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Nabeel M. El-Bardeesy, PhD

Publications

  • Deschênes-Simard X, Lessard F, Gaumont-Leclerc MF, Bardeesy N, Ferbeyre G.Cellular senescence and protein degradation: Breaking down cancer.Cell Cycle. 2014 May 27;13(12).
    24866342
  • Sakamaki J, Fu A, Reeks C, Baird S, Depatie C, Al Azzabi M, Bardeesy N, Gingras AC, Yee SP, Screaton RA.Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.Nat Cell Biol. 2014 Mar;16(3):234-44.
    24561619
  • Borger DR, Goyal L, Yau T, Poon RT, Ancukiewicz M, Deshpande V, Christiani DC, Liebman HM, Yang H, Kim H, Yen K, Faris JE, Iafrate AJ, Kwak EL, Clark JW, Allen JN, Blaszkowsky LS, Murphy JE, Saha SK, Hong TS, Wo JY, Ferrone CR, Tanabe KK, Bardeesy N, Straley KS, Agresta S, Schenkein DP, Ellisen LW, Ryan DP, Zhu AX.Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma.Clin Cancer Res. 2014 Apr 1;20(7):1884-90.
    24478380
  • Fuchs BC, Hoshida Y, Fujii T, Wei L, Yamada S, Lauwers GY, McGinn CM, Deperalta DK, Chen X, Kuroda T, Lanuti M, Schmitt AD, Gupta S, Crenshaw A, Onofrio R, Taylor B, Winckler W, Bardeesy N, Caravan P, Golub TR, Tanabe KK.Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma.Hepatology. 2014 Apr;59(4):1577-90.
    24677197
  • Akbay EA, Moslehi J, Christensen CL, Saha S, Tchaicha JH, Ramkissoon SH, Stewart KM, Carretero J, Kikuchi E, Zhang H, Cohoon TJ, Murray S, Liu W, Uno K, Fisch S, Jones K, Gurumurthy S, Gliser C, Choe S, Keenan M, Son J, Stanley I, Losman JA, Padera R, Bronson RT, Asara JM, Abdel-Wahab O, Amrein PC, Fathi AT, Danial NN, Kimmelman AC, Kung AL, Ligon KL, Yen KE, Kaelin WG, Bardeesy N, Wong KK.D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice.Genes Dev. 2014 Mar 1;28(5):479-90.
    24589777
  • Gala MK, Mizukami Y, Le LP, Moriichi K, Austin T, Yamamoto M, Lauwers GY, Bardeesy N, Chung DC.Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas.Gastroenterology. 2014 Feb;146(2):520-9.
    24512911
  • Crose LE, Galindo KA, Kephart JG, Chen C, Fitamant J, Bardeesy N, Bentley RC, Galindo RL, Ashley Chi JT, Linardic CM.Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression.J Clin Invest. 2014 Jan 2;124(1):285-96.
    24334454
  • Bailey JM, Alsina J, Rasheed ZA, McAllister FM, Fu YY, Plentz R, Zhang H, Pasricha PJ, Bardeesy N, Matsui W, Maitra A, Leach SD.DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer.Gastroenterology. 2014 Jan;146(1):245-56.
    24096005
  • Nakada Y, Stewart TG, Peña CG, Zhang S, Zhao N, Bardeesy N, Sharpless NE, Wong KK, Hayes DN, Castrillon DH.The LKB1 tumor suppressor as a biomarker in mouse and human tissues.PLoS ONE. 2013;8(9):e73449.
    24086281
  • Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, Driggers EM, Zhang J, Bailey ST, Sharpless NE, Hayes DN, Patel NM, Janne PA, Bardeesy N, Engelman JA, Manning BD, Shaw RJ, Asara JM, Scully R, Kimmelman A, Byers LA, Gibbons DL, Wistuba II, Heymach JV, Kwiatkowski DJ, Kim WY, Kung AL, Gray NS, Root DE, Cantley LC, Wong KK.Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer.Cancer Discovery. 2013 Aug;3(8):870-9.
    23715154
  • Deschênes-Simard X, Mizukami Y, Bardeesy N.Macrophages in pancreatic cancer: starting things off on the wrong track.J Cell Biol. 2013 Aug 5;202(3):403-5.
    23918935
  • Keliher EJ, Reiner T, Earley S, Klubnick J, Tassa C, Lee AJ, Ramaswamy S, Bardeesy N, Hanahan D, Depinho RA, Castro CM, Weissleder R.Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection.Neoplasia. 2013 Jul;15(7):684-93.
    23814481
  • Gao T, Zhou D, Yang C, Singh T, Penzo-Méndez A, Maddipati R, Tzatsos A, Bardeesy N, Avruch J, Stanger BZ.Hippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas.Gastroenterology. 2013 Feb 27.
    23454691
  • Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, Depinho RA, Cantley LC, Kimmelman AC.Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.Nature. 2013 Mar 27.
    23535601
  • Burd CE, Sorrentino JA, Clark KS, Darr DB, Krishnamurthy J, Deal AM, Bardeesy N, Castrillon DH, Beach DH, Sharpless NE.Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model.Cell. 2013 Jan 17;152(1-2):340-51.
    23332765
  • Tzatsos A, Paskaleva P, Ferrari F, Deshpande V, Stoykova S, Contino G, Wong KK, Lan F, Trojer P, Park PJ, Bardeesy N.KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.J Clin Invest. 2013 Jan 16.
    23321669
  • Hirata A, Utikal J, Yamashita S, Aoki H, Watanabe A, Yamamoto T, Okano H, Bardeesy N, Kunisada T, Ushijima T, Hara A, Jaenisch R, Hochedlinger K, Yamada Y.Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium.Development. 2013 Jan 1;140(1):66-75.
    23222438
  • Avivar-Valderas A, Bobrovnikova-Marjon E, Alan Diehl J, Bardeesy N, Debnath J, Aguirre-Ghiso JA.Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK.Oncogene. 2012 Nov 19.
    23160380
  • Tumaneng K, Schlegelmilch K, Russell RC, Yimlamai D, Basnet H, Mahadevan N, Fitamant J, Bardeesy N, Camargo FD, Guan KL.YAP mediates crosstalk between the Hippo and PI(3)K-TOR pathways by suppressing PTEN via miR-29.Nat Cell Biol. 2012 Nov 11.
    23143395
  • Feng Y, Wang Y, Wang Z, Fang Z, Li F, Gao Y, Liu H, Xiao T, Li F, Zhou Y, Zhai Q, Liu X, Sun Y, Bardeesy N, Wong KK, Chen H, Xiong ZQ, Ji H.The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss.Cancer Res. 2012 Oct 16.
    23074285
  • Avruch J, Zhou D, Fitamant J, Bardeesy N, Mou F, Barrufet LR.Protein kinases of the Hippo pathway: Regulation and substrates.Semin Cell Dev Biol. 2012 Sep;23(7):770-84.
    22898666
  • Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, Smith BL, Ferrone CR, Hornicek FJ, Boucher Y, Munn LL, Jain RK.Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors.Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15101-8.
    22932871
  • Hezel AF, Deshpande V, Zimmerman SM, Contino G, Alagesan B, O'Dell MR, Rivera LB, Harper J, Lonning S, Brekken RA, Bardeesy N.TGF-β and αvβ6 integrin act in a common pathway to suppress pancreatic cancer progression.Cancer Res. 2012 Sep 15;72(18):4840-5.
    22787119
  • Perera RM, Bardeesy N.Ready, set, go: the EGF receptor at the pancreatic cancer starting line.Cancer Cell. 2012 Sep 11;22(3):281-2.
    22975369
  • Yu M, Ting DT, Stott SL, Wittner BS, Ozsolak F, Paul S, Ciciliano JC, Smas ME, Winokur D, Gilman AJ, Ulman MJ, Xega K, Contino G, Alagesan B, Brannigan BW, Milos PM, Ryan DP, Sequist LV, Bardeesy N, Ramaswamy S, Toner M, Maheswaran S, Haber DA.RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis.Nature. 2012 Jul 26;487(7408):510-3.
    22763454
  • Kottakis F, Bardeesy N.LKB1-AMPK axis revisited.Cell Res. 2012 Jul 17.
    22801477
  • Perera RM, Bardeesy N.On oncogenes and tumor suppressor genes in the mammary gland.Cold Spring Harb Perspect Biol. 2012 Jun;4(6).
    22661637
  • Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC.Pancreatic cancers require autophagy for tumor growth.Genes Dev. 2011 Apr 1;25(7):717-29.
    21406549
  • Teng Y, Kanasaki K, Bardeesy N, Sugimoto H, Kalluri R.Deletion of Smad4 in fibroblasts leads to defective chondrocyte maturation and cartilage production in a TGF type II receptor independent manner.Biochem Biophys Res Commun. 2011 Mar 3.
    21376704
  • Deshpande V, Nduaguba A, Zimmerman SM, Kehoe SM, Macconaill LE, Lauwers GY, Ferrone C, Bardeesy N, Zhu AX, Hezel AF.Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma.BMC Cancer. 2011;11:60.
    21303542
  • Ding Z, Wu CJ, Chu GC, Xiao Y, Ho D, Zhang J, Perry SR, Labrot ES, Wu X, Lis R, Hoshida Y, Hiller D, Hu B, Jiang S, Zheng H, Stegh AH, Scott KL, Signoretti S, Bardeesy N, Wang YA, Hill DE, Golub TR, Stampfer MJ, Wong WH, Loda M, Mucci L, Chin L, DePinho RA.SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.Nature. 2011 Feb 10;470(7333):269-73.
    21289624
  • Ting DT, Lipson D, Paul S, Brannigan BW, Akhavanfard S, Coffman EJ, Contino G, Deshpande V, Iafrate AJ, Letovsky S, Rivera MN, Bardeesy N, Maheswaran S, Haber DA.Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.Science. 2011 Feb 4;331(6017):593-6.
    21233348
  • Gurumurthy S, Bardeesy N.Uncapping NF-κB activity in pancreatic cancer.EMBO J. 2011 Jan 5;30(1):1-2.
    21206509
  • Avruch J, Zhou D, Fitamant J, Bardeesy N.Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development.Br J Cancer. 2011 Jan 4;104(1):24-32. Review.
    21102585
  • Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park PJ, Shirihai OS, Scadden DT, Bardeesy N.The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.Nature. 2010 Dec 2;468(7324):659-63.
    21124451
  • Ozsolak F, Ting DT, Wittner BS, Brannigan BW, Paul S, Bardeesy N, Ramaswamy S, Milos PM, Haber DA.Amplification-free digital gene expression profiling from minute cell quantities.Nat Methods. 2010 Aug;7(8):619-21.
    20639869
  • Sasajima J, Mizukami Y, Sugiyama Y, Nakamura K, Kawamoto T, Koizumi K, Fujii R, Motomura W, Sato K, Suzuki Y, Tanno S, Fujiya M, Sasaki K, Shimizu N, Karasaki H, Kono T, Kawabe J, Ii M, Yoshiara H, Kamiyama N, Ashida T, Bardeesy N, Chung DC, Kohgo Y.Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors.Cancer Res. 2010 Aug 1;70(15):6283-92.
    20631070
  • Seaman ME, Contino G, Bardeesy N, Kelly KA.Molecular imaging agents: impact on diagnosis and therapeutics in oncology.Expert Rev Mol Med. 2010;12:e20. Review.
    20633310
  • Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, Buttarazzi MS, Sanofsky BA, McNamara KL, Brandstetter KA, Walton ZE, Gu TL, Silva JC, Crosby K, Shapiro GI, Maira SM, Ji H, Castrillon DH, Kim CF, García-Echeverría C, Bardeesy N, Sharpless NE, Hayes ND, Kim WY, Engelman JA, Wong KK.Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.Cancer Cell. 2010 Jun 15;17(6):547-59.
    20541700
  • Kalender A, Selvaraj A, Kim SY, Gulati P, Brûlé S, Viollet B, Kemp BE, Bardeesy N, Dennis P, Schlager JJ, Marette A, Kozma SC, Thomas G.Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.Cell Metab. 2010 May 5;11(5):390-401.
    20444419
  • Dineen SP, Roland CL, Greer R, Carbon JG, Toombs JE, Gupta P, Bardeesy N, Sun H, Williams N, Minna JD, Brekken RA.Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer.Cancer Res. 2010 Apr 1;70(7):2852-61.
    20332237
  • Contreras CM, Akbay EA, Gallardo TD, Haynie JM, Sharma S, Tagao O, Bardeesy N, Takahashi M, Settleman J, Wong KK, Castrillon DH.Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy.Dis Model Mech.;3(3-4):181-93.
    20142330
  • Nakamura K, Sasajima J, Mizukami Y, Sugiyama Y, Yamazaki M, Fujii R, Kawamoto T, Koizumi K, Sato K, Fujiya M, Sasaki K, Tanno S, Okumura T, Shimizu N, Kawabe J, Karasaki H, Kono T, Ii M, Bardeesy N, Chung DC, Kohgo Y.Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells.PLoS ONE. 2010;5(1):e8824.
    20098680
  • Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, Bardeesy N.Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene.Cancer Cell. 2009 Nov 6;16(5):425-38.
    19878874
  • Granot Z, Swisa A, Magenheim J, Stolovich-Rain M, Fujimoto W, Manduchi E, Miki T, Lennerz JK, Stoeckert CJ, Meyuhas O, Seino S, Permutt MA, Piwnica-Worms H, Bardeesy N, Dor Y.LKB1 regulates pancreatic beta cell size, polarity, and function.Cell Metab. 2009 Oct;10(4):296-308.
    19808022
  • Fu A, Ng AC, Depatie C, Wijesekara N, He Y, Wang GS, Bardeesy N, Scott FW, Touyz RM, Wheeler MB, Screaton RA.Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice.Cell Metab. 2009 Oct;10(4):285-95.
    19808021
  • Grandinetti KB, Jelinic P, DiMauro T, Pellegrino J, Fernández Rodríguez R, Finnerty PM, Ruoff R, Bardeesy N, Logan SK, David G.Sin3B expression is required for cellular senescence and is up-regulated upon oncogenic stress.Cancer Res. 2009 Aug 15;69(16):6430-7.
    19654306
  • Vincent DF, Yan KP, Treilleux I, Gay F, Arfi V, Kaniewski B, Kaniewsky B, Marie JC, Lepinasse F, Martel S, Goddard-Leon S, Iovanna JL, Dubus P, Garcia S, Puisieux A, Rimokh R, Bardeesy N, Scoazec JY, Losson R, Bartholin L.Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas.PLoS Genet. 2009 Jul;5(7):e1000575.
    19629168
  • Singh A, Greninger P, Rhodes D, Koopman L, Violette S, Bardeesy N, Settleman J.A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival.Cancer Cell. 2009 Jun 2;15(6):489-500.
    19477428
  • Avruch J, Xavier R, Bardeesy N, Zhang XF, Praskova M, Zhou D, Xia F.Rassf family of tumor suppressor polypeptides.J Biol Chem. 2009 Apr 24;284(17):11001-5. Review.
    19091744
  • Awazawa M, Ueki K, Inabe K, Yamauchi T, Kaneko K, Okazaki Y, Bardeesy N, Ohnishi S, Nagai R, Kadowaki T.Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway.Biochem Biophys Res Commun. 2009 Apr 24;382(1):51-6.
    19254698
  • Wingo SN,Gallardo TD,Akbay EA,Liang MC,Contreras CM,Boren T,Shimamura T,Miller DS,Sharpless NE,Bardeesy N,Kwiatkowski DJ,Schorge JO,Wong KK,Castrillon DH.Somatic LKB1 mutations promote cervical cancer progression.PLoS ONE. 2009;4(4):e5137.
    19340305
  • Plentz R,Park JS,Rhim AD,Abravanel D,Hezel AF,Sharma SV,Gurumurthy S,Deshpande V,Kenific C,Settleman J,Majumder PK,Stanger BZ,Bardeesy N.Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma.Gastroenterology. 2009 May;136(5):1741-9.e6.
    19208345
  • Menon R,Zhang Q,Zhang Y,Fermin D,Bardeesy N,DePinho RA,Lu C,Hanash SM,Omenn GS,States DJ.Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer.Cancer Res. 2009 Jan 1;69(1):300-9.
    19118015
  • Hezel AF, Bardeesy N.LKB1; linking cell structure and tumor suppression.Oncogene. 2008 Nov 24;27(55):6908-19. Review.
    19029933
  • Tzatsos A, Bardeesy N.Ink4a/Arf regulation by let-7b and Hmga2: a genetic pathway governing stem cell aging.Cell Stem Cell. 2008 Nov 6;3(5):469-70.
    18983959
  • Hezel AF,Bardeesy N.Prognostic markers in pancreatic ductal adenocarcinomas.Cancer Biol Ther. 2008 Sep;7(9):1360-1.
    18836287
  • Feldmann G, Habbe N, Dhara S, Bisht S, Alvarez H, Fendrich V, Beaty R, Mullendore M, Karikari C, Bardeesy N, Ouellette MM, Yu W, Maitra A.Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer.Gut. 2008 Oct;57(10):1420-30.
    18515410
  • Lin KY,Maricevich M,Bardeesy N,Weissleder R,Mahmood U.In vivo quantitative microvasculature phenotype imaging of healthy and malignant tissues using a fiber-optic confocal laser microprobe.Transl Oncol. 2008 Jul;1(2):84-94.
    18633456
  • Faca VM,Song KS,Wang H,Zhang Q,Krasnoselsky AL,Newcomb LF,Plentz RR,Gurumurthy S,Redston MS,Pitteri SJ,Pereira-Faca SR,Ireton RC,Katayama H,Glukhova V,Phanstiel D,Brenner DE,Anderson MA,Misek D,Scholler N,Urban ND,Barnett MJ,Edelstein C,Goodman GE,Thornquist MD,McIntosh MW,DePinho RA,Bardeesy N,Hanash SM.A mouse to human search for plasma proteome changes associated with pancreatic tumor development.PLoS Med. 2008 Jun 10;5(6):e123.
    18547137
  • Zhang Q,Menon R,Deutsch EW,Pitteri SJ,Faca VM,Wang H,Newcomb LF,Depinho RA,Bardeesy N,Dinulescu D,Hung KE,Kucherlapati R,Jacks T,Politi K,Aebersold R,Omenn GS,States DJ,Hanash SM.A mouse plasma peptide atlas as a resource for disease proteomics.Genome Biol. 2008;9(6):R93.
    18522751
  • Kelly KA, Bardeesy N, Anbazhagan R, Gurumurthy S, Berger J, Alencar H, Depinho RA, Mahmood U, Weissleder R.Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma.PLoS Med. 2008 Apr 15;5(4):e85.
    18416599
  • Katajisto P, Vaahtomeri K, Ekman N, Ventela E, Ristimaki A, Bardeesy N, Feil R, DePinho RA, Makela TP.LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis.Nat Genet. 2008 Apr;40(4):455-9.
    18311138
  • Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, Depinho RA.Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.Mol Cell Biol. 2008 Apr;28(7):2414-25.
    18227155
  • Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, Janne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, Wong KK.LKB1 modulates lung cancer differentiation and metastasis.Nature. 2007 Aug 16;448(7155):807-10.
    17676035
  • Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA.Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.Genes Dev. 2006 Nov 15;20(22):3130-46.
    17114584
  • Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA.Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5947-52.
    16585505
  • Paliwal S, Pande S, Kovi RC, Sharpless NE, Bardeesy N, Grossman SR.Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis.Mol Cell Biol. 2006 Mar;26(6):2360-72.
    16508011
  • Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC.The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.Science. 2005 Dec 9;310(5754):1642-6.
    16308421
  • Ji H, Houghton AM, Mariani TJ, Perera S, Kim CB, Padera R, Tonon G, McNamara K, Marconcini LA, Hezel A, El-Bardeesy N, Bronson RT, Sugarbaker D, Maser RS, Shapiro SD, Wong KK.K-ras activation generates an inflammatory response in lung tumors.Oncogene. 2006 Mar 30;25(14):2105-12.
    16288213
  • Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y.Pten constrains centroacinar cell expansion and malignant transformation in the pancreas.Cancer Cell. 2005 Sep;8(3):185-95.
    16169464
  • Hezel AF, Bardeesy N, Maser RS.Telomere induced senescence: end game signaling.Curr Mol Med. 2005 Mar;5(2):145-52.
    15974867
  • Bardeesy N, Kim M, Xu J, Kim RS, Shen Q, Bosenberg MW, Wong WH, Chin L.Role of epidermal growth factor receptor signaling in RAS-driven melanoma.Mol Cell Biol. 2005 May;25(10):4176-88.
    15870287
  • Keller C, Arenkiel BR, Coffin CM, El-Bardeesy N, DePinho RA, Capecchi MR.Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.Genes Dev. 2004 Nov 1;18(21):2614-26.
    15489287
  • Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, Horner J, Redston MS, DePinho RA.Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma.Genes Dev. 2003 Dec 15;17(24):3112-26.
    14681207
  • Bardeesy N, DePinho RA.Pancreatic cancer biology and genetics.Nat Rev Cancer. 2002 Dec;2(12):897-909.
    12459728
  • Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA.Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation.Nature. 2002 Sep 12;419(6903):162-7.
    12226664
  • Bardeesy N, Morgan J, Sinha M, Signoretti S, Srivastava S, Loda M, Merlino G, DePinho RA.Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia.Mol Cell Biol. 2002 Jan;22(2):635-43.
    11756558