Karen Cichowski, PhD

Publications

• Beert E, Brems H, Daniëls B, De Wever I, Van Calenbergh F, Schoenaers J, Debiec-Rychter M, Gevaert O, De Raedt T, Van Den Bruel A, de Ravel T, Cichowski K, Kluwe L, Mautner V, Sciot R, Legius E.Atypical neurofibromas in neurofibromatosis type 1 are prema
  21987445
• De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Maertens O, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, Macleod KF, Cichowski K.Exploiting cancer cell vulnerabilities to develop a combination therapy for
  21907929
• Huson SM, Acosta MT, Belzberg AJ, Bernards A, Chernoff J, Cichowski K, Gareth Evans D, Ferner RE, Giovannini M, Korf BR, Listernick R, North KN, Packer RJ, Parada LF, Peltonen J, Ramesh V, Reilly KM, Risner JW, Schorry EK, Upadhyaya M, Viskochil DH, Zhu Y
  21271647
• Cichowski K, Jänne PA.Drug discovery: inhibitors that activate.Nature. 2010 Mar 18;464(7287):358-9.
  20237552
• Min J, Zaslavsky A, Fedele G, McLaughlin SK, Reczek EE, De Raedt T, Guney I, Strochlic DE, Macconaill LE, Beroukhim R, Bronson RT, Ryeom S, Hahn WC, Loda M, Cichowski K.An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately
  20154697
• McGillicuddy LT, Fromm JA, Hollstein PE, Kubek S, Beroukhim R, De Raedt T, Johnson BW, Williams SM, Nghiemphu P, Liau LM, Cloughesy TF, Mischel PS, Parret A, Seiler J, Moldenhauer G, Scheffzek K, Stemmer-Rachamimov AO, Sawyers CL, Brennan C, Messiaen L, M
  19573811
• Cichowski K,Hahn WC.Unexpected pieces to the senescence puzzle.Cell. 2008 Jun 13;133(6):958-61. Review.
  18555773
• Courtois-Cox S, Jones SL, Cichowski K.Many roads lead to oncogene-induced senescence.Oncogene. 2008 May 1;27(20):2801-9. Review.
  18193093
• Johannessen CM, Johnson BW, Williams SM, Chan AW, Reczek EE, Lynch RC, Rioth MJ, McClatchey A, Ryeom S, Cichowski K.TORC1 is essential for NF1-associated malignancies.Curr Biol. 2008 Jan 8;18(1):56-62.
  18164202
• Courtois-Cox S, Genther Williams SM, Reczek EE, Johnson BW, McGillicuddy LT, Johannessen CM, Hollstein PE, MacCollin M, Cichowski K.A negative feedback signaling network underlies oncogene-induced senescence.Cancer Cell. 2006 Dec;10(6):459-72.
  17157787
• Johannessen CM, Reczek EE, James MF, Brems H, Legius E, Cichowski K.The NF1 tumor suppressor critically regulates TSC2 and mTOR.Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8573-8.
  15937108
• Engelman JA, Jänne PA, Mermel C, Pearlberg J, Mukohara T, Fleet C, Cichowski K, Johnson BE, Cantley LC.ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines.Proc Natl Acad Sci U S A. 2005 Mar 8;102
  15731348
• Cichowski K, Santiago S, Jardim M, Johnson BW, Jacks T.Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor.Genes Dev. 2003 Feb 15;17(4):449-54.
  12600938
• Cichowski K, Jacks T.NF1 tumor suppressor gene function: narrowing the GAP.Cell. 2001 Feb 23;104(4):593-604.
  11239415
• Cichowski K, Shih TS, Schmitt E, Santiago S, Reilly K, McLaughlin ME, Bronson RT, Jacks T.Mouse models of tumor development in neurofibromatosis type 1.Science. 1999 Dec 10;286(5447):2172-6.
  10591652