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Todd R. Golub, MD

Publications

  • Duan Q, Flynn C, Niepel M, Hafner M, Muhlich JL, Fernandez NF, Rouillard AD, Tan CM, Chen EY, Golub TR, Sorger PK, Subramanian A, Ma'ayan A.LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures.Nucleic Acids Res. 2014 Jun 6.
    24906883
  • Lohr JG, Adalsteinsson VA, Cibulskis K, Choudhury AD, Rosenberg M, Cruz-Gordillo P, Francis JM, Zhang CZ, Shalek AK, Satija R, Trombetta JJ, Lu D, Tallapragada N, Tahirova N, Kim S, Blumenstiel B, Sougnez C, Lowe A, Wong B, Auclair D, Van Allen EM, Nakabayashi M, Lis RT, Lee GS, Li T, Chabot MS, Ly A, Taplin ME, Clancy TE, Loda M, Regev A, Meyerson M, Hahn WC, Kantoff PW, Golub TR, Getz G, Boehm JS, Love JC.Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer.Nat Biotechnol. 2014 May(5):479-84.
    24752078
  • Rampal R, Al-Shahrour F, Abdel-Wahab O, Patel J, Brunel JP, Mermel CH, Bass AJ, Pretz J, Ahn J, Hricik T, Kilpivaara O, Wadleigh M, Busque L, Gilliland DG, Golub TR, Ebert BL, Levine R.Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis.Blood. 2014 Apr 16.
    24740812
  • Fuchs BC, Hoshida Y, Fujii T, Wei L, Yamada S, Lauwers GY, McGinn CM, Deperalta DK, Chen X, Kuroda T, Lanuti M, Schmitt AD, Gupta S, Crenshaw A, Onofrio R, Taylor B, Winckler W, Bardeesy N, Caravan P, Golub TR, Tanabe KK.Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma.Hepatology. 2014 Apr;59(4):1577-90.
    24677197
  • Lawrence MS, Stojanov P, Mermel CH, Robinson JT, Garraway LA, Golub TR, Meyerson M, Gabriel SB, Lander ES, Getz G.Discovery and saturation analysis of cancer genes across 21 tumour types.Nature. 2014 Jan 23;505(7484):495-501.
    24390350
  • Lohr JG, Stojanov P, Carter SL, Cruz-Gordillo P, Lawrence MS, Auclair D, Sougnez C, Knoechel B, Gould J, Saksena G, Cibulskis K, McKenna A, Chapman MA, Straussman R, Levy J, Perkins LM, Keats JJ, Schumacher SE, Rosenberg M, , Getz G, Golub TR.Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy.Cancer Cell. 2014 Jan 13;25(1):91-101.
    24434212
  • Gustafsdottir SM, Ljosa V, Sokolnicki KL, Anthony Wilson J, Walpita D, Kemp MM, Petri Seiler K, Carrel HA, Golub TR, Schreiber SL, Clemons PA, Carpenter AE, Shamji AF.Multiplex cytological profiling assay to measure diverse cellular states.PLoS ONE. 2013;8(12):e80999.
    24312513
  • Hartwell KA, Miller PG, Mukherjee S, Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M, Järås M, Puram R, Dancik V, Al-Shahrour F, Kindler T, Tothova Z, Chattopadhyay S, Hasaka T, Narayan R, Dai M, Huang C, Shterental S, Chu LP, Haydu JE, Shieh JH, Steensma DP, Munoz B, Bittker JA, Shamji AF, Clemons PA, Tolliday NJ, Carpenter AE, Gilliland DG, Stern AM, Moore MA, Scadden DT, Schreiber SL, Ebert BL, Golub TR.Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.Nat Chem Biol. 2013 Dec;9(12):840-8.
    24161946
  • Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA, Whitesell L, Lindquist S.Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.Science. 2013 Jul 19;341(6143):1238303.
    23869022
  • Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A, Carter SL, Stewart C, Mermel CH, Roberts SA, Kiezun A, Hammerman PS, McKenna A, Drier Y, Zou L, Ramos AH, Pugh TJ, Stransky N, Helman E, Kim J, Sougnez C, Ambrogio L, Nickerson E, Shefler E, Cortés ML, Auclair D, Saksena G, Voet D, Noble M, DiCara D, Lin P, Lichtenstein L, Heiman DI, Fennell T, Imielinski M, Hernandez B, Hodis E, Baca S, Dulak AM, Lohr J, Landau DA, Wu CJ, Melendez-Zajgla J, Hidalgo-Miranda A, Koren A, McCarroll SA, Mora J, Lee RS, Crompton B, Onofrio R, Parkin M, Winckler W, Ardlie K, Gabriel SB, Roberts CW, Biegel JA, Stegmaier K, Bass AJ, Garraway LA, Meyerson M, Golub TR, Gordenin DA, Sunyaev S, Lander ES, Getz G.Mutational heterogeneity in cancer and the search for new cancer-associated genes.Nature. 2013 Jul 11;499(7457):214-8.
    23770567
  • Chen L, Monti S, Juszczynski P, Ouyang J, Chapuy B, Neuberg D, Doench JG, Bogusz AM, Habermann TM, Dogan A, Witzig TE, Kutok JL, Rodig SJ, Golub T, Shipp MA.SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas.Cancer Cell. 2013 Jun 10;23(6):826-38.
    23764004
  • Baca SC, Prandi D, Lawrence MS, Mosquera JM, Romanel A, Drier Y, Park K, Kitabayashi N, MacDonald TY, Ghandi M, Van Allen E, Kryukov GV, Sboner A, Theurillat JP, Soong TD, Nickerson E, Auclair D, Tewari A, Beltran H, Onofrio RC, Boysen G, Guiducci C, Barbieri CE, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Ramos AH, Winckler W, Cipicchio M, Ardlie K, Kantoff PW, Berger MF, Gabriel SB, Golub TR, Meyerson M, Lander ES, Elemento O, Getz G, Demichelis F, Rubin MA, Garraway LA.Punctuated evolution of prostate cancer genomes.Cell. 2013 Apr 25;153(3):666-77.
    23622249
  • Dulak AM, Stojanov P, Peng S, Lawrence MS, Fox C, Stewart C, Bandla S, Imamura Y, Schumacher SE, Shefler E, McKenna A, Carter SL, Cibulskis K, Sivachenko A, Saksena G, Voet D, Ramos AH, Auclair D, Thompson K, Sougnez C, Onofrio RC, Guiducci C, Beroukhim R, Zhou Z, Lin L, Lin J, Reddy R, Chang A, Landrenau R, Pennathur A, Ogino S, Luketich JD, Golub TR, Gabriel SB, Lander ES, Beer DG, Godfrey TE, Getz G, Bass AJ.Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity.Nat Genet. 2013 Mar 24.
    23525077
  • Hoshida Y, Villanueva A, Sangiovanni A, Sole M, Hur C, Andersson KL, Chung RT, Gould J, Kojima K, Gupta S, Taylor B, Crenshaw A, Gabriel S, Minguez B, Iavarone M, Friedman SL, Colombo M, Llovet JM, Golub TR.Prognostic gene expression signature for patients with hepatitis C-related early-stage cirrhosis.Gastroenterology. 2013 May;144(5):1024-30.
    23333348
  • Waldron L, Ogino S, Hoshida Y, Shima K, McCart Reed AE, Simpson PT, Baba Y, Nosho K, Segata N, Vargas AC, Cummings MC, Lakhani SR, Kirkner GJ, Giovannucci E, Quackenbush J, Golub TR, Fuchs CS, Parmigiani G, Huttenhower C.Expression Profiling of Archival Tumors for Long-term Health Studies.Clin Cancer Res. 2012 Nov 15;18(22):6136-6146.
    23136189
  • Cantley LC, Dalton WS, DuBois RN, Finn OJ, Futreal PA, Golub TR, Hait WN, Lozano G, Maris JM, Nelson WG, Sawyers CL, Schreiber SL, Spitz MR, Steeg PS.AACR Cancer Progress Report 2012.Clin Cancer Res. 2012 Nov 1;18(21 Suppl):S1-100.
    22977188
  • Jalili A, Wagner C, Pashenkov M, Pathria G, Mertz KD, Widlund HR, Lupien M, Brunet JP, Golub TR, Stingl G, Fisher DE, Ramaswamy S, Wagner SN.Dual Suppression of the Cyclin-Dependent Kinase Inhibitors CDKN2C and CDKN1A in Human Melanoma.Journal of the National Cancer Institute. 2012 Nov 7;104(21):1673-9.
    22997239
  • Monti S, Chapuy B, Takeyama K, Rodig SJ, Hao Y, Yeda KT, Inguilizian H, Mermel C, Currie T, Dogan A, Kutok JL, Beroukhim R, Neuberg D, Habermann TM, Getz G, Kung AL, Golub TR, Shipp MA.Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma.Cancer Cell. 2012 Sep 11;22(3):359-72.
    22975378
  • Lee RS, Stewart C, Carter SL, Ambrogio L, Cibulskis K, Sougnez C, Lawrence MS, Auclair D, Mora J, Golub TR, Biegel JA, Getz G, Roberts CW.A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers.J Clin Invest. 2012 Aug 1;122(8):2983-8.
    22797305
  • Straussman R, Morikawa T, Shee K, Barzily-Rokni M, Qian ZR, Du J, Davis A, Mongare MM, Gould J, Frederick DT, Cooper ZA, Chapman PB, Solit DB, Ribas A, Lo RS, Flaherty KT, Ogino S, Wargo JA, Golub TR.Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion.Nature. 2012 Jul 26;487(7408):500-4.
    22763439
  • Banerji S, Cibulskis K, Rangel-Escareno C, Brown KK, Carter SL, Frederick AM, Lawrence MS, Sivachenko AY, Sougnez C, Zou L, Cortes ML, Fernandez-Lopez JC, Peng S, Ardlie KG, Auclair D, Bautista-Piña V, Duke F, Francis J, Jung J, Maffuz-Aziz A, Onofrio RC, Parkin M, Pho NH, Quintanar-Jurado V, Ramos AH, Rebollar-Vega R, Rodriguez-Cuevas S, Romero-Cordoba SL, Schumacher SE, Stransky N, Thompson KM, Uribe-Figueroa L, Baselga J, Beroukhim R, Polyak K, Sgroi DC, Richardson AL, Jimenez-Sanchez G, Lander ES, Gabriel SB, Garraway LA, Golub TR, Melendez-Zajgla J, Toker A, Getz G, Hidalgo-Miranda A, Meyerson M.Sequence analysis of mutations and translocations across breast cancer subtypes.Nature. 2012 Jun 21;486(7403):405-9.
    22722202
  • Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, Theurillat JP, White TA, Stojanov P, Van Allen E, Stransky N, Nickerson E, Chae SS, Boysen G, Auclair D, Onofrio RC, Park K, Kitabayashi N, MacDonald TY, Sheikh K, Vuong T, Guiducci C, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Hussain WM, Ramos AH, Winckler W, Redman MC, Ardlie K, Tewari AK, Mosquera JM, Rupp N, Wild PJ, Moch H, Morrissey C, Nelson PS, Kantoff PW, Gabriel SB, Golub TR, Meyerson M, Lander ES, Getz G, Rubin MA, Garraway LA.Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.Nat Genet. 2012 Jun;44(6):685-9.
    22610119
  • Chapman MA, Lawrence MS, Keats JJ, Cibulskis K, Sougnez C, Schinzel AC, Harview CL, Brunet JP, Ahmann GJ, Adli M, Anderson KC, Ardlie KG, Auclair D, Baker A, Bergsagel PL, Bernstein BE, Drier Y, Fonseca R, Gabriel SB, Hofmeister CC, Jagannath S, Jakubowiak AJ, Krishnan A, Levy J, Liefeld T, Lonial S, Mahan S, Mfuko B, Monti S, Perkins LM, Onofrio R, Pugh TJ, Rajkumar SV, Ramos AH, Siegel DS, Sivachenko A, Stewart AK, Trudel S, Vij R, Voet D, Winckler W, Zimmerman T, Carpten J, Trent J, Hahn WC, Garraway LA, Meyerson M, Lander ES, Getz G, Golub TR.Initial genome sequencing and analysis of multiple myeloma.Nature. 2011 Mar 24;471(7339):467-72.
    21430775
  • Green MR, Monti S, Dalla-Favera R, Pasqualucci L, Walsh NC, Schmidt-Supprian M, Kutok JL, Rodig SJ, Neuberg DS, Rajewsky K, Golub TR, Alt FW, Shipp MA, Manis JP.Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program.Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2873-8.
    21282644
  • Berger MF, Lawrence MS, Demichelis F, Drier Y, Cibulskis K, Sivachenko AY, Sboner A, Esgueva R, Pflueger D, Sougnez C, Onofrio R, Carter SL, Park K, Habegger L, Ambrogio L, Fennell T, Parkin M, Saksena G, Voet D, Ramos AH, Pugh TJ, Wilkinson J, Fisher S, Winckler W, Mahan S, Ardlie K, Baldwin J, Simons JW, Kitabayashi N, MacDonald TY, Kantoff PW, Chin L, Gabriel SB, Gerstein MB, Golub TR, Meyerson M, Tewari A, Lander ES, Getz G, Rubin MA, Garraway LA.The genomic complexity of primary human prostate cancer.Nature. 2011 Feb 10;470(7333):214-20.
    21307934
  • Ding Z, Wu CJ, Chu GC, Xiao Y, Ho D, Zhang J, Perry SR, Labrot ES, Wu X, Lis R, Hoshida Y, Hiller D, Hu B, Jiang S, Zheng H, Stegh AH, Scott KL, Signoretti S, Bardeesy N, Wang YA, Hill DE, Golub TR, Stampfer MJ, Wong WH, Loda M, Mucci L, Chin L, DePinho RA.SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.Nature. 2011 Feb 10;470(7333):269-73.
    21289624
  • Novershtern N, Subramanian A, Lawton LN, Mak RH, Haining WN, McConkey ME, Habib N, Yosef N, Chang CY, Shay T, Frampton GM, Drake AC, Leskov I, Nilsson B, Preffer F, Dombkowski D, Evans JW, Liefeld T, Smutko JS, Chen J, Friedman N, Young RA, Golub TR, Regev A, Ebert BL.Densely interconnected transcriptional circuits control cell states in human hematopoiesis.Cell. 2011 Jan 21;144(2):296-309.
    21241896
  • Green MR, Monti S, Rodig SJ, Juszczynski P, Currie T, O'Donnell E, Chapuy B, Takeyama K, Neuberg D, Golub TR, Kutok JL, Shipp MA.Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.Blood. 2010 Oct 28;116(17):3268-77.
    20628145
  • Berger MF, Lawrence MS, Demichelis F, Cibulskis K, Sivachenko A, Sboner A, Esgueva R, Pflueger D, Sougnez C, Onofrio R, Carter S, Drier Y, Ambrogio L, Fenne T, Parkin M, Gordon S, Voet D, Ramos A, Pugh T, Wilkinson J, Fisher S, Winckler W, Mahan S, Ardlie K, Baldwin J, Kitabayashi N, MacDonald TY, Kantoff PW, Gabriel SB, Gerstein MB, Golub TR, Meyerson M, Tewari A, Lander ES, Getz G, Rubin MA, Garraway LA.Characterization of complex chromosomal aberrations in primary prostate cancer genomes.Nature..
  • Guo S, Lu J, Schlanger R, Zhang H, Wang JY, Fox MC, Purton LE, Fleming HH, Cobb B, Merkenschlager M, Golub TR, Scadden DT.MicroRNA miR-125a controls hematopoietic stem cell number.Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14229-34.
    20616003
  • Zimmer M, Lamb J, Ebert BL, Lynch M, Neil C, Schmidt E, Golub TR, Iliopoulos O.The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.Cancer Res. 2010 Apr 15;70(8):3071-9.
    20354189
  • Oliver TG, Mercer KL, Sayles LC, Burke JR, Mendus D, Lovejoy KS, Cheng MH, Subramanian A, Mu D, Powers S, Crowley D, Bronson RT, Whittaker CA, Bhutkar A, Lippard SJ, Golub T, Thomale J, Jacks T, Sweet-Cordero EA.Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer.Genes Dev. 2010 Apr 15;24(8):837-52.
    20395368
  • Sboner A, Demichelis F, Calza S, Pawitan Y, Setlur SR, Hoshida Y, Perner S, Adami HO, Fall K, Mucci LA, Kantoff PW, Stampfer M, Andersson SO, Varenhorst E, Johansson JE, Gerstein MB, Golub TR, Rubin MA, Andren O.Molecular sampling of prostate cancer: a dilemma for predicting disease progression.BMC Med Genomics. 2010 Mar 16;3(1):8.
    20233430
  • Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L, Greulich H, Reich M, Winckler W, Lawrence MS, Weir BA, Tanaka KE, Chiang DY, Bass AJ, Loo A, Hoffman C, Prensner J, Liefeld T, Gao Q, Yecies D, Signoretti S, Maher E, Kaye FJ, Sasaki H, Tepper JE, Fletcher JA, Tabernero J, Baselga J, Tsao MS, Demichelis F, Rubin MA, Janne PA, Daly MJ, Nucera C, Levine RL, Ebert BL, Gabriel S, Rustgi AK, Antonescu CR, Ladanyi M, Letai A, Garraway LA, Loda M, Beer DG, True LD, Okamoto A, Pomeroy SL, Singer S, Golub TR, Lander ES, Getz G, Sellers WR, Meyerson M.The landscape of somatic copy-number alteration across human cancers.Nature. 2010 Feb 18;463(7283):899-905.
    20164920
  • Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, Miller CR, Ding L, Golub T, Mesirov JP, Alexe G, Lawrence M, O'Kelly M, Tamayo P, Weir BA, Gabriel S, Winckler W, Gupta S, Jakkula L, Feiler HS, Hodgson JG, James CD, Sarkaria JN, Brennan C, Kahn A, Spellman PT, Wilson RK, Speed TP, Gray JW, Meyerson M, Getz G, Perou CM, Hayes DN, .Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.Cancer Cell. 2010 Jan 19;17(1):98-110.
    20129251
  • Kumar MS, Pester RE, Chen CY, Lane K, Chin C, Lu J, Kirsch DG, Golub TR, Jacks T.Dicer1 functions as a haploinsufficient tumor suppressor.Genes Dev. 2009 Dec 1;23(23):2700-4.
    19903759
  • Margolin AA, Ong SE, Schenone M, Gould R, Schreiber SL, Carr SA, Golub TR.Empirical Bayes analysis of quantitative proteomics experiments.PLoS ONE. 2009;4(10):e7454.
    19829701
  • Hahn CK, Berchuck JE, Ross KN, Kakoza RM, Clauser K, Schinzel AC, Ross L, Galinsky I, Davis TN, Silver SJ, Root DE, Stone RM, DeAngelo DJ, Carroll M, Hahn WC, Carr SA, Golub TR, Kung AL, Stegmaier K.Proteomic and genetic approaches identify Syk as an AML target.Cancer Cell. 2009 Oct 6;16(4):281-94.
    19800574
  • Olson P, Lu J, Zhang H, Shai A, Chun MG, Wang Y, Libutti SK, Nakakura EK, Golub TR, Hanahan D.MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer.Genes Dev. 2009 Sep 15;23(18):2152-65.
    19759263
  • Hoshida Y, Nijman SM, Kobayashi M, Chan JA, Brunet JP, Chiang DY, Villanueva A, Newell P, Ikeda K, Hashimoto M, Watanabe G, Gabriel S, Friedman SL, Kumada H, Llovet JM, Golub TR.Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma.Cancer Res. 2009 Sep 15;69(18):7385-92.
    19723656
  • Viswanathan SR, Mermel CH, Lu J, Lu CW, Golub TR, Daley GQ.microRNA expression during trophectoderm specification.PLoS ONE. 2009;4(7):e6143.
    19582159
  • Viswanathan SR,Powers JT,Einhorn W,Hoshida Y,Ng TL,Toffanin S,O'Sullivan M,Lu J,Phillips LA,Lockhart VL,Shah SP,Tanwar PS,Mermel CH,Beroukhim R,Azam M,Teixeira J,Meyerson M,Hughes TP,Llovet JM,Radich J,Mullighan CG,Golub TR,Sorensen PH,Daley GQ.Lin28 promotes transformation and is associated with advanced human malignancies.Nat Genet. 2009 Jul;41(7):843-8.
    19483683
  • Corsello SM,Roti G,Ross KN,Chow KT,Galinsky I,Deangelo DJ,Stone RM,Kung AL,Golub TR,Stegmaier K.Identification of AML1-ETO modulators by chemical genomics.Blood. 2009 Jun 11;113(24):6193-205.
    19377049
  • Hoshida Y,Golub TR.Prolonged therapy for hepatitis C with low-dose peginterferon.N Engl J Med. 2009 Mar 12;360(11):1152; author reply 1152-3.
    19283891
  • Ong SE,Schenone M,Margolin AA,Li X,Do K,Doud MK,Mani DR,Kuai L,Wang X,Wood JL,Tolliday NJ,Koehler AN,Marcaurelle LA,Golub TR,Gould RJ,Schreiber SL,Carr SA.Identifying the proteins to which small-molecule probes and drugs bind in cells.Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4617-22.
    19255428
  • Zimmer M,Ebert BL,Neil C,Brenner K,Papaioannou I,Melas A,Tolliday N,Lamb J,Pantopoulos K,Golub T,Iliopoulos O.Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.Mol Cell. 2008 Dec 26;32(6):838-48.
    19111663
  • Du J,Bernasconi P,Clauser KR,Mani DR,Finn SP,Beroukhim R,Burns M,Julian B,Peng XP,Hieronymus H,Maglathlin RL,Lewis TA,Liau LM,Nghiemphu P,Mellinghoff IK,Louis DN,Loda M,Carr SA,Kung AL,Golub TR.Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy.Nat Biotechnol. 2009 Jan;27(1):77-83.
    19098899
  • Luo B,Cheung HW,Subramanian A,Sharifnia T,Okamoto M,Yang X,Hinkle G,Boehm JS,Beroukhim R,Weir BA,Mermel C,Barbie DA,Awad T,Zhou X,Nguyen T,Piqani B,Li C,Golub TR,Meyerson M,Hacohen N,Hahn WC,Lander ES,Sabatini DM,Root DE.Highly parallel identification of essential genes in cancer cells.Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20380-5.
    19091943
  • Hoshida Y,Villanueva A,Kobayashi M,Peix J,Chiang DY,Camargo A,Gupta S,Moore J,Wrobel MJ,Lerner J,Reich M,Chan JA,Glickman JN,Ikeda K,Hashimoto M,Watanabe G,Daidone MG,Roayaie S,Schwartz M,Thung S,Salvesen HB,Gabriel S,Mazzaferro V,Bruix J,Friedman SL,Kumada H,Llovet JM,Golub TR.Gene expression in fixed tissues and outcome in hepatocellular carcinoma.N Engl J Med. 2008 Nov 6;359(19):1995-2004.
    18923165
  • Li Z,Lu J,Sun M,Mi S,Zhang H,Luo RT,Chen P,Wang Y,Yan M,Qian Z,Neilly MB,Jin J,Zhang Y,Bohlander SK,Zhang DE,Larson RA,Le Beau MM,Thirman MJ,Golub TR,Rowley JD,Chen J.Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15535-40.
    18832181
  • The Cancer Genome Atlas Research Network.Comprehensive genomic characterization defines human glioblastoma genes and core pathways.Nature.;455(7216):1061-8.
  • , Shedden K, Taylor JM, Enkemann SA, Tsao MS, Yeatman TJ, Gerald WL, Eschrich S, Jurisica I, Giordano TJ, Misek DE, Chang AC, Zhu CQ, Strumpf D, Hanash S, Shepherd FA, Ding K, Seymour L, Naoki K, Pennell N, Weir B, Verhaak R, Ladd-Acosta C, Golub T, Gruidl M, Sharma A, Szoke J, Zakowski M, Rusch V, Kris M, Viale A, Motoi N, Travis W, Conley B, Seshan VE, Meyerson M, Kuick R, Dobbin KK, Lively T, Jacobson JW, Beer DG.Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study.Nat Med. 2008 Aug;14(8):822-7.
    18641660
  • Haining WN, Ebert BL, Subrmanian A, Wherry EJ, Eichbaum Q, Evans JW, Mak R, Rivoli S, Pretz J, Angelosanto J, Smutko JS, Walker BD, Kaech SM, Ahmed R, Nadler LM, Golub TR.Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells.J Immunol. 2008 Aug 1;181(3):1859-68.
    18641323
  • Hahn CK,Ross KN,Warrington IM,Mazitschek R,Kanegai CM,Wright RD,Kung AL,Golub TR,Stegmaier K.Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation.Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9751-6.
    18607002
  • Huang G,Eisenberg R,Yan M,Monti S,Lawrence E,Fu P,Walbroehl J,Lowenberg E,Golub T,Merchan J,Tenen DG,Markowitz SD,Halmos B.15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer.Cancer Res. 2008 Jul 1;68(13):5040-8.
    18593902
  • Tam WF,Gu TL,Chen J,Lee BH,Bullinger L,Frohling S,Wang A,Monti S,Golub TR,Gilliland DG.Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells.Blood. 2008 Sep 1;112(5):1981-92.
    18559972
  • Lu J, Guo S, Ebert BL, Zhang H, Peng X, Bosco J, Pretz J, Schlanger R, Wang JY, Mak RH, Dombkowski DM, Preffer FI, Scadden DT, Golub TR.MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors.Dev Cell. 2008 Jun;14(6):843-53.
    18539114
  • Setlur SR,Mertz KD,Hoshida Y,Demichelis F,Lupien M,Perner S,Sboner A,Pawitan Y,Andren O,Johnson LA,Tang J,Adami HO,Calza S,Chinnaiyan AM,Rhodes D,Tomlins S,Fall K,Mucci LA,Kantoff PW,Stampfer MJ,Andersson SO,Varenhorst E,Johansson JE,Brown M,Golub TR,Rubin MA.Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer.Journal of the National Cancer Institute. 2008 Jun 4;100(11):815-25.
    18505969
  • Antipova AA, Stockwell BR, Golub TR.Gene expression-based screening for inhibitors of PDGFR signaling.Genome Biol. 2008 Mar 1;9(3):R47.
    18312689
  • Wagner BK, Kitami T, Gilbert TJ, Peck D, Ramanathan A, Schreiber SL, Golub TR, Mootha VK.Large-scale chemical dissection of mitochondrial function.Nat Biotechnol. 2008 Mar;26(3):343-51.
    18297058
  • Ebert BL, Galili N, Tamayo P, Bosco J, Mak R, Pretz J, Tanguturi S, Ladd-Acosta C, Stone R, Golub TR, Raza A.An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome.PLoS Med. 2008 Feb;5(2):e35.
    18271621
  • Lin WM, Baker AC, Beroukhim R, Winckler W, Feng W, Marmion JM, Laine E, Greulich H, Tseng H, Gates C, Hodi FS, Dranoff G, Sellers WR, Thomas RK, Meyerson M, Golub TR, Dummer R, Herlyn M, Getz G, Garraway LA.Modeling genomic diversity and tumor dependency in malignant melanoma.Cancer Res. 2008 Feb 1;68(3):664-73.
    18245465
  • Ebert BL, Pretz J, Bosco J, Chang CY, Tamayo P, Galili N, Raza A, Root DE, Attar E, Ellis SR, Golub TR.Identification of RPS14 as a 5q- syndrome gene by RNA interference screen.Nature. 2008 Jan 17;451(7176):335-9.
    18202658
  • Takeyama K, Monti S, Manis JP, Cin PD, Getz G, Beroukhim R, Dutt S, Aster JC, Alt FW, Golub TR, Shipp MA.Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas.Oncogene. 2008 Jan 10;27(3):318-22.
    17637749
  • Beroukhim R, Getz G, Nghiemphu L, Barretina J, Hsueh T, Linhart D, Vivanco I, Lee JC, Huang JH, Alexander S, Du J, Kau T, Thomas RK, Shah K, Soto H, Perner S, Prensner J, Debiasi RM, Demichelis F, Hatton C, Rubin MA, Garraway LA, Nelson SF, Liau L, Mischel PS, Cloughesy TF, Meyerson M, Golub TA, Lander ES, Mellinghoff IK, Sellers WR.Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma.Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20007-12.
    18077431
  • Frohling S, Scholl C, Levine RL, Loriaux M, Boggon TJ, Bernard OA, Berger R, Dohner H, Dohner K, Ebert BL, Teckie S, Golub TR, Jiang J, Schittenhelm MM, Lee BH, Griffin JD, Stone RM, Heinrich MC, Deininger MW, Druker BJ, Gilliland DG.Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles.Cancer Cell. 2007 Dec;12(6):501-13.
    18068628
  • Mi S, Lu J, Sun M, Li Z, Zhang H, Neilly MB, Wang Y, Qian Z, Jin J, Zhang Y, Bohlander SK, Le Beau MM, Larson RA, Golub TR, Rowley JD, Chen J.MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia.Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19971-6.
    18056805
  • Hoshida Y, Brunet JP, Tamayo P, Golub TR, Mesirov JP.Subclass mapping: identifying common subtypes in independent disease data sets.PLoS ONE. 2007;2(11):e1195.
    18030330
  • Xu Q, Majumder PK, Ross K, Shim Y, Golub TR, Loda M, Sellers WR.Identification of prostate cancer modifier pathways using parental strain expression mapping.Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17771-6.
    17978178
  • Getz G, Hofling H, Mesirov JP, Golub TR, Meyerson M, Tibshirani R, Lander ES.Comment on "The consensus coding sequences of human breast and colorectal cancers".Science. 2007 Sep 14;317(5844):1500.
    17872428
  • Shin J, Monti S, Aires DJ, Duvic M, Golub T, Jones DA, Kupper TS.Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome.Blood. 2007 Oct 15;110(8):3015-27.
    17638852
  • Vivanco I, Palaskas N, Tran C, Finn SP, Getz G, Kennedy NJ, Jiao J, Rose J, Xie W, Loda M, Golub T, Mellinghoff IK, Davis RJ, Wu H, Sawyers CL.Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.Cancer Cell. 2007 Jun;11(6):555-69.
    17560336
  • Golub TR.Genomics: global views of leukaemia.Nature. 2007 Apr 12;446(7137):739-40.
    17429386
  • Stegmaier K, Wong JS, Ross KN, Chow KT, Peck D, Wright RD, Lessnick SL, Kung AL, Golub TR.Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma.PLoS Med. 2007 Apr;4(4):e122.
    17425403
  • Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T.Impaired microRNA processing enhances cellular transformation and tumorigenesis.Nat Genet. 2007 May;39(5):673-7.
    17401365
  • Sherwood RI, Jitianu C, Cleaver O, Shaywitz DA, Lamenzo JO, Chen AE, Golub TR, Melton DA.Prospective isolation and global gene expression analysis of definitive and visceral endoderm.Dev Biol. 2007 Apr 15;304(2):541-55.
    17328885
  • Byers RJ, Di Vizio D, O'connell F, Tholouli E, Levenson RM, Gossard K, Twomey D, Yang Y, Benedettini E, Rose J, Ligon KL, Finn SP, Golub TR, Loda M.Semiautomated multiplexed quantum dot-based in situ hybridization and spectral deconvolution.J Mol Diagn. 2007 Feb;9(1):20-9.
    17251332
  • Pegtel DM, Subramanian A, Meritt D, Tsai CH, Sheen TS, Golub TR, Thorley-Lawson DA.IFN-alpha-stimulated genes and Epstein-Barr virus gene expression distinguish WHO type II and III nasopharyngeal carcinomas.Cancer Res. 2007 Jan 15;67(2):474-81.
    17234754
  • Kobayashi S, Shimamura T, Monti S, Steidl U, Hetherington CJ, Lowell AM, Golub T, Meyerson M, Tenen DG, Shapiro GI, Halmos B.Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling.Cancer Res. 2006 Dec 1;66(23):11389-98.
    17145885
  • Wei G, Twomey D, Lamb J, Schlis K, Agarwal J, Stam RW, Opferman JT, Sallan SE, den Boer ML, Pieters R, Golub TR, Armstrong SA.Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance.Cancer Cell. 2006 Oct;10(4):331-42.
    17010674
  • Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC, Chiosis G, Golub TR.Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.Cancer Cell. 2006 Oct;10(4):321-30.
    17010675
  • Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR.The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.Science. 2006 Sep 29;313(5795):1929-35.
    17008526
  • Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, Faber J, Levine JE, Wang J, Hahn WC, Gilliland DG, Golub TR, Armstrong SA.Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.Nature. 2006 Aug 17;442(7104):818-22.
    16862118
  • Tholouli E, Hoyland JA, Di Vizio D, O'Connell F, Macdermott SA, Twomey D, Levenson R, Yin JA, Golub TR, Loda M, Byers R.Imaging of multiple mRNA targets using quantum dot based in situ hybridization and spectral deconvolution in clinical biopsies.Biochem Biophys Res Commun. 2006 Sep 22;348(2):628-36.
    16893519
  • Peck D, Crawford ED, Ross KN, Stegmaier K, Golub TR, Lamb J.A Method for High-Throughput Gene Expression Signature Analysis.Genome Biol. 2006 Jul 19;7(7):R61.
    16859521
  • Pikman Y, Lee BH, Mercher T, McDowell E, Ebert BL, Gozo M, Cuker A, Wernig G, Moore S, Galinsky I, Deangelo DJ, Clark JJ, Lee SJ, Golub TR, Wadleigh M, Gilliland DG, Levine RL.MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia.PLoS Med. 2006 Jul 18;3(7):e270.
    16834459
  • Smith R, Owen LA, Trem DJ, Wong JS, Whangbo JS, Golub TR, Lessnick SL.Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma.Cancer Cell. 2006 May;9(5):405-16.
    16697960
  • Stanbrough M, Bubley GJ, Ross K, Golub TR, Rubin MA, Penning TM, Febbo PG, Balk SP.Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer.Cancer Res. 2006 Mar 1;66(5):2815-25.
    16510604
  • Bourquin JP, Subramanian A, Langebrake C, Reinhardt D, Bernard O, Ballerini P, Baruchel A, Cav H, Dastugue N, Hasle H, Kaspers GL, Lessard M, Michaux L, Vyas P, van Wering E, Zwaan CM, Golub TR, Orkin SH.Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3339-44.
    16492768
  • Bassres DS, Levantini E, Ji H, Monti S, Elf S, Dayaram T, Fenyus M, Kocher O, Golub T, Wong KK, Halmos B, Tenen DG.Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice.Mol Cell Biol. 2006 Feb;26(3):1109-23.
    16428462
  • Febbo PG, Thorner A, Rubin MA, Loda M, Kantoff PW, Oh WK, Golub T, George D.Application of oligonucleotide microarrays to assess the biological effects of neoadjuvant imatinib mesylate treatment for localized prostate cancer.Clin Cancer Res. 2006 Jan 1;12(1):152-8.
    16397037
  • Pegtel DM, Subramanian A, Sheen TS, Tsai CH, Golub TR, Thorley-Lawson DA.Epstein-Barr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasis.J Virol. 2005 Dec;79(24):15430-42.
    16306614
  • Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, Basso A, Ye Q, Lobo JM, She Y, Osman I, Golub TR, Sebolt-Leopold J, Sellers WR, Rosen N.BRAF mutation predicts sensitivity to MEK inhibition.Nature. 2006 Jan 19;439(7074):358-62.
    16273091
  • Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP.Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50.
    16199517
  • Shepard JL, Amatruda JF, Stern HM, Subramanian A, Finkelstein D, Ziai J, Finley KR, Pfaff KL, Hersey C, Zhou Y, Barut B, Freedman M, Lee C, Spitsbergen J, Neuberg D, Weber G, Golub TR, Glickman JN, Kutok JL, Aster JC, Zon LI.A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13194-9.
    16150706
  • Feuerhake F, Kutok JL, Monti S, Chen W, Lacasce AS, Cattoretti G, Kurtin P, Pinkus GS, de Leval L, Harris NL, Savage KJ, Neuberg D, Habermann TM, Dalla-Favera R, Golub TR, Aster JC, Shipp MA.NF{kappa}B activity, function and target gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes.Blood. 2005 Aug 15;106(4):1392-9.
    15870177
  • Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR.Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.Nature. 2005 Jul 7;436(7047):117-22.
    16001072
  • Stegmaier K, Corsello SM, Ross KN, Wong JS, Deangelo DJ, Golub TR.Gefitinib induces myeloid differentiation of acute myeloid leukemia.Blood. 2005 Oct 15;106(8):2841-8.
    15998836
  • Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR.MicroRNA expression profiles classify human cancers.Nature. 2005 Jun 9;435(7043):834-8.
    15944708
  • Ebert BL, Lee MM, Pretz JL, Subramanian A, Mak R, Golub TR, Sieff CA.An RNA interference model of RPS19 deficiency in Diamond Blackfan Anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone responsive genes by microarray.Blood. 2005 Jun 15;105(12):4620-6.
    15755903
  • Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJ, Boggon TJ, Wlodarska I, Clark JJ, Moore S, Adelsperger J, Koo S, Lee JC, Gabriel S, Mercher T, D'Andrea A, Frohling S, Dohner K, Marynen P, Vandenberghe P, Mesa RA, Tefferi A, Griffin JD, Eck MJ, Sellers WR, Meyerson M, Golub TR, Lee SJ, Gilliland DG.Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.Cancer Cell. 2005 Apr;7(4):387-97.
    15837627
  • Febbo PG, Lowenberg M, Thorner AR, Brown M, Loda M, Golub TR.Androgen mediated regulation and functional implications of fkbp51 expression in prostate cancer.J Urol. 2005 May;173(5):1772-7.
    15821585
  • Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub TR, Armstrong SA, Akashi K, Korsmeyer SJ.Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.EMBO J. 2005 Jan 26;24(2):368-81.
    15635450
  • Sweet-Cordero A, Mukherjee S, Subramanian A, You H, Roix JJ, Ladd-Acosta C, Mesirov J, Golub TR, Jacks T.An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis.Nat Genet..
  • Berger R, Febbo PG, Majumder PK, Zhao JJ, Mukherjee S, Signoretti S, Campbell KT, Sellers WR, Roberts TM, Loda M, Golub TR, Hahn WC.Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.Cancer Res. 2004 Dec 15;64(24):8867-75.
    15604246
  • Monti S, Savage KJ, Kutok JL, Feuerhake F, Kurtin P, Mihm M, Wu B, Pasqualucci L, Neuberg D, Aguiar RC, Dal Cin P, Ladd C, Pinkus GS, Salles G, Harris NL, Dalla-Favera R, Habermann TM, Aster JC, Golub TR, Shipp MA.Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response.Blood. 2005 Mar 1;105(5):1851-61.
    15550490
  • Halmos B, Bassres DS, Monti S, D'Al F, Dayaram T, Ferenczi K, Wouters BJ, Huettner CS, Golub TR, Tenen DG.A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3 beta as a novel tumor suppressor in lung cancer.Cancer Res. 2004 Jun 15;64(12):4137-47.
    15205324
  • Majumder PK, Febbo PG, Bikoff R, Berger R, Xue Q, McMahon LM, Manola J, Brugarolas J, McDonnell TJ, Golub TR, Loda M, Lane HA, Sellers WR.mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.Nat Med. 2004 Jun;10(6):594-601.
    15156201
  • Fernandez-Teijeiro A, Betensky RA, Sturla LM, Kim JY, Tamayo P, Pomeroy SL.Combining gene expression profiles and clinical parameters for risk stratification in medulloblastomas.J Clin Oncol. 2004 Mar 15;22(6):994-8.
    14970184
  • Stegmaier K, Ross KN, Colavito SA, O'Malley S, Stockwell BR, Golub TR.Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation.Nat Genet. 2004 Mar;36(3):257-63.
    14770183
  • Armstrong SA, Golub TR, Korsmeyer SJ.MLL-rearranged leukemias: insights from gene expression profiling.Semin Hematol. 2003 Oct;40(4):268-73.
    14582077
  • Savage KJ, Monti S, Kutok JL, Cattoretti G, Neuberg D, De Leval L, Kurtin P, Dal Cin P, Ladd C, Feuerhake F, Aguiar RC, Li S, Salles G, Berger F, Jing W, Pinkus GS, Habermann T, Dalla-Favera R, Harris NL, Aster JC, Golub TR, Shipp MA.The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.Blood. 2003 Dec 1;102(12):3871-9.
    12933571
  • Lamb J, Ramaswamy S, Ford HL, Contreras B, Martinez RV, Kittrell FS, Zahnow CA, Patterson N, Golub TR, Ewen ME.A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer.Cell. 2003 Aug 8;114(3):323-34.
    12914697
  • Majumder PK, Yeh JJ, George DJ, Febbo PG, Kum J, Xue Q, Bikoff R, Ma H, Kantoff PW, Golub TR, Loda M, Sellers WR.Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7841-6.
    12799464
  • Golub TR.Mining the genome for combination therapies.Nat Med. 2003 May;9(5):510-1.
    12724758
  • Nutt CL, Mani DR, Betensky RA, Tamayo P, Cairncross JG, Ladd C, Pohl U, Hartmann C, McLaughlin ME, Batchelor TT, Black PM, von Deimling A, Pomeroy SL, Golub TR, Louis DN.Gene expression-based classification of malignant gliomas correlates better with survival than histological classification.Cancer Res. 2003 Apr 1;63(7):1602-7.
    12670911
  • Armstrong SA, Kung AL, Mabon ME, Silverman LB, Stam RW, Den Boer ML, Pieters R, Kersey JH, Sallan SE, Fletcher JA, Golub TR, Griffin JD, Korsmeyer SJ.Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification.Cancer Cell. 2003 Feb;3(2):173-83.
    12620411
  • Antipova AA, Tamayo P, Golub TR.A strategy for oligonucleotide microarray probe reduction.Genome Biol. 2002;3(12):RESEARCH0073.
    12537562
  • Ramaswamy S, Ross KN, Lander ES, Golub TR.A molecular signature of metastasis in primary solid tumors.Nat Genet. 2003 Jan;33(1):49-54.
    12469122
  • Kuwata T, Gongora C, Kanno Y, Sakaguchi K, Tamura T, Kanno T, Basrur V, Martinez R, Appella E, Golub T, Ozato K.Gamma interferon triggers interaction between ICSBP (IRF-8) and TEL, recruiting the histone deacetylase HDAC3 to the interferon-responsive element.Mol Cell Biol. 2002 Nov;22(21):7439-48.
    12370291
  • Humpherys D, Eggan K, Akutsu H, Friedman A, Hochedlinger K, Yanagimachi R, Lander ES, Golub TR, Jaenisch R.Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei.Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12889-94.
    12235366
  • McGill GG, Horstmann M, Widlund HR, Du J, Motyckova G, Nishimura EK, Lin YL, Ramaswamy S, Avery W, Ding HF, Jordan SA, Jackson IJ, Korsmeyer SJ, Golub TR, Fisher DE.Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.Cell. 2002 Jun 14;109(6):707-18.
    12086670
  • Lessnick SL, Dacwag CS, Golub TR.The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts.Cancer Cell. 2002 May;1(4):393-401.
    12086853
  • Singh D, Febbo PG, Ross K, Jackson DG, Manola J, Ladd C, Tamayo P, Renshaw AA, D'Amico AV, Richie JP, Lander ES, Loda M, Kantoff PW, Golub TR, Sellers WR.Gene expression correlates of clinical prostate cancer behavior.Cancer Cell. 2002 Mar;1(2):203-9.
    12086878
  • Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC, Behm FG, Pui CH, Downing JR, Gilliland DG, Lander ES, Golub TR, Look AT.Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.Cancer Cell. 2002 Feb;1(1):75-87.
    12086890
  • Ramaswamy S, Golub TR.DNA microarrays in clinical oncology.J Clin Oncol. 2002 Apr 1;20(7):1932-41.
    11919254
  • Kitareewan S, Pitha-Rowe I, Sekula D, Lowrey CH, Nemeth MJ, Golub TR, Freemantle SJ, Dmitrovsky E.UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia.Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3806-11.
    11891284
  • Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, McLaughlin ME, Kim JY, Goumnerova LC, Black PM, Lau C, Allen JC, Zagzag D, Olson JM, Curran T, Wetmore C, Biegel JA, Poggio T, Mukherjee S, Rifkin R, Califano A, Stolovitzky G, Louis DN, Mesirov JP, Lander ES, Golub TR.Prediction of central nervous system embryonal tumour outcome based on gene expression.Nature. 2002 Jan 24;415(6870):436-42.
    11807556
  • Shipp MA, Ross KN, Tamayo P, Weng AP, Kutok JL, Aguiar RC, Gaasenbeek M, Angelo M, Reich M, Pinkus GS, Ray TS, Koval MA, Last KW, Norton A, Lister TA, Mesirov J, Neuberg DS, Lander ES, Aster JC, Golub TR.Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning.Nat Med. 2002 Jan;8(1):68-74.
    11786909
  • Ramaswamy S, Tamayo P, Rifkin R, Mukherjee S, Yeang CH, Angelo M, Ladd C, Reich M, Latulippe E, Mesirov JP, Poggio T, Gerald W, Loda M, Lander ES, Golub TR.Multiclass cancer diagnosis using tumor gene expression signatures.Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15149-54.
    11742071
  • Armstrong SA, Staunton JE, Silverman LB, Pieters R, den Boer ML, Minden MD, Sallan SE, Lander ES, Golub TR, Korsmeyer SJ.MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia.Nat Genet. 2002 Jan;30(1):41-7.
    11731795
  • Bhattacharjee A, Richards WG, Staunton J, Li C, Monti S, Vasa P, Ladd C, Beheshti J, Bueno R, Gillette M, Loda M, Weber G, Mark EJ, Lander ES, Wong W, Johnson BE, Golub TR, Sugarbaker DJ, Meyerson M.Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses.Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13790-5.
    11707567
  • Golub TR.Genomic approaches to the pathogenesis of hematologic malignancy.Curr Opin Hematol. 2001 Jul;8(4):252-61.
    11561164
  • Staunton JE, Slonim DK, Coller HA, Tamayo P, Angelo MJ, Park J, Scherf U, Lee JK, Reinhold WO, Weinstein JN, Mesirov JP, Lander ES, Golub TR.Chemosensitivity prediction by transcriptional profiling.Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10787-92.
    11553813
  • Yeang CH, Ramaswamy S, Tamayo P, Mukherjee S, Rifkin RM, Angelo M, Reich M, Lander E, Mesirov J, Golub T.Molecular classification of multiple tumor types.Bioinformatics. 2001;17 Suppl 1:S316-22.
    11473023
  • Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG.c-Myc is a critical target for c/EBPalpha in granulopoiesis.Mol Cell Biol. 2001 Jun;21(11):3789-806.
    11340171
  • Golub TR.Genome-wide views of cancer.N Engl J Med. 2001 Feb 22;344(8):601-2.
    11207357
  • Butte AJ, Tamayo P, Slonim D, Golub TR, Kohane IS.Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks.Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12182-6.
    11027309
  • Clark EA, Golub TR, Lander ES, Hynes RO.Genomic analysis of metastasis reveals an essential role for RhoC.Nature. 2000 Aug 3;406(6795):532-5.
    10952316
  • Coller HA, Grandori C, Tamayo P, Colbert T, Lander ES, Eisenman RN, Golub TR.Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion.Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3260-5.
    10737792
  • Dickson MA, Hahn WC, Ino Y, Ronfard V, Wu JY, Weinberg RA, Louis DN, Li FP, Rheinwald JG.Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.Mol Cell Biol. 2000 Feb;20(4):1436-47.
    10648628
  • Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, Bloomfield CD, Lander ES.Molecular classification of cancer: class discovery and class prediction by gene expression monitoring.Science. 1999 Oct 15;286(5439):531-7.
    10521349
  • Wang LC, Swat W, Fujiwara Y, Davidson L, Visvader J, Kuo F, Alt FW, Gilliland DG, Golub TR, Orkin SH.The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow.Genes Dev. 1998 Aug 1;12(15):2392-402.
    9694803
  • Wang LC, Kuo F, Fujiwara Y, Gilliland DG, Golub TR, Orkin SH.Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL.EMBO J. 1997 Jul 16;16(14):4374-83.
    9250681