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Omid C. Farokhzad, MD

Publications

  • Shi J, Xu Y, Xu X, Zhu X, Pridgen E, Wu J, Votruba AR, Archana S, Zetter BR, Farokhzad OC.Hybrid lipid-polymer nanoparticles for sustained siRNA delivery and gene silencing.Nanomedicine : Nanotechnology, Biology, And Medicine. 2014 Mar 17.
    24650883
  • Gadde S, Even-Or O, Kamaly N, Hasija A, Gagnon PG, Adusumilli KH, Erakovic A, Pal AK, Zhang XQ, Kolishetti N, Shi J, Fisher EA, Farokhzad OC.Development of Therapeutic Polymeric Nanoparticles for the Resolution of Inflammation.Adv Healthc Mater. 2014 Mar 24.
    24659608
  • Ilyinskii PO, Roy CJ, O'Neil CP, Browning EA, Pittet LA, Altreuter DH, Alexis F, Tonti E, Shi J, Basto PA, Iannacone M, Radovic-Moreno AF, Langer RS, Farokhzad OC, von Andrian UH, Johnston LP, Kishimoto TK.Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release.Vaccine. 2014 Mar 1.
    24593999
  • Lim JM, Bertrand N, Valencia PM, Rhee M, Langer R, Jon S, Farokhzad OC, Karnik R.Parallel microfluidic synthesis of size-tunable polymeric nanoparticles using 3D flow focusing towards in vivo study.Nanomedicine : Nanotechnology, Biology, And Medicine. 2014 Feb;10(2):401-9.
    23969105
  • Valencia PM, Pridgen EM, Rhee M, Langer R, Farokhzad OC, Karnik R.Microfluidic platform for combinatorial synthesis and optimization of targeted nanoparticles for cancer therapy.ACS Nano. 2013 Dec 23;7(12):10671-80.
    24215426
  • Pridgen EM, Alexis F, Kuo TT, Levy-Nissenbaum E, Karnik R, Blumberg RS, Langer R, Farokhzad OC.Transepithelial transport of Fc-targeted nanoparticles by the neonatal fc receptor for oral delivery.Sci Transl Med. 2013 Nov 27;5(213):213ra167.
    24285486
  • Kim Y, Fay F, Cormode DP, Sanchez-Gaytan BL, Tang J, Hennessy EJ, Ma M, Moore K, Farokhzad OC, Fisher EA, Mulder WJ, Langer R, Fayad ZA.Single step reconstitution of multifunctional high-density lipoprotein-derived nanomaterials using microfluidics.ACS Nano. 2013 Nov 26;7(11):9975-83.
    24079940
  • Xu X, Xie K, Zhang XQ, Pridgen EM, Park GY, Cui DS, Shi J, Wu J, Kantoff PW, Lippard SJ, Langer R, Walker GC, Farokhzad OC.Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug.Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18638-43.
    24167294
  • Mieszawska AJ, Kim Y, Gianella A, van Rooy I, Priem B, Labarre MP, Ozcan C, Cormode DP, Petrov A, Langer R, Farokhzad OC, Fayad ZA, Mulder WJ.Synthesis of polymer-lipid nanoparticles for image-guided delivery of dual modality therapy.Bioconjug Chem. 2013 Sep 18;24(9):1429-34.
    23957728
  • Johnstone TC, Kulak N, Pridgen EM, Farokhzad OC, Langer R, Lippard SJ.Nanoparticle encapsulation of mitaplatin and the effect thereof on in vivo properties.ACS Nano. 2013 Jul 23;7(7):5675-83.
    23697579
  • Prabhakar U, Maeda H, Jain RK, Sevick-Muraca EM, Zamboni W, Farokhzad OC, Barry ST, Gabizon A, Grodzinski P, Blakey DC.Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology.Cancer Res. 2013 Apr 15;73(8):2412-2417.
    23423979
  • Xiao Z, Ji C, Shi J, Pridgen EM, Frieder J, Wu J, Farokhzad OC.DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy.Angew Chem Int Ed Engl. 2012 Nov 19;51(47):11853-7.
    23081716
  • Zhao W, Cui CH, Bose S, Guo D, Shen C, Wong WP, Halvorsen K, Farokhzad OC, Teo GS, Phillips JA, Dorfman DM, Karnik R, Karp JM.Bioinspired multivalent DNA network for capture and release of cells.Proc Natl Acad Sci U S A. 2012 Nov 12.
    23150586
  • Salvador-Morales C, Valencia PM, Gao W, Karnik R, Farokhzad OC.Spontaneous Formation of Heterogeneous Patches on Polymer-Lipid Core-Shell Particle Surfaces during Self-Assembly.Small. 2012 Oct 26.
    23109494
  • Zhang XQ, Xu X, Bertrand N, Pridgen E, Swami A, Farokhzad OC.Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine.Adv Drug Deliv Rev. 2012 Oct;64(13):1363-84.
    22917779
  • Valencia PM, Pridgen EM, Perea B, Gadde S, Sweeney C, Kantoff PW, Bander NH, Lippard SJ, Langer R, Karnik R, Farokhzad OC.Synergistic cytotoxicity of irinotecan and cisplatin in dual-drug targeted polymeric nanoparticles.Nanomed. 2012 Oct 17.
    23075285
  • Farokhzad OC.Using ligands to target cancer cells.Clin Adv Hematol Oncol. 2012 Aug;10(8):543-4.
    23073055
  • Valencia PM, Farokhzad OC, Karnik R, Langer R.Microfluidic technologies for accelerating the clinical translation of nanoparticles.Nat Nanotechnol. 2012 Oct 8;7(10):623-9.
    23042546
  • Kim Y, Lee Chung B, Ma M, Mulder WJ, Fayad ZA, Farokhzad OC, Langer R.Mass production and size control of lipid-polymer hybrid nanoparticles through controlled microvortices.Nano Lett. 2012 Jul 11;12(7):3587-91.
    22716029
  • Dhar S, Kolishetti N, Lippard SJ, Farokhzad OC.Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo.Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1850-5.
    21233423
  • Gao W, Chan J, Farokhzad OC.pH-responsive Nanoparticles for Drug Delivery.Mol Pharm. 2010 Dec 6;7(6):1913-20.
    20836539
  • Kolishetti N, Dhar S, Valencia PM, Lin LQ, Karnik R, Lippard SJ, Langer R, Farokhzad OC.Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy.Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17939-44.
    20921363
  • Shi J, Votruba AR, Farokhzad OC, Langer R.Nanotechnology in drug delivery and tissue engineering: from discovery to applications.Nano Lett. 2010 Sep 8;10(9):3223-30.
    20726522
  • Gao W, Langer R, Farokhzad OC.Poly(ethylene glycol) with observable shedding.Angew Chem Int Ed Engl. 2010 Sep 3;49(37):6567-71.
    20677297
  • Wang AZ, Yuet K, Zhang L, Gu FX, Huynh-Le M, Radovic-Moreno AF, Kantoff PW, Bander NH, Langer R, Farokhzad OC.ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation.Nanomed. 2010 Apr;5(3):361-8.
    20394530
  • Gao W, Xiao Z, Radovic-Moreno A, Shi J, Langer R, Farokhzad OC.Progress in siRNA delivery using multifunctional nanoparticles.Methods Mol Biol. 2010;629:53-67. Review.
    20387142
  • Valencia PM, Basto PA, Zhang L, Rhee M, Langer R, Farokhzad OC, Karnik R.Single-Step Assembly of Homogenous Lipid-Polymeric and Lipid-Quantum Dot Nanoparticles Enabled by Microfluidic Rapid Mixing.ACS Nano. 2010 Mar 23;4(3):1671-9.
    20166699
  • Alexis F, Pridgen EM, Langer R, Farokhzad OC.Nanoparticle technologies for cancer therapy.Handb Exp Pharmacol. 2010(197):55-86. Review.
    20217526
  • Chan JM, Valencia PM, Zhang L, Langer R, Farokhzad OC.Polymeric nanoparticles for drug delivery.Methods Mol Biol. 2010;624:163-75.
    20217595
  • Mamo T, Moseman EA, Kolishetti N, Salvador-Morales C, Shi J, Kuritzkes DR, Langer R, von Andrian U, Farokhzad OC.Emerging nanotechnology approaches for HIV/AIDS treatment and prevention.Nanomed. 2010 Feb;5(2):269-85. Review.
    20148638
  • Chan JM, Zhang L, Tong R, Ghosh D, Gao W, Liao G, Yuet KP, Gray D, Rhee JW, Cheng J, Golomb G, Libby P, Langer R, Farokhzad OC.Spatiotemporal controlled delivery of nanoparticles to injured vasculature.Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2213-8.
    20133865
  • Gu F,Langer R,Farokhzad OC.Formulation/Preparation of functionalized nanoparticles for in vivo targeted drug delivery.Methods Mol Biol. 2009;544:589-98.
    19488725
  • Bassett EK,Slocum AH,Masiakos PT,Pryor HI 2nd,Farokhzad OC,Karp JM.Design of a mechanical clutch-based needle-insertion device.Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5540-5.
    19307560
  • Farokhzad OC,Langer R.Impact of nanotechnology on drug delivery.ACS Nano. 2009 Jan 27;3(1):16-20. Review.
    19206243
  • Zhang L,Chan JM,Gu FX,Rhee JW,Wang AZ,Radovic-Moreno AF,Alexis F,Langer R,Farokhzad OC.Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform.ACS Nano. 2008 Aug;2(8):1696-702.
    19206374
  • Salvador-Morales C,Gao W,Ghatalia P,Murshed F,Aizu W,Langer R,Farokhzad OC.Multifunctional nanoparticles for prostate cancer therapy.Expert Rev Anticancer Ther. 2009 Feb;9(2):211-21. Review.
    19192959
  • Salvador-Morales C,Zhang L,Langer R,Farokhzad OC.Immunocompatibility properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups.Biomaterials. 2009 Apr;30(12):2231-40.
    19167749
  • Chan JM,Zhang L,Yuet KP,Liao G,Rhee JW,Langer R,Farokhzad OC.PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery.Biomaterials. 2009 Mar;30(8):1627-34.
    19111339
  • Alexis F,Basto P,Levy-Nissenbaum E,Radovic-Moreno AF,Zhang L,Pridgen E,Wang AZ,Marein SL,Westerhof K,Molnar LK,Farokhzad OC.HER-2-targeted nanoparticle-affibody bioconjugates for cancer therapy.ChemMedChem. 2008 Dec;3(12):1839-43.
    19012296
  • Dhar S,Gu FX,Langer R,Farokhzad OC,Lippard SJ.Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles.Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17356-61.
    18978032
  • Farokhzad OC.Nanotechnology for drug delivery: the perfect partnership.Expert Opin Drug Deliv. 2008 Sep;5(9):927-9.
    18754745
  • Alexis F,Pridgen E,Molnar LK,Farokhzad OC.Factors affecting the clearance and biodistribution of polymeric nanoparticles.Mol Pharm. 2008 Jul-Aug;5(4):505-15. Review.
    18672949
  • Karnik R,Gu F,Basto P,Cannizzaro C,Dean L,Kyei-Manu W,Langer R,Farokhzad OC.Microfluidic platform for controlled synthesis of polymeric nanoparticles.Nano Lett. 2008 Sep;8(9):2906-12.
    18656990
  • Peer D,Karp JM,Hong S,Farokhzad OC,Margalit R,Langer R.Nanocarriers as an emerging platform for cancer therapy.Nat Nanotechnol. 2007 Dec;2(12):751-60.
    18654426
  • Wang AZ,Gu F,Zhang L,Chan JM,Radovic-Moreno A,Shaikh MR,Farokhzad OC.Biofunctionalized targeted nanoparticles for therapeutic applications.Expert Opin Biol Ther. 2008 Aug;8(8):1063-70. Review.
    18613759
  • Wang AZ,Bagalkot V,Vasilliou CC,Gu F,Alexis F,Zhang L,Shaikh M,Yuet K,Cima MJ,Langer R,Kantoff PW,Bander NH,Jon S,Farokhzad OC.Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy.ChemMedChem. 2008 Sep;3(9):1311-5.
    18613203
  • Levy-Nissenbaum E,Radovic-Moreno AF,Wang AZ,Langer R,Farokhzad OC.Nanotechnology and aptamers: applications in drug delivery.Trends Biotechnol. 2008 Aug;26(8):442-9. Review.
    18571753
  • Gu F, Zhang L, Teply BA, Mann N, Wang A, Radovic-Moreno AF, Langer R, Farokhzad OC.Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers.Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2586-91.
    18272481
  • Alexis F, Rhee JW, Richie JP, Radovic-Moreno AF, Langer R, Farokhzad OC.New frontiers in nanotechnology for cancer treatment.Urol Oncol. 2008 Jan-Feb;26(1):74-85. Review.
    18190835
  • Teply BA, Tong R, Jeong SY, Luther G, Sherifi I, Yim CH, Khademhosseini A, Farokhzad OC, Langer RS, Cheng J.The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules.Biomaterials. 2008 Mar;29(9):1216-23.
    18082254
  • Pridgen EM, Langer R, Farokhzad OC.Biodegradable, polymeric nanoparticle delivery systems for cancer therapy.Nanomed. 2007 Oct;2(5):669-80. Review.
    17976029
  • Zhang L, Gu FX, Chan JM, Wang AZ, Langer RS, Farokhzad OC.Nanoparticles in medicine: therapeutic applications and developments.Clin Pharmacol Ther. 2008 May;83(5):761-9.
    17957183
  • Bagalkot V, Zhang L, Levy-Nissenbaum E, Jon S, Kantoff PW, Langer R, Farokhzad OC.Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bi-fluorescence resonance energy transfer.Nano Lett. 2007 Oct;7(10):3065-70.
    17854227
  • Park H, Cannizzaro C, Vunjak-Novakovic G, Langer R, Vacanti CA, Farokhzad OC.Nanofabrication and Microfabrication of Functional Materials for Tissue Engineering.Tissue Eng. 2007 Aug;13(8):1867-77. Review.
    17518744
  • Zhang L, Radovic-Moreno AF, Alexis F, Gu FX, Basto PA, Bagalkot V, Jon S, Langer RS, Farokhzad OC.Co-delivery of hydrophobic and hydrophilic drugs from nanoparticle-aptamer bioconjugates.ChemMedChem. 2007 Sep;2(9):1268-71.
    17600796
  • Bagalkot V, Farokhzad OC, Langer R, Jon S.An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform.Angew Chem Int Ed Engl. 2006 Dec 11;45(48):8149-52.
    17099918
  • Farokhzad OC, Langer R.Nanomedicine: developing smarter therapeutic and diagnostic modalities.Adv Drug Deliv Rev. 2006 Dec 1;58(14):1456-9. Review.
    17070960
  • Cheng J, Teply BA, Sherifi I, Sung J, Luther G, Gu FX, Levy-Nissenbaum E, Radovic-Moreno AF, Langer R, Farokhzad OC.Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery.Biomaterials. 2007 Feb;28(5):869-76.
    17055572
  • Farokhzad OC, Dimitrakov JD, Karp JM, Khademhosseini A, Freeman MR, Langer R.Drug delivery systems in urology--getting "smarter".Urology. 2006 Sep;68(3):463-9. Review.
    17010721
  • Farokhzad OC, Karp JM, Langer R.Nanoparticle-aptamer bioconjugates for cancer targeting.Expert Opin Drug Deliv. 2006 May;3(3):311-24. Review.
    16640493
  • Farokhzad OC, Cheng J, Teply BA, Sherifi I, Jon S, Kantoff PW, Richie JP, Langer R.Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo.Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6315-20.
    16606824
  • Cheng J, Teply BA, Jeong SY, Yim CH, Ho D, Sherifi I, Jon S, Farokhzad OC, Khademhosseini A, Langer RS.Magnetically responsive polymeric microparticles for oral delivery of protein drugs.Pharm Res. 2006 Mar;23(3):557-64.
    16388405
  • Khademhosseini A, Yeh J, Eng G, Karp J, Kaji H, Borenstein J, Farokhzad OC, Langer R.Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays.Lab Chip. 2005 Dec;5(12):1380-6.
    16286969
  • Fukuda J, Khademhosseini A, Yeh J, Eng G, Cheng J, Farokhzad OC, Langer R.Micropatterned cell co-cultures using layer-by-layer deposition of extracellular matrix components.Biomaterials. 2006 Mar;27(8):1479-86.
    16242769
  • Farokhzad OC, Khademhosseini A, Jon S, Hermmann A, Cheng J, Chin C, Kiselyuk A, Teply B, Eng G, Langer R.Microfluidic system for studying the interaction of nanoparticles and microparticles with cells.Anal Chem. 2005 Sep 1;77(17):5453-9.
    16131052
  • Farokhzad OC, Jon S, Khademhosseini A, Tran TN, Lavan DA, Langer R.Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells.Cancer Res. 2004 Nov 1;64(21):7668-72.
    15520166
  • Nicolaou F, Teodoridis JM, Park H, Georgakis A, Farokhzad OC, Böttinger EP, Da Silva N, Rousselot P, Chomienne C, Ferenczi K, Arnaout MA, Shelley CS.CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD.Blood. 2003 May 15;101(10):4033-41.
    12576324
  • Shelley CS, Teodoridis JM, Park H, Farokhzad OC, Böttinger EP, Arnaout MA.During differentiation of the monocytic cell line U937, Pur alpha mediates induction of the CD11c beta 2 integrin gene promoter.J Immunol. 2002 Apr 15;168(8):3887-93.
    11937543
  • Song JC, Hanson CM, Tsai V, Farokhzad OC, Lotz M, Matthews JB.Regulation of epithelial transport and barrier function by distinct protein kinase C isoforms.Am J Physiol Cell Physiol. 2001 Aug;281(2):C649-61.
    11443064
  • Farokhzad OC, Teodoridis JM, Park H, Arnaout MA, Shelley CS.CD43 gene expression is mediated by a nuclear factor which binds pyrimidine-rich single-stranded DNA.Nucleic Acids Res. 2000 Jun 1;28(11):2256-67.
    10871347
  • Song JC, Hrnjez BJ, Farokhzad OC, Matthews JB.PKC-epsilon regulates basolateral endocytosis in human T84 intestinal epithelia: role of F-actin and MARCKS.Am J Physiol. 1999 Dec;277(6 Pt 1):C1239-49.
    10600776
  • Farokhzad OC, Sagar GD, Mun EC, Sicklick JK, Lotz M, Smith JA, Song JC, O'Brien TC, Sharma CP, Kinane TB, Hodin RA, Matthews JB.Protein kinase C activation downregulates the expression and function of the basolateral Na+/K+/2Cl(-) cotransporter.J Cell Physiol. 1999 Dec;181(3):489-98.
    10528235
  • Farokhzad OC, Mun EC, Sicklick JK, Smith JA, Matthews JB.Effects of bryostatin 1, a novel anticancer agent, on intestinal transport and barrier function: role of protein kinase C.Surgery. 1998 Aug;124(2):380-6; discussion 386-7.
    9706162
  • Mun EC, Mayol JM, Riegler M, O'Brien TC, Farokhzad OC, Song JC, Pothoulakis C, Hrnjez BJ, Matthews JB.Levamisole inhibits intestinal Cl- secretion via basolateral K+ channel blockade.Gastroenterology. 1998 Jun;114(6):1257-67.
    9609763
  • Farokhzad OC, Shelley CS, Arnaout MA.Induction of the CD11b gene during activation of the monocytic cell line U937 requires a novel nuclear factor MS-2.J Immunol. 1996 Dec 15;157(12):5597-605.
    8955212
  • Böttinger EP, Shelley CS, Farokhzad OC, Arnaout MA.The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements.Mol Cell Biol. 1994 Apr;14(4):2604-15.
    7511209
  • Shelley CS, Farokhzad OC, Arnaout MA.Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene.Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5364-8.
    8099450