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Malcolm Whitman, PhD


  • Ho DM, Yeo CY, Whitman M.The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo.Mech Dev.;127(9-12):485-95.
  • Danciu TE, Whitman M.Oxidative stress drives disulfide bond formation between basic helix-loop-helix transcription factors.J Cell Biochem. 2010 Feb 1;109(2):417-24.
  • Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A.Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response.Science. 2009 Jun 5;324(5932):1334-8.
  • Onuma Y,Watanabe A,Aburatani H,Asashima M,Whitman M.TRIQK, a novel family of small proteins localized to the endoplasmic reticulum membrane, is conserved across vertebrates.Zoolog Sci. 2008 Jul;25(7):706-13.
  • Ho DM, Whitman M.TGF-beta signaling is required for multiple processes during Xenopus tail regeneration.Dev Biol. 2008 Mar 1;315(1):203-16.
  • Anderson SB, Goldberg AL, Whitman M.Identification of a novel pool of extracellular pro-myostatin in skeletal muscle.J Biol Chem. 2008 Mar 14;283(11):7027-35.
  • Onuma Y, Asashima M, Whitman M.A Serpin family gene, Protease nexin-1 has an activity distinct from protease inhibition in early Xenopus embryos.Mech Dev. 2006 Jun;123(6):463-71.
  • Kolk SM, Whitman MC, Yun ME, Shete P, Donoghue MJ.A unique subpopulation of Tbr1-expressing deep layer neurons in the developing cerebral cortex.Mol Cell Neurosci. 2006 May-Jun;32(1-2):200-14.
  • Ho DM, Chan J, Bayliss P, Whitman M.Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo.Dev Biol. 2006 Jul 15;295(2):730-42.
  • Weisberg E, Winnier GE, Chen X, Farnsworth CL, Hogan BL, Whitman M.A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis.Mech Dev. 1998 Dec;79(1-2):17-27.
  • Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M.Smad4 and FAST-1 in the assembly of activin-responsive factor.Nature. 1997 Sep 4;389(6646):85-9.
  • LaBonne C, Whitman M.Localization of MAP kinase activity in early Xenopus embryos: implications for endogenous FGF signaling.Dev Biol. 1997 Mar 1;183(1):9-20.
  • Chen X, Rubock MJ, Whitman M.A transcriptional partner for MAD proteins in TGF-beta signalling.Nature. 1996 Oct 24;383(6602):691-6.
  • Huang HC, Murtaugh LC, Vize PD, Whitman M.Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo.EMBO J. 1995 Dec 1;14(23):5965-73.
  • LaBonne C, Burke B, Whitman M.Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development.Development. 1995 May;121(5):1475-86.
  • LaBonne C, Whitman M.Mesoderm induction by activin requires FGF-mediated intracellular signals.Development. 1994 Feb;120(2):463-72.
  • Whitman M, Melton DA.Involvement of p21ras in Xenopus mesoderm induction.Nature. 1992 May 21;357(6375):252-4.
  • Thomsen G, Woolf T, Whitman M, Sokol S, Vaughan J, Vale W, Melton DA.Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures.Cell. 1990 Nov 2;63(3):485-93.
  • Hall DJ, Jones SD, Kaplan DR, Whitman M, Rollins BJ, Stiles CD.Evidence for a novel signal transduction pathway activated by platelet-derived growth factor and by double-stranded RNA.Mol Cell Biol. 1989 Apr;9(4):1705-13.
  • Whitman M, Downes CP, Keeler M, Keller T, Cantley L.Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate.Nature. 1988 Apr 14;332(6165):644-6.
  • Whitman M, Kaplan D, Roberts T, Cantley L.Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation.Biochem J. 1987 Oct 1;247(1):165-74.
  • Kaplan DR, Whitman M, Schaffhausen B, Pallas DC, White M, Cantley L, Roberts TM.Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity.Cell. 1987 Sep 25;50(7):1021-9.
  • Kaplan DR, Whitman M, Schaffhausen B, Raptis L, Garcea RL, Pallas D, Roberts TM, Cantley L.Phosphatidylinositol metabolism and polyoma-mediated transformation.Proc Natl Acad Sci U S A. 1986 Jun;83(11):3624-8.
  • Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM.Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation.Nature. 1985 May 16-22;315(6016):239-42.
  • Sugimoto Y, Whitman M, Cantley LC, Erikson RL.Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.Proc Natl Acad Sci U S A. 1984 Apr;81(7):2117-21.