James W. Mier, MD

Publications

• Pandya SS, Mier JW, McDermott DF, Cho DC.Addition of gemcitabine at the time of sunitinib resistance in metastatic renal cell cancer.BJU Int. 2011 Feb 14.
  21320274
• Bhatt RS, Wang X, Zhang L, Collins MP, Signoretti S, Alsop DC, Goldberg SN, Atkins MB, Mier JW.Renal cancer resistance to antiangiogenic therapy is delayed by restoration of angiostatic signaling.Mol Cancer Ther. 2010 Oct;9(10):2793-802.
  20699227
• Panka DJ, Sullivan RJ, Mier JW.An inexpensive, specific and highly sensitive protocol to detect the BrafV600E mutation in melanoma tumor biopsies and blood.Melanoma Res. 2010 Oct;20(5):401-7.
  20679909
• Cho DC, Cohen MB, Panka DJ, Collins M, Ghebremichael M, Atkins MB, Signoretti S, Mier JW.The Efficacy of the Novel Dual PI3-Kinase/mTOR Inhibitor NVP-BEZ235 Compared with Rapamycin in Renal Cell Carcinoma.Clin Cancer Res. 2010 Jul 15;16(14):3628-38.
  20606035
• Bhatt RS, Zhang L, Bullock A, Moreno K, Signoretti S, Atkins M, Sabbadini R, Mier J.Sphingosine-1-phosphate (S1P) as a novel target in renal cancer (RCC).AACR Proceedings 2010..
• Bullock AJ, Zhang L, AM O’Neill, Percy A, Sukhatme V, Mier JW, Atkins MB, Bhatt RS.Plasma angiopoietin-2 (ANG2) as an angiogenic biomarker in renal cell carcinoma (RCC).J Clin Oncology AACR Proceedings 2010.;28(15s).
• Panka DJ, Collins M, Atkins MB, Signoretti S, Mier JW.Enhancement of efficacy of sorafenib and sunitinib with the HDM2 antagonist MI-319 in RCC tumor xenografts.AACR Proceedings..
• Bhatt R, Wang X, Zhang L, Bhasin M, Libermann T, O’Neil A, Signoretti S, Atkins M, Mier J, Goldberg SN.Cox-2 inhibition delays resistance to sunitinib in RCC xenograft models.AACR Proceedings 2009..
• Atkins MB, Bukowski RM, Escudier BJ, Figlin RA, Hudes GH, Kaelin WG, Linehan WM, McDermott DF, Mier JW, Pedrosa I, Rini BI, Signoretti S, Sosman JA, Teh BT, Wood CG, Zurita AJ, King L.Innovations and challenges in renal cancer: summary statement from the
  19402064
• Cho DC,Puzanov I,Regan MM,Schwarzberg T,Seery V,Lee MY,Liu V,Bhatt R,Koon H,Mier JW,Sosman JA,Atkins MB,McDermott DF.Retrospective analysis of the safety and efficacy of interleukin-2 after prior VEGF-targeted therapy in patients with advanced renal cell
  19238017
• Sosman JA, Carrillo C, Urba WJ, Flaherty L, Atkins MB, Clark JI, Dutcher J, Margolin KA, Mier J, Gollob J, Kirkwood JM, Panka DJ, Crosby NA, O'Boyle K, LaFleur B, Ernstoff MS.Three phase II cytokine working group trials of gp100 (210M) peptide plus h
  18467720
• Negin B, Panka D, Wang W, Siddiqui M, Tawa N, Mullen J, Tahan S, Mandato L, Polivy A, Mier J, Atkins M.Effect of melanoma on immune function in the regional lymph node basin.Clin Cancer Res. 2008 Feb 1;14(3):654-9.
  18245524
• Panka DJ, Cho DC, Atkins MB, Mier JW.GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines.J Biol Chem. 2008 Jan 11;283(2):726-32.
  17991738
• Cho D, Signoretti S, Regan M, Mier JW, Atkins MB.The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer.Clin Cancer Res. 2007 Jan 15;13(2 Pt 2):758s-763s. Review.
  17255306
• Cho D, Panka P, Panka D, Atkins MB, Mier JW.Sensitivity of renal cell carcinoma (RCC) cell lines to Sorafenib in vitro is dependent upon Akt and GSK3ß activity.J Am Diet Assoc. 2006 SEP 01;2006:4515.
• Robertson MJ, Mier JW, Logan T, Atkins M, Koon H, Koch KM, Kathman S, Pandite LN, Oei C, Kirby LC, Jewell RC, Bell WN, Thurmond LM, Weisenbach J, Roberts S, Dar MM.Clinical and biological effects of recombinant human interleukin-18 administered by intrave
  16857801
• Panka DJ, Atkins MB, Mier JW.Targeting the mitogen-activated protein kinase pathway in the treatment of malignant melanoma.Clin Cancer Res. 2006 Apr 1;12(7 Pt 2):2371s-2375s. Review.
  16609061
• Atkins MB, Elder DE, Essner R, Flaherty KT, Gajewski TF, Haluska FG, Hwu P, Keilholz U, Kirkwood JM, Mier JW, Ross MI, Slingluff CL, Sondak VK, Sosman JA, Weinstock MA, King L.Innovations and challenges in melanoma: summary statement from the first Cambri
  16609047
• Panka DJ, Wang W, Atkins MB, Mier JW.The Raf inhibitor BAY 43-9006 (Sorafenib) induces caspase-independent apoptosis in melanoma cells.Cancer Res. 2006 Feb 1;66(3):1611-9.
  16452220
• Cho D, Atkins MB, Mier JW.Inhibition of glycogen synthase 3b (GSK3b) enhances the in vitro activity of the Akt inhibitor perifosine in renal cell carcinoma (RCC) cell lines.J Am Diet Assoc. 2007:1823.
• Atkins M, Regan M, McDermott D, Mier J, Stanbridge E, Youmans A, Febbo P, Upton M, Lechpammer M, Signoretti S.Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer.Clin Cancer Res. 2005 May 15;11(10):3714-21.
  15897568
• Zea AH, Rodriguez PC, Atkins MB, Hernandez C, Signoretti S, Zabaleta J, McDermott D, Quiceno D, Youmans A, O'Neill A, Mier J, Ochoa AC.Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion.Cancer R
  15833831
• McDermott DF, Regan MM, Clark JI, Flaherty LE, Weiss GR, Logan TF, Kirkwood JM, Gordon MS, Sosman JA, Ernstoff MS, Tretter CP, Urba WJ, Smith JW, Margolin KA, Mier JW, Gollob JA, Dutcher JP, Atkins MB.Randomized phase III trial of high-dose interleukin-2
  15625368
• Avigan D, Vasir B, Gong J, Borges V, Wu Z, Uhl L, Atkins M, Mier J, McDermott D, Smith T, Giallambardo N, Stone C, Schadt K, Dolgoff J, Tetreault JC, Villarroel M, Kufe D.Fusion cell vaccination of patients with metastatic breast and renal cancer induces
  15269142
• Panka DJ, Mier JW.Canstatin inhibits Akt activation and induces Fas-dependent apoptosis in endothelial cells.J Biol Chem. 2003 Sep 26;278(39):37632-6.
  12876280
• Gollob JA, Veenstra KG, Parker RA, Mier JW, McDermott DF, Clancy D, Tutin L, Koon H, Atkins MB.Phase I trial of concurrent twice-weekly recombinant human interleukin-12 plus low-dose IL-2 in patients with melanoma or renal cell carcinoma.J Clin Oncol. 200
  12829677
• Mier JW.Immunotherapy With Low-Dose IL-2 in Combination With GM-CSF.J Immunother. 2003 Mar-Apr;26(2):95-6.
  12616100
• Janssen RA, Kim PN, Mier JW, Morrison DK.Overexpression of kinase suppressor of Ras upregulates the high-molecular-weight tropomyosin isoforms in ras-transformed NIH 3T3 fibroblasts.Mol Cell Biol. 2003 Mar;23(5):1786-97.
  12588996
• Atkins MB, Gollob JA, Sosman JA, McDermott DF, Tutin L, Sorokin P, Parker RA, Mier JW.A phase II pilot trial of concurrent biochemotherapy with cisplatin, vinblastine, temozolomide, interleukin 2, and IFN-alpha 2B in patients with metastatic melanoma.Clin
  12374674
• Dutcher J, Atkins MB, Margolin K, Weiss G, Clark J, Sosman J, Logan T, Aronson F, Mier J,.Kidney cancer: the Cytokine Working Group experience (1986-2001): part II. Management of IL-2 toxicity and studies with other cytokines.Med Oncol. 2001;18(3):209-19.
  11917945
• Atkins MB, Dutcher J, Weiss G, Margolin K, Clark J, Sosman J, Logan T, Aronson F, Mier J,.Kidney cancer: the Cytokine Working Group experience (1986-2001): part I. IL-2-based clinical trials.Med Oncol. 2001;18(3):197-207.
  11917944
• Gollob JA, Mier JW, Atkins MB.Clinical use of systemic IL-12 therapy.Cancer Chemother Biol Response Modif. 2001;19:353-69.
  11686023
• Flaherty LE, Atkins M, Sosman J, Weiss G, Clark JI, Margolin K, Dutcher J, Gordon MS, Lotze M, Mier J, Sorokin P, Fisher RI, Appel C, Du W.Outpatient biochemotherapy with interleukin-2 and interferon alfa-2b in patients with metastatic malignant melanoma:
  11432886
• Atkins MB, Redman B, Mier J, Gollob J, Weber J, Sosman J, MacPherson BL, Plasse T.A phase I study of CNI-1493, an inhibitor of cytokine release, in combination with high-dose interleukin-2 in patients with renal cancer and melanoma.Clin Cancer Res. 2001 M
  11297238
• Gollob JA, Veenstra KG, Mier JW, Atkins MB.Agranulocytosis and hemolytic anemia in patients with renal cell cancer treated with interleukin-12.J Immunother. 2001 Jan-Feb;24(1):91-8.
  11211153
• Panka DJ, Mano T, Suhara T, Walsh K, Mier JW.Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells.J Biol Chem. 2001 Mar 9;276(10):6893-6.
  11145953
• Gollob JA, Veenstra KG, Jyonouchi H, Kelly AM, Ferrieri P, Panka DJ, Altare F, Fieschi C, Casanova JL, Frank DA, Mier JW.Impairment of STAT activation by IL-12 in a patient with atypical mycobacterial and staphylococcal infections.J Immunol. 2000 Oct 1;16
  11034424
• Dutcher JP, Logan T, Gordon M, Sosman J, Weiss G, Margolin K, Plasse T, Mier J, Lotze M, Clark J, Atkins M.Phase II trial of interleukin 2, interferon alpha, and 5-fluorouracil in metastatic renal cell cancer: a cytokine working group study.Clin Cancer Re
  10999727
• McDermott DF, Mier JW, Lawrence DP, van den Brink MR, Clancy MA, Rubin KM, Atkins MB.A phase II pilot trial of concurrent biochemotherapy with cisplatin, vinblastine, dacarbazine, interleukin 2, and interferon alpha-2B in patients with metastatic melanoma
  10873069
• Gollob JA, Mier JW, Veenstra K, McDermott DF, Clancy D, Clancy M, Atkins MB.Phase I trial of twice-weekly intravenous interleukin 12 in patients with metastatic renal cell cancer or malignant melanoma: ability to maintain IFN-gamma induction is associated
  10815886
• Kamphaus GD, Colorado PC, Panka DJ, Hopfer H, Ramchandran R, Torre A, Maeshima Y, Mier JW, Sukhatme VP, Kalluri R.Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth.J Biol Chem. 2000 Jan 14;275(2):1209-15.
  10625665
• Vannier E, Kaser A, Atkins MB, Fantuzzi G, Dinarello CA, Mier JW, Tilg H.Elevated circulating levels of soluble interleukin-1 receptor type II during interleukin-2 immunotherapy.Eur Cytokine Netw. 1999 Mar;10(1):37-42.
  10210771
• Janssen RA, Veenstra KG, Jonasch P, Jonasch E, Mier JW.Ras- and Raf-induced down-modulation of non-muscle tropomyosin are MEK-independent.J Biol Chem. 1998 Nov 27;273(48):32182-6.
  9822696
• Sosman JA, Aronson FR, Sznol M, Atkins MB, Dutcher JP, Weiss GR, Isaacs RE, Margolin KA, Fisher RI, Ernest ML, Mier J, Oleksowicz L, Eckhardt JR, Levitt D, Doroshow JH.Concurrent phase I trials of intravenous interleukin 6 in solid tumor patients: reversi
  9815535
• Atkins MB, Robertson MJ, Gordon M, Lotze MT, DeCoste M, DuBois JS, Ritz J, Sandler AB, Edington HD, Garzone PD, Mier JW, Canning CM, Battiato L, Tahara H, Sherman ML.Phase I evaluation of intravenous recombinant human interleukin 12 in patients with advan
  9815699
• Trehu EG, Mier JW, Dubois JS, Sorce D, Klempner MS, Epstein M, Dinarello CA, Shapiro L, Kappler K, Ronayne L, Atkins MB.Phase I trial of interleukin 2 in combination with the soluble tumor necrosis factor receptor p75 IgG chimera.Clin Cancer Res. 1996 Aug
  9816306
• Potter DA, Tirnauer JS, Janssen R, Croall DE, Hughes CN, Fiacco KA, Mier JW, Maki M, Herman IM.Calpain regulates actin remodeling during cell spreading.J Cell Biol. 1998 May 4;141(3):647-62.
  9566966
• McDermott DF, Trehu EG, Mier JW, Sorce D, Rand W, Ronayne L, Kappler K, Clancy M, Klempner M, Atkins MB.A two-part phase I trial of high-dose interleukin 2 in combination with soluble (Chinese hamster ovary) interleukin 1 receptor.Clin Cancer Res. 1998 Ma
  9607578
• Tilg H, Dinarello CA, Mier JW.IL-6 and APPs: anti-inflammatory and immunosuppressive mediators.Immunol Today. 1997 Sep;18(9):428-32.
  9293158
• Janssen RA, Mier JW.Tropomyosin-2 cDNA lacking the 3' untranslated region riboregulator induces growth inhibition of v-Ki-ras-transformed fibroblasts.Mol Biol Cell. 1997 May;8(5):897-908.
  9168473
• Du Bois JS, Trehu EG, Mier JW, Shapiro L, Epstein M, Klempner M, Dinarello C, Kappler K, Ronayne L, Rand W, Atkins MB.Randomized placebo-controlled clinical trial of high-dose interleukin-2 in combination with a soluble p75 tumor necrosis factor receptor
  9060545
• Stoddart JH, Jasuja RR, Sikorski MA, von Andrian UH, Mier JW.Protease-resistant L-selectin mutants. Down-modulation by cross-linking but not cellular activation.J Immunol. 1996 Dec 15;157(12):5653-9.
  8955218
• Sikorski MA, Staunton DE, Mier JW.L-selectin crosslinking induces integrin-dependent adhesion: evidence for a signaling pathway involving PTK but not PKC.Cell Adhes Commun. 1996 Nov;4(4-5):355-67.
  9117353
• Ryan CM, Atkins MB, Mier JW, Gelfand JA, Tompkins RG.Effects of malignancy and interleukin-2 infusion on gut macromolecular permeability.Crit Care Med. 1995 Nov;23(11):1801-6.
  7587254
• Tilg H, Atkins MB, Dinarello CA, Mier JW.Induction of circulating interleukin 10 by interleukin 1 and interleukin 2, but not interleukin 6 immunotherapy.Cytokine. 1995 Oct;7(7):734-9.
  8580384
• Atkins MB, Kappler K, Mier JW, Isaacs RE, Berkman EM.Interleukin-6-associated anemia: determination of the underlying mechanism.Blood. 1995 Aug 15;86(4):1288-91.
  7632934
• Tilg H, Shapiro L, Vannier E, Poutsiaka DD, Trehu E, Atkins MB, Dinarello CA, Mier JW.Induction of circulating antagonists to IL-1 and TNF by IL-2 administration and their effects on IL-2 induced cytokine production in vitro.J Immunol. 1994 Mar 15;152(6):
  8144913
• Tilg H, Trehu E, Atkins MB, Dinarello CA, Mier JW.Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55.Blood. 1994 Jan 1;83(1):113-8.
  8274730
• Tilg H, Vannier E, Vachino G, Dinarello CA, Mier JW.Antiinflammatory properties of hepatic acute phase proteins: preferential induction of interleukin 1 (IL-1) receptor antagonist over IL-1 beta synthesis by human peripheral blood mononuclear cells.J Exp
  7693853
• Tilg H, Shapiro L, Atkins MB, Dinarello CA, Mier JW.Induction of circulating and erythrocyte-bound IL-8 by IL-2 immunotherapy and suppression of its in vitro production by IL-1 receptor antagonist and soluble tumor necrosis factor receptor (p75) chimera.J
  8397255
• Tilg H, Mier JW, Vogel W, Aulitzky WE, Wiedermann CJ, Vannier E, Huber C, Dinarello CA.Induction of circulating IL-1 receptor antagonist by IFN treatment.J Immunol. 1993 May 15;150(10):4687-92.
  8482853
• Numerof RP, Sipe JD, Trehu EG, Dinarello CA, Mier JW.Suppression of IL-2-induced SAA gene expression in mice by the administration of an IL-1 receptor antagonist.Cytokine. 1992 Nov;4(6):555-60.
  1292638
• Vachino G, Gelfand JA, Atkins MB, Tamerius JD, Demchak P, Mier JW.Complement activation in cancer patients undergoing immunotherapy with interleukin-2 (IL-2): binding of complement and C-reactive protein by IL-2-activated lymphocytes.Blood. 1991 Nov 15;78
  1824247
• Mier JW, Vachino G, Klempner MS, Aronson FR, Noring R, Smith S, Brandon EP, Laird W, Atkins MB.Inhibition of interleukin-2-induced tumor necrosis factor release by dexamethasone: prevention of an acquired neutrophil chemotaxis defect and differential supp
  2242421
• Klempner MS, Noring R, Mier JW, Atkins MB.An acquired chemotactic defect in neutrophils from patients receiving interleukin-2 immunotherapy.N Engl J Med. 1990 Apr 5;322(14):959-65.
  2156163
• Mier JW, Brandon EP, Libby P, Janicka MW, Aronson FR.Activated endothelial cells resist lymphokine-activated killer cell-mediated injury. Possible role of induced cytokines in limiting capillary leak during IL-2 therapy.J Immunol. 1989 Oct 1;143(7):2407-1
  2528594
• Numerof RP, Aronson FR, Mier JW.IL-2 stimulates the production of IL-1 alpha and IL-1 beta by human peripheral blood mononuclear cells.J Immunol. 1988 Dec 15;141(12):4250-7.
  3143761
• Aronson FR, Libby P, Brandon EP, Janicka MW, Mier JW.IL-2 rapidly induces natural killer cell adhesion to human endothelial cells. A potential mechanism for endothelial injury.J Immunol. 1988 Jul 1;141(1):158-63.
  3259966
• Mier JW, Dinarello CA, Atkins MB, Punsal PI, Perlmutter DH.Regulation of hepatic acute phase protein synthesis by products of interleukin 2 (IL 2)-stimulated human peripheral blood mononuclear cells.J Immunol. 1987 Aug 15;139(4):1268-72.
  2440951
• Dempsey RA, Dinarello CA, Mier JW, Rosenwasser LJ, Allegretta M, Brown TE, Parkinson DR.The differential effects of human leukocyte pyrogen/lymphocyte-activating factor, T cell growth factor, and interferon on human natural killer activity.J Immunol. 1982
  6982930
• Krensky AM, Reiss CS, Mier JW, Strominger JL, Burakoff SJ.Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+.Proc Natl Acad Sci U S A. 1982 Apr;79(7):2365-9.
  6980419
• Mier JW, Gallo RC.The purification and properties of human T cell growth factor.J Immunol. 1982 Mar;128(3):1122-7.
  6976987
• Gootenberg JE, Ruscetti FW, Mier JW, Gazdar A, Gallo RC.Human cutaneous T cell lymphoma and leukemia cell lines produce and respond to T cell growth factor.J Exp Med. 1981 Nov 1;154(5):1403-18.
  6975346
• Poiesz BJ, Ruscetti FW, Mier JW, Woods AM, Gallo RC.T-cell lines established from human T-lymphocytic neoplasias by direct response to T-cell growth factor.Proc Natl Acad Sci U S A. 1980 Nov;77(11):6815-9.
  6256763
• Mier JW, Gallo RC.Purification and some characteristics of human T-cell growth factor from phytohemagglutinin-stimulated lymphocyte-conditioned media.Proc Natl Acad Sci U S A. 1980 Oct;77(10):6134-8.
  6969402
• Reiss CS, Hemler ME, Englehard VH, Mier JW, Strominger JL, Burakoff SJ.Development and characterization of allospecific long-term human cytolytic T-cell lines.Proc Natl Acad Sci U S A. 1980 Sep;77(9):5432-6.
  6968913
• Ruscetti FW, Mier JW, Gallo RC.Human T-cell growth factor: parameters for production.J Supramol Struct. 1980;13(2):229-41.
  6972470