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Chin-Lee Wu, MD, PhD

Publications

  • Wirth GJ, Psutka SP, Chapin BF, Wu S, Wu CL, Dahl DM.Midterm oncological outcomes of laparoscopic vs open radical prostatectomy (RP).BJU Int. 2013 Apr 19.
    23601185
  • Tse JY, Wu S, Shinagare SA, Lauwers GY, Yilmaz O, Wu CL, Deshpande V.Peutz-Jeghers syndrome: a critical look at colonic Peutz-Jeghers polyps.Mod Pathol. 2013 Apr 19.
    23599156
  • Chekaluk Y, Wu CL, Rosenberg J, Riester M, Dai Q, Lin S, Guo Y, McDougal WS, Kwiatkowski DJ.Identification of nine genomic regions of amplification in urothelial carcinoma, correlation with stage, and potential prognostic and therapeutic value.PLoS ONE. 2013;8(4):e60927.
    23593348
  • Guo Y, Chekaluk Y, Zhang J, Du J, Gray NS, Wu CL, Kwiatkowski DJ.TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.J Pathol. 2013 May;230(1):17-27.
    23401075
  • Wu CL, Schroeder BE, Ma XJ, Cutie CJ, Wu S, Salunga R, Zhang Y, Kattan MW, Schnabel CA, Erlander MG, McDougal WS.Development and validation of a 32-gene prognostic index for prostate cancer progression.Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6121-6.
    23533275
  • Miyamoto DT, Lee RJ, Stott SL, Ting DT, Wittner BS, Ulman M, Smas ME, Lord JB, Brannigan BW, Trautwein J, Bander NH, Wu CL, Sequist LV, Smith MR, Ramaswamy S, Toner M, Maheswaran S, Haber DA.Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer.Cancer Discovery. 2012 Nov;2(11):995-1003.
    23093251
  • Zhong WD, Qin GQ, Dai QS, Han ZD, Chen SM, Ling XH, Fu X, Cai C, Chen JH, Chen XB, Lin ZY, Deng YH, Wu SL, He HC, Wu CL.SOXs in human prostate cancer: implication as progression and prognosis factors.BMC Cancer. 2012;12:248.
    22703285
  • Aizer AA, Paly JJ, Zietman AL, Nguyen PL, Beard CJ, Rao SK, Kaplan ID, Niemierko A, Hirsch MS, Wu CL, Olumi AF, Michaelson MD, D'Amico AV, Efstathiou JA.Multidisciplinary care and pursuit of active surveillance in low-risk prostate cancer.J Clin Oncol. 2012 Sep 1;30(25):3071-6.
    22851571
  • Li X, Wan L, Geng J, Wu CL, Bai X.Aldehyde dehydrogenase 1A1 possesses stem-like properties and predicts lung cancer patient outcome.J Thorac Oncol. 2012 Aug;7(8):1235-45.
    22617249
  • Lu J, Wirth GJ, Wu S, Chen J, Dahl DM, Olumi AF, Young RH, McDougal WS, Wu CL.A close surgical margin after radical prostatectomy is an independent predictor of recurrence.J Urol. 2012 Jul;188(1):91-7.
    22578729
  • Psutka SP, Feldman AS, Rodin D, Olumi AF, Wu CL, McDougal WS.Men With Organ-confined Prostate Cancer and Positive Surgical Margins Develop Biochemical Failure at a Similar Rate to Men With Extracapsular Extension.Urology. 2011 Mar 14.
    21411125
  • Zhong WD, Liang YX, Lin SX, Li L, He HC, Bi XC, Han ZD, Dai QS, Ye YK, Chen QB, Wang YS, Zeng GH, Zhu G, Zhang Z, Chen ZN, Wu CL.Expression of CD147 is associated with prostate cancer progression.Int J Cancer. 2011 Feb 15.
    21328337
  • Kaufman DS, Zietman AL, Dahl DM, Harisinghani MG, Wu CL.Case records of the Massachusetts General Hospital. Case 5-2011. A 65-year-old man with hematuria after treatment for prostate cancer.N Engl J Med. 2011 Feb 17;364(7):667-75.
    21323545
  • Niu Y, Ge R, Hu L, Diaz C, Wang Z, Wu CL, Olumi AF.Reduced levels of 5-α reductase 2 in adult prostate tissue and implications for BPH therapy.Prostate. 2011 Feb 9.
    21308715
  • Kaul D, Wu CL, Adkins CB, Jordan KW, Defeo EM, Habbel P, Peterson RT, McDougal WS, Pohl U, Cheng LL.Assessing prostate cancer growth with mRNA of spermine metabolic enzymes.Cancer Biol Ther. 2010 May;9(9):736-42.
    20215859
  • Leung YK, Lam HM, Wu S, Song D, Levin L, Cheng L, Wu CL, Ho SM.Estrogen receptor {beta}2 and {beta}5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion.Endocr. Relat. Cancer. 2010;17(3):675-689.
    20501637
  • Passer BJ, Cheema T, Zhou B, Wakimoto H, Zaupa C, Razmjoo M, Sarte J, Wu S, Wu CL, Noah JW, Li Q, Buolamwini JK, Yen Y, Rabkin SD, Martuza RL.Identification of the ENT1 antagonists dipyridamole and dilazep as amplifiers of oncolytic herpes simplex virus-1 replication.Cancer Res. 2010 May 15;70(10):3890-5.
    20424118
  • Stott SL, Lee RJ, Nagrath S, Yu M, Miyamoto DT, Ulkus L, Inserra EJ, Ulman M, Springer S, Nakamura Z, Moore AL, Tsukrov DI, Kempner ME, Dahl DM, Wu CL, Iafrate AJ, Smith MR, Tompkins RG, Sequist LV, Toner M, Haber DA, Maheswaran S.Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer.Sci Transl Med. 2010 Mar 31;2(25):25ra23.
    20424012
  • Maxeiner A, Adkins CB, Zhang Y, Taupitz M, Halpern EF, McDougal WS, Wu CL, Cheng LL.Retrospective analysis of prostate cancer recurrence potential with tissue metabolomic profiles.Prostate. 2010 May 15;70(7):710-7.
    20017167
  • Wu CL, Jordan KW, Ratai EM, Sheng J, Adkins CB, Defeo EM, Jenkins BG, Ying L, McDougal WS, Cheng LL.Metabolomic imaging for human prostate cancer detection.Sci Transl Med. 2010 Jan 27;2(16):16ra8.
    20371475
  • McMahon GT, Blake MA, Wu CL.Case records of the Massachusetts General Hospital. Case 1-2010. A 75-year-old man with hypertension, hyperglycemia, and edema.N Engl J Med. 2010 Jan 14;362(2):156-66.
    20071706
  • Wilbur DC, Madi K, Colvin RB, Duncan LM, Faquin WC, Ferry JA, Frosch MP, Houser SL, Kradin RL, Lauwers GY, Louis DN, Mark EJ, Mino-Kenudson M, Misdraji J, Nielsen GP, Pitman MB, Rosenberg AE, Smith RN, Sohani AR, Stone JR, Tambouret RH, Wu CL, Young RH, Zembowicz A, Klietmann W.Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations.Arch Pathol Lab Med. 2009 Dec;133(12):1949-53.
    19961250
  • Kubota K, Anjum R, Yu Y, Kunz RC, Andersen JN, Kraus M, Keilhack H, Nagashima K, Krauss S, Paweletz C, Hendrickson RC, Feldman AS, Wu CL, Rush J, Villén J, Gygi SP.Sensitive multiplexed analysis of kinase activities and activity-based kinase identification.Nat Biotechnol. 2009 Oct;27(10):933-40.
    19801977
  • Kaufman DS, McDougal WS, Harisinghani MG, Wu CL.Case records of the Massachusetts General Hospital. Case 30-2009. A 77-year-old man with recurrent transitional-cell carcinoma of the ureter.N Engl J Med. 2009 Sep 24;361(13):1292-9.
    19776411
  • Huang J, Wu S, Wu CL, Manning BD.Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors.Cancer Res. 2009 Aug 1;69(15):6107-14.
    19602587
  • Zhang HH, Huang J, Düvel K, Boback B, Wu S, Squillace RM, Wu CL, Manning BD.Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.PLoS ONE. 2009;4(7):e6189.
    19593385
  • Shackelford DB, Vasquez DS, Corbeil J, Wu S, Leblanc M, Wu CL, Vera DR, Shaw RJ.mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11137-42.
    19541609
  • Goel HL, Moro L, Murphy-Ullrich JE, Hsieh CC, Wu CL, Jiang Z, Languino LR.Beta1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1.Cancer Res. 2009 Jul 1;69(13):5374-82.
    19549894
  • Feldman AS,Banyard J,Wu CL,McDougal WS,Zetter BR.Cystatin B as a tissue and urinary biomarker of bladder cancer recurrence and disease progression.Clin Cancer Res. 2009 Feb 1;15(3):1024-31.
    19188175
  • Jiang Z,Chu PG,Woda BA,Liu Q,Balaji KC,Rock KL,Wu CL.Combination of quantitative IMP3 and tumor stage: a new system to predict metastasis for patients with localized renal cell carcinomas.Clin Cancer Res. 2008 Sep 1;14(17):5579-84.
    18765551
  • Jiang Z, Lohse CM, Chu PG, Wu CL, Woda BA, Rock KL, Kwon ED.Oncofetal protein IMP3: a novel molecular marker that predicts metastasis of papillary and chromophobe renal cell carcinomas.Cancer. 2008 Jun 15;112(12):2676-82.
    18412154
  • Zhang H,Zhang Y,Duan HO,Kirley SD,Lin SX,McDougal WS,Xiao H,Wu CL.TIP30 is associated with progression and metastasis of prostate cancer.Int J Cancer. 2008 Aug 15;123(4):810-6.
    18528861
  • Barry MJ,Kaufman DS,Wu CL.Case records of the Massachusetts General Hospital. Case 15-2008. A 55-year-old man with an elevated prostate-specific antigen level and early-stage prostate cancer.N Engl J Med. 2008 May 15;358(20):2161-8.
    18480209
  • Coston WM, Loera S, Lau SK, Ishizawa S, Jiang Z, Wu CL, Yen Y, Weiss LM, Chu PG.Distinction of hepatocellular carcinoma from benign hepatic mimickers using Glypican-3 and CD34 immunohistochemistry.Am J Surg Pathol. 2008 Mar;32(3):433-44.
    18300806
  • Li W, Wu CL, Febbo PG, Olumi AF.Stromally expressed c-Jun regulates proliferation of prostate epithelial cells.Am J Pathol. 2007 Oct;171(4):1189-98.
    17702894
  • Dahl DM, He W, Lazarus R, McDougal WS, Wu CL.Pathologic outcome of laparoscopic and open radical prostatectomy.Urology. 2006 Dec;68(6):1253-6.
    17141845
  • Jiang Z, Chu PG, Woda BA, Rock KL, Liu Q, Hsieh CC, Li C, Chen W, Duan HO, McDougal S, Wu CL.Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study.Lancet Oncol. 2006 Jul;7(7):556-64.
    16814207
  • Zhang H, Duan HO, Kirley SD, Zukerberg LR, Wu CL.Aberrant splicing of cables gene, a CDK regulator, in human cancers.Cancer Biol Ther. 2005 Nov;4(11):1211-5.
    16177568
  • Burns MA, Taylor JL, Wu CL, Zepeda AG, Bielecki A, Cory D, Cheng LL.Reduction of spinning sidebands in proton NMR of human prostate tissue with slow high-resolution magic angle spinning.Magn Reson Med. 2005 Jul;54(1):34-42.
    15968646
  • Kohane DS, Ingelfinger JR, Nimkin K, Wu CL.Case records of the Massachusetts General Hospital. Case 16-2005. A nine-year-old girl with headaches and hypertension.N Engl J Med. 2005 May 26;352(21):2223-31.
    15917388
  • Chakravarti A, Winter K, Wu CL, Kaufman D, Hammond E, Parliament M, Tester W, Hagan M, Grignon D, Heney N, Pollack A, Sandler H, Shipley W.Expression of the epidermal growth factor receptor and Her-2 are predictors of favorable outcome and reduced complete response rates, respectively, in patients with muscle-invading bladder cancers treated by concurrent radiation and cisplatin-based chemot.Int J Radiat Oncol Biol Phys. 2005 Jun 1;62(2):309-17.
    15890569
  • Cheng LL, Burns MA, Taylor JL, He W, Halpern EF, McDougal WS, Wu CL.Metabolic characterization of human prostate cancer with tissue magnetic resonance spectroscopy.Cancer Res. 2005 Apr 15;65(8):3030-4.
    15833828
  • Dluhy RG, Maher MM, Wu CL.Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 7-2005. A 59-year-old woman with an incidentally discovered adrenal nodule.N Engl J Med. 2005 Mar 10;352(10):1025-32.
    15758014
  • Han WK, Alinani A, Wu CL, Michaelson D, Loda M, McGovern FJ, Thadhani R, Bonventre JV.Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma.J Am Soc Nephrol. 2005 Apr;16(4):1126-34.
    15744000
  • Burns MA, He W, Wu CL, Cheng LL.Quantitative pathology in tissue MR spectroscopy based human prostate metabolomics.Technol Cancer Res Treat. 2004 Dec;3(6):591-8.
    15560717
  • Jiang Z, Wu CL, Woda BA, Iczkowski KA, Chu PG, Tretiakova MS, Young RH, Weiss LM, Blute RD, Brendler CB, Krausz T, Xu JC, Rock KL, Amin MB, Yang XJ.Alpha-methylacyl-CoA racemase: a multi-institutional study of a new prostate cancer marker.Histopathology. 2004 Sep;45(3):218-25.
    15330799
  • Jiang Z, Woda BA, Wu CL, Yang XJ.Discovery and clinical application of a novel prostate cancer marker: alpha-methylacyl CoA racemase (P504S).Am J Clin Pathol. 2004 Aug;122(2):275-89.
    15323145
  • Wu CL, Yang XJ, Tretiakova M, Patton KT, Halpern EF, Woda BA, Young RH, Jiang Z.Analysis of alpha-methylacyl-CoA racemase (P504S) expression in high-grade prostatic intraepithelial neoplasia.Hum Pathol. 2004 Aug;35(8):1008-13.
    15297968
  • Taylor JL, Wu CL, Cory D, Gonzalez RG, Bielecki A, Cheng LL.High-resolution magic angle spinning proton NMR analysis of human prostate tissue with slow spinning rates.Magn Reson Med. 2003 Sep;50(3):627-32.
    12939772