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T. Keith Blackwell, MD, PhD

Publications

  • Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ.GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3781-6.
    24556985
  • Ruf V, Holzem C, Peyman T, Walz G, Blackwell TK, Neumann-Haefelin E.TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development.Dev Biol. 2013 Dec 15;384(2):214-27.
    23973804
  • Glover-Cutter KM, Lin S, Blackwell TK.Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf.PLoS Genet. 2013;9(9):e1003701.
    24068940
  • Paek J, Lo JY, Narasimhan SD, Nguyen TN, Glover-Cutter K, Robida-Stubbs S, Suzuki T, Yamamoto M, Blackwell TK, Curran SP.Mitochondrial SKN-1/Nrf Mediates a Conserved Starvation Response.Cell Metab. 2012 Oct 3;16(4):526-37.
    23040073
  • Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TK, Kahn CR.Role of microRNA processing in adipose tissue in stress defense and longevity.Cell Metab. 2012 Sep 5;16(3):336-47.
    22958919
  • Wang J, Robida-Stubbs S, Tullet JM, Rual JF, Vidal M, Blackwell TK.RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition.PLoS Genet. 2010;6(8).
    20700440
  • Abate JP, Blackwell TK.Life is short, if sweet.Cell Metab. 2009 Nov;10(5):338-9.
    19883611
  • Oliveira RP, Abate JP, Dilks K, Landis J, Ashraf J, Murphy CT, Blackwell TK.Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.Aging Cell. 2009 Sep;8(5):524-41.
    19575768
  • Hammell CM,Lubin I,Boag PR,Blackwell TK,Ambros V.nhl-2 Modulates microRNA activity in Caenorhabditis elegans.Cell. 2009 Mar 6;136(5):926-38.
    19269369
  • Olahova M,Taylor SR,Khazaipoul S,Wang J,Morgan BA,Matsumoto K,Blackwell TK,Veal EA.A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance.Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19839-44.
    19064914
  • Blackwell TK,Walker AK.OMA-gosh, where's that TAF?.Cell. 2008 Oct 3;135(1):18-20.
    18854150
  • Gartner A,Boag PR,Blackwell TK.Germline survival and apoptosis.WormBook. 2008:1-20. Review.
    18781708
  • Boag PR,Atalay A,Robida S,Reinke V,Blackwell TK.Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis.J Cell Biol. 2008 Aug 11;182(3):543-57.
    18695045
  • Gartner A, Boag RP, Blackwell TK.Germ cell survival and apoptosis.Wormbook, the C. elegans Research Community..
  • Tullet JM,Hertweck M,An JH,Baker J,Hwang JY,Liu S,Oliveira RP,Baumeister R,Blackwell TK.Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.Cell. 2008 Mar 21;132(6):1025-38.
    18358814
  • Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, Blackwell TK.Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.Cell.;132:915-6.
  • Lehtinen MK, Yuan Z, Boag PR, Yang Y, VillÚn J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A.A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.Cell. 2006 Jun 2;125(5):987-1001.
    16751106
  • An JH, Vranas K, Lucke M, Inoue H, Hisamoto N, Matsumoto K, Blackwell TK.Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3.Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16275-80.
    16251270
  • Boag PR, Nakamura A, Blackwell TK.A conserved RNA-protein complex component involved in physiological germline apoptosis regulation in C. elegans.Development. 2005 Nov;132(22):4975-86.
    16221731
  • Inoue H, Hisamoto N, An JH, Oliveira RP, Nishida E, Blackwell TK, Matsumoto K.The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response.Genes Dev. 2005 Oct 1;19(19):2278-83.
    16166371
  • Navarro RE, Blackwell TK.Requirement for P granules and meiosis for accumulation of the germline RNA helicase CGH-1.Genesis. 2005 Jul;42(3):172-80.
    15986473
  • Wang JC, Walker A, Blackwell TK, Yamamoto KR.The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis.J Biol Chem. 2004 Jul 9;279(28):29270-7.
    15073178
  • Blackwell TK.Germ cells: finding programs of mass repression.Curr Biol. 2004 Mar 23;14(6):R229-30.
    15043831
  • Stoecklin G, Stubbs T, Kedersha N, Wax S, Rigby WF, Blackwell TK, Anderson P.MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay.EMBO J. 2004 Mar 24;23(6):1313-1324.
    15014438
  • Walker AK, Shi Y, Blackwell TK.An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription.J Biol Chem. 2004 Apr 9;279(15):15339-47.
    14726532
  • Blackwell TK, Walker AK.Transcription elongation: TLKing to chromatin?.Curr Biol. 2003 Dec 2;13(23):R915-6.
    14654017
  • Shi Y, Blackwell TK.A two-tiered transcription regulation mechanism that protects germ cell identity.Mol Cell. 2003 Nov;12(5):1062-4.
    14636565
  • An JH, Blackwell TK.SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response.Genes Dev. 2003 Aug 1;17(15):1882-93.
    12869585
  • Zhang F, Barboric M, Blackwell TK, Peterlin BM.A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb.Genes Dev. 2003 Mar 15;17(6):748-58.
    12651893
  • Takagi T, Walker AK, Sawa C, Diehn F, Takase Y, Blackwell TK, Buratowski S.The Caenorhabditis elegans mRNA 5'-capping enzyme. In vitro and in vivo characterization.J Biol Chem. 2003 Apr 18;278(16):14174-84.
    12576476
  • Walker AK, Blackwell TK.A broad but restricted requirement for TAF-5 (human TAFII100) for embryonic transcription in Caenorhabditis elegans.J Biol Chem. 2003 Feb 21;278(8):6181-6.
    12458202
  • Shim EY, Walker AK, Shi Y, Blackwell TK.CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo.Genes Dev. 2002 Aug 15;16(16):2135-46.
    12183367
  • Shim EY, Walker AK, Blackwell TK.Broad requirement for the mediator subunit RGR-1 for transcription in the Caenorhabditis elegans embryo.J Biol Chem. 2002 Aug 23;277(34):30413-6.
    12089139
  • Johnson BA, Blackwell TK.Multiple tristetraprolin sequence domains required to induce apoptosis and modulate responses to TNFalpha through distinct pathways.Oncogene. 2002 Jun 20;21(27):4237-46.
    12082611
  • Blackwell TK, Walker AK.Getting the right dose of repression.Genes Dev. 2002 Apr 1;16(7):769-72.
    11937484
  • Johnson BA, Stehn JR, Yaffe MB, Blackwell TK.Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms.J Biol Chem. 2002 May 17;277(20):18029-36.
    11886850
  • Walker AK, Rothman JH, Shi Y, Blackwell TK.Distinct requirements for C.elegans TAF(II)s in early embryonic transcription.EMBO J. 2001 Sep 17;20(18):5269-79.
    11566890
  • Navarro RE, Shim EY, Kohara Y, Singson A, Blackwell TK.cgh-1, a conserved predicted RNA helicase required for gametogenesis and protection from physiological germline apoptosis in C. elegans.Development. 2001 Sep;128(17):3221-32.
    11546739
  • Walker AK, See R, Batchelder C, Kophengnavong T, Gronniger JT, Shi Y, Blackwell TK.A conserved transcription motif suggesting functional parallels between Caenorhabditis elegans SKN-1 and Cap'n'Collar-related basic leucine zipper proteins.J Biol Chem. 2000 Jul 21;275(29):22166-71.
    10764775
  • Johnson BA, Geha M, Blackwell TK.Similar but distinct effects of the tristetraprolin/TIS11 immediate-early proteins on cell survival.Oncogene. 2000 Mar 23;19(13):1657-64.
    10763822
  • Kophengnavong T, Michnowicz JE, Blackwell TK.Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations.Mol Cell Biol. 2000 Jan;20(1):261-72.
    10594029
  • Kophengnavong T, Carroll AS, Blackwell TK.The SKN-1 amino-terminal arm is a DNA specificity segment.Mol Cell Biol. 1999 Apr;19(4):3039-50.
    10082571
  • De J, Lai WS, Thorn JM, Goldsworthy SM, Liu X, Blackwell TK, Blackshear PJ.Identification of four CCCH zinc finger proteins in Xenopus, including a novel vertebrate protein with four zinc fingers and severely restricted expression.Gene. 1999 Mar 4;228(1-2):133-45.
    10072766
  • Batchelder C, Dunn MA, Choy B, Suh Y, Cassie C, Shim EY, Shin TH, Mello C, Seydoux G, Blackwell TK.Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1.Genes Dev. 1999 Jan 15;13(2):202-12.
    9925644
  • Carroll AS, Gilbert DE, Liu X, Cheung JW, Michnowicz JE, Wagner G, Ellenberger TE, Blackwell TK.SKN-1 domain folding and basic region monomer stabilization upon DNA binding.Genes Dev. 1997 Sep 1;11(17):2227-38.
    9303538
  • Huang J, Blackwell TK, Kedes L, Weintraub H.Differences between MyoD DNA binding and activation site requirements revealed by functional random sequence selection.Mol Cell Biol. 1996 Jul;16(7):3893-900.
    8668207
  • Blackwell TK.Selection of protein binding sites from random nucleic acid sequences.Methods Enzymol. 1995;254:604-18.
    8531718
  • Blackwell TK, Bowerman B, Priess JR, Weintraub H.Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements.Science. 1994 Oct 28;266(5185):621-8.
    7939715
  • Blackwell TK, Huang J, Ma A, Kretzner L, Alt FW, Eisenman RN, Weintraub H.Binding of myc proteins to canonical and noncanonical DNA sequences.Mol Cell Biol. 1993 Sep;13(9):5216-24.
    8395000
  • Blackwell TK, Kretzner L, Blackwood EM, Eisenman RN, Weintraub H.Sequence-specific DNA binding by the c-Myc protein.Science. 1990 Nov 23;250(4984):1149-51.
    2251503
  • Blackwell TK, Weintraub H.Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection.Science. 1990 Nov 23;250(4984):1104-10.
    2174572
  • Blackwell TK, Moore MW, Yancopoulos GD, Suh H, Lutzker S, Selsing E, Alt FW.Recombination between immunoglobulin variable region gene segments is enhanced by transcription.Nature. 1986 Dec 11-17;324(6097):585-9.
    3491327