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Donald M. Coen, PhD


  • Pan D, Flores O, Umbach JL, Pesola JM, Bentley P, Rosato PC, Leib DA, Cullen BR, Coen DM.A Neuron-Specific Host MicroRNA Targets Herpes Simplex Virus-1 ICP0 Expression and Promotes Latency.Cell Host Microbe. 2014 Apr 9;15(4):446-56.
  • Terrell SL, Pesola JM, Coen DM.Roles of conserved residues within the pre-NH2-terminal domain of herpes simplex virus 1 DNA polymerase in replication and latency in mice.J Gen Virol. 2014 Apr;95(Pt 4):940-7.
  • Jurak I, Hackenberg M, Kim JY, Pesola JM, Everett RD, Preston CM, Wilson AC, Coen DM.Expression of herpes simplex virus 1 microRNAs in cell culture models of quiescent and latent infection.J Virol. 2014 Feb;88(4):2337-9.
  • Pan D, Kaye SB, Hopkins M, Kirwan R, Hart IJ, Coen DM.Common and new acyclovir resistant herpes simplex virus-1 mutants causing bilateral recurrent herpetic keratitis in an immunocompetent patient.J Infect Dis. 2014 Feb 1;209(3):345-9.
  • Sharma M, Kamil JP, Coughlin M, Reim NI, Coen DM.Human cytomegalovirus UL50 and UL53 recruit viral protein kinase UL97, not protein kinase C, for disruption of nuclear lamina and nuclear egress in infected cells.J Virol. 2014 Jan;88(1):249-62.
  • Reim NI, Kamil JP, Wang D, Lin A, Sharma M, Ericsson M, Pesola JM, Golan DE, Coen DM.Inactivation of Retinoblastoma Protein Does Not Overcome the Requirement for Human Cytomegalovirus UL97 in Lamina Disruption and Nuclear Egress.J Virol. 2013 May;87(9):5019-27.
  • Cliffe AR, Coen DM, Knipe DM.Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection.MBio. 2013;4(1).
  • Terrell SL, Coen DM.The pre-NH(2)-terminal domain of the herpes simplex virus 1 DNA polymerase catalytic subunit is required for efficient viral replication.J Virol. 2012 Oct;86(20):11057-65.
  • Strang BL, Bender BJ, Sharma M, Pesola JM, Sanders RL, Spector DH, Coen DM.A mutation deleting sequences encoding the amino terminus of human cytomegalovirus UL84 impairs interaction with UL44 and capsid localization.J Virol. 2012 Oct;86(20):11066-77.
  • Pan D, Coen DM.Net -1 frameshifting on a noncanonical sequence in a herpes simplex virus drug-resistant mutant is stimulated by nonstop mRNA.Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14852-7.
  • Weller SK, Coen DM.Herpes simplex viruses: mechanisms of DNA replication.Cold Spring Harb Perspect Biol. 2012 Sep;4(9):a013011.
  • Jurak I, Silverstein LB, Sharma M, Coen DM.Herpes simplex virus is equipped with RNA- and protein-based mechanisms to repress expression of ATRX, an effector of intrinsic immunity.J Virol. 2012 Sep;86(18):10093-102.
  • Silva LA, Loregian A, Pari GS, Strang BL, Coen DM.The carboxy-terminal segment of the human cytomegalovirus DNA polymerase accessory subunit UL44 is crucial for viral replication.J Virol. 2010 Nov;84(21):11563-8.
  • Tran K, Kamil JP, Coen DM, Spector DH.Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.J Virol. 2010 Oct;84(20):10832-43.
  • Strang BL, Geballe AP, Coen DM.Association Of Human Cytomegalovirus Proteins IRS1 And TRS1 With The Viral DNA Polymerase Accessory Subunit UL44.J Gen Virol. 2010 Sep;91(Pt 9):2167-75.
  • Gentry BG, Kamil JP, Coen DM, Zemlicka J, Drach JC.Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir.Antimicrob Agents Chemother. 2010 Aug;54(8):3093-8.
  • Strang BL, Coen DM.Interaction of the Human Cytomegalovirus Uracil DNA Glycosylase UL114 with the Viral DNA Polymerase Catalytic Subunit UL54.J Gen Virol. 2010 Aug;91(Pt 8):2029-33.
  • Jurak I, Kramer MF, Mellor JC, van Lint AL, Roth FP, Knipe DM, Coen DM.Numerous Conserved and Divergent MicroRNAs Expressed by Herpes Simplex Viruses 1 and 2.J Virol. 2010 May;84(9):4659-72.
  • Strang BL, Boulant S, Coen DM.Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication.J Virol. 2010 Feb;84(4):1771-84.
  • Baltz JL, Filman DJ, Ciustea M, Silverman JE, Lautenschlager CL, Coen DM, Ricciardi RP, Hogle JM.The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus.J Virol. 2009 Dec;83(23):12215-28.
  • Kamil JP, Hume AJ, Jurak I, M√ľnger K, Kalejta RF, Coen DM.Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase.Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16823-8.
  • Jiang C,Komazin-Meredith G,Tian W,Coen DM,Hwang CB.Mutations that Increase DNA binding by the Processivity Factor of Herpes Simplex Virus Affect Virus Production and DNA Replication Fidelity.J Virol. 2009 Aug;83(15):7573-80.
  • Strang BL,Sinigalia E,Silva LA,Coen DM,Loregian A.Analysis of the Association of the Human Cytomegalovirus DNA Polymerase Subunit UL44 with the Viral DNA Replication Factor UL84.J Virol. 2009 Aug;83(15):7581-9.
  • Hamirally S,Kamil JP,Ndassa-Colday YM,Lin AJ,Jahng WJ,Baek MC,Noton S,Silva LA,Simpson-Holley M,Knipe DM,Golan DE,Marto JA,Coen DM.Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress.PLoS Pathog. 2009 Jan;5(1):e1000275.
  • Sam MD,Evans BT,Coen DM,Hogle JM.Biochemical, biophysical, and mutational analyses of subunit interactions of the human cytomegalovirus nuclear egress complex.J Virol. 2009 Apr;83(7):2996-3006.
  • Sinigalia E,Alvisi G,Mercorelli B,Coen DM,Pari GS,Jans DA,Ripalti A,Palu G,Loregian A.Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells.J Virol. 2008 Dec;82(24):12574-9.
  • Bryant KF,Macari ER,Malik N,Boyce M,Yuan J,Coen DM.ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells.Virology. 2008 Sep 30;379(2):197-204.
  • Komazin-Meredith G,Petrella RJ,Santos WL,Filman DJ,Hogle JM,Verdine GL,Karplus M,Coen DM.The human cytomegalovirus UL44 C clamp wraps around DNA.Structure. 2008 Aug 6;16(8):1214-25.
  • Umbach JL,Kramer MF,Jurak I,Karnowski HW,Coen DM,Cullen BR.MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs.Nature. 2008 Aug 7;454(7205):780-3.
  • Hume AJ, Finkel JS, Kamil JP, Coen DM, Culbertson MR, Kalejta RF.Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function.Science. 2008 May 9;320(5877):797-9.
  • Komazin-Meredith G, Santos WL, Filman DJ, Hogle JM, Verdine GL, Coen DM.The positively charged surface of herpes simplex virus UL42 mediates DNA binding.J Biol Chem. 2008 Mar 7;283(10):6154-61.
  • Bryant KF, Coen DM.Inhibition of translation by a short element in the 5' leader of the herpes simplex virus 1 DNA polymerase transcript.J Virol. 2008 Jan;82(1):77-85.
  • Jiang C, Hwang YT, Wang G, Randell JC, Coen DM, Hwang CB.Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis.J Virol. 2007 Nov;81(21):12077-9.
  • Kamil JP, Coen DM.Human cytomegalovirus protein kinase UL97 forms a complex with the tegument phosphoprotein pp65.J Virol. 2007 Oct;81(19):10659-68.
  • Loregian A, Sinigalia E, Mercorelli B, Palu G, Coen DM.Binding parameters and thermodynamics of the interaction of the human cytomegalovirus DNA polymerase accessory protein, UL44, with DNA: implications for the processivity mechanism.Nucleic Acids Res. 2007;35(14):4779-91.
  • Dodson AW, Taylor TJ, Knipe DM, Coen DM.Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach.Virology. 2007 Sep 30;366(2):340-8.
  • Besecker MI, Furness CL, Coen DM, Griffiths A.Expression of extremely low levels of thymidine kinase from an acyclovir-resistant herpes simplex virus mutant supports reactivation from latently infected mouse trigeminal ganglia.J Virol. 2007 Aug;81(15):8356-60.
  • Pesola JM, Coen DM.In vivo fitness and virulence of a drug-resistant herpes simplex virus 1 mutant.J Gen Virol. 2007 May;88(Pt 5):1410-4.
  • Jiang C, Hwang YT, Randell JC, Coen DM, Hwang CB.Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication.J Virol. 2007 Apr;81(7):3495-502.
  • Griffiths A, Link MA, Furness CL, Coen DM.Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase.J Virol. 2006 Jul;80(13):6568-74.
  • Cui C, Griffiths A, Li G, Silva LM, Kramer MF, Gaasterland T, Wang XJ, Coen DM.Prediction and identification of herpes simplex virus 1-encoded microRNAs.J Virol. 2006 Jun;80(11):5499-508.
  • Prichard MN, Gao N, Jairath S, Mulamba G, Krosky P, Coen DM, Parker BO, Pari GS.A recombinant human cytomegalovirus with a large deletion in UL97 has a severe replication deficiency.J Virol. 1999 Jul;73(7):5663-70.
  • Huang L, Ishii KK, Zuccola H, Gehring AM, Hwang CB, Hogle J, Coen DM.The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases.Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):447-52.
  • Weisshart K, Chow CS, Coen DM.Herpes simplex virus processivity factor UL42 imparts increased DNA-binding specificity to the viral DNA polymerase and decreased dissociation from primer-template without reducing the elongation rate.J Virol. 1999 Jan;73(1):55-66.
  • Burkham J, Coen DM, Weller SK.ND10 protein PML is recruited to herpes simplex virus type 1 prereplicative sites and replication compartments in the presence of viral DNA polymerase.J Virol. 1998 Dec;72(12):10100-7.
  • Chen SH, Cook WJ, Grove KL, Coen DM.Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant.J Virol. 1998 Aug;72(8):6710-5.
  • Mulamba GB, Hu A, Azad RF, Anderson KP, Coen DM.Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922).Antimicrob Agents Chemother. 1998 Apr;42(4):971-3.
  • Jacobson JG, Chen SH, Cook WJ, Kramer MF, Coen DM.Importance of the herpes simplex virus UL24 gene for productive ganglionic infection in mice.Virology. 1998 Mar 1;242(1):161-9.
  • Pelosi E, Mulamba GB, Coen DM.Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants.Antiviral Res. 1998 Jan;37(1):17-28.
  • Kramer MF, Chen SH, Knipe DM, Coen DM.Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus.J Virol. 1998 Feb;72(2):1177-85.
  • Chen SH, Kramer MF, Schaffer PA, Coen DM.A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus.J Virol. 1997 Aug;71(8):5878-84.
  • Weisshart K, Kuo AA, Hwang CB, Kumura K, Coen DM.Structural and functional organization of herpes simplex virus DNA polymerase investigated by limited proteolysis.J Biol Chem. 1994 Sep 9;269(36):22788-96.
  • Hwang CB, Horsburgh B, Pelosi E, Roberts S, Digard P, Coen DM.A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant.Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5461-5.
  • Davar G, Kramer MF, Garber D, Roca AL, Andersen JK, Bebrin W, Coen DM, Kosz-Vnenchak M, Knipe DM, Breakefield XO.Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors.J Comp Neurol. 1994 Jan 1;339(1):3-11.
  • Digard P, Chow CS, Pirrit L, Coen DM.Functional analysis of the herpes simplex virus UL42 protein.J Virol. 1993 Mar;67(3):1159-68.
  • Weisshart K, Kuo AA, Painter GR, Wright LL, Furman PA, Coen DM.Conformational changes induced in herpes simplex virus DNA polymerase upon DNA binding.Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):1028-32.