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Henning Willers, MD


  • Wang M, Kern AM, Hülskötter M, Greninger P, Singh A, Pan Y, Chowdhury D, Krause M, Baumann M, Benes CH, Efstathiou JA, Settleman J, Willers H.EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells against Ionizing Radiation.Cancer Res. 2014 Apr 28.
  • Pfäffle HN, Wang M, Gheorghiu L, Ferraiolo N, Greninger P, Borgmann K, Settleman J, Benes CH, Sequist LV, Zou L, Willers H.EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.Cancer Res. 2013 Oct 15;73(20):6254-63.
  • Rosenzweig KE, Chang JY, Chetty IJ, Decker RH, Ginsburg ME, Kestin LL, Kong FM, Lally BE, Langer CJ, Movsas B, Videtic GM, Willers H.ACR appropriateness criteria nonsurgical treatment for non-small-cell lung cancer: poor performance status or palliative intent.J Am Coll Radiol. 2013 Sep;10(9):654-64.
  • Seco J, Gu G, Marcelos T, Kooy H, Willers H.Proton arc reduces range uncertainty effects and improves conformality compared with photon volumetric modulated arc therapy in stereotactic body radiation therapy for non-small cell lung cancer.Int J Radiat Oncol Biol Phys. 2013 Sep 1;87(1):188-94.
  • Kong FM, Lally BE, Chang JY, Chetty IJ, Decker RH, Ginsburg ME, Kestin LL, Langer CJ, Movsas B, Videtic GM, Willers H, Rosenzweig KE, .ACR Appropriateness Criteria® Radiation Therapy for Small-Cell Lung Cancer.Am J Clin Oncol. 2013 Apr;36(2):206-213.
  • Grassberger C, Dowdell S, Lomax A, Sharp G, Shackleford J, Choi N, Willers H, Paganetti H.Motion Interplay as a Function of Patient Parameters and Spot Size in Spot Scanning Proton Therapy for Lung Cancer.Int J Radiat Oncol Biol Phys. 2013 Feb 22.
  • Goldberg SB, Willers H, Heist RS.Multidisciplinary management of small cell lung cancer.Surg Oncol Clin N Am. 2013 Apr;22(2):329-43.
  • Birkelbach M, Ferraiolo N, Gheorghiu L, Pfäffle HN, Daly B, Ebright MI, Spencer C, O'Hara C, Whetstine JR, Benes CH, Sequist LV, Zou L, Dahm-Daphi J, Kachnic LA, Willers H.Detection of impaired homologous recombination repair in NSCLC cells and tissues.J Thorac Oncol. 2013 Mar;8(3):279-86.
  • Kachnic LA, Li L, Fournier L, Ferraiolo N, Dahm-Daphi J, Borgmann K, Willers H.FANCD2 but not FANCA promotes cellular resistance to type II topoisomerase poisons.Cancer Lett. 2011 Jun 1;305(1):86-93.
  • Eichler AF, Kahle KT, Wang DL, Joshi VA, Willers H, Engelman JA, Lynch TJ, Sequist LV.EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer.Neuro Oncology. 2010 Nov;12(11):1193-9.
  • Kachnic LA, Li L, Fournier L, Willers H.Fanconi Anemia pathway heterogeneity revealed by cisplatin and oxaliplatin treatments.Cancer Lett. 2010 Jun 1;292(1):73-9.
  • Zhuang J, Jiang G, Willers H, Xia F.Exonuclease function of human Mre11 promotes deletional nonhomologous end joining.J Biol Chem. 2009 Oct 30;284(44):30565-73.
  • Willers H, Taghian AG, Luo CM, Treszezamsky A, Sgroi DC, Powell SN.Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies.Mol Cancer Res. 2009 Aug;7(8):1304-9.
  • Kuhnert VM,Kachnic LA,Li L,Purschke M,Gheorghiu L,Lee R,Held KD,Willers H.FANCD2-deficient human fibroblasts are hypersensitive to ionising radiation at oxygen concentrations of 0% and 3% but not under normoxic conditions.Int J Radiat Biol. 2009 Jun;85(6):523-31.
  • Nanda A,Dias-Santagata DC,Stubbs H,O'Hara CJ,Zaner KS,Lynch TJ,Willers H.Unusual tumor response and toxicity from radiation and concurrent erlotinib for non-small-cell lung cancer.Clin Lung Cancer. 2008 Sep;9(5):285-7.
  • Shi W,Ma Z,Willers H,Akhtar K,Scott SP,Zhang J,Powell S,Zhang J.Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation.J Biol Chem. 2008 Nov 14;283(46):31608-16.
  • Mansour WY,Schumacher S,Rosskopf R,Rhein T,Schmidt-Petersen F,Gatzemeier F,Haag F,Borgmann K,Willers H,Dahm-Daphi J.Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks.Nucleic Acids Res. 2008 Jul;36(12):4088-98.
  • Schulte-Uentrop L, El-Awady RA, Schliecker L, Willers H, Dahm-Daphi J.Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks.Nucleic Acids Res. 2008 May;36(8):2561-9.
  • Willers H, Husson J, Lee LW, Hubbe P, Gazemeier F, Powell SN, Dahm-Daphi J.Distinct mechanisms of nonhomologous end joining in the repair of site-directed chromosomal breaks with noncomplementary and complementary ends.Radiat Res. 2006 Oct;166(4):567-74.
  • Willers H, Held KD.Introduction to clinical radiation biology.Hematol Oncol Clin North Am. 2006 Feb;20(1):1-24. Review.
  • Zhuang J, Zhang J, Willers H, Wang H, Chung JH, van Gent DC, Hallahan DE, Powell SN, Xia F.Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining.Cancer Res. 2006 Feb 1;66(3):1401-8.
  • Dahm-Daphi J, Hubbe P, Horvath F, El-Awady RA, Bouffard KE, Powell SN, Willers H.Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53.Oncogene. 2005 Mar 3;24(10):1663-72.
  • Romanova LY, Willers H, Blagosklonny MV, Powell SN.The interaction of p53 with replication protein A mediates suppression of homologous recombination.Oncogene. 2004 Dec 2;23(56):9025-33.
  • Willers H, Dahm-Daphi J, Powell SN.Repair of radiation damage to DNA.Br J Cancer. 2004 Apr 5;90(7):1297-301.
  • Zhang J, Willers H, Feng Z, Ghosh JC, Kim S, Weaver DT, Chung JH, Powell SN, Xia F.Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair.Mol Cell Biol. 2004 Jan;24(2):708-18.
  • Suit HD, Willers H.Comment on "Tumor response to radiotherapy regulated by endothelial cell apoptosis" (I).Science. 2003 Dec 12;302(5652):1894; author reply 1894.
  • Powell SN, Willers H, Xia F.BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer?.Mol Cell. 2002 Dec;10(6):1262-3.
  • Willers H, Xia F, Powell SN.Recombinational DNA Repair in Cancer and Normal Cells: The Challenge of Functional Analysis.J Biomed Biotechnol. 2002;2(2):86-93.
  • Willers H, McCarthy EE, Hubbe P, Dahm-Daphi J, Powell SN.Homologous recombination in extrachromosomal plasmid substrates is not suppressed by p53.Carcinogenesis. 2001 Nov;22(11):1757-63.
  • Xia F, Taghian DG, DeFrank JS, Zeng ZC, Willers H, Iliakis G, Powell SN.Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining.Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8644-9.
  • Willers H, McCarthy EE, Alberti W, Dahm-Daphi J, Powell SN.Loss of wild-type p53 function is responsible for upregulated homologous recombination in immortal rodent fibroblasts.Int J Radiat Biol. 2000 Aug;76(8):1055-62.
  • Willers H, McCarthy EE, Wu B, Wunsch H, Tang W, Taghian DG, Xia F, Powell SN.Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control.Oncogene. 2000 Feb 3;19(5):632-9.
  • Tang W, Willers H, Powell SN.p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts.Cancer Res. 1999 Jun 1;59(11):2562-5.
  • Willers H, Wrschmidt F, Bnemann H, Heilmann HP.High-dose radiation therapy alone for inoperable non-small cell lung cancer--experience with prolonged overall treatment times.Acta Oncol. 1998;37(1):101-5.
  • Willers H, Prosch B, Beck-Bornholdt HP.Impact of the interfraction interval on clonogenic cell survival in split-dose irradiation of R1H rhabdomyosarcoma of the rat in vitro.Radiother Oncol. 1997 Apr;43(1):93-6.
  • Beck-Bornholdt HP, Dubben HH, Liertz-Petersen C, Willers H.Hyperfractionation: where do we stand?.Radiother Oncol. 1997 Apr;43(1):1-21.
  • Willers H, Beck-Bornholdt HP.Origins of radiotherapy and radiobiology: separation of the influence of dose per fraction and overall treatment time on normal tissue damage by Reisner and Miescher in the 1930s.Radiother Oncol. 1996 Feb;38(2):171-3.
  • Willers H, Hug EB, Spiro IJ, Efird JT, Rosenberg AE, Wang CC.Adult soft tissue sarcomas of the head and neck treated by radiation and surgery or radiation alone: patterns of failure and prognostic factors.Int J Radiat Oncol Biol Phys. 1995 Oct 15;33(3):585-93.