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Brendan D. Price, PhD


  • Ayrapetov MK, Gursoy-Yuzugullu O, Xu C, Xu Y, Price BD.DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin.Proc Natl Acad Sci U S A. 2014 Jun 9.
  • Madlener S, Ströbel T, Vose S, Saydam O, Price BD, Demple B, Saydam N.Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenance.Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17844-9.
  • Park E, Kim H, Kim JM, Primack B, Vidal-Cardenas S, Xu Y, Price BD, Mills AA, D'Andrea AD.FANCD2 activates transcription of TAp63 and suppresses tumorigenesis.Mol Cell. 2013 Jun 27;50(6):908-18.
  • Price BD, D'Andrea AD.Chromatin remodeling at DNA double-strand breaks.Cell. 2013 Mar 14;152(6):1344-54.
  • Berbeco RI, Korideck H, Ngwa W, Kumar R, Patel J, Sridhar S, Johnson S, Price BD, Kimmelman A, Makrigiorgos GM.DNA Damage Enhancement from Gold Nanoparticles for Clinical MV Photon Beams.Radiat Res. 2012 Nov 13.
  • Xu Y, Ayrapetov MK, Xu C, Gursoy-Yuzugullu O, Hu Y, Price BD.Histone H2A.Z Controls a Critical Chromatin Remodeling Step Required for DNA Double-Strand Break Repair.Mol Cell. 2012 Oct 30.
  • Xu C, Xu Y, Gursoy-Yuzugullu O, Price BD.The histone variant macroH2A1.1 is recruited to DSBs through a mechanism involving PARP1.FEBS Lett. 2012 Nov 2;586(21):3920-5.
  • Xu Y, Price BD.Chromatin dynamics and the repair of DNA double strand breaks.Cell Cycle. 2011 Jan 15;10(2).
  • Xu Y, Sun Y, Jiang X, Ayrapetov MK, Moskwa P, Yang S, Weinstock DM, Price BD.The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair.J Cell Biol. 2010 Oct 4;191(1):31-43.
  • Weng D, Cunin MC, Song B, Price BD, Eller MS, Gilchrest BA, Calderwood SK, Gong J.Radiosensitization of mammary carcinoma cells by telomere homolog oligonucleotide pretreatment.Breast Cancer Res. 2010 Sep 16;12(5):R71.
  • Lin CI, Whang EE, Donner DB, Du J, Lorch J, He F, Jiang X, Price BD, Moore FD, Ruan DT.Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer.Mol Cancer Res. 2010 Sep;8(9):1217-26.
  • Jiang X, Xu Y, Price BD.Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway.FEBS Lett. 2010 Jul 2;584(13):2926-30.
  • Sun Y, Jiang X, Price BD.Tip60: Connecting chromatin to DNA damage signaling.Cell Cycle. 2010 Mar 11;9(5).
  • Lin CI, Whang EE, Abramson MA, Jiang X, Price BD, Donner DB, Moore FD, Ruan DT.Autophagy: a new target for advanced papillary thyroid cancer therapy.Surgery. 2009 Dec;146(6):1208-14.
  • Kim K, Pollard JM, Norris AJ, McDonald JT, Sun Y, Micewicz E, Pettijohn K, Damoiseaux R, Iwamoto KS, Sayre JW, Price BD, Gatti RA, McBride WH.High-throughput screening identifies two classes of antibiotics as radioprotectors: tetracyclines and fluoroquinolones.Clin Cancer Res. 2009 Dec 1;15(23):7238-45.
  • Sun Y, Jiang X, Xu Y, Ayrapetov MK, Moreau LA, Whetstine JR, Price BD.Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.Nat Cell Biol. 2009 Nov;11(11):1376-82.
  • Lin CI, Whang EE, Donner DB, Jiang X, Price BD, Carothers AM, Delaine T, Leffler H, Nilsson UJ, Nose V, Moore FD, Ruan DT.Galectin-3 targeted therapy with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer.Mol Cancer Res. 2009 Oct;7(10):1655-62.
  • Sun Y, Xu Y, Roy K, Price BD.DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.Mol Cell Biol. 2007 Dec;27(24):8502-9.
  • Fernandes ND, Sun Y, Price BD.Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells.J Biol Chem. 2007 Jun 1;282(22):16577-84.
  • Sun Y, Jiang X, Chen S, Price BD.Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation.FEBS Lett. 2006 Aug 7;580(18):4353-6.
  • Roy K, Wang L, Makrigiorgos GM, Price BD.Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity.Biochem Biophys Res Commun. 2006 Jun 9;344(3):821-6.
  • Jiang X, Sun Y, Chen S, Roy K, Price BD.The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.J Biol Chem. 2006 Jun 9;281(23):15741-6.
  • Sun Y, Jiang X, Chen S, Fernandes N, Price BD.A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13182-7.
  • Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD.DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.J Biol Chem. 2005 Apr 15;280(15):15158-64.
  • Wang G, Brennan C, Rook M, Wolfe JL, Leo C, Chin L, Pan H, Liu WH, Price B, Makrigiorgos GM.Balanced-PCR amplification allows unbiased identification of genomic copy changes in minute cell and tissue samples.Nucleic Acids Res. 2004 May;32(9):e76.
  • Chen S, Wang G, Makrigiorgos GM, Price BD.Stable siRNA-mediated silencing of ATM alters the transcriptional profile of HeLa cells.Biochem Biophys Res Commun. 2004 May 14;317(4):1037-44.
  • Chen S, Paul P, Price BD.ATM's leucine-rich domain and adjacent sequences are essential for ATM to regulate the DNA damage response.Oncogene. 2003 Sep 25;22(41):6332-9.
  • Kaur M, Zhang Y, Liu WH, Tetradis S, Price BD, Makrigiorgos GM.Ligation of a primer at a mutation: a method to detect low level mutations in DNA.Mutagenesis. 2002 Sep;17(5):365-74.
  • Makrigiorgos GM, Chakrabarti S, Zhang Y, Kaur M, Price BD.A PCR-based amplification method retaining the quantitative difference between two complex genomes.Nat Biotechnol. 2002 Sep;20(9):936-9.
  • Zhang Y, Kaur M, Price BD, Tetradis S, Makrigiorgos GM.An amplification and ligation-based method to scan for unknown mutations in DNA.Hum Mutat. 2002 Aug;20(2):139-47.
  • Turenne GA, Paul P, Laflair L, Price BD.Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53.Oncogene. 2001 Aug 23;20(37):5100-10.
  • Turenne GA, Price BD.Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity.BMC Cell Biol. 2001;2:12.
  • Zhang Y, Price BD, Tetradis S, Chakrabarti S, Maulik G, Makrigiorgos GM.Reproducible and inexpensive probe preparation for oligonucleotide arrays.Nucleic Acids Res. 2001 Jul 1;29(13):E66-6.
  • Chakrabarti S, Price BD, Tetradis S, Fox EA, Zhang Y, Maulik G, Makrigiorgos GM.Highly selective isolation of unknown mutations in diverse DNA fragments: toward new multiplex screening in cancer.Cancer Res. 2000 Jul 15;60(14):3732-7.
  • Palayoor ST, Youmell MY, Calderwood SK, Coleman CN, Price BD.Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen.Oncogene. 1999 Dec 2;18(51):7389-94.
  • Blasina A, Price BD, Turenne GA, McGowan CH.Caffeine inhibits the checkpoint kinase ATM.Curr Biol. 1999 Oct 7;9(19):1135-8.
  • Howard SP, Park SJ, Hughes-Davies L, Coleman CN, Price BD.Suramin increases p53 protein levels but does not activate the p53-dependent G1 checkpoint.Clin Cancer Res. 1996 Feb;2(2):269-76.
  • Rosenzweig KE, Youmell MB, Palayoor ST, Price BD.Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.Clin Cancer Res. 1997 Jul;3(7):1149-56.
  • Maulik N, Sato M, Price BD, Das DK.An essential role of NFkappaB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia.FEBS Lett. 1998 Jun 16;429(3):365-9.
  • Basu S, Rosenzweig KR, Youmell M, Price BD.The DNA-dependent protein kinase participates in the activation of NF kappa B following DNA damage.Biochem Biophys Res Commun. 1998 Jun 9;247(1):79-83.
  • Youmell M, Park SJ, Basu S, Price BD.Regulation of the p53 protein by protein kinase C alpha and protein kinase C zeta.Biochem Biophys Res Commun. 1998 Apr 17;245(2):514-8.
  • Cahill CM, Lin HS, Price BD, Bruce JL, Calderwood SK.Potential role of heat shock transcription factor in the expression of inflammatory cytokines.Adv Exp Med Biol. 1997;400B:625-30.
  • Chu B, Soncin F, Price BD, Stevenson MA, Calderwood SK.Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1.J Biol Chem. 1996 Nov 29;271(48):30847-57.
  • Price BD, Youmell MB.The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage.Cancer Res. 1996 Jan 15;56(2):246-50.
  • Tishler RB, Lamppu DM, Park S, Price BD.Microtubule-active drugs taxol, vinblastine, and nocodazole increase the levels of transcriptionally active p53.Cancer Res. 1995 Dec 15;55(24):6021-5.
  • Price BD, Hughes-Davies L, Park SJ.Cdk2 kinase phosphorylates serine 315 of human p53 in vitro.Oncogene. 1995 Jul 6;11(1):73-80.
  • Price BD, Park SJ.DNA damage increases the levels of MDM2 messenger RNA in wtp53 human cells.Cancer Res. 1994 Feb 15;54(4):896-9.
  • Price BD, Calderwood SK.Increased sequence-specific p53-DNA binding activity after DNA damage is attenuated by phorbol esters.Oncogene. 1993 Nov;8(11):3055-62.
  • Calderwood SK, Stevenson MA, Price BD.Activation of phospholipase C by heat shock requires GTP analogs and is resistant to pertussis toxin.J Cell Physiol. 1993 Jul;156(1):153-9.
  • Tishler RB, Calderwood SK, Coleman CN, Price BD.Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents.Cancer Res. 1993 May 15;53(10 Suppl):2212-6.
  • Bruce JL, Price BD, Coleman CN, Calderwood SK.Oxidative injury rapidly activates the heat shock transcription factor but fails to increase levels of heat shock proteins.Cancer Res. 1993 Jan 1;53(1):12-5.
  • Price BD, Calderwood SK.Heat-induced transcription from RNA polymerases II and III and HSF binding activity are co-ordinately regulated by the products of the heat shock genes.J Cell Physiol. 1992 Nov;153(2):392-401.
  • Price BD.Signalling across the endoplasmic reticulum membrane: potential mechanisms.Cell Signal. 1992 Sep;4(5):465-70.
  • Price BD, Mannheim-Rodman LA, Calderwood SK.Brefeldin A, thapsigargin, and AIF4- stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis.J Cell Physiol. 1992 Sep;152(3):545-52.
  • Price BD, Calderwood SK.Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins.Cancer Res. 1992 Jul 1;52(13):3814-7.
  • Bader SB, Price BD, Mannheim-Rodman LA, Calderwood SK.Inhibition of heat shock gene expression does not block the development of thermotolerance.J Cell Physiol. 1992 Apr;151(1):56-62.
  • Price BD, Calderwood SK.Ca2+ is essential for multistep activation of the heat shock factor in permeabilized cells.Mol Cell Biol. 1991 Jun;11(6):3365-8.
  • Price BD, Morris JD, Hall A.Stimulation of phosphatidylcholine breakdown and diacylglycerol production by growth factors in Swiss-3T3 cells.Biochem J. 1989 Dec 1;264(2):509-15.
  • Price BD, Morris JD, Marshall CJ, Hall A.Stimulation of phosphatidylcholine hydrolysis, diacylglycerol release, and arachidonic acid production by oncogenic ras is a consequence of protein kinase C activation.J Biol Chem. 1989 Oct 5;264(28):16638-43.
  • Price BD, Morris JD, Marshall CJ, Hall A.Scrape-loaded p21ras down-regulates agonist-stimulated inositol phosphate production by a mechanism involving protein kinase C.Biochem J. 1989 May 15;260(1):157-61.
  • Brand MD, Al-Shawi MK, Brown GC, Price BD.Thermodynamic and steady-state-kinetic investigation of the effect of NN'-dicyclohexylcarbodi-imide on H+ translocation by the mitochondrial cytochrome bc1 complex.Biochem J. 1985 Jan 15;225(2):407-11.
  • Price BD, Brand MD.Chemical modification of the mitochondrial bc1 complex by N,N'-dicyclohexylcarbodiimide inhibits proton translocation.Eur J Biochem. 1983 May 16;132(3):595-601.
  • Price BD, Brand MD.Proton translocation by the mitochondrial cytochrome b-c1 complex is inhibited by NN'-dicyclohexylcarbodi-imide.Biochem J. 1982 Aug 15;206(2):419-21.