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Stephen J. Elledge, PhD

Publications

  • Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ.GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3781-6.
    24556985
  • Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA.Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells.Stem Cells. 2013 Dec;31(12):2833-41.
    23765749
  • Larman HB, Liang AC, Elledge SJ, Zhu J.Discovery of protein interactions using parallel analysis of translated ORFs (PLATO).Nat Protoc. 2014 Jan;9(1):90-103.
    24336473
  • Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ.Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome.Cell. 2013 Nov 7;155(4):948-62.
    24183448
  • Pavlova NN, Pallasch C, Elia AE, Braun CJ, Westbrook TF, Hemann M, Elledge SJ.A role for PVRL4-driven cell-cell interactions in tumorigenesis.Elife. 2013;2:e00358.
    23682311
  • Benjamin Larman H, Salajegheh M, Nazareno R, Lam T, Sauld J, Steen H, Won Kong S, Pinkus JL, Amato AA, Elledge SJ, Greenberg SA.Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis.Ann Neurol. 2013 Mar;73(3):408-18.
    23596012
  • Liu Q, Xu C, Kirubakaran S, Zhang X, Hur W, Liu Y, Kwiatkowski NP, Wang J, Westover KD, Gao P, Ercan D, Niepel M, Thoreen CC, Kang SA, Patricelli MP, Wang Y, Tupper T, Altabef A, Kawamura H, Held KD, Chou DM, Elledge SJ, Janne PA, Wong KK, Sabatini DM, Gray NS.Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR.Cancer Res. 2013 Apr 15;73(8):2574-2586.
    23436801
  • Zhu J, Larman HB, Gao G, Somwar R, Zhang Z, Laserson U, Ciccia A, Pavlova N, Church G, Zhang W, Kesari S, Elledge SJ.Protein interaction discovery using parallel analysis of translated ORFs (PLATO).Nat Biotechnol. 2013 Apr;31(4):331-4.
    23503679
  • Larman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC, Elledge SJ.PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis.J Autoimmun. 2013 Mar 13.
    23497938
  • Wang CI, Alekseyenko AA, LeRoy G, Elia AE, Gorchakov AA, Britton LM, Elledge SJ, Kharchenko PV, Garcia BA, Kuroda MI.Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila.Nat Struct Mol Biol. 2013 Feb;20(2):202-9.
    23295261
  • Solimini NL, Liang AC, Xu C, Pavlova NN, Xu Q, Davoli T, Li MZ, Wong KK, Elledge SJ.STOP gene Phactr4 is a tumor suppressor.Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):E407-14.
    23319639
  • Tan X, Hu L, Luquette LJ, Gao G, Liu Y, Qu H, Xi R, Lu ZJ, Park PJ, Elledge SJ.Systematic identification of synergistic drug pairs targeting HIV.Nat Biotechnol. 2012 Nov;30(11):1125-30.
    23064238
  • Larman HB, Jing Xu G, Pavlova NN, Elledge SJ.Construction of a rationally designed antibody platform for sequencing-assisted selection.Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18523-8.
    23064642
  • Elia AE, Elledge SJ.BRCA1 as tumor suppressor: lord without its RING?.Breast Cancer Res. 2012;14(2):306.
    22494569
  • Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ.Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.Mol Cell. 2012 Aug 10;47(3):396-409.
    22704558
  • Solimini NL, Xu Q, Mermel CH, Liang AC, Schlabach MR, Luo J, Burrows AE, Anselmo AN, Bredemeyer AL, Li MZ, Beroukhim R, Meyerson M, Elledge SJ.Recurrent hemizygous deletions in cancers may optimize proliferative potential.Science. 2012 Jul 6;337(6090):104-9.
    22628553
  • Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ.A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.Nat Cell Biol. 2012;14(3):318-28.
    22344029
  • Fellmann C, Zuber J, McJunkin K, Chang K, Malone CD, Dickins RA, Xu Q, Hengartner MO, Elledge SJ, Hannon GJ, Lowe SW.Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay.Mol Cell. 2011 Mar 18;41(6):733-46.
    21353615
  • Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF.Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase.Cell. 2011 Mar 4;144(5):703-18.
    21376233
  • Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, Schiff R, Rosen JM, Westbrook TF, Elledge SJ.The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo.Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3665-70.
    21307310
  • Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ.Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action.Mol Syst Biol. 2010 Dec 21;6:451.
    21179023
  • O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW.A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.Mol Cell. 2010 Nov 24;40(4):645-57.
    21055985
  • Chou DM, Adamson B, Dephoure NE, Tan X, Nottke AC, Hurov KE, Gygi SP, Colaiácovo MP, Elledge SJ.A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage.Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18475-80.
    20937877
  • Ciccia A, Elledge SJ.The DNA damage response: making it safe to play with knives.Mol Cell. 2010 Oct 22;40(2):179-204.
    20965415
  • Hurov KE, Cotta-Ramusino C, Elledge SJ.A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.Genes Dev. 2010 Sep 1;24(17):1939-50.
    20810650
  • Burrows AE, Smogorzewska A, Elledge SJ.Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14280-5.
    20660729
  • Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ.Wnt signaling regulates mitochondrial physiology and insulin sensitivity.Genes Dev. 2010 Jul 15;24(14):1507-18.
    20634317
  • Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME, Clark AB, Kunkel TA, Harper JW, Colaiácovo MP, Elledge SJ.A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.Mol Cell. 2010 Jul 9;39(1):36-47.
    20603073
  • Song EJ, Werner SL, Neubauer J, Stegmeier F, Aspden J, Rio D, Harper JW, Elledge SJ, Kirschner MW, Rape M.The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.Genes Dev. 2010 Jul 1;24(13):1434-47.
    20595234
  • Swedlow JR, Cotta-Ramusino C, Elledge SJ.Cell biology forum: Genome-wide view of mitosis.Nature. 2010 Apr 1;464(7289):684-5.
    20360724
  • Schlabach MR, Hu JK, Li M, Elledge SJ.Synthetic design of strong promoters.Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2538-43.
    20133776
  • Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ.The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.Cell. 2009 Dec 24;139(7):1243-54.
    20064371
  • Knipscheer P, Räschle M, Smogorzewska A, Enoiu M, Ho TV, Schärer OD, Elledge SJ, Walter JC.The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.Science. 2009 Dec 18;326(5960):1698-701.
    19965384
  • Ciccia A, Bredemeyer AL, Sowa ME, Terret ME, Jallepalli PV, Harper JW, Elledge SJ.The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart.Genes Dev. 2009 Oct 15;23(20):2415-25.
    19793862
  • Li Q, Brass AL, Ng A, Hu Z, Xavier RJ, Liang TJ, Elledge SJ.A genome-wide genetic screen for host factors required for hepatitis C virus propagation.Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16410-5.
    19717417
  • Shen X, Do H, Li Y, Chung WH, Tomasz M, de Winter JP, Xia B, Elledge SJ, Wang W, Li L.Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication.Mol Cell. 2009 Sep 11;35(5):716-23.
    19748364
  • Naylor ML, Li JM, Osborn AJ, Elledge SJ.Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork.Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12765-70.
    19515819
  • Svendsen JM, Smogorzewska A, Sowa ME, O'Connell BC, Gygi SP, Elledge SJ, Harper JW.Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.Cell. 2009 Jul 10;138(1):63-77.
    19596235
  • Hu G,Kim J,Xu Q,Leng Y,Orkin SH,Elledge SJ.A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal.Genes Dev. 2009 Apr 1;23(7):837-48.
    19339689
  • Luo J,Solimini NL,Elledge SJ.Principles of cancer therapy: oncogene and non-oncogene addiction.Cell. 2009 Mar 6;136(5):823-37.
    19269363
  • Wang B,Hurov K,Hofmann K,Elledge SJ.NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.Genes Dev. 2009 Mar 15;23(6):729-39.
    19261749
  • Xu Q,Schlabach MR,Hannon GJ,Elledge SJ.Design of 240,000 orthogonal 25mer DNA barcode probes.Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2289-94.
    19171886
  • Xiao A,Li H,Shechter D,Ahn SH,Fabrizio LA,Erdjument-Bromage H,Ishibe-Murakami S,Wang B,Tempst P,Hofmann K,Patel DJ,Elledge SJ,Allis CD.WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.Nature. 2009 Jan 1;457(7225):57-62.
    19092802
  • Mulligan P,Westbrook TF,Ottinger M,Pavlova N,Chang B,Macia E,Shi YJ,Barretina J,Liu J,Howley PM,Elledge SJ,Shi Y.CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.Mol Cell. 2008 Dec 5;32(5):718-26.
    19061646
  • Collis SJ,Ciccia A,Deans AJ,Horejsi Z,Martin JS,Maslen SL,Skehel JM,Elledge SJ,West SC,Boulton SJ.FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex.Mol Cell. 2008 Nov 7;32(3):313-24.
    18995830
  • Yen HC,Elledge SJ.Identification of SCF ubiquitin ligase substrates by global protein stability profiling.Science. 2008 Nov 7;322(5903):923-9.
    18988848
  • Yen HC,Xu Q,Chou DM,Zhao Z,Elledge SJ.Global protein stability profiling in mammalian cells.Science. 2008 Nov 7;322(5903):918-23.
    18988847
  • Li JM,Tetzlaff MT,Elledge SJ.Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants.Cell Cycle. 2008 Nov 1;7(21):3388-98.
    18948746
  • Ishiai M,Kitao H,Smogorzewska A,Tomida J,Kinomura A,Uchida E,Saberi A,Kinoshita E,Kinoshita-Kikuta E,Koike T,Tashiro S,Elledge SJ,Takata M.FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway.Nat Struct Mol Biol. 2008 Nov;15(11):1138-46.
    18931676
  • Lee YD,Wang J,Stubbe J,Elledge SJ.Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase.Mol Cell. 2008 Oct 10;32(1):70-80.
    18851834
  • Krishnan MN,Ng A,Sukumaran B,Gilfoy FD,Uchil PD,Sultana H,Brass AL,Adametz R,Tsui M,Qian F,Montgomery RR,Lev S,Mason PW,Koski RA,Elledge SJ,Xavier RJ,Agaisse H,Fikrig E.RNA interference screen for human genes associated with West Nile virus infection.Nature. 2008 Sep 11;455(7210):242-5.
    18690214
  • Dephoure N,Zhou C,Villen J,Beausoleil SA,Bakalarski CE,Elledge SJ,Gygi SP.A quantitative atlas of mitotic phosphorylation.Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7.
    18669648
  • Luo J,Elledge SJ.Cancer: Deconstructing oncogenesis.Nature. 2008 Jun 19;453(7198):995-6.
    18563141
  • Burrows AE,Elledge SJ.How ATR turns on: TopBP1 goes on ATRIP with ATR.Genes Dev. 2008 Jun 1;22(11):1416-21.
    18519633
  • Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ.SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.Nature. 2008 Mar 20;452(7185):370-4.
    18354483
  • Silva JM, Marran K, Parker JS, Silva J, Golding M, Schlabach MR, Elledge SJ, Hannon GJ, Chang K.Profiling essential genes in human mammary cells by multiplex RNAi screening.Science. 2008 Feb 1;319(5863):617-20.
    18239125
  • Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, Hannon GJ, Elledge SJ.Cancer proliferation gene discovery through functional genomics.Science. 2008 Feb 1;319(5863):620-4.
    18239126
  • Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ.Identification of host proteins required for HIV infection through a functional genomic screen.Science. 2008 Feb 15;319(5865):921-6.
    18187620
  • Harper JW, Elledge SJ.The DNA damage response: ten years after.Mol Cell. 2007 Dec 14;28(5):739-45. Review.
    18082599
  • Wang B, Elledge SJ.Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20759-63.
    18077395
  • Stewart GS, Stankovic T, Byrd PJ, Wechsler T, Miller ES, Huissoon A, Drayson MT, West SC, Elledge SJ, Taylor AM.RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling.Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16910-5.
    17940005
  • Solimini NL, Luo J, Elledge SJ.Non-oncogene addiction and the stress phenotype of cancer cells.Cell. 2007 Sep 21;130(6):986-8.
    17889643
  • Popov N, Wanzel M, Madiredjo M, Zhang D, Beijersbergen R, Bernards R, Moll R, Elledge SJ, Eilers M.The ubiquitin-specific protease USP28 is required for MYC stability.Nat Cell Biol. 2007 Jul;9(7):765-74.
    17558397
  • Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ.Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.Nature. 2007 Apr 19;446(7138):876-81.
    17443180
  • Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW, Elledge SJ.A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.Nat Cell Biol. 2007 May;9(5):556-64.
    17417629
  • Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER, Hurov KE, Luo J, Ballif BA, Gygi SP, Hofmann K, D'Andrea AD, Elledge SJ.Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair.Cell. 2007 Apr 20;129(2):289-301.
    17412408
  • Zaugg K, Su YW, Reilly PT, Moolani Y, Cheung CC, Hakem R, Hirao A, Elledge SJ, Mak TW.Cross-talk between Chk1 and Chk2 in double-mutant thymocytes.Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3805-10.
    17360434
  • Li MZ, Elledge SJ.Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC.Nat Methods. 2007 Mar;4(3):251-6.
    17293868
  • Chou DM, Elledge SJ.Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function.Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18143-7.
    17116885
  • Chang K, Elledge SJ, Hannon GJ.Lessons from Nature: microRNA-based shRNA libraries.Nat Methods. 2006 Sep;3(9):707-14. Review.
    16929316
  • Zhang D, Zaugg K, Mak TW, Elledge SJ.A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response.Cell. 2006 Aug 11;126(3):529-42.
    16901786
  • Wang X, Zou L, Lu T, Bao S, Hurov KE, Hittelman WN, Elledge SJ, Li L.Rad17 phosphorylation is required for claspin recruitment and chk1 activation in response to replication stress.Mol Cell. 2006 Aug 4;23(3):331-41.
    16885023
  • Westbrook TF, Stegmeier F, Elledge SJ.Dissecting cancer pathways and vulnerabilities with RNAi.Cold Spring Harb Symp Quant Biol. 2005;70:435-44. Review.
    16869781
  • Cao L, Kim S, Xiao C, Wang RH, Coumoul X, Wang X, Li WM, Xu XL, De Soto JA, Takai H, Mai S, Elledge SJ, Motoyama N, Deng CX.ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency.EMBO J. 2006 May 17;25(10):2167-77.
    16675955
  • Lee YD, Elledge SJ.Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1.Genes Dev. 2006 Feb 1;20(3):334-44.
    16452505
  • Turnell AS, Stewart GS, Grand RJ, Rookes SM, Martin A, Yamano H, Elledge SJ, Gallimore PH.The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.Nature. 2005 Dec 1;438(7068):690-5.
    16319895
  • Adams MM, Wang B, Xia Z, Morales JC, Lu X, Donehower LA, Bochar DA, Elledge SJ, Carpenter PB.53BP1 oligomerization is independent of its methylation by PRMT1.Cell Cycle. 2005 Dec;4(12):1854-61.
    16294047
  • Lin SY, Rai R, Li K, Xu ZX, Elledge SJ.BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly.Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15105-9.
    16217032
  • Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ.A genetic screen for candidate tumor suppressors identifies REST.Cell. 2005 Jun 17;121(6):837-48.
    15960972
  • Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW.Systematic analysis and nomenclature of mammalian F-box proteins.Genes Dev. 2004 Nov 1;18(21):2573-80.
    15520277
  • Paddison PJ, Silva JM, Conklin DS, Schlabach M, Li M, Aruleba S, Balija V, O'Shaughnessy A, Gnoj L, Scobie K, Chang K, Westbrook T, Cleary M, Sachidanandam R, McCombie WR, Elledge SJ, Hannon GJ.A resource for large-scale RNA-interference-based screens in mammals.Nature. 2004 Mar 25;428(6981):427-31.
    15042091
  • Tetzlaff MT, Bai C, Finegold M, Wilson J, Harper JW, Mahon KA, Elledge SJ.Cyclin F disruption compromises placental development and affects normal cell cycle execution.Mol Cell Biol. 2004 Mar;24(6):2487-98.
    14993286
  • Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW.SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.Genes Dev. 2003 Dec 15;17(24):3062-74.
    14681206
  • Zou L, Liu D, Elledge SJ.Replication protein A-mediated recruitment and activation of Rad17 complexes.Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13827-32.
    14605214
  • Xu L, Wei Y, Reboul J, Vaglio P, Shin TH, Vidal M, Elledge SJ, Harper JW.BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.Nature. 2003 Sep 18;425(6955):316-21.
    13679922
  • Osborn AJ, Elledge SJ.Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.Genes Dev. 2003 Jul 15;17(14):1755-67.
    12865299
  • Lin SY, Elledge SJ.Multiple tumor suppressor pathways negatively regulate telomerase.Cell. 2003 Jun 27;113(7):881-9.
    12837246
  • Zou L, Elledge SJ.Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.Science. 2003 Jun 6;300(5625):1542-8.
    12791985
  • Wang Y, Shirogane T, Liu D, Harper JW, Elledge SJ.Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling.Cell. 2003 Mar 7;112(5):697-709.
    12628189
  • Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ.MDC1 is a mediator of the mammalian DNA damage checkpoint.Nature. 2003 Feb 27;421(6926):961-6.
    12607005
  • Elledge SJ, Amon A.The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients.Cancer Cell. 2002 Mar;1(2):129-32.
    12086871
  • Bachant J, Alcasabas A, Blat Y, Kleckner N, Elledge SJ.The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II.Mol Cell. 2002 Jun;9(6):1169-82.
    12086615
  • Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP.Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.Nature. 2002 Apr 18;416(6882):703-9.
    11961546
  • Zou L, Cortez D, Elledge SJ.Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin.Genes Dev. 2002 Jan 15;16(2):198-208.
    11799063
  • Li Y, Bachant J, Alcasabas AA, Wang Y, Qin J, Elledge SJ.The mitotic spindle is required for loading of the DASH complex onto the kinetochore.Genes Dev. 2002 Jan 15;16(2):183-97.
    11799062
  • Zhang P, Li MZ, Elledge SJ.Towards genetic genome projects: genomic library screening and gene-targeting vector construction in a single step.Nat Genet. 2002 Jan;30(1):31-9.
    11753384
  • Hu F, Wang Y, Liu D, Li Y, Qin J, Elledge SJ.Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints.Cell. 2001 Nov 30;107(5):655-65.
    11733064
  • Cortez D, Guntuku S, Qin J, Elledge SJ.ATR and ATRIP: partners in checkpoint signaling.Science. 2001 Nov 23;294(5547):1713-6.
    11721054
  • Alcasabas AA, Osborn AJ, Bachant J, Hu F, Werler PJ, Bousset K, Furuya K, Diffley JF, Carr AM, Elledge SJ.Mrc1 transduces signals of DNA replication stress to activate Rad53.Nat Cell Biol. 2001 Nov;3(11):958-65.
    11715016
  • Gasch AP, Huang M, Metzner S, Botstein D, Elledge SJ, Brown PO.Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p.Mol Biol Cell. 2001 Oct;12(10):2987-3003.
    11598186
  • Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ.Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.Science. 2001 Oct 5;294(5540):173-7.
    11533444
  • Wang H, Liu D, Wang Y, Qin J, Elledge SJ.Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function.Genes Dev. 2001 Jun 1;15(11):1361-72.
    11390356
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