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Kwok Kin Wong, MD, PhD

Publications

  • Chen Z, Sasaki T, Tan X, Carretero J, Shimamura T, Li D, Xu C, Wang Y, Aldelmant GO, Capelletti M, Lee HJ, Rodig SJ, Borgman CL, Park SI, Kim HR, Padera RF, Marto J, Gray N, Kung AL, Shapiro GI, Janne PA, Wong KK.Inhibition of ALK, PI3K/MEK and HSP90 in M
    20952506
  • Gao Y, Xiao Q, Ma H, Li L, Liu J, Feng Y, Fang Z, Wu J, Han X, Zhang J, Sun Y, Wu G, Padera R, Chen H, Wong KK, Ge G, Ji H.LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling.Proc Natl Acad Sci U S A. 2010 Nov 2
    20956321
  • Marcinkowska M, Wong KK, Kwiatkowski DJ, Kozlowski P.Design and generation of MLPA probe sets for combined copy number and small-mutation analysis of human genes: EGFR as an example.ScientificWorldJournal. 2010;10:2003-18.
    20953551
  • Curtis SJ, Sinkevicius KW, Li D, Lau AN, Roach RR, Zamponi R, Woolfenden AE, Kirsch DG, Wong KK, Kim CF.Primary tumor genotype is an important determinant in identification of lung cancer propagating cells.Cell Stem Cell. 2010 Jul 2;7(1):127-33.
    20621056
  • Johnson SM, Torrice CD, Bell JF, Monahan KB, Jiang Q, Wang Y, Ramsey MR, Jin J, Wong KK, Su L, Zhou D, Sharpless NE.Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.J Clin Invest. 2010 Ju
    20577054
  • Sequist LV, Besse B, Lynch TJ, Miller VA, Wong KK, Gitlitz B, Eaton K, Zacharchuk C, Freyman A, Powell C, Ananthakrishnan R, Quinn S, Soria JC.Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients
    20479403
  • Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, Buttarazzi MS, Sanofsky BA, McNamara KL, Brandstetter KA, Walton ZE, Gu TL, Silva JC, Crosby K, Shapiro GI, Maira SM, Ji H, Castrillon DH, Kim CF, García-Echeverría C, Bardeesy N,
    20541700
  • Yang JY, Chang CJ, Xia W, Wang Y, Wong KK, Engelman JA, Du Y, Andreeff M, Hortobagyi GN, Hung MC.Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer
    20484037
  • Faber AC, Wong KK, Engelman JA.Differences underlying EGFR and HER2 oncogene addiction.Cell Cycle. 2010 Mar 1;9(5):851-2.
    20160489
  • Sharma SV, Lee DY, Li B, Quinlan MP, Takahashi F, Maheswaran S, McDermott U, Azizian N, Zou L, Fischbach MA, Wong KK, Brandstetter K, Wittner B, Ramaswamy S, Classon M, Settleman J.A chromatin-mediated reversible drug-tolerant state in cancer cell subpopu
    20371346
  • Wong KK, Jacks T, Dranoff G.NF-kappaB fans the flames of lung carcinogenesis.Cancer Prev Res (Phila Pa). 2010 Apr;3(4):403-5. Review.
    20354166
  • Schoeberl B, Faber AC, Li D, Liang MC, Crosby K, Onsum M, Burenkova O, Pace E, Walton Z, Nie L, Fulgham A, Song Y, Nielsen UB, Engelman JA, Wong KK.An ErbB3 Antibody, MM-121, Is Active in Cancers with Ligand-Dependent Activation.Cancer Res. 2010 Mar 15;70
    20215504
  • Contreras CM, Akbay EA, Gallardo TD, Haynie JM, Sharma S, Tagao O, Bardeesy N, Takahashi M, Settleman J, Wong KK, Castrillon DH.Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monoth
    20142330
  • Wong KK, Engelman JA, Cantley LC.Targeting the PI3K signaling pathway in cancer.Curr Opin Genet Dev. 2010 Feb;20(1):87-90. Review.
    20006486
  • Roccaro AM, Sacco A, Husu EN, Pitsillides C, Vesole S, Azab AK, Azab F, Melhem M, Ngo HT, Quang P, Maiso P, Runnels J, Liang MC, Wong KK, Lin C, Ghobrial IM.Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobuline
    19965685
  • Zhou W, Ercan D, Chen L, Yun CH, Li D, Capelletti M, Cortot AB, Chirieac L, Iacob RE, Padera R, Engen JR, Wong KK, Eck MJ, Gray NS, Jänne PA.Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.Nature. 2009 Dec 24;462(7276):1070-4.
    20033049
  • Faber AC, Li D, Song Y, Liang MC, Yeap BY, Bronson RT, Lifshits E, Chen Z, Maira SM, García-Echeverría C, Wong KK, Engelman JA.Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.Proc Natl Acad Sci U S A. 2009
    19850869
  • Sos ML, Fischer S, Ullrich R, Peifer M, Heuckmann JM, Koker M, Heynck S, Stückrath I, Weiss J, Fischer F, Michel K, Goel A, Regales L, Politi KA, Perera S, Getlik M, Heukamp LC, Ansén S, Zander T, Beroukhim R, Kashkar H, Shokat KM, Sellers WR, Rauh D, O
    19805051
  • Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O'Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V,
    19801978
  • Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O'Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V,
  • Kim WY, Perera S, Zhou B, Carretero J, Yeh JJ, Heathcote SA, Jackson AL, Nikolinakos P, Ospina B, Naumov G, Brandstetter KA, Weigman VJ, Zaghlul S, Hayes DN, Padera RF, Heymach JV, Kung AL, Sharpless NE, Kaelin WG, Wong KK.HIF2alpha cooperates with RAS to
    19662677
  • Scott KL, Kabbarah O, Liang MC, Ivanova E, Anagnostou V, Wu J, Dhakal S, Wu M, Chen S, Feinberg T, Huang J, Saci A, Widlund HR, Fisher DE, Xiao Y, Rimm DL, Protopopov A, Wong KK, Chin L.GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer.
    19553991
  • Sos ML,Michel K,Zander T,Weiss J,Frommolt P,Peifer M,Li D,Ullrich R,Koker M,Fischer F,Shimamura T,Rauh D,Mermel C,Fischer S,Stuckrath I,Heynck S,Beroukhim R,Lin W,Winckler W,Shah K,LaFramboise T,Moriarty WF,Hanna M,Tolosi L,Rahnenfuhrer J,Verhaak R,Chiang
    19451690
  • Wingo SN,Gallardo TD,Akbay EA,Liang MC,Contreras CM,Boren T,Shimamura T,Miller DS,Sharpless NE,Bardeesy N,Kwiatkowski DJ,Schorge JO,Wong KK,Castrillon DH.Somatic LKB1 mutations promote cervical cancer progression.PLoS ONE. 2009;4(4):e5137.
    19340305
  • Gandhi L,McNamara KL,Li D,Borgman CL,McDermott U,Brandstetter KA,Padera RF,Chirieac LR,Settleman JE,Wong KK.Sunitinib prolongs survival in genetically engineered mouse models of multistep lung carcinogenesis.Cancer Prev Res (Phila Pa). 2009 Apr;2(4):330-7
    19336729
  • Wong KK,Fracasso PM,Bukowski RM,Lynch TJ,Munster PN,Shapiro GI,Janne PA,Eder JP,Naughton MJ,Ellis MJ,Jones SF,Mekhail T,Zacharchuk C,Vermette J,Abbas R,Quinn S,Powell C,Burris HA.A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor
    19318484
  • Schittenhelm MM,Kollmannsberger C,Oechsle K,Harlow A,Morich J,Honecker F,Kurek R,Storkel S,Kanz L,Corless CL,Wong KK,Bokemeyer C,Heinrich MC.Molecular determinants of response to matuzumab in combination with paclitaxel for patients with advanced non-smal
    19276157
  • Perera SA,Li D,Shimamura T,Raso MG,Ji H,Chen L,Borgman CL,Zaghlul S,Brandstetter KA,Kubo S,Takahashi M,Chirieac LR,Padera RF,Bronson RT,Shapiro GI,Greulich H,Meyerson M,Guertler U,Chesa PG,Solca F,Wistuba II,Wong KK.HER2YVMA drives rapid development of ad
    19122144
  • Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, Padera RF, García-Echeverría C, Weissleder R, Mahmood U, Cantley LC, Wong KK.Effective use of PI
    19029981
  • Girnun GD,Chen L,Silvaggi J,Drapkin R,Chirieac LR,Padera RF,Upadhyay R,Vafai SB,Weissleder R,Mahmood U,Naseri E,Buckley S,Li D,Force J,McNamara K,Demetri G,Spiegelman BM,Wong KK.Regression of drug-resistant lung cancer by the combination of rosiglitazone
    18927287
  • Li D, Ambrogio L, Shimamura T, Kubo S, Takahashi M, Chirieac LR, Padera RF, Shapiro GI, Baum A, Himmelsbach F, Rettig WJ, Meyerson M, Solca F, Greulich H, Wong KK.BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer mo
    18408761
  • Shimamura T,Li D,Ji H,Haringsma HJ,Liniker E,Borgman CL,Lowell AM,Minami Y,McNamara K,Perera SA,Zaghlul S,Thomas RK,Greulich H,Kobayashi S,Chirieac LR,Padera RF,Kubo S,Takahashi M,Tenen DG,Meyerson M,Wong KK,Shapiro GI.Hsp90 inhibition suppresses mutant E
    18632637
  • Koivunen JP, Kim J, Lee J, Rogers AM, Park JO, Zhao X, Naoki K, Okamoto I, Nakagawa K, Yeap BY, Meyerson M, Wong KK, Richards WG, Sugarbaker DJ, Johnson BE, Jänne PA.Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasia
    18594528
  • Akbay EA,Contreras CM,Perera SA,Sullivan JP,Broaddus RR,Schorge JO,Ashfaq R,Saboorian H,Wong KK,Castrillon DH.Differential roles of telomere attrition in type I and II endometrial carcinogenesis.Am J Pathol. 2008 Aug;173(2):536-44.
    18599611
  • Zhou X,Bao H,Al-Hashem R,Ji H,Albert M,Wong KK,Sun Y.Magnetic resonance imaging of the response of a mouse model of non-small cell lung cancer to tyrosine kinase inhibitor treatment.Comp Med. 2008 Jun;58(3):276-81.
    18589870
  • Dutt A,Salvesen HB,Chen TH,Ramos AH,Onofrio RC,Hatton C,Nicoletti R,Winckler W,Grewal R,Hanna M,Wyhs N,Ziaugra L,Richter DJ,Trovik J,Engelsen IB,Stefansson IM,Fennell T,Cibulskis K,Zody MC,Akslen LA,Gabriel S,Wong KK,Sellers WR,Meyerson M,Greulich H.Drug-
    18552176
  • Wong KK.Searching for a magic bullet in NSCLC: the role of epidermal growth factor receptor mutations and tyrosine kinase inhibitors.Lung Cancer. 2008 Jun;60 Suppl 2:S10-8. Review.
    18513579
  • Perera SA, Maser RS, Xia H, McNamara K, Protopopov A, Chen L, Hezel AF, Kim CF, Bronson RT, Castrillon DH, Chin L, Bardeesy N, Depinho RA, Wong KK.Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung
    18283039
  • Yun CH, Mengwasser KE, Toms AV, Woo MS, Greulich H, Wong KK, Meyerson M, Eck MJ.The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP.Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2070-5.
    18227510
  • Garcia-Barceló MM, Lau DK, Ngan ES, Leon TY, Liu T, So M, Miao X, Lui VC, Wong KK, Ganster RW, Cass DT, Croaker GD, Tam PK.Evaluation of the NK2 Homeobox 1 Gene (NKX2-1) as a Hirschsprung's Disease Locus.Ann Hum Genet. 2008 Mar;72(Pt 2):170-7.
    18081917
  • Contreras CM, Gurumurthy S, Haynie JM, Shirley LJ, Akbay EA, Wingo SN, Schorge JO, Broaddus RR, Wong KK, Bardeesy N, Castrillon DH.Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.Cancer Res. 2008 Feb 1;68(3):759-66.
    18245476
  • Dong Q, Wong KK, Avram AM.Sacral Nerve Root Neurolymphomatosis Diagnosed on FDG-PET/CT and Magnetic Resonance Imaging.Clin Nucl Med. 2008 Jan;33(1):30-1.
    18097253
  • Deng J, Shimamura T, Perera S, Carlson NE, Cai D, Shapiro GI, Wong KK, Letai A.Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion.Cancer Res. 2007 Dec 15;67(24):118
    18089817
  • Engelman JA, Zejnullahu K, Gale CM, Lifshits E, Gonzales AJ, Shimamura T, Zhao F, Vincent PW, Naumov GN, Bradner JE, Althaus IW, Gandhi L, Shapiro GI, Nelson JM, Heymach JV, Meyerson M, Wong KK, Jänne PA.PF00299804, an irreversible pan-ERBB inhibitor, is
    18089823
  • O'Neil J, Tchinda J, Gutierrez A, Moreau L, Maser RS, Wong KK, Li W, McKenna K, Liu XS, Feng B, Neuberg D, Silverman L, DeAngelo DJ, Kutok JL, Rothstein R, DePinho RA, Chin L, Lee C, Look AT.Alu elements mediate MYB gene tandem duplication in human T
    18070937
  • Mok SC,Kwong J,Welch WR,Samimi G,Ozbun L,Bonome T,Birrer MJ,Berkowitz RS,Wong KK.Etiology and pathogenesis of epithelial ovarian cancer.Dis Markers. 2007;23(5-6):367-76. Review.
    18057520
  • Yuza Y, Glatt KA, Jiang J, Greulich H, Minami Y, Woo MS, Shimamura T, Shapiro G, Lee JC, Ji H, Feng W, Chen TH, Yanagisawa H, Wong KK, Meyerson M.Allele-Dependent Variation in the Relative Cellular Potency of Distinct EGFR Inhibitors.Cancer Biol Ther. 200
    17495523
  • Tan PK, Wang J, Littler PL, Wong KK, Sweetnam TA, Keefe W, Nash NR, Reding EC, Piu F, Brann MR, Schiffer HH.Monitoring interactions between receptor tyrosine kinases and their downstream effector proteins in living cells using bioluminescence resonance en
    17715395
  • Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC
    17676035
  • Lynch TJ, Bonomi PD, Butts C, Davies AM, Engelman J, Govindan R, Herbst RS, Heymach JV, Johnson BE, Martins RG, Perez-Soler R, Riely GJ, Sandler AB, Sequist LV, Socinski MA, Wong KK, Hart CS.Novel agents in the treatment of lung cancer: Fourth Cambridge C
    17671145
  • Wong KK.HKI-272 in non small cell lung cancer.Clin Cancer Res. 2007 Aug 1;13(15 Pt 2):s4593-6. Review.
    17671147
  • Minami Y, Shimamura T, Shah K, Laframboise T, Glatt KA, Liniker E, Borgman CL, Haringsma HJ, Feng W, Weir BA, Lowell AM, Lee JC, Wolf J, Shapiro GI, Wong KK, Meyerson M, Thomas RK.The major lung cancer-derived mutants of ERBB2 are oncogenic and are associ
    17311002
  • Li D, Shimamura T, Ji H, Chen L, Haringsma HJ, McNamara K, Liang MC, Perera SA, Zaghlul S, Borgman CL, Kubo S, Takahashi M, Sun Y, Chirieac LR, Padera RF, Lindeman NI, Jänne PA, Thomas RK, Meyerson ML, Eck MJ, Engelman JA, Shapiro GI, Wong KK.Bronchial an
    17613438
  • Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, Edkins S, Stevens C, Brennan C, Martin ES, Wiedemeyer R, Kabbarah O, Nogueira C, Histen G, As
    17515920
  • Birrer MJ, Johnson ME, Hao K, Wong KK, Park DC, Bell A, Welch WR, Berkowitz RS, Mok SC.Whole genome oligonucleotide-based array comparative genomic hybridization analysis identified fibroblast growth factor 1 as a prognostic marker for advanced-stage sero
    17538174
  • Ji H, Wang Z, Perera SA, Li D, Liang MC, Zaghlul S, McNamara K, Chen L, Albert M, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Thomas RK, Garraway LA, Jänne PA, Johnson BE, Chin L, Wong KK.Mutations in BRAF and KRAS converge on activation of the
    17510423
  • Wong KK, Maser RS, Sahin E, Bailey ST, Xia H, Ji H, McNamara K, Naylor M, Bronson RT, Ghosh S, Welsh R, Depinho RA.Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres.Oncogene. 2007 May 3;26(20):2815-21.
    17072335
  • Christiani DC, Pao W, DeMartini JC, Linnoila RI, Malkinson AM, Onn A, Politi KA, Sharp M, Wong KK, Kim K.BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models.J Thorac Oncol. 2006 Nov;1(9 Suppl):S2-7.
    17409996
  • Thomas RK, Baker AC, Debiasi RM, Winckler W, Laframboise T, Lin WM, Wang M, Feng W, Zander T, Macconnaill LE, Lee JC, Nicoletti R, Hatton C, Goyette M, Girard L, Majmudar K, Ziaugra L, Wong KK, Gabriel S, Beroukhim R, Peyton M, Barretina J, Dutt A, Emery
    17392811
  • Thomas RK, Baker AC, Debiasi RM, Winckler W, Laframboise T, Lin WM, Wang M, Feng W, Zander T, MacConaill L, Lee JC, Nicoletti R, Hatton C, Goyette M, Girard L, Majmudar K, Ziaugra L, Wong KK, Gabriel S, Beroukhim R, Peyton M, Barretina J, Dutt A, Emery C,
    17293865
  • Ngan ES, Sit FY, Lee K, Miao X, Yuan Z, Wang W, Nicholls JM, Wong KK, Garcia-Barcelo M, Lui VC, Tam PK.Implications of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression.Clin Cancer Res.
    17289879
  • Li D, Ji H, Zaghlul S, McNamara K, Liang MC, Shimamura T, Kubo S, Takahashi M, Chirieac LR, Padera RF, Scott AM, Jungbluth AA, Cavenee WK, Old LJ, Demetri GD, Wong KK.Therapeutic anti-EGFR antibody 806 generates responses in murine de novo EGFR mutant-dep
    17256054
  • Mok SC, Elias KM, Wong KK, Ho K, Bonome T, Birrer MJ.Biomarker discovery in epithelial ovarian cancer by genomic approaches.Adv Cancer Res.;96:1-22.
  • Wong KK, deLeeuw RJ, Dosanjh NS, Kimm LR, Cheng Z, Horsman DE, MacAulay C, Ng RT, Brown CJ, Eichler EE, Lam WL.A comprehensive analysis of common copy-number variations in the human genome.Am J Hum Genet. 2007 Jan;80(1):91-104.
    17160897
  • Maser RS, Wong KK, Sahin E, Xia H, Naylor M, Hedberg HM, Artandi SE, DePinho RA.DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.Mol Cell Biol. 2007
    17145779
  • Ji H, Sharpless NE, Wong KK.EGFR targeted therapy: view from biological standpoint.Cell Cycle. 2006 Sep;5(18):2072-6. Review.
    16969107
  • Tonon G, Brennan C, Protopopov A, Maulik G, Feng B, Zhang Y, Khatry DB, You MJ, Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Wong KK, Depinho RA.Common and Contrasting Genomic Profiles among the Major Human Lung Cancer Subtypes.Cold Spring Harb Symp Quant
    16869734
  • Dutt A, Wong KK.Mouse models of lung cancer.Clin Cancer Res. 2006 Jul 15;12(14):4396s-402s. Review.
    16857817
  • Lynch TJ, Adjei AA, Bunn PA, Eisen TG, Engelman J, Goss GD, Haber DA, Heymach JV, Jänne PA, Johnson BE, Johnson DH, Lilenbaum RC, Meyerson M, Sandler AB, Sequist LV, Settleman J, Wong KK, Hart CS.Summary statement: novel agents in the treatment of lung ca
    16857812
  • Shimamura T, Ji H, Minami Y, Thomas RK, Lowell AM, Shah K, Greulich H, Glatt KA, Meyerson M, Shapiro GI, Wong KK.Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal
    16818618
  • Thomas RK, Nickerson E, Simons JF, Janne PA, Tengs T, Yuza Y, Garraway LA, LaFramboise T, Lee JC, Shah K, O'Neill K, Sasaki H, Lindeman N, Wong KK, Borras AM, Gutmann EJ, Dragnev KH, DeBiasi R, Chen TH, Glatt KA, Greulich H, Desany B, Lubeski CK, Bro
    16799556
  • Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, Jänne PA, Shapiro GI, Tenen D, Johnson BE, Weissleder R, Sharpless NE, Wong KK.The impact of human EGFR kinase d
    16730237
  • Ji H, Zhao X, Yuza Y, Shimamura T, Li D, Protopopov A, Jung BL, McNamara K, Xia H, Glatt KA, Thomas RK, Sasaki H, Horner JW, Eck M, Mitchell A, Sun Y, Al-Hashem R, Bronson RT, Rabindran SK, Discafani CM, Maher E, Shapiro GI, Meyerson M, Wong KK.Epidermal
    16672372
  • Bassères DS, Levantini E, Ji H, Monti S, Elf S, Dayaram T, Fenyus M, Kocher O, Golub T, Wong KK, Halmos B, Tenen DG.Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor
    16428462
  • Ji H, Houghton AM, Mariani TJ, Perera S, Kim CB, Padera R, Tonon G, McNamara K, Marconcini LA, Hezel A, El-Bardeesy N, Bronson RT, Sugarbaker D, Maser RS, Shapiro SD, Wong KK.K-ras activation generates an inflammatory response in lung tumors.Oncogene. 200
    16288213
  • Kobayashi S, Ji H, Yuza Y, Meyerson M, Wong KK, Tenen DG, Halmos B.An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.Cancer Res. 2005 Aug 15;65(16):7096-101.
    16103058
  • Tonon G, Wong KK, Maulik G, Brennan C, Feng B, Zhang Y, Khatry DB, Protopopov A, You MJ, Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Depinho RA.High-resolution genomic profiles of human lung cancer.Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9625-30.
    15983384
  • Wong KK, DePinho RA.Walking the telomere plank into cancer.J Natl Cancer Inst. 2003 Aug 20;95(16):1184-6.
    12928335
  • DePinho RA, Wong KK.The age of cancer: telomeres, checkpoints, and longevity.J Clin Invest. 2003 Apr;111(7):S9-14.
    12688272
  • Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA.Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.Nature. 2003 Feb 6;421(6923):643-8.
    12540856
  • Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, Artandi SE, Rudolph KL, Gottlieb GJ, Chin L, Alt FW, DePinho RA.Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.Nat Genet. 2000 Sep;26(1):85-8.
    10973255
  • Bardeesy N, Wong KK, DePinho RA, Chin L.Animal models of melanoma: recent advances and future prospects.Adv Cancer Res. 2000;79:123-56.
    10818679