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Joyce E. Bischoff, PhD


  • Wylie-Sears J, Levine RA, Bischoff J.Losartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-β-induced phosphorylation of ERK.Biochem Biophys Res Commun. 2014 Apr 18;446(4):870-5.
  • Smadja DM, Guerin CL, Boscolo E, Bieche I, Mulliken JB, Bischoff J.α6-Integrin is required for the adhesion and vasculogenic potential of hemangioma stem cells.Stem Cells. 2014 Mar;32(3):684-93.
  • Allen P, Kang KT, Bischoff J.Rapid onset of perfused blood vessels after implantation of ECFCs and MPCs in collagen, PuraMatrix and fibrin provisional matrices.Journal Of Tissue Engineering And Regenerative Medicine. 2013 Aug 16.
  • Kang KT, Coggins M, Xiao C, Rosenzweig A, Bischoff J.Human vasculogenic cells form functional blood vessels and mitigate adverse remodeling after ischemia reperfusion injury in rats.Angiogenesis. 2013 May 12.
  • Boscolo E, Mulliken JB, Bischoff J.Pericytes from infantile hemangioma display proangiogenic properties and dysregulated angiopoietin-1.Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):501-9.
  • Stiles J, Amaya C, Pham R, Rowntree RK, Lacaze M, Mulne A, Bischoff J, Kokta V, Boucheron LE, Mitchell DC, Bryan BA.Propranolol treatment of infantile hemangioma endothelial cells: A molecular analysis.Exp Ther Med. 2012 Oct;4(4):594-604.
  • Smadja DM, Mulliken JB, Bischoff J.E-selectin mediates stem cell adhesion and formation of blood vessels in a murine model of infantile hemangioma.Am J Pathol. 2012 Dec;181(6):2239-47.
  • Greenberger S, Bischoff J.Infantile Hemangioma-Mechanism(s) of Drug Action on a Vascular Tumor.Cold Spring Harb Perspect Med. 2011 Sep;1(1):a006460.
  • Kang KT, Allen P, Bischoff J.Bioengineered human vascular networks transplanted into secondary mice reconnect with the host vasculature and re-establish perfusion.Blood. 2011 Dec 15;118(25):6718-21.
  • Boscolo E, Mulliken JB, Bischoff J.VEGFR-1 Mediates Endothelial Differentiation and Formation of Blood Vessels in a Murine Model of Infantile Hemangioma.Am J Pathol. 2011 Sep 20.
  • Greenberger S, Yuan S, Walsh LA, Boscolo E, Kang KT, Matthews B, Mulliken JB, Bischoff J.Rapamycin Suppresses Self-Renewal and Vasculogenic Potential of Stem Cells Isolated from Infantile Hemangioma.J Invest Dermatol. 2011 Sep 22.
  • Boscolo E, Stewart CL, Greenberger S, Wu JK, Durham JT, Herman IM, Mulliken JB, Kitajewski J, Bischoff J.JAGGED1 Signaling Regulates Hemangioma Stem Cell-to-Pericyte/Vascular Smooth Muscle Cell Differentiation.Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2181-92.
  • Bischoff J, Aikawa E.Progenitor Cells Confer Plasticity to Cardiac Valve Endothelium.J Cardiovasc Transl Res. 2011 Jul 26.
  • Allen P, Melero-Martin J, Bischoff J.Type I collagen, fibrin and PuraMatrix matrices provide permissive environments for human endothelial and mesenchymal progenitor cells to form neovascular networks.Journal Of Tissue Engineering And Regenerative Medicine. 2011 Apr;5(4):e74-86.
  • Wylie-Sears J, Aikawa E, Levine RA, Yang JH, Bischoff J.Mitral valve endothelial cells with osteogenic differentiation potential.Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):598-607.
  • Allen P, Melero-Martin J, Bischoff J.Type I collagen, fibrin and PuraMatrix matrices provide permissive environments for human endothelial and mesenchymal progenitor cells to form neovascular networks.Journal Of Tissue Engineering And Regenerative Medicine. 2011 Jan 10.
  • Greenberger S, Adini I, Boscolo E, Mulliken JB, Bischoff J.Targeting NF-κB in infantile hemangioma-derived stem cells reduces VEGF-A expression.Angiogenesis. 2010 Dec;13(4):327-35.
  • Melero-Martin J, De Obaldia ME, Allen P, Dudley AC, Klagsbrun M, Bischoff J.Host myeloid cells are necessary for creating bio-engineered human vascular networks in vivo.Tissue Eng Part A. 2010 Aug;16(8):2457-66.
  • Hjortnaes J, Gottlieb D, Figueiredo JL, Melero-Martin J, Kohler RH, Bischoff J, Weissleder R, Mayer J, Aikawa E.Intravital Molecular Imaging of Small-Diameter Tissue-Engineered Vascular Grafts: A Feasibility Study.Tissue Engineering. Part C, Methods. 2010 Aug;16(4):597-607.
  • Wu JK, Adepoju O, De Silva D, Baribault K, Boscolo E, Bischoff J, Kitajewski J.A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma.Angiogenesis. 2010 Mar;13(1):15-23.
  • Greenberger S, Boscolo E, Adini I, Mulliken JB, Bischoff J.Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells.N Engl J Med. 2010 Mar 18;362(11):1005-13.
  • Jang GH, Park IS, Yang JH, Bischoff J, Lee YM.Differential functions of genes regulated by VEGF-NFATc1 signaling pathway in the migration of pulmonary valve endothelial cells.FEBS Lett. 2010 Jan 4;584(1):141-6.
  • Elmasri H, Karaaslan C, Teper Y, Ghelfi E, Weng M, Ince TA, Kozakewich H, Bischoff J, Cataltepe S.Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells.FASEB J. 2009 Nov;23(11):3865-73.
  • Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Handschumacher MD, Sullivan S, Johnson B, Titus JS, Iwamoto Y, Wylie-Sears J, Levine RA, Carpentier A.Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation.Circulation. 2009 Jul 28;120(4):334-42.
  • Boscolo E, Bischoff J.Vasculogenesis in infantile hemangioma.Angiogenesis. 2009;12(2):197-207. Review.
  • Ignatov A, Hoffman O, Smith B, Fahlke J, Peters B, Bischoff J, Costa SD.An 11-year retrospective study of totally implanted central venous access ports: Complications and patient satisfaction.Eur J Surg Oncol. 2009 Mar;35(3):241-6.
  • Dudley AC,Khan ZA,Shih SC,Kang SY,Zwaans BM,Bischoff J,Klagsbrun M.Calcification of multipotent prostate tumor endothelium.Cancer Cell. 2008 Sep 9;14(3):201-11.
  • Yang JH, Wylie-Sears J, Bischoff J.Opposing actions of Notch1 and VEGF in post-natal cardiac valve endothelial cells.Biochem Biophys Res Commun. 2008 Sep 26;374(3):512-6.
  • Melero-Martin JM,De Obaldia ME,Kang SY,Khan ZA,Yuan L,Oettgen P,Bischoff J.Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells.Circ Res. 2008 Jul 18;103(2):194-202.
  • Khan ZA,Boscolo E,Picard A,Psutka S,Melero-Martin JM,Bartch TC,Mulliken JB,Bischoff J.Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice.J Clin Invest. 2008 Jul;118(7):2592-9.
  • Bischoff J, Griffioen AW.In memoriam Dr. Judah Folkman.Angiogenesis. 2008 Mar;11(1):1-2.
  • Picard A, Boscolo E, Khan ZA, Bartch TC, Mulliken JB, Vazquez MP, Bischoff J.IGF-2 and FLT-1/VEGF-R1 mRNA levels reveal distinctions and similarities between congenital and common infantile hemangioma.Pediatr Res. 2008 Mar;63(3):263-7.
  • Malumbres M, Pevarello P, Barbacid M, Bischoff JR.CDK inhibitors in cancer therapy: what is next?.Trends Pharmacol Sci. 2008 Jan;29(1):16-21.
  • Wu X, Lensch MW, Wylie-Sears J, Daley GQ, Bischoff J.Hemogenic endothelial progenitor cells isolated from human umbilical cord blood.Stem Cells. 2007 Nov;25(11):2770-6.
  • Mulliken JB, Bischoff J, Kozakewich HP.Multifocal rapidly involuting congenital hemangioma: a link to chorangioma.Am J Med Genet A. 2007 Dec 15;143(24):3038-46.
  • Melero-Martin JM, Khan ZA, Picard A, Wu X, Paruchuri S, Bischoff J.In vivo vasculogenic potential of human blood-derived endothelial progenitor cells.Blood. 2007 Jun 1;109(11):4761-8.
  • Paruchuri S, Yang JH, Aikawa E, Melero-Martin JM, Khan ZA, Loukogeorgakis S, Schoen FJ, Bischoff J.Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2.Circ Res. 2006 Oct 13;99(8):861-9.
  • Khan ZA, Melero-Martin JM, Wu X, Paruchuri S, Boscolo E, Mulliken JB, Bischoff J.Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to endostatin.Blood. 2006 Aug 1;108(3):915-21.
  • Yu Y, Wylie-Sears J, Boscolo E, Mulliken JB, Bischoff J.Genomic Imprinting of IGF2 is Maintained in Infantile Hemangioma despite its High Level of Expression.Mol Med.;10(7-12):117-23.
  • Yu Y, Fuhr J, Boye E, Gyorffy S, Soker S, Atala A, Mulliken JB, Bischoff J.Mesenchymal stem cells and adipogenesis in hemangioma involution.Stem Cells. 2006 Jun;24(6):1605-12.
  • Lee YM, Cope JJ, Ackermann GE, Goishi K, Armstrong EJ, Paw BH, Bischoff J.Vascular endothelial growth factor receptor signaling is required for cardiac valve formation in zebrafish.Dev Dyn. 2006 Jan;235(1):29-37.
  • Frieden IJ, Haggstrom AN, Drolet BA, Mancini AJ, Friedlander SF, Boon L, Chamlin SL, Baselga E, Garzon MC, Nopper AJ, Siegel DH, Mathes EW, Goddard DS, Bischoff J, North PE, Esterly NB.Infantile hemangiomas: current knowledge, future directions. Proceedings of a research workshop on infantile hemangiomas, April 7-9, 2005, Bethesda, Maryland, USA.Pediatr Dermatol. 2005 Sep-Oct;22(5):383-406.
  • Armstrong EJ, Bischoff J.Heart valve development: endothelial cell signaling and differentiation.Circ Res. 2004 Sep 3;95(5):459-70.
  • Wu X, Rabkin-Aikawa E, Guleserian KJ, Perry TE, Masuda Y, Sutherland FW, Schoen FJ, Mayer JE, Bischoff J.Tissue-engineered microvessels on three-dimensional biodegradable scaffolds using human endothelial progenitor cells.Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H480-7.
  • Yu Y, Moulton KS, Khan MK, Vineberg S, Boye E, Davis VM, O'Donnell PE, Bischoff J, Milstone DS.E-selectin is required for the antiangiogenic activity of endostatin.Proc Natl Acad Sci U S A. 2004 May 25;101(21):8005-10.
  • Yu Y, Flint AF, Mulliken JB, Wu JK, Bischoff J.Endothelial progenitor cells in infantile hemangioma.Blood. 2004 Feb 15;103(4):1373-5.
  • Dvorin EL, Jacobson J, Roth SJ, Bischoff J.Human pulmonary valve endothelial cells express functional adhesion molecules for leukocytes.J Heart Valve Dis. 2003 Sep;12(5):617-24.
  • Li Q, Yu Y, Bischoff J, Mulliken JB, Olsen BR.Differential expression of CD146 in tissues and endothelial cells derived from infantile haemangioma and normal human skin.J Pathol. 2003 Oct;201(2):296-302.
  • Dvorin EL, Wylie-Sears J, Kaushal S, Martin DP, Bischoff J.Quantitative evaluation of endothelial progenitors and cardiac valve endothelial cells: proliferation and differentiation on poly-glycolic acid/poly-4-hydroxybutyrate scaffold in response to vascular endothelial growth factor and transforming growth facto.Tissue Eng. 2003 Jun;9(3):487-93.
  • Perry TE, Kaushal S, Sutherland FW, Guleserian KJ, Bischoff J, Sacks M, Mayer JE.Thoracic Surgery Directors Association Award. Bone marrow as a cell source for tissue engineering heart valves.Ann Thorac Surg. 2003 Mar;75(3):761-7; discussion 767.
  • Johnson EN, Lee YM, Sander TL, Rabkin E, Schoen FJ, Kaushal S, Bischoff J.NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells.J Biol Chem. 2003 Jan 17;278(3):1686-92.
  • Bischoff J.Monoclonal expansion of endothelial cells in hemangioma: an intrinsic defect with extrinsic consequences?.Trends Cardiovasc Med. 2002 Jul;12(5):220-4.
  • Yu Y, Flint A, Dvorin EL, Bischoff J.AC133-2, a novel isoform of human AC133 stem cell antigen.J Biol Chem. 2002 Jun 7;277(23):20711-6.
  • Yu Y, Varughese J, Brown LF, Mulliken JB, Bischoff J.Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells.Am J Pathol. 2001 Dec;159(6):2271-80.
  • Paranya G, Vineberg S, Dvorin E, Kaushal S, Roth SJ, Rabkin E, Schoen FJ, Bischoff J.Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-beta-mediated transdifferentiation in vitro.Am J Pathol. 2001 Oct;159(4):1335-43.
  • Kaushal S, Amiel GE, Guleserian KJ, Shapira OM, Perry T, Sutherland FW, Rabkin E, Moran AM, Schoen FJ, Atala A, Soker S, Bischoff J, Mayer JE.Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo.Nat Med. 2001 Sep;7(9):1035-40.
  • Boye E, Yu Y, Paranya G, Mulliken JB, Olsen BR, Bischoff J.Clonality and altered behavior of endothelial cells from hemangiomas.J Clin Invest. 2001 Mar;107(6):745-52.
  • Luo J, Kato M, Wang H, Bernfield M, Bischoff J.Heparan sulfate and chondroitin sulfate proteoglycans inhibit E-selectin binding to endothelial cells.J Cell Biochem. 2001;80(4):522-31.
  • Tomlinson J, Wang JL, Barsky SH, Lee MC, Bischoff J, Nguyen M.Human colon cancer cells express multiple glycoprotein ligands for E-selectin.Int J Oncol. 2000 Feb;16(2):347-53.
  • Smith LE, Shen W, Perruzzi C, Soker S, Kinose F, Xu X, Robinson G, Driver S, Bischoff J, Zhang B, Schaeffer JM, Senger DR.Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor.Nat Med. 1999 Dec;5(12):1390-5.
  • Luo J, Paranya G, Bischoff J.Noninflammatory expression of E-selectin is regulated by cell growth.Blood. 1999 Jun 1;93(11):3785-91.
  • Razon MJ, Krling BM, Mulliken JB, Bischoff J.Increased apoptosis coincides with onset of involution in infantile hemangioma.Microcirculation. 1998;5(2-3):189-95.
  • Krling BM, Bischoff J.A simplified method for growth of human microvascular endothelial cells results in decreased senescence and continued responsiveness to cytokines and growth factors.In Vitro Cell Dev Biol Anim. 1998 Apr;34(4):308-15.
  • Luo J, Lin J, Paranya G, Bischoff J.Angiostatin upregulates E-selectin in proliferating endothelial cells.Biochem Biophys Res Commun. 1998 Apr 28;245(3):906-11.
  • Bischoff J.Cell adhesion and angiogenesis.J Clin Invest. 1997 Dec 1;100(11 Suppl):S37-9.
  • Nguyen M, Corless CL, Krling BM, Tran C, Atha T, Bischoff J, Barsky SH.Vascular expression of E-selectin is increased in estrogen-receptor-negative breast cancer: a role for tumor-cell-secreted interleukin-1 alpha.Am J Pathol. 1997 Apr;150(4):1307-14.
  • Znd G, Nelson DP, Neufeld EJ, Dzus AL, Bischoff J, Mayer JE, Colgan SP.Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells.Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7075-80.
  • Krling BM, Razon MJ, Boon LM, Zurakowski D, Seachord C, Darveau RP, Mulliken JB, Corless CL, Bischoff J.E-selectin is present in proliferating endothelial cells in human hemangiomas.Am J Pathol. 1996 Apr;148(4):1181-91.
  • Bischoff J, Brasel C.Regulation of P-selectin by tumor necrosis factor-alpha.Biochem Biophys Res Commun. 1995 May 5;210(1):174-80.
  • Nguyen M, Strubel NA, Bischoff J.A role for sialyl Lewis-X/A glycoconjugates in capillary morphogenesis.Nature. 1993 Sep 16;365(6443):267-9.
  • Strubel NA, Nguyen M, Kansas GS, Tedder TF, Bischoff J.Isolation and characterization of a bovine cDNA encoding a functional homolog of human P-selectin.Biochem Biophys Res Commun. 1993 Apr 30;192(2):338-44.
  • Nguyen M, Folkman J, Bischoff J.1-Deoxymannojirimycin inhibits capillary tube formation in vitro. Analysis of N-linked oligosaccharides in bovine capillary endothelial cells.J Biol Chem. 1992 Dec 25;267(36):26157-65.
  • Bischoff J, Moremen K, Lodish HF.Isolation, characterization, and expression of cDNA encoding a rat liver endoplasmic reticulum alpha-mannosidase.J Biol Chem. 1990 Oct 5;265(28):17110-7.
  • Bischoff J, Libresco S, Shia MA, Lodish HF.The H1 and H2 polypeptides associate to form the asialoglycoprotein receptor in human hepatoma cells.J Cell Biol. 1988 Apr;106(4):1067-74.
  • Bischoff J, Lodish HF.Two asialoglycoprotein receptor polypeptides in human hepatoma cells.J Biol Chem. 1987 Aug 25;262(24):11825-32.
  • Bischoff J, Kornfeld R.The soluble form of rat liver alpha-mannosidase is immunologically related to the endoplasmic reticulum membrane alpha-mannosidase.J Biol Chem. 1986 Apr 5;261(10):4758-65.
  • Bischoff J, Kornfeld R.The effect of 1-deoxymannojirimycin on rat liver alpha-mannosidases.Biochem Biophys Res Commun. 1984 Nov 30;125(1):324-31.
  • Bischoff J, Kornfeld R.Evidence for an alpha-mannosidase in endoplasmic reticulum of rat liver.J Biol Chem. 1983 Jul 10;258(13):7907-10.