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Jon C. Aster, MD, PhD


  • South AP, Purdie KJ, Watt SA, Haldenby S, den Breems NY, Dimon M, Arron ST, Kluk MJ, Aster JC, McHugh A, Xue DJ, Dayal JH, Robinson KS, Rizvi SM, Proby CM, Harwood CA, Leigh IM.NOTCH1 Mutations Occur Early during Cutaneous Squamous Cell Carcinogenesis.J Invest Dermatol. 2014 Mar 24.
  • Knoechel B, Roderick JE, Williamson KE, Zhu J, Lohr JG, Cotton MJ, Gillespie SM, Fernandez D, Ku M, Wang H, Piccioni F, Silver SJ, Jain M, Pearson D, Kluk MJ, Ott CJ, Shultz LD, Brehm MA, Greiner DL, Gutierrez A, Stegmaier K, Kung AL, Root DE, Bradner JE, Aster JC, Kelliher MA, Bernstein BE.An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.Nat Genet. 2014 Apr;46(4):364-70.
  • Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, Gimotty PA, Epstein JA, Speck N, Bigas A, Pear WS.The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.Genes Dev. 2014 Mar 15;28(6):576-93.
  • Puissant A, Fenouille N, Alexe G, Pikman Y, Bassil CF, Mehta S, Du J, Kazi JU, Luciano F, Rönnstrand L, Kung AL, Aster JC, Galinsky I, Stone RM, DeAngelo DJ, Hemann MT, Stegmaier K.SYK is a critical regulator of FLT3 in acute myeloid leukemia.Cancer Cell. 2014 Feb 10;25(2):226-42.
  • O'Neill AF, Dearling JL, Wang Y, Tupper T, Sun Y, Aster JC, Calicchio ML, Perez-Atayde AR, Packard AB, Kung AL.Targeted imaging of Ewing sarcoma in preclinical models using a 64Cu-labeled anti-CD99 antibody.Clin Cancer Res. 2014 Feb 1;20(3):678-87.
  • Gutierrez A, Pan L, Groen RW, Baleydier F, Kentsis A, Marineau J, Grebliunaite R, Kozakewich E, Reed C, Pflumio F, Poglio S, Uzan B, Clemons P, VerPlank L, An F, Burbank J, Norton S, Tolliday N, Steen H, Weng AP, Yuan H, Bradner JE, Mitsiades C, Look AT, Aster JC.Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.J Clin Invest. 2014 Feb 3;124(2):644-55.
  • Wang H, Zang C, Taing L, Arnett KL, Wong YJ, Pear WS, Blacklow SC, Liu XS, Aster JC.NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):705-10.
  • Andrawes MB, Xu X, Liu H, Ficarro SB, Marto JA, Aster JC, Blacklow SC.Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.J Biol Chem. 2013 Aug 30;288(35):25477-89.
  • Kluk MJ, Ashworth T, Wang H, Knoechel B, Mason EF, Morgan EA, Dorfman D, Pinkus G, Weigert O, Hornick JL, Chirieac LR, Hirsch M, Oh DJ, South AP, Leigh IM, Pourreyron C, Cassidy AJ, Deangelo DJ, Weinstock DM, Krop IE, Dillon D, Brock JE, Lazar AJ, Peto M, Cho RJ, Stoeck A, Haines BB, Sathayanrayanan S, Rodig S, Aster JC.Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry.PLoS ONE. 2013;8(6):e67306.
  • Ngondo-Mbongo RP, Myslinski E, Aster JC, Carbon P.Modulation of gene expression via overlapping binding sites exerted by ZNF143, Notch1 and THAP11.Nucleic Acids Res. 2013 Apr 1;41(7):4000-14.
  • Roti G, Carlton A, Ross KN, Markstein M, Pajcini K, Su AH, Perrimon N, Pear WS, Kung AL, Blacklow SC, Aster JC, Stegmaier K.Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer.Cancer Cell. 2013 Mar 18;23(3):390-405.
  • Aster JC, DeAngelo DJ.Resistance revealed in acute lymphoblastic leukemia.Nat Med. 2013 Mar;19(3):264-5.
  • Giambra V, Jenkins CR, Wang H, Lam SH, Shevchuk OO, Nemirovsky O, Wai C, Gusscott S, Chiang MY, Aster JC, Humphries RK, Eaves C, Weng AP.NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.Nat Med. 2012 Nov;18(11):1693-8.
  • Chiang MY, Shestova O, Xu L, Aster JC, Pear WS.Divergent effects of supraphysiological Notch signals on leukemia stem cells and hematopoietic stem cells.Blood. 2012 Oct 31.
  • McAuliffe SM, Morgan SL, Wyant GA, Tran LT, Muto KW, Chen YS, Chin KT, Partridge JC, Poole BB, Cheng KH, Daggett J, Cullen K, Kantoff E, Hasselbatt K, Berkowitz J, Muto MG, Berkowitz RS, Aster JC, Matulonis UA, Dinulescu DM.Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy.Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):E2939-48.
  • Tan MJ, White EA, Sowa ME, Harper JW, Aster JC, Howley PM.Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling.Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):E1473-80.
  • Schwartz BE, Hofer MD, Lemieux ME, Bauer DE, Cameron MJ, West NH, Agoston ES, Reynoird N, Khochbin S, Ince TA, Christie A, Janeway KA, Vargas SO, Perez-Atayde AR, Aster JC, Sallan SE, Kung AL, Bradner JE, French CA.Differentiation of NUT Midline Carcinoma by Epigenomic Reprogramming.Cancer Res. 2011 Apr 1;71(7):2686-96.
  • Van de Walle I, De Smet G, Gärtner M, De Smedt M, Waegemans E, Vandekerckhove B, Leclercq G, Plum J, Aster JC, Bernstein ID, Guidos CJ, Kyewski B, Taghon T.Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.Blood. 2011 Mar 3.
  • Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W.SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.Nature. 2011 Mar 3;471(7336):104-9.
  • Jeannet R, Mastio J, Macias-Garcia A, Oravecz A, Ashworth T, Geimer Le Lay AS, Jost B, Le Gras S, Ghysdael J, Gridley T, Honjo T, Radtke F, Aster JC, Chan S, Kastner P.Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.Blood. 2010 Dec 16;116(25):5443-54.
  • Ashworth TD, Pear WS, Chiang MY, Blacklow SC, Mastio J, Xu L, Kelliher M, Kastner P, Chan S, Aster JC.Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.Blood. 2010 Dec 16;116(25):5455-64.
  • Aster JC, Blacklow SC, Pear WS.Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.J Pathol. 2011 Jan;223(2):262-73.
  • Roper N, Deangelo DJ, Kuo F, Cin PD, Ghobrial I, Aster JC.An asymptomatic 61-year-old man with BCR-ABL-positive bone marrow following autologous transplantation for multiple myeloma.Am J Hematol. 2010 Dec;85(12):944-6.
  • Arnett KL, Hass M, McArthur DG, Ilagan MX, Aster JC, Kopan R, Blacklow SC.Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.Nat Struct Mol Biol. 2010 Nov;17(11):1312-7.
  • Bertrand KA, Birmann BM, Chang ET, Spiegelman D, Aster JC, Zhang SM, Laden F.A prospective study of Epstein-Barr virus antibodies and risk of non-Hodgkin lymphoma.Blood. 2010 Nov 4;116(18):3547-53.
  • Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS.Notch dimerization is required for leukemogenesis and T-cell development.Genes Dev. 2010 Nov 1;24(21):2395-407.
  • Laden F, Bertrand KA, Altshul L, Aster JC, Korrick SA, Sagiv SK.Plasma organochlorine levels and risk of non-Hodgkin lymphoma in the Nurses' Health Study.Cancer Epidemiol Biomarkers Prev. 2010 May;19(5):1381-4.
  • Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, Pandya D, Lu Y, Mills GB, Aster JC, Artavanis-Tsakonas S, Brugge JS.Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5012-7.
  • Bertrand KA, Spiegelman D, Aster JC, Altshul LM, Korrick SA, Rodig SJ, Zhang SM, Kurth T, Laden F.Plasma organochlorine levels and risk of non-Hodgkin lymphoma in a cohort of men.Epidemiology. 2010 Mar;21(2):172-80.
  • Aste-Amézaga M, Zhang N, Lineberger JE, Arnold BA, Toner TJ, Gu M, Huang L, Vitelli S, Vo KT, Haytko P, Zhao JZ, Baleydier F, L'Heureux S, Wang H, Gordon WR, Thoryk E, Andrawes MB, Tiyanont K, Stegmaier K, Roti G, Ross KN, Franlin LL, Wang H, Wang F, Chastain M, Bett AJ, Audoly LP, Aster JC, Blacklow SC, Huber HE.Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.PLoS ONE. 2010;5(2):e9094.
  • Dal Cin P, Aster JC, DeAngelo DJ.When to go FISHing.Am J Clin Pathol. 2010 Mar;133(3):351-3.
  • Lin YW, Beharry ZM, Hill EG, Song JH, Wang W, Xia Z, Zhang Z, Aplan PD, Aster JC, Smith CD, Kraft AS.A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.Blood. 2010 Jan 28;115(4):824-33.
  • Yoda A, Yoda Y, Chiaretti S, Bar-Natan M, Mani K, Rodig SJ, West N, Xiao Y, Brown JR, Mitsiades C, Sattler M, Kutok JL, DeAngelo DJ, Wadleigh M, Piciocchi A, Dal Cin P, Bradner JE, Griffin JD, Anderson KC, Stone RM, Ritz J, Foà R, Aster JC, Frank DA, Weinstock DM.Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):252-7.
  • Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, Bradner JE.Direct inhibition of the NOTCH transcription factor complex.Nature. 2009 Nov 12;462(7270):182-8.
  • Haack H,Johnson LA,Fry CJ,Crosby K,Polakiewicz RD,Stelow EB,Hong SM,Schwartz BE,Cameron MJ,Rubin MA,Chang MC,Aster JC,French CA.Diagnosis of NUT Midline Carcinoma Using a NUT-specific Monoclonal Antibody.Am J Surg Pathol. 2009 Jul;33(7):984-91.
  • Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, Bradner J.Direct inhibition of the Notch transcription factor complex.Nature..
  • Gordon WR, Vardar-Ulu D, L'Heureux S, Ashworth T, Malecki MJ, Sanchez-Irizarry C, McArthur DG, Histen G, Mitchell JL, Aster JC, Blacklow SC.Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.PLoS ONE. 2009;4(8):e6613.
  • Aster JC.Notch targeting 2.0.Blood. 2009 Jun 11;113(24):6044-5.
  • Cornejo MG,Kharas MG,Werneck MB,Le Bras S,Moore SA,Ball B,Beylot-Barry M,Rodig SJ,Aster JC,Lee BH,Cantor H,Merlio JP,Gilliland DG,Mercher T.Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models.Blood. 2009 Mar 19;113(12):2746-54.
  • Gordon WR,Roy M,Vardar-Ulu D,Garfinkel M,Mansour MR,Aster JC,Blacklow SC.Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.Blood. 2009 Apr 30;113(18):4381-90.
  • Joshi I,Minter LM,Telfer J,Demarest RM,Capobianco AJ,Aster JC,Sicinski P,Fauq A,Golde TE,Osborne BA.Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases.Blood. 2009 Feb 19;113(8):1689-98.
  • Mercher T,Cornejo MG,Sears C,Kindler T,Moore SA,Maillard I,Pear WS,Aster JC,Gilliland DG.Notch signaling specifies megakaryocyte development from hematopoietic stem cells.Cell Stem Cell. 2008 Sep 11;3(3):314-26.
  • Chiang MY,Xu L,Shestova O,Histen G,L'heureux S,Romany C,Childs ME,Gimotty PA,Aster JC,Pear WS.Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.J Clin Invest. 2008 Sep;118(9):3181-94.
  • Poitras JL,Dal Cin P,Aster JC,Deangelo DJ,Morton CC.Novel SSBP2-JAK2 fusion gene resulting from a t(5;9)(q14.1;p24.1) in pre-B acute lymphocytic leukemia.Genes Chromosomes Cancer. 2008 Oct;47(10):884-9.
  • Stelow EB, Bellizzi AM, Taneja K, Mills SE, Legallo RD, Kutok JL, Aster JC, French CA.NUT Rearrangement in Undifferentiated Carcinomas of the Upper Aerodigestive Tract.Am J Surg Pathol. 2008 Jun;32(6):828-34.
  • Maillard I, Koch U, Dumortier A, Shestova O, Xu L, Sai H, Pross SE, Aster JC, Bhandoola A, Radtke F, Pear WS.Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells.Cell Stem Cell. 2008 Apr 10;2(4):356-66.
  • French CA, Ramirez CL, Kolmakova J, Hickman TT, Cameron MJ, Thyne ME, Kutok JL, Toretsky JA, Tadavarthy AK, Kees UR, Fletcher JA, Aster JC.BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.Oncogene. 2008 Apr 3;27(15):2237-42.
  • Li K, Li Y, Wu W, Gordon WR, Chang DW, Lu M, Scoggin S, Fu T, Vien L, Histen G, Zheng J, Martin-Hollister R, Duensing T, Singh S, Blacklow SC, Yao Z, Aster JC, Zhou BB.Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3.J Biol Chem. 2008 Mar 21;283(12):8046-54.
  • Takeyama K, Monti S, Manis JP, Cin PD, Getz G, Beroukhim R, Dutt S, Aster JC, Alt FW, Golub TR, Shipp MA.Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas.Oncogene. 2008 Jan 10;27(3):318-22.
  • Del Bianco C, Aster JC, Blacklow SC.Mutational and energetic studies of Notch 1 transcription complexes.J Mol Biol. 2008 Feb 8;376(1):131-40.
  • Aster JC, Pear WS, Blacklow SC.Notch signaling in leukemia.Annu Rev Pathol. 2008;3:587-613. Review.
  • Rodig SJ, Payne EG, Degar BA, Rollins B, Feldman AL, Jaffe ES, Androkites A, Silverman LB, Longtine JA, Kutok JL, Fleming MD, Aster JC.Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1.Am J Hematol. 2008 Feb;83(2):116-21.
  • Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, Edkins S, Stevens C, Brennan C, Martin ES, Wiedemeyer R, Kabbarah O, Nogueira C, Histen G, Aster J, Mansour M, Duke V, Foroni L, Fielding AK, Goldstone AH, Rowe JM, Wang YA, Look AT, Stratton MR, Chin L, Futreal PA, DePinho RA.Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.Nature. 2007 Jun 21;447(7147):966-71.
  • Chan SM, Weng AP, Tibshirani R, Aster JC, Utz PJ.Notch signals positively regulate activity of the mTOR pathway in T cell acute lymphoblastic leukemia.Blood. 2007 Jul 1;110(1):278-86.
  • Fung E, Tang SM, Canner JP, Morishige K, Arboleda-Velasquez JF, Cardoso AA, Carlesso N, Aster JC, Aikawa M.Delta-Like 4 Induces Notch Signaling in Macrophages. Implications for Inflammation.Circulation. 2007 Jun 12;115(23):2948-56.
  • Gordon WR, Vardar-Ulu D, Histen G, Sanchez-Irizarry C, Aster JC, Blacklow SC.Structural basis for autoinhibition of Notch.Nat Struct Mol Biol. 2007 Apr;14(4):295-300.
  • Robertson MJ, Kahl BS, Vose JM, de Vos S, Laughlin M, Flynn PJ, Rowland K, Cruz JC, Goldberg SL, Musib L, Darstein C, Enas N, Kutok JL, Aster JC, Neuberg D, Savage KJ, LaCasce A, Thornton D, Slapak CA, Shipp MA.Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma.J Clin Oncol. 2007 May 1;25(13):1741-6.
  • Nam Y, Sliz P, Pear WS, Aster JC, Blacklow SC.Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription.Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2103-8.
  • Chen J, Jette C, Kanki JP, Aster JC, Look AT, Griffin JD.NOTCH1-induced T-cell leukemia in transgenic zebrafish.Leukemia. 2007 Mar;21(3):462-71.
  • Shepard JL, Amatruda JF, Finkelstein D, Ziai J, Finley KR, Stern HM, Chiang K, Hersey C, Barut B, Freeman JL, Lee C, Glickman JN, Kutok JL, Aster JC, Zon LI.A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.Genes Dev. 2007 Jan 1;21(1):55-9.
  • Roy M, Pear WS, Aster JC.The multifaceted role of Notch in cancer.Curr Opin Genet Dev. 2007 Feb;17(1):52-9. Review.
  • Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O'Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, Califano A, Ferrando AA.NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18261-6.
  • Keeshan K, He Y, Wouters BJ, Shestova O, Xu L, Sai H, Rodriguez CG, Maillard I, Tobias JW, Valk P, Carroll M, Aster JC, Delwel R, Pear WS.Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.Cancer Cell. 2006 Nov;10(5):401-11.
  • Palomero T, McKenna K, O-Neil J, Galinsky I, Stone R, Suzukawa K, Stiakaki E, Kalmanti M, Fox EA, Caligiuri MA, Aster JC, Look AT, Ferrando AA.Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias.Leukemia. 2006 Nov;20(11):1963-6.
  • Chen A, Zhao B, Kieff E, Aster JC, Wang F.EBNA-3B- and EBNA-3C-regulated cellular genes in Epstein-Barr virus-immortalized lymphoblastoid cell lines.J Virol. 2006 Oct;80(20):10139-50.
  • Chiang MY, Xu ML, Histen G, Shestova O, Roy M, Nam Y, Blacklow SC, Sacks DB, Pear WS, Aster JC.Identification of a Conserved Negative Regulatory Sequence That Influences the Leukemogenic Activity of NOTCH1.Mol Cell Biol. 2006 Aug;26(16):6261-71.
  • Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, Del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, Pear WS, Aster.c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.Genes Dev. 2006 Aug 1;20(15):2096-109.
  • Takahashi H, Feuerhake F, Kutok JL, Monti S, Dal Cin P, Neuberg D, Aster JC, Shipp MA.FAS death domain deletions and cellular FADD-like interleukin 1beta converting enzyme inhibitory protein (long) overexpression: alternative mechanisms for deregulating the extrinsic apoptotic pathway in diffuse large B-cell lymphoma subtypes.Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3265-71.
  • Malecki MJ, Sanchez-Irizarry C, Mitchell JL, Histen G, Xu ML, Aster JC, Blacklow SC.Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes.Mol Cell Biol. 2006 Jun;26(12):4642-51.
  • van Vlierberghe P, Meijerink JP, Lee C, Ferrando AA, Look AT, van Wering ER, Beverloo HB, Aster JC, Pieters R.A new recurrent 9q34 duplication in pediatric T-cell acute lymphoblastic leukemia.Leukemia. 2006 Jul;20(7):1245-53.
  • Bilello JP, Lang SM, Wang F, Aster JC, Desrosiers RC.Infection and persistence of rhesus monkey rhadinovirus in immortalized B-cell lines.J Virol. 2006 Apr;80(7):3644-9.
  • Nam Y, Sliz P, Song L, Aster JC, Blacklow SC.Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.Cell. 2006 Mar 10;124(5):973-83.
  • Bismar TA, Demichelis F, Riva A, Kim R, Varambally S, He L, Kutok J, Aster JC, Tang J, Kuefer R, Hofer MD, Febbo PG, Chinnaiyan AM, Rubin MA.Defining aggressive prostate cancer using a 12-gene model.Neoplasia. 2006 Jan;8(1):59-68.
  • Pasqualucci L, Compagno M, Houldsworth J, Monti S, Grunn A, Nandula SV, Aster JC, Murty VV, Shipp MA, Dalla-Favera R.Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma.J Exp Med. 2006 Feb 20;203(2):311-7.
  • Takahashi H, Feuerhake F, Monti S, Kutok JL, Aster JC, Shipp MA.Lack of IKBA coding region mutations in primary mediastinal large B-cell lymphoma and the host response subtype of diffuse large B-cell lymphoma.Blood. 2006 Jan 15;107(2):844-5.
  • O'neil J, Calvo J, McKenna K, Krishnamoorthy V, Aster JC, Bassing CH, Alt FW, Kelliher M, Look AT.Activating Notch1 mutations in mouse models of T-ALL.Blood. 2006 Jan 15;107(2):781-5.
  • Aster JC.Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities.Int J Hematol. 2005 Nov;82(4):295-301.
  • Shepard JL, Amatruda JF, Stern HM, Subramanian A, Finkelstein D, Ziai J, Finley KR, Pfaff KL, Hersey C, Zhou Y, Barut B, Freedman M, Lee C, Spitsbergen J, Neuberg D, Weber G, Golub TR, Glickman JN, Kutok JL, Aster JC, Zon LI.A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13194-9.
  • Feuerhake F, Kutok JL, Monti S, Chen W, Lacasce AS, Cattoretti G, Kurtin P, Pinkus GS, de Leval L, Harris NL, Savage KJ, Neuberg D, Habermann TM, Dalla-Favera R, Golub TR, Aster JC, Shipp MA.NF{kappa}B activity, function and target gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes.Blood. 2005 Aug 15;106(4):1392-9.
  • Sambandam A, Maillard I, Zediak VP, Xu L, Gerstein RM, Aster JC, Pear WS, Bhandoola A.Notch signaling controls the generation and differentiation of early T lineage progenitors.Nat Immunol. 2005 Jul;6(7):663-70.
  • Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF, Murphey RD, Berghmans S, Mayhall EA, Traver D, Fletcher CD, Aster JC, Granter SR, Look AT, Lee C, Fisher DE, Zon LI.BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.Curr Biol. 2005 Feb 8;15(3):249-54.
  • Rodig SJ, Savage KJ, Nguyen V, Pinkus GS, Shipp MA, Aster JC, Kutok JL.TRAF1 expression and c-Rel activation are useful adjuncts in distinguishing classical Hodgkin lymphoma from a subset of morphologically or immunophenotypically similar lymphomas.Am J Surg Pathol. 2005 Feb;29(2):196-203.
  • Monti S, Savage KJ, Kutok JL, Feuerhake F, Kurtin P, Mihm M, Wu B, Pasqualucci L, Neuberg D, Aguiar RC, Dal Cin P, Ladd C, Pinkus GS, Salles G, Harris NL, Dalla-Favera R, Habermann TM, Aster JC, Golub TR, Shipp MA.Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response.Blood. 2005 Mar 1;105(5):1851-61.
  • Pear WS, Aster JC.T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling.Curr Opin Hematol. 2004 Nov;11(6):426-33.
  • Sanchez-Irizarry C, Carpenter AC, Weng AP, Pear WS, Aster JC, Blacklow SC.Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats.Mol Cell Biol. 2004 Nov;24(21):9265-73.
  • Weng AP, Ferrando AA, Lee W, Morris JP, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC.Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.Science. 2004 Oct 8;306(5694):269-71.
  • Maillard I, Weng AP, Carpenter AC, Rodriguez CG, Sai H, Xu L, Allman D, Aster JC, Pear WS.Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.Blood. 2004 Sep 15;104(6):1696-702.
  • Rivailler P, Carville A, Kaur A, Rao P, Quink C, Kutok JL, Westmoreland S, Klumpp S, Simon M, Aster JC, Wang F.Experimental Rhesus Lymphocryptovirus Infection in Immunosuppressed Macaques: An Animal Model for Epstein-Barr Virus Pathogenesis in the Immunosuppressed Host.Blood. 2004 Sep 1;104(5):1482-9.
  • Das I, Craig C, Funahashi Y, Jung KM, Kim TW, Byers R, Weng AP, Kutok JL, Aster JC, Kitajewski J.Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.J Biol Chem. 2004 Jul 16;279(29):30771-80.
  • Weng AP, Aster JC.Multiple niches for Notch in cancer: context is everything.Curr Opin Genet Dev. 2004 Feb;14(1):48-54.
  • Kutok JL, Klumpp S, Simon M, MacKey JJ, Nguyen V, Middeldorp JM, Aster JC, Wang F.Molecular evidence for rhesus lymphocryptovirus infection of epithelial cells in immunosuppressed rhesus macaques.J Virol. 2004 Apr;78(7):3455-61.
  • Weng AP, Aster JC.No T without D3: a critical role for cyclin D3 in normal and malignant precursor T cells.Cancer Cell. 2003 Dec;4(6):417-8.
  • Hu QD, Ang BT, Karsak M, Hu WP, Cui XY, Duka T, Takeda Y, Chia W, Sankar N, Ng YK, Ling EA, Maciag T, Small D, Trifonova R, Kopan R, Okano H, Nakafuku M, Chiba S, Hirai H, Aster JC, Schachner M, Pallen CJ, Watanabe K, Xiao ZC.F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation.Cell. 2003 Oct 17;115(2):163-75.
  • Savage KJ, Monti S, Kutok JL, Cattoretti G, Neuberg D, De Leval L, Kurtin P, Dal Cin P, Ladd C, Feuerhake F, Aguiar RC, Li S, Salles G, Berger F, Jing W, Pinkus GS, Habermann T, Dalla-Favera R, Harris NL, Aster JC, Golub TR, Shipp MA.The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.Blood. 2003 Dec 1;102(12):3871-9.
  • Wilkinson K, Velloso ER, Lopes LF, Lee C, Aster JC, Shipp MA, Aguiar RC.Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib.Blood. 2003 Dec 1;102(12):4187-90.
  • Vardar D, North CL, Sanchez-Irizarry C, Aster JC, Blacklow SC.Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1.Biochemistry. 2003 Jun 17;42(23):7061-7.
  • Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA.The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.J Biol Chem. 2003 Jun 13;278(24):21930-7.
  • Nam Y, Weng AP, Aster JC, Blacklow SC.Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex.J Biol Chem. 2003 Jun 6;278(23):21232-9.
  • Langenau DM, Traver D, Ferrando AA, Kutok JL, Aster JC, Kanki JP, Lin S, Prochownik E, Trede NS, Zon LI, Look AT.Myc-induced T cell leukemia in transgenic zebrafish.Science. 2003 Feb 7;299(5608):887-90.
  • Weng AP, Nam Y, Wolfe MS, Pear WS, Griffin JD, Blacklow SC, Aster JC.Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.Mol Cell Biol. 2003 Jan;23(2):655-64.
  • Kutok JL, Aster JC.Molecular biology of anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma.J Clin Oncol. 2002 Sep 1;20(17):3691-702.
  • Weijzen S, Rizzo P, Braid M, Vaishnav R, Jonkheer SM, Zlobin A, Osborne BA, Gottipati S, Aster JC, Hahn WC, Rudolf M, Siziopikou K, Kast WM, Miele L.Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells.Nat Med. 2002 Sep;8(9):979-86.
  • Nam Y, Aster JC, Blacklow SC.Notch signaling as a therapeutic target.Curr Opin Chem Biol. 2002 Aug;6(4):501-9.
  • Million RP, Aster J, Gilliland DG, Van Etten RA.The Tel-Abl (ETV6-Abl) tyrosine kinase, product of complex (9;12) translocations in human leukemia, induces distinct myeloproliferative disease in mice.Blood. 2002 Jun 15;99(12):4568-77.
  • Izon DJ, Aster JC, He Y, Weng A, Karnell FG, Patriub V, Xu L, Bakkour S, Rodriguez C, Allman D, Pear WS.Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.Immunity. 2002 Feb;16(2):231-43.
  • Shipp MA, Ross KN, Tamayo P, Weng AP, Kutok JL, Aguiar RC, Gaasenbeek M, Angelo M, Reich M, Pinkus GS, Ray TS, Koval MA, Last KW, Norton A, Lister TA, Mesirov J, Neuberg DS, Lander ES, Aster JC, Golub TR.Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning.Nat Med. 2002 Jan;8(1):68-74.
  • Andreasson P, Schwaller J, Anastasiadou E, Aster J, Gilliland DG.The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo.Cancer Genet Cytogenet. 2001 Oct 15;130(2):93-104.
  • Allman D, Karnell FG, Punt JA, Bakkour S, Xu L, Myung P, Koretzky GA, Pui JC, Aster JC, Pear WS.Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells.J Exp Med. 2001 Jul 2;194(1):99-106.
  • Rangarajan A, Talora C, Okuyama R, Nicolas M, Mammucari C, Oh H, Aster JC, Krishna S, Metzger D, Chambon P, Miele L, Aguet M, Radtke F, Dotto GP.Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation.EMBO J. 2001 Jul 2;20(13):3427-36.
  • Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD.MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.Nat Genet. 2000 Dec;26(4):484-9.
  • Schwaller J, Parganas E, Wang D, Cain D, Aster JC, Williams IR, Lee CK, Gerthner R, Kitamura T, Frantsve J, Anastasiadou E, Loh ML, Levy DE, Ihle JN, Gilliland DG.Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.Mol Cell. 2000 Sep;6(3):693-704.
  • Aster JC, Xu L, Karnell FG, Patriub V, Pui JC, Pear WS.Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1.Mol Cell Biol. 2000 Oct;20(20):7505-15.
  • Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT.Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.J Neurochem. 2000 Aug;75(2):583-93.
  • Xiao S, McCarthy JG, Aster JC, Fletcher JA.ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain.Blood. 2000 Jul 15;96(2):699-704.
  • Liu Q, Schwaller J, Kutok J, Cain D, Aster JC, Williams IR, Gilliland DG.Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia.EMBO J. 2000 Apr 17;19(8):1827-38.
  • Tomasson MH, Sternberg DW, Williams IR, Carroll M, Cain D, Aster JC, Ilaria RL, Van Etten RA, Gilliland DG.Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581.J Clin Invest. 2000 Feb;105(4):423-32.
  • Rand MD, Grimm LM, Artavanis-Tsakonas S, Patriub V, Blacklow SC, Sklar J, Aster JC.Calcium depletion dissociates and activates heterodimeric notch receptors.Mol Cell Biol. 2000 Mar;20(5):1825-35.
  • Aster JC, Simms WB, Zavala-Ruiz Z, Patriub V, North CL, Blacklow SC.The folding and structural integrity of the first LIN-12 module of human Notch1 are calcium-dependent.Biochemistry. 1999 Apr 13;38(15):4736-42.