T. Keith Blackwell, MD, PhD

Publications

Wang J, Robida-Stubbs S, Tullet JM, Rual JF, Vidal M, Blackwell TK.RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition.PLoS Genet. 2010;6(8).
20700440
Abate JP, Blackwell TK.Life is short, if sweet.Cell Metab. 2009 Nov;10(5):338-9.
19883611
Oliveira RP, Abate JP, Dilks K, Landis J, Ashraf J, Murphy CT, Blackwell TK.Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.Aging Cell. 2009 Sep;8(5):524-41.
19575768
Hammell CM,Lubin I,Boag PR,Blackwell TK,Ambros V.nhl-2 Modulates microRNA activity in Caenorhabditis elegans.Cell. 2009 Mar 6;136(5):926-38.
19269369
Olahova M,Taylor SR,Khazaipoul S,Wang J,Morgan BA,Matsumoto K,Blackwell TK,Veal EA.A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance.Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):198
19064914
Blackwell TK,Walker AK.OMA-gosh, where's that TAF?.Cell. 2008 Oct 3;135(1):18-20.
18854150
Gartner A,Boag PR,Blackwell TK.Germline survival and apoptosis.WormBook. 2008:1-20. Review.
18781708
Boag PR,Atalay A,Robida S,Reinke V,Blackwell TK.Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis.J Cell Biol. 2008 Aug 11;182(3):543-57.
18695045
Gartner A, Boag RP, Blackwell TK.Germ cell survival and apoptosis.Wormbook, the C. elegans Research Community..
Tullet JM,Hertweck M,An JH,Baker J,Hwang JY,Liu S,Oliveira RP,Baumeister R,Blackwell TK.Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.Cell. 2008 Mar 21;132(6):1025-38.
18358814
Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, Blackwell TK.Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.Cell.;132:915-6.
Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villén J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A.A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.Cell. 2006 Jun 2;125(5):987-1001.
16751106
An JH, Vranas K, Lucke M, Inoue H, Hisamoto N, Matsumoto K, Blackwell TK.Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3.Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16275-80.
16251270
Boag PR, Nakamura A, Blackwell TK.A conserved RNA-protein complex component involved in physiological germline apoptosis regulation in C. elegans.Development. 2005 Nov;132(22):4975-86.
16221731
Inoue H, Hisamoto N, An JH, Oliveira RP, Nishida E, Blackwell TK, Matsumoto K.The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response.Genes Dev. 2005 Oct 1;19(19):2278-83.
16166371
Navarro RE, Blackwell TK.Requirement for P granules and meiosis for accumulation of the germline RNA helicase CGH-1.Genesis. 2005 Jul;42(3):172-80.
15986473
Wang JC, Walker A, Blackwell TK, Yamamoto KR.The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis.J Biol Chem. 2004 Jul 9;279(28):29270-7.
15073178
Blackwell TK.Germ cells: finding programs of mass repression.Curr Biol. 2004 Mar 23;14(6):R229-30.
15043831
Stoecklin G, Stubbs T, Kedersha N, Wax S, Rigby WF, Blackwell TK, Anderson P.MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay.EMBO J. 2004 Mar 24;23(6):1313-1324.
15014438
Walker AK, Shi Y, Blackwell TK.An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription.J Biol Chem. 2004 Apr 9;279(15):15339-47.
14726532
Blackwell TK, Walker AK.Transcription elongation: TLKing to chromatin?.Curr Biol. 2003 Dec 2;13(23):R915-6.
14654017
Shi Y, Blackwell TK.A two-tiered transcription regulation mechanism that protects germ cell identity.Mol Cell. 2003 Nov;12(5):1062-4.
14636565
An JH, Blackwell TK.SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response.Genes Dev. 2003 Aug 1;17(15):1882-93.
12869585
Zhang F, Barboric M, Blackwell TK, Peterlin BM.A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb.Genes Dev. 2003 Mar 15;17(6):748-58.
12651893
Takagi T, Walker AK, Sawa C, Diehn F, Takase Y, Blackwell TK, Buratowski S.The Caenorhabditis elegans mRNA 5'-capping enzyme. In vitro and in vivo characterization.J Biol Chem. 2003 Apr 18;278(16):14174-84.
12576476
Walker AK, Blackwell TK.A broad but restricted requirement for TAF-5 (human TAFII100) for embryonic transcription in Caenorhabditis elegans.J Biol Chem. 2003 Feb 21;278(8):6181-6.
12458202
Shim EY, Walker AK, Shi Y, Blackwell TK.CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo.Genes Dev. 2002 Aug 15;16(16):2135-46.
12183367
Shim EY, Walker AK, Blackwell TK.Broad requirement for the mediator subunit RGR-1 for transcription in the Caenorhabditis elegans embryo.J Biol Chem. 2002 Aug 23;277(34):30413-6.
12089139
Johnson BA, Blackwell TK.Multiple tristetraprolin sequence domains required to induce apoptosis and modulate responses to TNFalpha through distinct pathways.Oncogene. 2002 Jun 20;21(27):4237-46.
12082611
Blackwell TK, Walker AK.Getting the right dose of repression.Genes Dev. 2002 Apr 1;16(7):769-72.
11937484
Johnson BA, Stehn JR, Yaffe MB, Blackwell TK.Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms.J Biol Chem. 2002 May 17;277(20):18029-36.
11886850
Walker AK, Rothman JH, Shi Y, Blackwell TK.Distinct requirements for C.elegans TAF(II)s in early embryonic transcription.EMBO J. 2001 Sep 17;20(18):5269-79.
11566890
Navarro RE, Shim EY, Kohara Y, Singson A, Blackwell TK.cgh-1, a conserved predicted RNA helicase required for gametogenesis and protection from physiological germline apoptosis in C. elegans.Development. 2001 Sep;128(17):3221-32.
11546739
Walker AK, See R, Batchelder C, Kophengnavong T, Gronniger JT, Shi Y, Blackwell TK.A conserved transcription motif suggesting functional parallels between Caenorhabditis elegans SKN-1 and Cap'n'Collar-related basic leucine zipper proteins.J Biol
10764775
Johnson BA, Geha M, Blackwell TK.Similar but distinct effects of the tristetraprolin/TIS11 immediate-early proteins on cell survival.Oncogene. 2000 Mar 23;19(13):1657-64.
10763822
Kophengnavong T, Michnowicz JE, Blackwell TK.Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations.Mol Cell Biol. 2000 Jan;20(1):261-72.
10594029
Kophengnavong T, Carroll AS, Blackwell TK.The SKN-1 amino-terminal arm is a DNA specificity segment.Mol Cell Biol. 1999 Apr;19(4):3039-50.
10082571
De J, Lai WS, Thorn JM, Goldsworthy SM, Liu X, Blackwell TK, Blackshear PJ.Identification of four CCCH zinc finger proteins in Xenopus, including a novel vertebrate protein with four zinc fingers and severely restricted expression.Gene. 1999 Mar 4;228(1-2
10072766
Batchelder C, Dunn MA, Choy B, Suh Y, Cassie C, Shim EY, Shin TH, Mello C, Seydoux G, Blackwell TK.Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1.Genes Dev. 1999 Jan 15;13(2):202-12.
9925644
Carroll AS, Gilbert DE, Liu X, Cheung JW, Michnowicz JE, Wagner G, Ellenberger TE, Blackwell TK.SKN-1 domain folding and basic region monomer stabilization upon DNA binding.Genes Dev. 1997 Sep 1;11(17):2227-38.
9303538
Huang J, Blackwell TK, Kedes L, Weintraub H.Differences between MyoD DNA binding and activation site requirements revealed by functional random sequence selection.Mol Cell Biol. 1996 Jul;16(7):3893-900.
8668207
Blackwell TK.Selection of protein binding sites from random nucleic acid sequences.Methods Enzymol. 1995;254:604-18.
8531718
Blackwell TK, Bowerman B, Priess JR, Weintraub H.Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements.Science. 1994 Oct 28;266(5185):621-8.
7939715
Blackwell TK, Huang J, Ma A, Kretzner L, Alt FW, Eisenman RN, Weintraub H.Binding of myc proteins to canonical and noncanonical DNA sequences.Mol Cell Biol. 1993 Sep;13(9):5216-24.
8395000
Blackwell TK, Weintraub H.Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection.Science. 1990 Nov 23;250(4984):1104-10.
2174572
Blackwell TK, Kretzner L, Blackwood EM, Eisenman RN, Weintraub H.Sequence-specific DNA binding by the c-Myc protein.Science. 1990 Nov 23;250(4984):1149-51.
2251503
Blackwell TK, Moore MW, Yancopoulos GD, Suh H, Lutzker S, Selsing E, Alt FW.Recombination between immunoglobulin variable region gene segments is enhanced by transcription.Nature. 1986 Dec 11-17;324(6097):585-9.
3491327

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Keith Blackwell, MD, PhD Publications Wang J, Robida-Stubbs S, Tullet JM, Rual JF, Vidal M, Blackwell TK.RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition.PLoS Genet. 2010;6(8). 20700440 Abate JP, Blackwell TK.Life is short, if sweet.Cell Metab. 2009 Nov;10(5):338-9. 19883611 Oliveira RP, Abate JP, Dilks K, Landis J, Ashraf J, Murphy CT, Blackwell TK.Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.Aging Cell. 2009 Sep;8(5):524-41. 19575768 Hammell CM,Lubin I,Boag PR,Blackwell TK,Ambros V.nhl-2 Modulates microRNA activity in Caenorhabditis elegans.Cell. 2009 Mar 6;136(5):926-38. 19269369 Olahova M,Taylor SR,Khazaipoul S,Wang J,Morgan BA,Matsumoto K,Blackwell TK,Veal EA.A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance.Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):198 19064914 Blackwell TK,Walker AK.OMA-gosh, where's that TAF?.Cell. 2008 Oct 3;135(1):18-20. 18854150 Gartner A,Boag PR,Blackwell TK.Germline survival and apoptosis.WormBook. 2008:1-20. Review. 18781708 Boag PR,Atalay A,Robida S,Reinke V,Blackwell TK.Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis.J Cell Biol. 2008 Aug 11;182(3):543-57. 18695045 Gartner A, Boag RP, Blackwell TK.Germ cell survival and apoptosis.Wormbook, the C. elegans Research Community.. Tullet JM,Hertweck M,An JH,Baker J,Hwang JY,Liu S,Oliveira RP,Baumeister R,Blackwell TK.Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.Cell. 2008 Mar 21;132(6):1025-38. 18358814 Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, Blackwell TK.Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.Cell.;132:915-6. Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villén J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A.A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.Cell. 2006 Jun 2;125(5):987-1001. 16751106 An JH, Vranas K, Lucke M, Inoue H, Hisamoto N, Matsumoto K, Blackwell TK.Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3.Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16275-80. 16251270 Boag PR, Nakamura A, Blackwell TK.A conserved RNA-protein complex component involved in physiological germline apoptosis regulation in C. elegans.Development. 2005 Nov;132(22):4975-86. 16221731 Inoue H, Hisamoto N, An JH, Oliveira RP, Nishida E, Blackwell TK, Matsumoto K.The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response.Genes Dev. 2005 Oct 1;19(19):2278-83. 16166371 Navarro RE, Blackwell TK.Requirement for P granules and meiosis for accumulation of the germline RNA helicase CGH-1.Genesis. 2005 Jul;42(3):172-80. 15986473 Wang JC, Walker A, Blackwell TK, Yamamoto KR.The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis.J Biol Chem. 2004 Jul 9;279(28):29270-7. 15073178 Blackwell TK.Germ cells: finding programs of mass repression.Curr Biol. 2004 Mar 23;14(6):R229-30. 15043831 Stoecklin G, Stubbs T, Kedersha N, Wax S, Rigby WF, Blackwell TK, Anderson P.MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay.EMBO J. 2004 Mar 24;23(6):1313-1324. 15014438 Walker AK, Shi Y, Blackwell TK.An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription.J Biol Chem. 2004 Apr 9;279(15):15339-47. 14726532 Blackwell TK, Walker AK.Transcription elongation: TLKing to chromatin?.Curr Biol. 2003 Dec 2;13(23):R915-6. 14654017 Shi Y, Blackwell TK.A two-tiered transcription regulation mechanism that protects germ cell identity.Mol Cell. 2003 Nov;12(5):1062-4. 14636565 An JH, Blackwell TK.SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response.Genes Dev. 2003 Aug 1;17(15):1882-93. 12869585 Zhang F, Barboric M, Blackwell TK, Peterlin BM.A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb.Genes Dev. 2003 Mar 15;17(6):748-58. 12651893 Takagi T, Walker AK, Sawa C, Diehn F, Takase Y, Blackwell TK, Buratowski S.The Caenorhabditis elegans mRNA 5'-capping enzyme. In vitro and in vivo characterization.J Biol Chem. 2003 Apr 18;278(16):14174-84. 12576476 Walker AK, Blackwell TK.A broad but restricted requirement for TAF-5 (human TAFII100) for embryonic transcription in Caenorhabditis elegans.J Biol Chem. 2003 Feb 21;278(8):6181-6. 12458202 Shim EY, Walker AK, Shi Y, Blackwell TK.CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo.Genes Dev. 2002 Aug 15;16(16):2135-46. 12183367 Shim EY, Walker AK, Blackwell TK.Broad requirement for the mediator subunit RGR-1 for transcription in the Caenorhabditis elegans embryo.J Biol Chem. 2002 Aug 23;277(34):30413-6. 12089139 Johnson BA, Blackwell TK.Multiple tristetraprolin sequence domains required to induce apoptosis and modulate responses to TNFalpha through distinct pathways.Oncogene. 2002 Jun 20;21(27):4237-46. 12082611 Blackwell TK, Walker AK.Getting the right dose of repression.Genes Dev. 2002 Apr 1;16(7):769-72. 11937484 Johnson BA, Stehn JR, Yaffe MB, Blackwell TK.Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms.J Biol Chem. 2002 May 17;277(20):18029-36. 11886850 Walker AK, Rothman JH, Shi Y, Blackwell TK.Distinct requirements for C.elegans TAF(II)s in early embryonic transcription.EMBO J. 2001 Sep 17;20(18):5269-79. 11566890 Navarro RE, Shim EY, Kohara Y, Singson A, Blackwell TK.cgh-1, a conserved predicted RNA helicase required for gametogenesis and protection from physiological germline apoptosis in C. elegans.Development. 2001 Sep;128(17):3221-32. 11546739 Walker AK, See R, Batchelder C, Kophengnavong T, Gronniger JT, Shi Y, Blackwell TK.A conserved transcription motif suggesting functional parallels between Caenorhabditis elegans SKN-1 and Cap'n'Collar-related basic leucine zipper proteins.J Biol 10764775 Johnson BA, Geha M, Blackwell TK.Similar but distinct effects of the tristetraprolin/TIS11 immediate-early proteins on cell survival.Oncogene. 2000 Mar 23;19(13):1657-64. 10763822 Kophengnavong T, Michnowicz JE, Blackwell TK.Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations.Mol Cell Biol. 2000 Jan;20(1):261-72. 10594029 Kophengnavong T, Carroll AS, Blackwell TK.The SKN-1 amino-terminal arm is a DNA specificity segment.Mol Cell Biol. 1999 Apr;19(4):3039-50. 10082571 De J, Lai WS, Thorn JM, Goldsworthy SM, Liu X, Blackwell TK, Blackshear PJ.Identification of four CCCH zinc finger proteins in Xenopus, including a novel vertebrate protein with four zinc fingers and severely restricted expression.Gene. 1999 Mar 4;228(1-2 10072766 Batchelder C, Dunn MA, Choy B, Suh Y, Cassie C, Shim EY, Shin TH, Mello C, Seydoux G, Blackwell TK.Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1.Genes Dev. 1999 Jan 15;13(2):202-12. 9925644 Carroll AS, Gilbert DE, Liu X, Cheung JW, Michnowicz JE, Wagner G, Ellenberger TE, Blackwell TK.SKN-1 domain folding and basic region monomer stabilization upon DNA binding.Genes Dev. 1997 Sep 1;11(17):2227-38. 9303538 Huang J, Blackwell TK, Kedes L, Weintraub H.Differences between MyoD DNA binding and activation site requirements revealed by functional random sequence selection.Mol Cell Biol. 1996 Jul;16(7):3893-900. 8668207 Blackwell TK.Selection of protein binding sites from random nucleic acid sequences.Methods Enzymol. 1995;254:604-18. 8531718 Blackwell TK, Bowerman B, Priess JR, Weintraub H.Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements.Science. 1994 Oct 28;266(5185):621-8. 7939715 Blackwell TK, Huang J, Ma A, Kretzner L, Alt FW, Eisenman RN, Weintraub H.Binding of myc proteins to canonical and noncanonical DNA sequences.Mol Cell Biol. 1993 Sep;13(9):5216-24. 8395000 Blackwell TK, Weintraub H.Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection.Science. 1990 Nov 23;250(4984):1104-10. 2174572 Blackwell TK, Kretzner L, Blackwood EM, Eisenman RN, Weintraub H.Sequence-specific DNA binding by the c-Myc protein.Science. 1990 Nov 23;250(4984):1149-51. 2251503 Blackwell TK, Moore MW, Yancopoulos GD, Suh H, Lutzker S, Selsing E, Alt FW.Recombination between immunoglobulin variable region gene segments is enhanced by transcription.Nature. 1986 Dec 11-17;324(6097):585-9. 3491327
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