stuber M.Off-resonance angiography: a new method to depict vessels--phantom and rabbit studies.Radiology. 2008 Nov;249(2):501-9.
    18780823
  • Gounaris E,Tung CH,Restaino C,Maehr R,Kohler R,Joyce JA,Ploegh HL,Barrett TA,Weissleder R,Khazaie K.Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth.PLoS ONE. 2008;3(8):e2916.
    18698347
  • Lee H, Sun E, Ham D, Weissleder R.Chip-NMR biosensor for detection and molecular analysis of cells.Nat Med. 2008 Aug;14(8):869-74.
    18607350
  • Hilderbrand SA,Kelly KA,Niedre M,Weissleder R.Near infrared fluorescence-based bacteriophage particles for ratiometric pH imaging.Bioconjug Chem. 2008 Aug;19(8):1635-9.
    18666791
  • Gee MS,Upadhyay R,Bergquist H,Alencar H,Reynolds F,Maricevich M,Weissleder R,Josephson L,Mahmood U.Human breast cancer tumor models: molecular imaging of drug susceptibility and dosing during HER2/neu-targeted therapy.Radiology. 2008 Sep;248(3):925-35.
    18647846
  • Shah K, Hingtgen S, Kasmieh R, Figueiredo JL, Garcia-Garcia E, Martinez-Serrano A, Breakefield X, Weissleder R.Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model.J Neurosci. 2008 Apr 23;28(17):4406-13.
    18434519
  • Kelly KA, Bardeesy N, Anbazhagan R, Gurumurthy S, Berger J, Alencar H, Depinho RA, Mahmood U, Weissleder R.Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma.PLoS Med. 2008 Apr 15;5(4):e85.
    18416599
  • Weissleder R, Pittet MJ.Imaging in the era of molecular oncology.Nature. 2008 Apr 3;452(7187):580-9. Review.
    18385732
  • Kelly KA, Setlur SR, Ross R, Anbazhagan R, Waterman P, Rubin MA, Weissleder R.Detection of early prostate cancer using a hepsin-targeted imaging agent.Cancer Res. 2008 Apr 1;68(7):2286-91.
    18381435
  • Guimaraes AR, Tabatabei S, Dahl D, McDougal WS, Weissleder R, Harisinghani MG.Pilot study evaluating use of lymphotrophic nanoparticle-enhanced magnetic resonance imaging for assessing lymph nodes in renal cell cancer.Urology. 2008 Apr;71(4):708-12.
    18295316
  • Harisinghani M, Ross RW, Guimaraes AR, Weissleder R.Utility of a new bolus-injectable nanoparticle for clinical cancer staging.Neoplasia. 2007 Dec;9(12):1160-5.
    18084623
  • Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K.Mast cells are an essential hematopoietic component for polyp development.Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19977-82.
    18077429
  • Kurozumi K, Hardcastle J, Thakur R, Yang M, Christoforidis G, Fulci G, Hochberg FH, Weissleder R, Carson W, Chiocca EA, Kaur B.Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy.Journal of the National Cancer Institute. 2007 Dec 5;99(23):1768-81.
    18042934
  • Swirski FK, Berger CR, Figueiredo JL, Mempel TR, von Andrian UH, Pittet MJ, Weissleder R.A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses.PLoS ONE. 2007;2(10):e1075.
    17957257
  • Fulci G, Dmitrieva N, Gianni D, Fontana EJ, Pan X, Lu Y, Kaufman CS, Kaur B, Lawler SE, Lee RJ, Marsh CB, Brat DJ, van Rooijen N, Stemmer-Rachamimov AO, Hochberg FH, Weissleder R, Martuza RL, Chiocca EA.Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses.Cancer Res. 2007 Oct 1;67(19):9398-406.
    17909049
  • Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K.MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas.Cancer Res. 2007 Oct 1;67(19):8994-9000.
    17908999
  • Arwert E, Hingtgen S, Figueiredo JL, Bergquist H, Mahmood U, Weissleder R, Shah K.Visualizing the Dynamics of EGFR Activity and Antiglioma Therapies In vivo.Cancer Res. 2007 Aug 1;67(15):7335-42.
    17671203
  • Pittet MJ, Grimm J, Berger CR, Tamura T, Wojtkiewicz G, Nahrendorf M, Romero P, Swirski FK, Weissleder R.In vivo imaging of T cell delivery to tumors after adoptive transfer therapy.Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12457-61.
    17640914
  • Alencar H, Funovics MA, Figueiredo J, Sawaya H, Weissleder R, Mahmood U.Colonic Adenocarcinomas: Near-Infrared Microcatheter Imaging of Smart Probes for Early Detection--Study in Mice.Radiology. 2007 Jul;244(1):232-8.
    17507718
  • Kock N, Kasmieh R, Weissleder R, Shah K.Tumor therapy mediated by lentiviral expression of shBcl-2 and S-TRAIL.Neoplasia. 2007 May;9(5):435-42.
    17534449
  • Montet X, Figueiredo JL, Alencar H, Ntziachristos V, Mahmood U, Weissleder R.Tomographic fluorescence imaging of tumor vascular volume in mice.Radiology. 2007 Mar;242(3):751-8.
    17325064
  • Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T.Restoration of p53 function leads to tumour regression in vivo.Nature. 2007 Feb 8;445(7128):661-5.
    17251932
  • Kim DE, Tsuji K, Kim YR, Mueller FJ, Eom HS, Snyder EY, Lo EH, Weissleder R, Schellingerhout D.Neural stem cell transplant survival in brains of mice: assessing the effect of immunity and ischemia by using real-time bioluminescent imaging.Radiology. 2006 Dec;241(3):822-30.
    17114629
  • Campanella GS, Grimm J, Manice LA, Colvin RA, Medoff BD, Wojtkiewicz GR, Weissleder R, Luster AD.Oligomerization of CXCL10 is necessary for endothelial cell presentation and in vivo activity.J Immunol. 2006 Nov 15;177(10):6991-8.
    17082614
  • Lamfers ML, Fulci G, Gianni D, Tang Y, Kurozumi K, Kaur B, Moeniralm S, Saeki Y, Carette JE, Weissleder R, Vandertop WP, van Beusechem VW, Dirven CM, Chiocca EA.Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging.Mol Ther. 2006 Dec;14(6):779-88.
    16996314
  • Funovics MA, Alencar H, Montet X, Weissleder R, Mahmood U.Simultaneous fluorescence imaging of protease expression and vascularity during murine colonoscopy for colonic lesion characterization.Gastrointest Endosc. 2006 Oct;64(4):589-97.
    16996355
  • Newton JR, Kelly KA, Mahmood U, Weissleder R, Deutscher SL.In vivo selection of phage for the optical imaging of PC-3 human prostate carcinoma in mice.Neoplasia. 2006 Sep;8(9):772-80.
    16984734
  • Hynynen K, McDannold N, Vykhodtseva N, Raymond S, Weissleder R, Jolesz FA, Sheikov N.Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery.J Neurosurg. 2006 Sep;105(3):445-54.
    16961141
  • Fulci G, Breymann L, Gianni D, Kurozomi K, Rhee SS, Yu J, Kaur B, Louis DN, Weissleder R, Caligiuri MA, Chiocca EA.Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses.Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12873-8.
    16908838
  • Kim CF, Jackson EL, Kirsch DG, Grimm J, Shaw AT, Lane K, Kissil J, Olive KP, Sweet-Cordero A, Weissleder R, Jacks T.Mouse models of human non-small-cell lung cancer: raising the bar.Cold Spring Harb Symp Quant Biol. 2005;70:241-50. Review.
    16869760
  • Chen JW, Querol Sans M, Bogdanov A, Weissleder R.Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates.Radiology. 2006 Aug;240(2):473-81.
    16864673
  • Mempel TR, Pittet MJ, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Andrian UH.Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation.Immunity. 2006 Jul;25(1):129-41.
    16860762
  • Galande AK, Hilderbrand SA, Weissleder R, Tung CH.Enzyme-targeted fluorescent imaging probes on a multiple antigenic Peptide core.J Med Chem. 2006 Jul 27;49(15):4715-20.
    16854078
  • Choi Y, Weissleder R, Tung CH.Selective antitumor effect of novel protease-mediated photodynamic agent.Cancer Res. 2006 Jul 15;66(14):7225-9.
    16849570
  • Montet X, Weissleder R, Josephson L.Imaging pancreatic cancer with a Peptide-nanoparticle conjugate targeted to normal pancreas.Bioconjug Chem. 2006 Jul-Aug;17(4):905-11.
    16848396
  • Hsiao JK, Law B, Weissleder R, Tung CH.In-vivo imaging of tumor associated urokinase-type plasminogen activator activity.J Biomed Opt. 2006 May-Jun;11(3):34013.
    16822063
  • Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R.Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10340-5.
    16801531
  • Kelly KA, Clemons PA, Yu AM, Weissleder R.High-throughput identification of phage-derived imaging agents.Mol Imaging. 2006 Jan-Mar;5(1):24-30.
    16779967
  • Trhin R, Figueiredo JL, Pittet MJ, Weissleder R, Josephson L, Mahmood U.Fluorescent nanoparticle uptake for brain tumor visualization.Neoplasia. 2006 Apr;8(4):302-11.
    16756722
  • Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, Jnne PA, Shapiro GI, Tenen D, Johnson BE, Weissleder R, Sharpless NE, Wong KK.The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.Cancer Cell. 2006 Jun;9(6):485-95.
    16730237
  • Weissleder R.Molecular imaging in cancer.Science. 2006 May 26;312(5777):1168-71.
    16728630
  • Deramaudt TB, Takaoka M, Upadhyay R, Bowser MJ, Porter J, Lee A, Rhoades B, Johnstone CN, Weissleder R, Hingorani SR, Mahmood U, Rustgi AK.N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption.Mol Cell Biol. 2006 Jun;26(11):4185-200.
    16705170
  • Tannous BA, Grimm J, Perry KF, Chen JW, Weissleder R, Breakefield XO.Metabolic biotinylation of cell surface receptors for in vivo imaging.Nat Methods. 2006 May;3(5):391-6.
    16628210
  • Montet X, Montet-Abou K, Reynolds F, Weissleder R, Josephson L.Nanoparticle imaging of integrins on tumor cells.Neoplasia. 2006 Mar;8(3):214-22.
    16611415
  • Law B, Weissleder R, Tung CH.Peptide-based biomaterials for protease-enhanced drug delivery.Biomacromolecules. 2006 Apr;7(4):1261-5.
    16602747
  • Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA.Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5947-52.
    16585505
  • Kamal SM, Turner B, He Q, Rasenack J, Bianchi L, Al Tawil A, Nooman A, Massoud M, Koziel MJ, Afdhal NH.Progression of fibrosis in hepatitis C with and without schistosomiasis: correlation with serum markers of fibrosis.Hepatology. 2006 Apr;43(4):771-9.
    16557547
  • Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC.Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries.RNA. 2006 May;12(5):797-806.
    16556935
  • Quinti L, Weissleder R, Tung CH.A fluorescent nanosensor for apoptotic cells.Nano Lett. 2006 Mar;6(3):488-90.
    16522048
  • Vianello F, Papeta N, Chen T, Kraft P, White N, Hart WK, Kircher MF, Swart E, Rhee S, Pal G, Irimia D, Toner M, Weissleder R, Poznansky MC.Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control.J Immunol. 2006 Mar 1;176(5):2902-14.
    16493048
  • Rabin O, Manuel Perez J, Grimm J, Wojtkiewicz G, Weissleder R.An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles.Nat Mater. 2006 Feb;5(2):118-22.
    16444262
  • Binstadt BA, Patel PR, Alencar H, Nigrovic PA, Lee DM, Mahmood U, Weissleder R, Mathis D, Benoist C.Particularities of the vasculature can promote the organ specificity of autoimmune attack.Nat Immunol. 2006 Mar;7(3):284-92.
    16444258
  • Messerli SM, Prabhakar S, Tang Y, Mahmood U, Weissleder R, Bronson R, Martuza R, Rabkin S, Breakefield XO.Treatment of schwannomas with an oncolytic recombinant herpes simplex virus in murine models of neurofibromatosis type 2.Hum Gene Ther. 2006 Jan;17(1):20-30.
    16409122
  • Brown AB, Mahmood U, Cortes ML, Tang Y, Dai G, Stemmer-Rachamimov A, Prabhakar S, Leishear K, Onda H, Kwiatkowski D, Weissleder R, Breakefield X.Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery.Hum Gene Ther. 2005 Dec;16(12):1367-76.
    16390268
  • McCarthy JR, Perez JM, Brckner C, Weissleder R.Polymeric nanoparticle preparation that eradicates tumors.Nano Lett. 2005 Dec;5(12):2552-6.
    16351214
  • Zacharakis G, Kambara H, Shih H, Ripoll J, Grimm J, Saeki Y, Weissleder R, Ntziachristos V.Volumetric tomography of fluorescent proteins through small animals in vivo.Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18252-7.
    16344470
  • Shih HA, Harisinghani M, Zietman AL, Wolfgang JA, Saksena M, Weissleder R.Mapping of nodal disease in locally advanced prostate cancer: rethinking the clinical target volume for pelvic nodal irradiation based on vascular rather than bony anatomy.Int J Radiat Oncol Biol Phys. 2005 Nov 15;63(4):1262-9.
    16253781
  • Tang Y, Kim M, Carrasco D, Kung AL, Chin L, Weissleder R.In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging.Cancer Res. 2005 Sep 15;65(18):8324-30.
    16166309
  • Chen WT, Khazaie K, Zhang G, Weissleder R, Tung CH.Detection of dysplastic intestinal adenomas using a fluorescent folate imaging probe.Mol Imaging. 2005 Jan-Mar;4(1):67-74.
    15967128
  • Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K.Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo.Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):419-24.
    15623559
  • Shah K, Tung CH, Chang CH, Slootweg E, O'Loughlin T, Breakefield XO, Weissleder R.In Vivo Imaging of HIV Protease Activity in Amplicon Vector-transduced Gliomas.Cancer Res. 2004 Jan 1;64(1):273-8.
    14729634
  • Funovics MA, Alencar H, Su HS, Khazaie K, Weissleder R, Mahmood U.Miniaturized multichannel near infrared endoscope for mouse imaging.Mol Imaging. 2003 Oct;2(4):350-7.
    14717334
  • Shah K, Tang Y, Breakefield X, Weissleder R.Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo.Oncogene. 2003 Oct 9;22(44):6865-72.
    14534533
  • Tang Y, Shah K, Messerli SM, Snyder E, Breakefield X, Weissleder R.In vivo tracking of neural progenitor cell migration to glioblastomas.Hum Gene Ther. 2003 Sep 1;14(13):1247-54.
    12952596
  • Ntziachristos V, Bremer C, Graves EE, Ripoll J, Weissleder R.In vivo tomographic imaging of near-infrared fluorescent probes.Mol Imaging. 2002 Apr-Jun;1(2):82-8.
    12920848
  • Schellenberger EA, Bogdanov A, Hgemann D, Tait J, Weissleder R, Josephson L.Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI.Mol Imaging. 2002 Apr-Jun;1(2):102-7.
    12920851
  • Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, de la Rosette J, Weissleder R.Noninvasive detection of clinically occult lymph-node metastases in prostate cancer.N Engl J Med. 2003 Jun 19;348(25):2491-9.
    12815134
  • Kim YR, Savellano MD, Weissleder R, Bogdanov A.Steady-state and dynamic contrast MR imaging of human prostate cancer xenograft tumors: a comparative study.Technol Cancer Res Treat. 2002 Dec;1(6):489-95.
    12625776
  • Rudin M, Weissleder R.Molecular imaging in drug discovery and development.Nat Rev Drug Discov. 2003 Feb;2(2):123-31.
    12563303
  • Bremer C, Mustafa M, Bogdanov A, Ntziachristos V, Petrovsky A, Weissleder R.Steady-state blood volume measurements in experimental tumors with different angiogenic burdens a study in mice.Radiology. 2003 Jan;226(1):214-20.
    12511693
  • Ichikawa T, Hgemann D, Saeki Y, Tyminski E, Terada K, Weissleder R, Chiocca EA, Basilion JP.MRI of transgene expression: correlation to therapeutic gene expression.Neoplasia. 2002 Nov-Dec;4(6):523-30.
    12407446
  • Tung CH, Mueller S, Weissleder R.Novel branching membrane translocational peptide as gene delivery vector.Bioorg Med Chem. 2002 Nov;10(11):3609-14.
    12213476
  • Tung CH, Lin Y, Moon WK, Weissleder R.A receptor-targeted near-infrared fluorescence probe for in vivo tumor imaging.Chembiochem. 2002 Aug 2;3(8):784-6.
    12203978
  • Harisinghani MG, Barentsz JO, Hahn PF, Deserno W, de la Rosette J, Saini S, Marten K, Weissleder R.MR lymphangiography for detection of minimal nodal disease in patients with prostate cancer.Acad Radiol. 2002 Aug;9 Suppl 2:S312-3.
    12188258
  • Bremer C, Tung CH, Weissleder R.Molecular imaging of MMP expression and therapeutic MMP inhibition.Acad Radiol. 2002 Aug;9 Suppl 2:S314-5.
    12188259
  • Schellenberger EA, Hgemann D, Josephson L, Weissleder R.Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI.Acad Radiol. 2002 Aug;9 Suppl 2:S310-1.
    12188257
  • Ntziachristos V, Bremer C, Tung C, Weissleder R.Imaging cathepsin B up-regulation in HT-1080 tumor models using fluorescence-mediated molecular tomography (FMT).Acad Radiol. 2002 Aug;9 Suppl 2:S323-5.
    12188262
  • Mahmood U, Tung CH, Tang Y, Weissleder R.Feasibility of in vivo multichannel optical imaging of gene expression: experimental study in mice.Radiology. 2002 Aug;224(2):446-51.
    12147841
  • Perez JM, Josephson L, O'Loughlin T, Hgemann D, Weissleder R.Magnetic relaxation switches capable of sensing molecular interactions.Nat Biotechnol. 2002 Aug;20(8):816-20.
    12134166
  • Zhao M, Kircher MF, Josephson L, Weissleder R.Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake.Bioconjug Chem. 2002 Jul-Aug;13(4):840-4.
    12121140
  • Ntziachristos V, Tung CH, Bremer C, Weissleder R.Fluorescence molecular tomography resolves protease activity in vivo.Nat Med. 2002 Jul;8(7):757-60.
    12091907
  • Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA.Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.Cancer Cell. 2002 Apr;1(3):269-77.
    12086863
  • Mahmood U, Weissleder R.Some tools for molecular imaging.Acad Radiol. 2002 Jun;9(6):629-31.
    12061735
  • Chen J, Tung CH, Mahmood U, Ntziachristos V, Gyurko R, Fishman MC, Huang PL, Weissleder R.In vivo imaging of proteolytic activity in atherosclerosis.Circulation. 2002 Jun 11;105(23):2766-71.
    12057992
  • Ntziachristos V, Weissleder R.Charge-coupled-device based scanner for tomography of fluorescent near-infrared probes in turbid media.Med Phys. 2002 May;29(5):803-9.
    12033576
  • Josephson L, Kircher MF, Mahmood U, Tang Y, Weissleder R.Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes.Bioconjug Chem. 2002 May-Jun;13(3):554-60.
    12009946
  • Lin Y, Weissleder R, Tung CH.Novel near-infrared cyanine fluorochromes: synthesis, properties, and bioconjugation.Bioconjug Chem. 2002 May-Jun;13(3):605-10.
    12009952
  • Bogdanov AA, Lin CP, Simonova M, Matuszewski L, Weissleder R.Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment.Neoplasia. 2002 May-Jun;4(3):228-36.
    11988842
  • Moore A, Sun PZ, Cory D, Hgemann D, Weissleder R, Lipes MA.MRI of insulitis in autoimmune diabetes.Magn Reson Med. 2002 Apr;47(4):751-8.
    11948737
  • Melder RJ, Munn LL, Stoll BR, Marecos EM, Baxter LT, Weissleder R, Jain RK.Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model.Neoplasia. 2002 Jan-Feb;4(1):3-8.
    11922388
  • Tung CH, Gerszten RE, Jaffer FA, Weissleder R.A novel near-infrared fluorescence sensor for detection of thrombin activation in blood.Chembiochem. 2002 Mar 1;3(2-3):207-11.
    11921399
  • Wunderbaldinger P, Josephson L, Weissleder R.Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles.Bioconjug Chem. 2002 Mar-Apr;13(2):264-8.
    11906263
  • Weissleder R.Scaling down imaging: molecular mapping of cancer in mice.Nat Rev Cancer. 2002 Jan;2(1):11-8.
    11902581
  • Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D.Arthritis critically dependent on innate immune system players.Immunity. 2002 Feb;16(2):157-68.
    11869678
  • Bremer C, Tung CH, Bogdanov A, Weissleder R.Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes.Radiology. 2002 Mar;222(3):814-8.
    11867806
  • Marten K, Bremer C, Khazaie K, Sameni M, Sloane B, Tung CH, Weissleder R.Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice.Gastroenterology. 2002 Feb;122(2):406-14.
    11832455
  • Wunderbaldinger P, Josephson L, Bremer C, Moore A, Weissleder R.Detection of lymph node metastases by contrast-enhanced MRI in an experimental model.Magn Reson Med. 2002 Feb;47(2):292-7.
    11810672
  • Kang HW, Josephson L, Petrovsky A, Weissleder R, Bogdanov A.Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture.Bioconjug Chem. 2002 Jan-Feb;13(1):122-7.
    11792187
  • Bremer C, Bredow S, Mahmood U, Weissleder R, Tung CH.Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model.Radiology. 2001 Nov;221(2):523-9.
    11687699
  • Harisinghani MG, Saini S, Weissleder R, Rubin D, deLange E, Harms S, Weinreb J, Small W, Sukerkar A, Brown JJ, Zelch J, Lucas M, Morris M, Hahn PF.Splenic imaging with ultrasmall superparamagnetic iron oxide ferumoxtran-10 (AMI-7227): preliminary observations.J Comput Assist Tomogr. 2001 Sep-Oct;25(5):770-6.
    11584239
  • Harisinghani MG, Jhaveri KS, Weissleder R, Schima W, Saini S, Hahn PF, Mueller PR.MRI contrast agents for evaluating focal hepatic lesions.Clin Radiol. 2001 Sep;56(9):714-25.
    11585393
  • Moore A, Josephson L, Bhorade RM, Basilion JP, Weissleder R.Human transferrin receptor gene as a marker gene for MR imaging.Radiology. 2001 Oct;221(1):244-50.
    11568347
  • Dodd CH, Hsu HC, Chu WJ, Yang P, Zhang HG, Mountz JD, Zinn K, Forder J, Josephson L, Weissleder R, Mountz JM, Mountz JD.Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticles.J Immunol Methods. 2001 Oct 1;256(1-2):89-105.
    11516758
  • Spear MA, Breakefield XO, Beltzer J, Schuback D, Weissleder R, Pardo FS, Ladner R.Isolation, characterization, and recovery of small peptide phage display epitopes selected against viable malignant glioma cells.Cancer Gene Ther. 2001 Jul;8(7):506-11.
    11498772
  • Bremer C, Tung CH, Weissleder R.In vivo molecular target assessment of matrix metalloproteinase inhibition.Nat Med. 2001 Jun;7(6):743-8.
    11385514
  • Weissleder R, Mahmood U.Molecular imaging.Radiology. 2001 May;219(2):316-33.
    11323453
  • Weissleder R, Bogdanov A, Tung CH, Weinmann HJ.Size optimization of synthetic graft copolymers for in vivo angiogenesis imaging.Bioconjug Chem. 2001 Mar-Apr;12(2):213-9.
    11312682
  • Simonova M, Wall A, Weissleder R, Bogdanov A.Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells.Cancer Res. 2000 Dec 1;60(23):6656-62.
    11118049
  • Tung CH, Mahmood U, Bredow S, Weissleder R.In vivo imaging of proteolytic enzyme activity using a novel molecular reporter.Cancer Res. 2000 Sep 1;60(17):4953-8.
    10987312
  • Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R.Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells.Nat Biotechnol. 2000 Apr;18(4):410-4.
    10748521
  • Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca EA, Basilion JP.In vivo magnetic resonance imaging of transgene expression.Nat Med. 2000 Mar;6(3):351-5.
    10700241
  • Moore A, Marecos E, Bogdanov A, Weissleder R.Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model.Radiology. 2000 Feb;214(2):568-74.
    10671613
  • Weissleder R, Tung CH, Mahmood U, Bogdanov A.In vivo imaging of tumors with protease-activated near-infrared fluorescent probes.Nat Biotechnol. 1999 Apr;17(4):375-8.
    10207887
  • Josephson L, Tung CH, Moore A, Weissleder R.High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates.Bioconjug Chem. 1999 Mar-Apr;10(2):186-91.
    10077466
  • Moore A, Basilion JP, Chiocca EA, Weissleder R.Measuring transferrin receptor gene expression by NMR imaging.Biochim Biophys Acta. 1998 Apr 24;1402(3):239-49.
    9606982
  • Mandeville JB, Marota JJ, Kosofsky BE, Keltner JR, Weissleder R, Rosen BR, Weisskoff RM.Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation.Magn Reson Med. 1998 Apr;39(4):615-24.
    9543424
  • Weissleder R, Simonova M, Bogdanova A, Bredow S, Enochs WS, Bogdanov A.MR imaging and scintigraphy of gene expression through melanin induction.Radiology. 1997 Aug;204(2):425-9.
    9240530
  • Enochs WS, Petherick P, Bogdanova A, Mohr U, Weissleder R.Paramagnetic metal scavenging by melanin: MR imaging.Radiology. 1997 Aug;204(2):417-23.
    9240529
  • Zimmer C, Wright SC, Engelhardt RT, Johnson GA, Kramm C, Breakefield XO, Weissleder R.Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface.Exp Neurol. 1997 Jan;143(1):61-9.
    9000446
  • Weissleder R, Cheng HC, Bogdanova A, Bogdanov A.Magnetically labeled cells can be detected by MR imaging.J Magn Reson Imaging. 1997 Jan-Feb;7(1):258-63.
    9039625
  • Bogdanov A, Wright SC, Marecos EM, Bogdanova A, Martin C, Petherick P, Weissleder R.A long-circulating co-polymer in "passive targeting" to solid tumors.J Drug Target. 1997;4(5):321-30.
    9169989
  • Muldoon LL, Nilaver G, Kroll RA, Pagel MA, Breakefield XO, Chiocca EA, Davidson BL, Weissleder R, Neuwelt EA.Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain.Am J Pathol. 1995 Dec;147(6):1840-51.
    7495307
  • Zimmer C, Weissleder R, Poss K, Bogdanova A, Wright SC, Enochs WS.MR imaging of phagocytosis in experimental gliomas.Radiology. 1995 Nov;197(2):533-8.
    7480707
  • Weissleder R, Poss K, Wilkinson R, Zhou C, Bogdanov A.Quantitation of slow drug release from an implantable and degradable gentamicin conjugate by in vivo magnetic resonance imaging.Antimicrob Agents Chemother. 1995 Apr;39(4):839-45.
    7785981
  • Bogdanov AA, Martin C, Weissleder R, Brady TJ.Trapping of dextran-coated colloids in liposomes by transient binding to aminophospholipid: preparation of ferrosomes.Biochim Biophys Acta. 1994 Jul 13;1193(1):212-8.
    7518693
  • Neuwelt EA, Weissleder R, Nilaver G, Kroll RA, Roman-Goldstein S, Szumowski J, Pagel MA, Jones RS, Remsen LG, McCormick CI.Delivery of virus-sized iron oxide particles to rodent CNS neurons.Neurosurgery. 1994 Apr;34(4):777-84.
    8008188