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Ulrike S. Eggert, PhD

Publications

  • Zhang X, Bedigian AV, Wang W, Eggert US.G protein-coupled receptors participate in cytokinesis.Cytoskeleton. 2012 Oct;69(10):810-8.
    22888021
  • Sörensen PM, Iacob RE, Fritzsche M, Engen JR, Brieher WM, Charras G, Eggert US.The natural product cucurbitacin E inhibits depolymerization of actin filaments.ACS Chem Biol. 2012 Sep 21;7(9):1502-8.
    22724897
  • Zhang X, Wang W, Bedigian AV, Coughlin ML, Mitchison TJ, Eggert US.Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI.Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12485-90.
    22802617
  • Castoreno AB, Eggert US.Small molecule probes of cellular pathways and networks.ACS Chem Biol. 2011 Jan 21;6(1):86-94.
    21087032
  • Zhou Q, Kee YS, Poirier CC, Jelinek C, Osborne J, Divi S, Surcel A, Will ME, Eggert US, Müller-Taubenberger A, Iglesias PA, Cotter RJ, Robinson DN.14-3-3 Coordinates Microtubules, Rac, and Myosin II to Control Cell Mechanics and Cytokinesis.Curr Biol. 2010 Nov 9;20(21):1881-9.
    20951045
  • Smurnyy Y, Toms AV, Hickson GR, Eck MJ, Eggert US.Binucleine 2, an Isoform-Specific Inhibitor of Drosophila Aurora B Kinase, Provides Insights into the Mechanism of Cytokinesis.ACS Chem Biol. 2010 Aug 30.
    20804174
  • Castoreno AB, Smurnyy Y, Torres AD, Vokes MS, Jones TR, Carpenter AE, Eggert US.Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis.Nat Chem Biol. 2010 Jun;6(6):457-63.
    20436488
  • Atilla-Gokcumen GE, Castoreno AB, Sasse S, Eggert US.Making the cut: the chemical biology of cytokinesis.ACS Chem Biol. 2010 Jan 15;5(1):79-90. Review.
    20014865
  • Jones TR,Carpenter AE,Lamprecht MR,Moffat J,Silver SJ,Grenier JK,Castoreno AB,Eggert US,Root DE,Golland P,Sabatini DM.Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning.Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1826-31.
    19188593
  • Maloney KN,Fujita M,Eggert US,Schroeder FC,Field CM,Mitchison TJ,Clardy J.Actin-Aggregating Cucurbitacins from Physocarpus capitatus.J Nat Prod. 2008 Oct 30.
    18959442
  • Ehrlich G, Hassfeld J, Eggert U, Kalesse M.The total synthesis of (+)-tedanolide--A macrocyclic polyketide from marine sponge Tedania ignis.Chemistry. 2008;14(7):2232-47.
    18165955
  • Eggert US, Superti-Furga G.Drugs in action.Nat Chem Biol. 2008 Jan;4(1):7-11.
    18084271
  • Perrimon N, Friedman A, Mathey-Prevot B, Eggert US.Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens.Drug Discov Today. 2007 Jan;12(1-2):28-33. Review.
    17198970
  • Eggert US, Field CM, Mitchison TJ.Small molecules in an RNAi world.Mol Biosyst. 2006 Feb;2(2):93-6. Review.
    16880926
  • Eggert US, Mitchison TJ, Field CM.Animal cytokinesis: from parts list to mechanisms.Annu Rev Biochem. 2006;75:543-66. Review.
    16756502
  • Eggert US, Mitchison TJ.Small molecule screening by imaging.Curr Opin Chem Biol. 2006 Jun;10(3):232-7. Review.
    16682248
  • Eggert US, Kiger AA, Richter C, Perlman ZE, Perrimon N, Mitchison TJ, Field CM.Parallel Chemical Genetic and Genome-Wide RNAi Screens Identify Cytokinesis Inhibitors and Targets.PLoS Biol. 2004 Dec;2(12):e379.
    15547975
  • Dong SD, Oberthr M, Losey HC, Anderson JW, Eggert US, Peczuh MW, Walsh CT, Kahne D.The structural basis for induction of VanB resistance.J Am Chem Soc. 2002 Aug 7;124(31):9064-5.
    12149006
  • Sun B, Chen Z, Eggert US, Shaw SJ, LaTour JV, Kahne D.Hybrid glycopeptide antibiotics.J Am Chem Soc. 2001 Dec 19;123(50):12722-3.
    11741455
  • Eggert US, Ruiz N, Falcone BV, Branstrom AA, Goldman RC, Silhavy TJ, Kahne D.Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin.Science. 2001 Oct 12;294(5541):361-4.
    11520949
  • Losey HC, Peczuh MW, Chen Z, Eggert US, Dong SD, Pelczer I, Kahne D, Walsh CT.Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.Biochemistry. 2001 Apr 17;40(15):4745-55.
    11294642