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Karen Cichowski, PhD

Publications

  • Malone CF, Fromm JA, Maertens O, De Raedt T, Ingraham R, Cichowski K.Defining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers.Cancer Discovery. 2014 Jun 9.
    24913553
  • Maertens O, Cichowski K.An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer.Adv Biol Regul. 2014 May;55C:1-14.
    24814062
  • Maertens O, Cichowski K.Paths of resistance to EGFR inhibitors: is NF enough?.Cancer Discovery. 2014 May;4(5):519-21.
    24795011
  • Widemann BC, Acosta MT, Ammoun S, Belzberg AJ, Bernards A, Blakeley J, Bretscher A, Cichowski K, Clapp DW, Dombi E, Evans GD, Ferner R, Fernandez-Valle C, Fisher MJ, Giovannini M, Gutmann DH, Hanemann CO, Hennigan R, Huson S, Ingram D, Kissil J, Korf BR, Legius E, Packer RJ, McClatchey AI, McCormick F, North K, Pehrsson M, Plotkin SR, Ramesh V, Ratner N, Schirmer S, Sherman L, Schorry E, Stevenson D, Stewart DR, Ullrich N, Bakker AC, Morrison H.CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies.Am J Med Genet A. 2014 Mar;164A(3):563-78.
    24443315
  • McLaughlin SK, Olsen SN, Dake B, De Raedt T, Lim E, Bronson RT, Beroukhim R, Polyak K, Brown M, Kuperwasser C, Cichowski K.The RasGAP gene, RASAL2, is a tumor and metastasis suppressor.Cancer Cell. 2013 Sep 9;24(3):365-78.
    24029233
  • Hollstein PE, Cichowski K.Identifying the ubiquitin ligase complex that regulates the NF1 tumor suppressor and Ras.Cancer Discovery. 2013 May 9.
    23661552
  • Maertens O, Johnson B, Hollstein P, Frederick DT, Cooper ZA, Messaien L, Bronson RT, McMahon M, Granter S, Flaherty KT, Wargo JA, Marais R, Cichowski K.Elucidating distinct roles for NF1 in melanomagenesis.Cancer Discovery. 2012 Nov 21.
    23171796
  • McClatchey AI, Cichowski K.SPRED proteins provide a NF-ty link to Ras suppression.Genes Dev. 2012 Jul 15;26(14):1515-9.
    22802525
  • Beert E, Brems H, Daniëls B, De Wever I, Van Calenbergh F, Schoenaers J, Debiec-Rychter M, Gevaert O, De Raedt T, Van Den Bruel A, de Ravel T, Cichowski K, Kluwe L, Mautner V, Sciot R, Legius E.Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors.Genes Chromosomes Cancer. 2011 Dec;50(12):1021-32.
    21987445
  • De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Maertens O, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, Macleod KF, Cichowski K.Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.Cancer Cell. 2011 Sep 13;20(3):400-13.
    21907929
  • Huson SM, Acosta MT, Belzberg AJ, Bernards A, Chernoff J, Cichowski K, Gareth Evans D, Ferner RE, Giovannini M, Korf BR, Listernick R, North KN, Packer RJ, Parada LF, Peltonen J, Ramesh V, Reilly KM, Risner JW, Schorry EK, Upadhyaya M, Viskochil DH, Zhu Y, Hunter-Schaedle K, Giancotti FG.Back to the future: proceedings from the 2010 NF Conference.Am J Med Genet A. 2011 Feb;155(2):307-21.
    21271647
  • Cichowski K, Jänne PA.Drug discovery: inhibitors that activate.Nature. 2010 Mar 18;464(7287):358-9.
    20237552
  • Min J, Zaslavsky A, Fedele G, McLaughlin SK, Reczek EE, De Raedt T, Guney I, Strochlic DE, Macconaill LE, Beroukhim R, Bronson RT, Ryeom S, Hahn WC, Loda M, Cichowski K.An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.Nat Med. 2010 Mar;16(3):286-94.
    20154697
  • McGillicuddy LT, Fromm JA, Hollstein PE, Kubek S, Beroukhim R, De Raedt T, Johnson BW, Williams SM, Nghiemphu P, Liau LM, Cloughesy TF, Mischel PS, Parret A, Seiler J, Moldenhauer G, Scheffzek K, Stemmer-Rachamimov AO, Sawyers CL, Brennan C, Messiaen L, Mellinghoff IK, Cichowski K.Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis.Cancer Cell. 2009 Jul 7;16(1):44-54.
    19573811
  • Cichowski K,Hahn WC.Unexpected pieces to the senescence puzzle.Cell. 2008 Jun 13;133(6):958-61. Review.
    18555773
  • Courtois-Cox S, Jones SL, Cichowski K.Many roads lead to oncogene-induced senescence.Oncogene. 2008 May 1;27(20):2801-9. Review.
    18193093
  • Johannessen CM, Johnson BW, Williams SM, Chan AW, Reczek EE, Lynch RC, Rioth MJ, McClatchey A, Ryeom S, Cichowski K.TORC1 is essential for NF1-associated malignancies.Curr Biol. 2008 Jan 8;18(1):56-62.
    18164202
  • Courtois-Cox S, Genther Williams SM, Reczek EE, Johnson BW, McGillicuddy LT, Johannessen CM, Hollstein PE, MacCollin M, Cichowski K.A negative feedback signaling network underlies oncogene-induced senescence.Cancer Cell. 2006 Dec;10(6):459-72.
    17157787
  • Johannessen CM, Reczek EE, James MF, Brems H, Legius E, Cichowski K.The NF1 tumor suppressor critically regulates TSC2 and mTOR.Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8573-8.
    15937108
  • Engelman JA, Jnne PA, Mermel C, Pearlberg J, Mukohara T, Fleet C, Cichowski K, Johnson BE, Cantley LC.ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines.Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3788-93.
    15731348
  • Cichowski K, Santiago S, Jardim M, Johnson BW, Jacks T.Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor.Genes Dev. 2003 Feb 15;17(4):449-54.
    12600938
  • Cichowski K, Jacks T.NF1 tumor suppressor gene function: narrowing the GAP.Cell. 2001 Feb 23;104(4):593-604.
    11239415
  • Cichowski K, Shih TS, Schmitt E, Santiago S, Reilly K, McLaughlin ME, Bronson RT, Jacks T.Mouse models of tumor development in neurofibromatosis type 1.Science. 1999 Dec 10;286(5447):2172-6.
    10591652