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Leif W. Ellisen, MD, PhD

Publications

  • Dienstmann R, Dong F, Borger D, Dias-Santagata D, Ellisen LW, Le LP, Iafrate AJ.Standardized decision support in next generation sequencing reports of somatic cancer variants.Mol Oncol. 2014 Apr 4.
    24768039
  • Wakimoto H, Tanaka S, Curry WT, Loebel F, Zhao D, Tateishi K, Chen J, Klofas LK, Lelic N, Kim JC, Dias-Santagata D, Ellisen LW, Borger DR, Fendt SM, Vander Heiden M, Batchelor TT, Iafrate AJ, Cahill DP, Chi AS.Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas.Clin Cancer Res. 2014 Apr 8.
    24714777
  • Borger DR, Goyal L, Yau T, Poon RT, Ancukiewicz M, Deshpande V, Christiani DC, Liebman HM, Yang H, Kim H, Yen K, Faris JE, Iafrate AJ, Kwak EL, Clark JW, Allen JN, Blaszkowsky LS, Murphy JE, Saha SK, Hong TS, Wo JY, Ferrone CR, Tanabe KK, Bardeesy N, Straley KS, Agresta S, Schenkein DP, Ellisen LW, Ryan DP, Zhu AX.Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma.Clin Cancer Res. 2014 Apr 1;20(7):1884-90.
    24478380
  • McBride SM, Rothenberg SM, Faquin WC, Chan AW, Clark JR, Ellisen LW, Wirth LJ.Mutation frequency in 15 common cancer genes in high-risk head and neck squamous cell carcinoma.Head Neck. 2013 Jul 15.
    23852799
  • Russo AL, Borger DR, Szymonifka J, Ryan DP, Wo JY, Blaszkowsky LS, Kwak EL, Allen JN, Wadlow RC, Zhu AX, Murphy JE, Faris JE, Dias-Santagata D, Haigis KM, Ellisen LW, Iafrate AJ, Hong TS.Mutational analysis and clinical correlation of metastatic colorectal cancer.Cancer. 2014 Feb 5.
    24500602
  • Forster N, Saladi SV, van Bragt M, Sfondouris ME, Jones FE, Li Z, Ellisen LW.Basal cell signaling by p63 controls luminal progenitor function and lactation via NRG1.Dev Cell. 2014 Jan 27;28(2):147-60.
    24412575
  • Akhavanfard S, Vargas SO, Han M, Nitta M, Chang CB, Le LP, Fazlollahi L, Nguyen Q, Ma Y, Cosper A, Dias-Santagata D, Han JY, Bergethon K, Borger DR, Ellisen LW, Pomeroy SL, Haber DA, Iafrate AJ, Rivera MN.Inactivation of the tumor suppressor WTX in a subset of pediatric tumors.Genes Chromosomes Cancer. 2014 Jan;53(1):67-77.
    24249259
  • Ramsey MR, Wilson C, Ory B, Rothenberg SM, Faquin W, Mills AA, Ellisen LW.FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma.J Clin Invest. 2013 Aug 1;123(8):3525-38.
    23867503
  • Chabner BA, Ellisen LW, Iafrate AJ.Personalized medicine: hype or reality.Oncologist. 2013 Jun;18(6):640-3.
    23814157
  • Chi AS, Batchelor TT, Yang D, Dias-Santagata D, Borger DR, Ellisen LW, Iafrate AJ, Louis DN.BRAF V600E mutation identifies a subset of low-grade diffusely infiltrating gliomas in adults.J Clin Oncol. 2013 May 10;31(14):e233-6.
    23547069
  • He L, Torres-Lockhart K, Forster N, Ramakrishnan S, Greninger P, Garnett MJ, McDermott U, Rothenberg SM, Benes CH, Ellisen LW.Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma.Cancer Discovery. 2013 Mar;3(3):324-37.
    23274910
  • Patenaude AF, Tung N, Ryan PD, Ellisen LW, Hewitt L, Schneider KA, Tercyak KP, Aldridge J, Garber JE.Young adult daughters of BRCA1/2 positive mothers: What do they know about hereditary cancer and how much do they worry?.Psycho Oncology. 2013 Feb 18.
    23417902
  • Ibrahim YH, García-García C, Serra V, He L, Torres-Lockhart K, Prat A, Anton P, Cozar P, Guzmán M, Grueso J, Rodríguez O, Calvo MT, Aura C, Díez O, Rubio IT, Pérez J, Rodón J, Cortés J, Ellisen LW, Scaltriti M, Baselga J.PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition.Cancer Discovery. 2012 Nov;2(11):1036-47.
    22915752
  • Gallant-Behm CL, Ramsey MR, Bensard CL, Nojek I, Tran J, Liu M, Ellisen LW, Espinosa JM.{Delta}Np63α represses anti-proliferative genes via H2A.Z deposition.Genes Dev. 2012 Oct 15;26(20):2325-36.
    23019126
  • Chi AS, Batchelor TT, Dias-Santagata D, Borger D, Stiles CD, Wang DL, Curry WT, Wen PY, Ligon KL, Ellisen L, Louis DN, Iafrate AJ.Prospective, high-throughput molecular profiling of human gliomas.J. Neurooncol. 2012 Oct;110(1):89-98.
    22821383
  • Rothenberg SM, Ellisen LW.The molecular pathogenesis of head and neck squamous cell carcinoma.J Clin Invest. 2012 Jun 1;122(6):1951-7. Review.
    22833868
  • Ramsey MR, He L, Forster N, Ory B, Ellisen LW.Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma.Cancer Res. 2011 Jul 1;71(13):4373-9.
    21527555
  • Ory B, Ramsey MR, Wilson C, Vadysirisack DD, Forster N, Rocco JW, Rothenberg SM, Ellisen LW.A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma.J Clin Invest. 2011 Feb 1;121(2):809-20.
    21293058
  • Ellisen LW.PARP inhibitors in cancer therapy: promise, progress, and puzzles.Cancer Cell. 2011 Feb 15;19(2):165-7.
    21316599
  • Yang C, Hayashida T, Forster N, Li C, Shen D, Maheswaran S, Chen L, Anderson KS, Ellisen LW, Sgroi D, Schmidt EV.The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers.Cancer Res. 2011 Feb 1;71(3):937-45.
    21127199
  • Ibrahim N, He L, Leong CO, Xing D, Karlan BY, Swisher EM, Rueda BR, Orsulic S, Ellisen LW.BRCA1-associated epigenetic regulation of p73 mediates an effector pathway for chemosensitivity in ovarian carcinoma.Cancer Res. 2010 Sep 15;70(18):7155-65.
    20807817
  • Ellisen LW.Smoking and emphysema: the stress connection.Nat Med. 2010 Jul;16(7):754-5.
    20613751
  • Dias-Santagata D, Akhavanfard S, David SS, Vernovsky K, Kuhlmann G, Boisvert SL, Stubbs H, McDermott U, Settleman J, Kwak EL, Clark JW, Isakoff SJ, Sequist LV, Engelman JA, Lynch TJ, Haber DA, Louis DN, Ellisen LW, Borger DR, Iafrate AJ.Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine.EMBO Mol Med. 2010 May;2(5):146-58.
    20432502
  • Horak P, Crawford AR, Vadysirisack DD, Nash ZM, DeYoung MP, Sgroi D, Ellisen LW.Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis.Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4675-80.
    20176937
  • Silver DP, Richardson AL, Eklund AC, Wang ZC, Szallasi Z, Li Q, Juul N, Leong CO, Calogrias D, Buraimoh A, Fatima A, Gelman RS, Ryan PD, Tung NM, De Nicolo A, Ganesan S, Miron A, Colin C, Sgroi DC, Ellisen LW, Winer EP, Garber JE.Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer.J Clin Oncol. 2010 Mar 1;28(7):1145-53.
    20100965
  • Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R.The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.Cell. 2010 Jan 22;140(2):280-93.
    20141841
  • Michaud WA,Nichols AC,Mroz EA,Faquin WC,Clark JR,Begum S,Westra WH,Wada H,Busse PM,Ellisen LW,Rocco JW.Bcl-2 blocks cisplatin-induced apoptosis and predicts poor outcome following chemoradiation treatment in advanced oropharyngeal squamous cell carcinoma.Clin Cancer Res. 2009 Mar 1;15(5):1645-54.
    19240170
  • Li N, Singh S, Cherukuri P, Li H, Yuan Z, Ellisen LW, Wang B, Robbins D, Direnzo J.Reciprocal Intra-Epithelial Interactions between TP63 and Hedgehog Signaling Regulate Quiescence and Activation of Progenitor Elaboration by Mammary Stem Cells.Stem Cells. 2008 May;26(5):1253-64.
    18292212
  • Harvey KF, Mattila J, Sofer A, Bennett FC, Ramsey MR, Ellisen LW, Puig O, Hariharan IK.FOXO-regulated transcription restricts overgrowth of Tsc mutant organs.J Cell Biol. 2008 Feb 25;180(4):691-6.
    18299344
  • DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW.Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.Genes Dev. 2008 Jan 15;22(2):239-51.
    18198340
  • Leong CO, Vidnovic N, Deyoung MP, Sgroi D, Ellisen LW.The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers.J Clin Invest. 2007 May;117(5):1370-80.
    17446929
  • Deyoung MP, Ellisen LW.p63 and p73 in human cancer: defining the network.Oncogene. 2007 Aug 9;26(36):5169-83. Review.
    17334395
  • Wang H, Kubica N, Ellisen LW, Jefferson LS, Kimball SR.Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1.J Biol Chem. 2006 Dec 22;281(51):39128-34.
    17074751
  • Deyoung MP, Johannessen CM, Leong CO, Faquin W, Rocco JW, Ellisen LW.Tumor-Specific p73 Up-regulation Mediates p63 Dependence in Squamous Cell Carcinoma.Cancer Res. 2006 Oct 1;66(19):9362-8.
    17018588
  • Carroll DK, Carroll JS, Leong CO, Cheng F, Brown M, Mills AA, Brugge JS, Ellisen LW.p63 regulates an adhesion programme and cell survival in epithelial cells.Nat Cell Biol. 2006 Jun;8(6):551-61.
    16715076
  • Rocco JW, Leong CO, Kuperwasser N, DeYoung MP, Ellisen LW.p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis.Cancer Cell. 2006 Jan;9(1):45-56.
    16413471
  • Ellisen LW.Growth Control Under Stress: mTOR Regulation through the REDD1-TSC Pathway.Cell Cycle. 2005 Nov;4(11):1500-02. Review.
    16258273
  • Sofer A, Lei K, Johannessen CM, Ellisen LW.Regulation of mTOR and cell growth in response to energy stress by REDD1.Mol Cell Biol. 2005 Jul;25(14):5834-45.
    15988001
  • Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WG.Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.Genes Dev. 2004 Dec 1;18(23):2893-904.
    15545625
  • Ellisen LW, Ramsayer KD, Johannessen CM, Yang A, Beppu H, Minda K, Oliner JD, McKeon F, Haber DA.REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species.Mol Cell. 2002 Nov;10(5):995-1005.
    12453409
  • Harkin DP, Bean JM, Miklos D, Song YH, Truong VB, Englert C, Christians FC, Ellisen LW, Maheswaran S, Oliner JD, Haber DA.Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.Cell. 1999 May 28;97(5):575-86.
    10367887
  • Ellisen LW, Haber DA.Hereditary breast cancer.Annu Rev Med. 1998;49:425-36.
    9509273
  • Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, Sklar J.TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.Cell. 1991 Aug 23;66(4):649-61.
    1831692