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Malcolm Whitman, PhD


  • Rienhoff HY, Yeo CY, Morissette R, Khrebtukova I, Melnick J, Luo S, Leng N, Kim YJ, Schroth G, Westwick J, Vogel H, McDonnell N, Hall JG, Whitman M.A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome.Am J Med Genet A. 2013 Aug;161A(8):2040-6.
  • Whitman M, Rosen V, Brivanlou AH, Groppe JC, Sebald W, Mueller T.Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3.Nat Med. 2013 Jul;19(7):809-10.
  • Ho DM, Yeo CY, Whitman M.The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo.Mech Dev.;127(9-12):485-95.
  • Danciu TE, Whitman M.Oxidative stress drives disulfide bond formation between basic helix-loop-helix transcription factors.J Cell Biochem. 2010 Feb 1;109(2):417-24.
  • Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A.Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response.Science. 2009 Jun 5;324(5932):1334-8.
  • Onuma Y,Watanabe A,Aburatani H,Asashima M,Whitman M.TRIQK, a novel family of small proteins localized to the endoplasmic reticulum membrane, is conserved across vertebrates.Zoolog Sci. 2008 Jul;25(7):706-13.
  • Ho DM, Whitman M.TGF-beta signaling is required for multiple processes during Xenopus tail regeneration.Dev Biol. 2008 Mar 1;315(1):203-16.
  • Anderson SB, Goldberg AL, Whitman M.Identification of a novel pool of extracellular pro-myostatin in skeletal muscle.J Biol Chem. 2008 Mar 14;283(11):7027-35.
  • Onuma Y, Asashima M, Whitman M.A Serpin family gene, Protease nexin-1 has an activity distinct from protease inhibition in early Xenopus embryos.Mech Dev. 2006 Jun;123(6):463-71.
  • Kolk SM, Whitman MC, Yun ME, Shete P, Donoghue MJ.A unique subpopulation of Tbr1-expressing deep layer neurons in the developing cerebral cortex.Mol Cell Neurosci. 2006 May-Jun;32(1-2):200-14.
  • Ho DM, Chan J, Bayliss P, Whitman M.Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo.Dev Biol. 2006 Jul 15;295(2):730-42.
  • Weisberg E, Winnier GE, Chen X, Farnsworth CL, Hogan BL, Whitman M.A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis.Mech Dev. 1998 Dec;79(1-2):17-27.
  • Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M.Smad4 and FAST-1 in the assembly of activin-responsive factor.Nature. 1997 Sep 4;389(6646):85-9.
  • LaBonne C, Whitman M.Localization of MAP kinase activity in early Xenopus embryos: implications for endogenous FGF signaling.Dev Biol. 1997 Mar 1;183(1):9-20.
  • Chen X, Rubock MJ, Whitman M.A transcriptional partner for MAD proteins in TGF-beta signalling.Nature. 1996 Oct 24;383(6602):691-6.
  • Huang HC, Murtaugh LC, Vize PD, Whitman M.Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo.EMBO J. 1995 Dec 1;14(23):5965-73.
  • LaBonne C, Burke B, Whitman M.Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development.Development. 1995 May;121(5):1475-86.
  • LaBonne C, Whitman M.Mesoderm induction by activin requires FGF-mediated intracellular signals.Development. 1994 Feb;120(2):463-72.
  • Whitman M, Melton DA.Involvement of p21ras in Xenopus mesoderm induction.Nature. 1992 May 21;357(6375):252-4.
  • Thomsen G, Woolf T, Whitman M, Sokol S, Vaughan J, Vale W, Melton DA.Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures.Cell. 1990 Nov 2;63(3):485-93.
  • Hall DJ, Jones SD, Kaplan DR, Whitman M, Rollins BJ, Stiles CD.Evidence for a novel signal transduction pathway activated by platelet-derived growth factor and by double-stranded RNA.Mol Cell Biol. 1989 Apr;9(4):1705-13.
  • Whitman M, Downes CP, Keeler M, Keller T, Cantley L.Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate.Nature. 1988 Apr 14;332(6165):644-6.
  • Whitman M, Kaplan D, Roberts T, Cantley L.Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation.Biochem J. 1987 Oct 1;247(1):165-74.
  • Kaplan DR, Whitman M, Schaffhausen B, Pallas DC, White M, Cantley L, Roberts TM.Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity.Cell. 1987 Sep 25;50(7):1021-9.
  • Kaplan DR, Whitman M, Schaffhausen B, Raptis L, Garcea RL, Pallas D, Roberts TM, Cantley L.Phosphatidylinositol metabolism and polyoma-mediated transformation.Proc Natl Acad Sci U S A. 1986 Jun;83(11):3624-8.
  • Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM.Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation.Nature. 1985 May 16-22;315(6016):239-42.
  • Sugimoto Y, Whitman M, Cantley LC, Erikson RL.Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.Proc Natl Acad Sci U S A. 1984 Apr;81(7):2117-21.