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David S. Milstone, M.D. Ph.D.


  • Tache V, Ciric A, Moretto-Zita M, Li Y, Peng J, Maltepe E, Milstone DS, Parast MM.Hypoxia and trophoblast differentiation: a key role for PPARĪ³.Stem Cells Dev. 2013 Nov 1;22(21):2815-24.
  • Rose JA, Rabenold JJ, Parast MM, Milstone DS, Abrahams VM, Riley JK.Peptidoglycan Induces Necrosis and Regulates Cytokine Production in Murine Trophoblast Stem Cells.Am J Reprod Immunol. 2011 Mar 9.
  • Parast MM, Yu H, Ciric A, Salata MW, Davis V, Milstone DS.PPARgamma regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation.PLoS ONE. 2009;4(11):e8055.
  • Ye CP, Duan SZ, Milstone DS, Mortensen RM.G(o) controls the hyperpolarization-activated current in embryonic stem cell-derived cardiocytes.Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H979-85.
  • Duan SZ, Christe M, Milstone DS, Mortensen RM.Go but not Gi2 or Gi3 is required for muscarinic regulation of heart rate and heart rate variability in mice.Biochem Biophys Res Commun. 2007 May 25;357(1):139-43.
  • Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Duquaine DC, Brosius FC, Gonzalez FJ, Vinson C, Pierre MA, Milstone DS, Mortensen RM.Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality.J Clin Invest. 2007 Mar;117(3):812-22.
  • Duan SZ, Ivashchenko CY, Russell MW, Milstone DS, Mortensen RM.Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice.Circ Res. 2005 Aug 19;97(4):372-9.
  • Friedrich EB, Liu E, Sinha S, Cook S, Milstone DS, MacRae CA, Mariotti M, Kuhlencordt PJ, Force T, Rosenzweig A, St-Arnaud R, Dedhar S, Gerszten RE.Integrin-linked kinase regulates endothelial cell survival and vascular development.Mol Cell Biol. 2004 Sep;24(18):8134-44.
  • Yu Y, Moulton KS, Khan MK, Vineberg S, Boye E, Davis VM, O’Donnell PE, Bischoff J, Milstone DS.E-Selectin Is Required For The Anti-angiogenic Activity of Endostatin.Proc Natl Acad Sci U S A. 2004 July 1;1:1.
  • Yu Y, Moulton KS, Khan MK, Vineberg S, Boye E, Davis VM, O'Donnell PE, Bischoff J, Milstone DS.E-selectin is required for the antiangiogenic activity of endostatin.Proc Natl Acad Sci U S A. 2004 May 25;101(21):8005-10.
  • Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW.The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.Nat Med. 2001 Jan;7(1):41-7.
  • Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, Spiegelman BM, Mortensen RM.PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro.Mol Cell. 1999 Oct;4(4):611-7.
  • Ye C, Sowell MO, Vassilev PM, Milstone DS, Mortensen RM.Galpha(i2), Galpha(i3)and Galpha(o) are all required for normal muscarinic inhibition of the cardiac calcium channels in nodal/atrial-like cultured cardiocytes.J Mol Cell Cardiol. 1999 Sep;31(9):1771-81.
  • Milstone DS, Fukumura D, Padgett RC, O'Donnell PE, Davis VM, Benavidez OJ, Monsky WL, Melder RJ, Jain RK, Gimbrone MA.Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium.Microcirculation. 1998;5(2-3):153-71.