Lucian R. Chirieac, MD

Publications

• Sugarbaker DJ, Wolf AS, Chirieac LR, Godleski JJ, Tilleman TR, Jaklitsch MT, Bueno R, Richards WG.Clinical and pathological features of three-year survivors of malignant pleural mesothelioma following extrapleural pneumonectomy.European Journal Of Cardio
  21310625
• Cagle PT, Allen TC, Dacic S, Beasley MB, Borczuk AC, Chirieac LR, Laucirica R, Ro JY, Kerr KM.Revolution in lung cancer: new challenges for the surgical pathologist.Arch Pathol Lab Med. 2011 Jan;135(1):110-6. Review.
  21204716
• Ettinger DS, Akerley W, Bepler G, Blum MG, Chang A, Cheney RT, Chirieac LR, D'Amico TA, Demmy TL, Govindan R, Grannis FW, Jahan T, Johnson DH, Kessinger A, Komaki R, Kong FM, Kris MG, Krug LM, Le QT, Lennes IT, Martins R, O'Malley J, Osarogiagbon
  21081786
• Wolf AS, Richards WG, Tilleman TR, Chirieac L, Hurwitz S, Bueno R, Sugarbaker DJ.Characteristics of malignant pleural mesothelioma in women.Ann Thorac Surg. 2010 Sep;90(3):949-56; discussion 956.
  20732523
• Chirieac LR, Dacic S.Targeted Therapies in Lung Cancer.Surgical Pathology Clinics. 2010 Mar 1;3(1):71-82.
  20680095
• Ettinger DS, Akerley W, Bepler G, Blum MG, Chang A, Cheney RT, Chirieac LR, D'Amico TA, Demmy TL, Ganti AK, Govindan R, Grannis FW, Jahan T, Jahanzeb M, Johnson DH, Kessinger A, Komaki R, Kong FM, Kris MG, Krug LM, Le QT, Lennes IT, Martins R, O'M
  20679538
• Sholl LM, Barletta JA, Yeap BY, Chirieac LR, Hornick JL.Sox2 protein expression is an independent poor prognostic indicator in stage I lung adenocarcinoma.Am J Surg Pathol. 2010 Aug;34(8):1193-8.
  20631605
• Benedettini E, Sholl LM, Peyton M, Reilly J, Ware C, Davis L, Vena N, Bailey D, Yeap BY, Fiorentino M, Ligon AH, Pan BS, Richon V, Minna JD, Gazdar AF, Draetta G, Bosari S, Chirieac LR, Lutterbach B, Loda M.Met Activation in Non-Small Cell Lung Cancer Is
  20489150
• McIntire MG, Santagata S, Ligon K, Chirieac LR.Epidermal growth factor receptor gene amplification in atypical adenomatous hyperplasia of the lung.Am J Transl Res. 2010;2(3):309-15.
  20589169
• Sasaki T, Rodig SJ, Chirieac LR, Jänne PA.The biology and treatment of EML4-ALK non-small cell lung cancer.Eur J Cancer. 2010 Jul;46(10):1773-80. Review.
  20418096
• Wolinsky JB, Liu R, Walpole J, Chirieac LR, Colson YL, Grinstaff MW.Prevention of in vivo lung tumor growth by prolonged local delivery of hydroxycamptothecin using poly(ester-carbonate)-collagen composites.J Control Release. 2010 Jun 15;144(3):280-7.
  20184934
• Bueno R, De Rienzo A, Dong L, Gordon GJ, Hercus CF, Richards WG, Jensen RV, Anwar A, Maulik G, Chirieac LR, Ho KF, Taillon BE, Turcotte CL, Hercus RG, Gullans SR, Sugarbaker DJ.Second generation sequencing of the mesothelioma tumor genome.PLoS ONE. 2010;5
  20485525
• Spivey KA, Banyard J, Solis LM, Wistuba II, Barletta JA, Gandhi L, Feldman HA, Rodig SJ, Chirieac LR, Zetter BR.Collagen XXIII: a potential biomarker for the detection of primary and recurrent non-small cell lung cancer.Cancer Epidemiol Biomarkers Prev. 2
  20447926
• Liu R, Wolinsky JB, Walpole J, Southard E, Chirieac LR, Grinstaff MW, Colson YL.Prevention of local tumor recurrence following surgery using low-dose chemotherapeutic polymer films.Ann Surg Oncol. 2010 Apr;17(4):1203-13.
  19957041
• Richards WG, Godleski JJ, Yeap BY, Corson JM, Chirieac LR, Zellos L, Mujoomdar A, Jaklitsch MT, Bueno R, Sugarbaker DJ.Proposed adjustments to pathologic staging of epithelial malignant pleural mesothelioma based on analysis of 354 cases.Cancer. 2010 Mar
  20108310
• Mino-Kenudson M, Chirieac LR, Law K, Hornick JL, Lindeman N, Mark EJ, Cohen DW, Johnson BE, Jänne PA, Iafrate AJ, Rodig SJ.A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistoc
  20179225
• Barletta JA,Perner S,Iafrate AJ,Yeap BY,Weir BA,Johnson LA,Johnson BE,Meyerson M,Rubin MA,Travis WD,Loda M,Chirieac LR.Clinical Significance of TTF-1 Protein Expression and TTF-1 Gene Amplification in Lung Adenocarcinoma.J Cell Mol Med. 2009 Aug;13(8B):19
  19040416
• Barletta JA, Yeap BY, Chirieac LR.Prognostic significance of grading in lung adenocarcinoma.Cancer. 2010 Feb 1;116(3):659-69.
  20014400
• Chirieac LR, Flieder DB.High-resolution computed tomography screening for lung cancer: unexpected findings and new controversies regarding adenocarcinogenesis.Arch Pathol Lab Med. 2010 Jan;134(1):41-8. Review.
  20073604
• Ramos AH, Dutt A, Mermel C, Perner S, Cho J, Lafargue CJ, Johnson LA, Stiedl AC, Tanaka KE, Bass AJ, Barretina J, Weir BA, Beroukhim R, Thomas RK, Minna JD, Chirieac LR, Lindeman NI, Giordano T, Beer DG, Wagner P, Wistuba II, Rubin MA, Meyerson M.Amplific
  19755855
• Zhou W, Ercan D, Chen L, Yun CH, Li D, Capelletti M, Cortot AB, Chirieac L, Iacob RE, Padera R, Engen JR, Wong KK, Eck MJ, Gray NS, Jänne PA.Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.Nature. 2009 Dec 24;462(7276):1070-4.
  20033049
• Ramos AH, Dutt A, Mermel C, Perner S, Cho J, Lafargue CJ, Johnson LA, Stiedl AC, Tanaka KE, Bass AJ, Barretina J, Weir BA, Beroukhim R, Thomas RK, Minna JD, Chirieac LR, Lindeman NI, Giordano T, Beer DG, Wagner P, Wistuba II, Rubin MA, Meyerson M.Amplific
• Sholl LM, Yeap BY, Iafrate AJ, Holmes-Tisch AJ, Chou YP, Wu MT, Goan YG, Su L, Benedettini E, Yu J, Loda M, Jänne PA, Christiani DC, Chirieac LR.Lung adenocarcinoma with EGFR amplification has distinct clinicopathologic and molecular features in never-sm
  19826035
• Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O'Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V,
  19801978
• Chirieac LR, Corson JM.Pathologic evaluation of malignant pleural mesothelioma.Semin Thorac Cardiovasc Surg. 2009;21(2):121-4. Review.
  19822283
• Sholl LM, Yeap BY, Iafrate AJ, Holmes-Tisch AJ, Chou YP, Wu MT, Goan YG, Su L, Benedettini E, Yu J, Loda M, Jänne PA, Christiani DC, Chirieac LR.Lung adenocarcinoma with EGFR amplification has distinct clinicopathologic and molecular features in never-sm
• Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O'Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V,
• Shaw AT, Yeap BY, Mino-Kenudson M, Digumarthy SR, Costa DB, Heist RS, Solomon B, Stubbs H, Admane S, McDermott U, Settleman J, Kobayashi S, Mark EJ, Rodig SJ, Chirieac LR, Kwak EL, Lynch TJ, Iafrate AJ.Clinical Features and Outcome of Patients With Non-Sm
  19667264
• Rodig SJ, Mino-Kenudson M, Dacic S, Yeap BY, Shaw A, Barletta JA, Stubbs H, Law K, Lindeman N, Mark E, Janne PA, Lynch T, Johnson BE, Iafrate AJ, Chirieac LR.Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western
  19671850
• Husain AN, Colby TV, Ordóñez NG, Krausz T, Borczuk A, Cagle PT, Chirieac LR, Churg A, Galateau-Salle F, Gibbs AR, Gown AM, Hammar SP, Litzky LA, Roggli VL, Travis WD, Wick MR.Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus sta
  19653732
• Husain AN, Colby TV, Ordóñez NG, Krausz T, Borczuk A, Cagle PT, Chirieac LR, Churg A, Galateau-Salle F, Gibbs AR, Gown AM, Hammar SP, Litzky LA, Roggli VL, Travis WD, Wick MR.Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus sta
• Chirieac LR, Corson JM.Pathologic evaluation of malignant pleural mesothelioma.Semin Oncol. 2009 Summer;21(2):121-4.
• Huang YT,Heist RS,Chirieac LR,Lin X,Skaug V,Zienolddiny S,Haugen A,Wu MC,Wang Z,Su L,Asomaning K,Christiani DC.Genome-wide analysis of survival in early-stage non-small-cell lung cancer.J Clin Oncol. 2009 Jun 1;27(16):2660-7.
  19414679
• Yu J,Kane S,Wu J,Benedettini E,Li D,Reeves C,Innocenti G,Wetzel R,Crosby K,Becker A,Ferrante M,Cheung WC,Hong X,Chirieac LR,Sholl LM,Haack H,Smith BL,Polakiewicz RD,Tan Y,Gu TL,Loda M,Zhou X,Comb MJ.Mutation-specific antibodies for the detection of EGFR m
  19366827
• Gandhi L,McNamara KL,Li D,Borgman CL,McDermott U,Brandstetter KA,Padera RF,Chirieac LR,Settleman JE,Wong KK.Sunitinib prolongs survival in genetically engineered mouse models of multistep lung carcinogenesis.Cancer Prev Res (Phila Pa). 2009 Apr;2(4):330-7
  19336729
• Zellos L,Richards WG,Capalbo L,Jaklitsch MT,Chirieac LR,Johnson BE,Bueno R,Sugarbaker DJ.A phase I study of extrapleural pneumonectomy and intracavitary intraoperative hyperthermic cisplatin with amifostine cytoprotection for malignant pleural mesotheliom
  19185169
• Perera SA,Li D,Shimamura T,Raso MG,Ji H,Chen L,Borgman CL,Zaghlul S,Brandstetter KA,Kubo S,Takahashi M,Chirieac LR,Padera RF,Bronson RT,Shapiro GI,Greulich H,Meyerson M,Guertler U,Chesa PG,Solca F,Wistuba II,Wong KK.HER2YVMA drives rapid development of ad
  19122144
• Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, Padera RF, García-Echeverría C, Weissleder R, Mahmood U, Cantley LC, Wong KK.Effective use of PI
  19029981
• Ding L,Getz G,Wheeler DA,Mardis ER,McLellan MD,Cibulskis K,Sougnez C,Greulich H,Muzny DM,Morgan MB,Fulton L,Fulton RS,Zhang Q,Wendl MC,Lawrence MS,Larson DE,Chen K,Dooling DJ,Sabo A,Hawes AC,Shen H,Jhangiani SN,Lewis LR,Hall O,Zhu Y,Mathew T,Ren Y,Yao J,S
  18948947
• Girnun GD,Chen L,Silvaggi J,Drapkin R,Chirieac LR,Padera RF,Upadhyay R,Vafai SB,Weissleder R,Mahmood U,Naseri E,Buckley S,Li D,Force J,McNamara K,Demetri G,Spiegelman BM,Wong KK.Regression of drug-resistant lung cancer by the combination of rosiglitazone
  18927287
• Saad AG,Yeap BY,Thunnissen FB,Pinkus GS,Pinkus JL,Loda M,Sugarbaker DJ,Johnson BE,Chirieac LR.Immunohistochemical markers associated with brain metastases in patients with nonsmall cell lung carcinoma.Cancer. 2008 Oct 15;113(8):2129-38.
  18720359
• Li D, Ambrogio L, Shimamura T, Kubo S, Takahashi M, Chirieac LR, Padera RF, Shapiro GI, Baum A, Himmelsbach F, Rettig WJ, Meyerson M, Solca F, Greulich H, Wong KK.BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer mo
  18408761
• Shimamura T,Li D,Ji H,Haringsma HJ,Liniker E,Borgman CL,Lowell AM,Minami Y,McNamara K,Perera SA,Zaghlul S,Thomas RK,Greulich H,Kobayashi S,Chirieac LR,Padera RF,Kubo S,Takahashi M,Tenen DG,Meyerson M,Wong KK,Shapiro GI.Hsp90 inhibition suppresses mutant E
  18632637
• Suehiro Y, Wong CW, Chirieac LR, Kondo Y, Shen L, Webb CR, Chan YW, Chan AS, Chan TL, Wu TT, Rashid A, Hamanaka Y, Hinoda Y, Shannon RL, Wang X, Morris J, Issa JP, Yuen ST, Leung SY, Hamilton SR.Epigenetic-Genetic Interactions in the APC/WNT, RAS/RAF, and
  18451217
• Ettinger DS, Akerley W, Bepler G, Chang A, Cheney RT, Chirieac LR, D'Amico TA, Demmy TL, Feigenberg SJ, Figlin RA, Govindan R, Grannis FW Jr, Jahan T, Jahanzeb M, Kessinger A, Komaki R, Kris MG, Langer CJ, Le QT, Martins R, Otterson GA, Patel JD, Robe
  18377844
• Sugarbaker DJ, Richards WG, Gordon GJ, Dong L, De Rienzo A, Maulik G, Glickman JN, Chirieac LR, Hartman ML, Taillon BE, Du L, Bouffard P, Kingsmore SF, Miller NA, Farmer AD, Jensen RV, Gullans SR, Bueno R.Transcriptome sequencing of malignant pleural meso
  18303113
• Tarkan JL,Woo SB,Pavlakis M,Johnson SR,Chirieac LR,Chimienti SN,Mandelbrot DA.Spotting the owl: surreptitious cytomegalovirus disease in a renal transplant recipient.Clin Transplant. 2008 May-Jun;22(3):391-5.
  18261119
• Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, Broderick S, Chang AC, Chiang DY, Chirieac LR, Cho J, Fujii Y, Gazdar AF, Giordano T, Greulich H, Hanna M
  17982442
• Richards W, Van Oss S, Glickman J, Chirieac L, Yeap B, Dong L, Gordon G, Mercer H, Gill K, Imrich A, Bueno R, Sugarbaker D.A microaliquoting technique for precise histological annotation and optimization of cell content in frozen tissue specimens.Biotech
  17917854
• Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC
  17676035
• Sholl LM, John Iafrate A, Chou YP, Wu MT, Goan YG, Su L, Huang YT, Christiani DC, Chirieac LR.Validation of chromogenic in situ hybridization for detection of EGFR copy number amplification in nonsmall cell lung carcinoma.Mod Pathol. 2007 Oct;20(10):1028-
  17673923
• Li D, Shimamura T, Ji H, Chen L, Haringsma HJ, McNamara K, Liang MC, Perera SA, Zaghlul S, Borgman CL, Kubo S, Takahashi M, Sun Y, Chirieac LR, Padera RF, Lindeman NI, Jänne PA, Thomas RK, Meyerson ML, Eck MJ, Engelman JA, Shapiro GI, Wong KK.Bronchial an
  17613438
• Freedman RA, Wirth LJ, Chirieac LR, Huang EC.Glioblastoma in a patient with early-stage tonsil cancer.J Clin Oncol. 2007 Jul 1;25(19):2848-50.
  17602090
• Finberg KE, Sequist LV, Joshi VA, Muzikansky A, Miller JM, Han M, Beheshti J, Chirieac LR, Mark EJ, Iafrate AJ.Mucinous differentiation correlates with absence of EGFR mutation and presence of KRAS mutation in lung adenocarcinomas with bronchioloalveolar
  17591931
• Heist RS, Zhou W, Chirieac LR, Cogan-Drew T, Liu G, Su L, Neuberg D, Lynch TJ, Wain JC, Christiani DC.MDM2 polymorphism, survival, and histology in early-stage non-small-cell lung cancer.J Clin Oncol. 2007 Jun 1;25(16):2243-7.
  17538168
• Ji H, Wang Z, Perera SA, Li D, Liang MC, Zaghlul S, McNamara K, Chen L, Albert M, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Thomas RK, Garraway LA, Jänne PA, Johnson BE, Chin L, Wong KK.Mutations in BRAF and KRAS converge on activation of the
  17510423
• Li D, Ji H, Zaghlul S, McNamara K, Liang MC, Shimamura T, Kubo S, Takahashi M, Chirieac LR, Padera RF, Scott AM, Jungbluth AA, Cavenee WK, Old LJ, Demetri GD, Wong KK.Therapeutic anti-EGFR antibody 806 generates responses in murine de novo EGFR mutant-dep
  17256054
• Wu TT, Chirieac LR, Abraham SC, Krasinskas AM, Wang H, Rashid A, Correa AM, Hofstetter WL, Ajani JA, Swisher SG.Excellent interobserver agreement on grading the extent of residual carcinoma after preoperative chemoradiation in esophageal and esophagogastr
• Chirieac LR, Rice DC, Raymond AK.Epithelioid hemangioendothelioma in a patient with unusual involvement of the rib and intercostal lymph nodes.J Thorac Cardiovasc Surg. 2006 Dec;132(6):1488-9.
  17140992
• Chirieac LR, Trent JC, Steinert DM, Choi H, Yang Y, Zhang J, Patel SR, Benjamin RS, Raymond AK.Correlation of immunophenotype with progression-free survival in patients with gastrointestinal stromal tumors treated with imatinib mesylate.Cancer. 2006 Nov 1
  16998931
• Ettinger DS, Bepler G, Bueno R, Chang A, Chang JY, Chirieac LR, D'Amico TA, Demmy TL, Feigenberg SJ, Grannis FW, Jahan T, Jahanzeb M, Kessinger A, Komaki R, Kris MG, Langer CJ, Le QT, Martins R, Otterson GA, Robert F, Sugarbaker DJ, Wood DE,.Non-small
  16813724
• Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, Jänne PA, Shapiro GI, Tenen D, Johnson BE, Weissleder R, Sharpless NE, Wong KK.The impact of human EGFR kinase d
  16730237
• Richards WG, Zellos L, Bueno R, Jaklitsch MT, Jänne PA, Chirieac LR, Yeap BY, Dekkers RJ, Hartigan PM, Capalbo L, Sugarbaker DJ.Phase I to II study of pleurectomy/decortication and intraoperative intracavitary hyperthermic cisplatin lavage for mesotheliom
  16575008
• Chirieac LR, Dekmezian RH, Ayala AG.Characterization of the myxoid variant of hibernoma.Ann Diagn Pathol. 2006 Apr;10(2):104-6.
  16546046
• Lin Q, Lai R, Chirieac LR, Li C, Thomazy VA, Grammatikakis I, Rassidakis GZ, Zhang W, Fujio Y, Kunisada K, Hamilton SR, Amin HM.Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apop
  16192633
• Jackman DM, Chirieac LR, Jänne PA.Bronchioloalveolar carcinoma: a review of the epidemiology, pathology, and treatment.Semin Respir Crit Care Med. 2005 Jun;26(3):342-52.
  16052436
• Niemisto A, Shmulevich I, Yli-Harja O, Chirieac LR, Hamilton SR.Automated quantification of lymph node size and number in surgical specimens of stage II colorectal cancer.Conf Proc IEEE Eng Med Biol Soc. 2005;6:6313-6.
• Swisher SG, Hofstetter W, Wu TT, Correa AM, Ajani JA, Komaki RR, Chirieac L, Hunt KK, Liao Z, Phan A, Rice DC, Vaporciyan AA, Walsh GL, Roth JA.Proposed revision of the esophageal cancer staging system to accommodate pathologic response (pP) following pre
  15849517
• Chirieac LR, Swisher SG, Correa AM, Ajani JA, Komaki RR, Rashid A, Hamilton SR, Wu TT.Signet-ring cell or mucinous histology after preoperative chemoradiation and survival in patients with esophageal or esophagogastric junction adenocarcinoma.Clin Cancer
  15788671
• Chirieac LR, Shen L, Catalano PJ, Issa JP, Hamilton SR.Phenotype of microsatellite-stable colorectal carcinomas with CpG island methylation.Am J Surg Pathol. 2005 Apr;29(4):429-36.
  15767794
• Chirieac LR, Swisher SG, Ajani JA, Komaki RR, Correa AM, Morris JS, Roth JA, Rashid A, Hamilton SR, Wu TT.Posttherapy pathologic stage predicts survival in patients with esophageal carcinoma receiving preoperative chemoradiation.Cancer. 2005 Apr 1;103(7):
  15719440
• Chirieac DV, Chirieac LR, Corsetti JP, Cianci J, Sparks CE, Sparks JD.Glucose-stimulated insulin secretion suppresses hepatic triglyceride-rich lipoprotein and apoB production.Am J Physiol Endocrinol Metab. 2000 Nov;279(5):E1003-11.
  11052954