DF/HCC Program Affiliation

Research Abstract

Publications

• Hu CK, Coughlin M, Field CM, Mitchison TJ.Cell polarization during monopolar cytokinesis.J Cell Biol 2008 Apr 21;181(2):195-202.
  18411311
• Niethammer P, Kueh HY, Mitchison TJ.Spatial patterning of metabolism by mitochondria, oxygen, and energy sinks in a model cytoplasm.Curr Biol 2008 Apr 22;18(8):586-91.
  18406136
• Mitchison TJ, Charras GT, Mahadevan L.Implications of a poroelastic cytoplasm for the dynamics of animal cell shape.Semin Cell Dev Biol 2008 Jun;19(3):215-23.
  18395478
• Salic A, Mitchison TJ.A chemical method for fast and sensitive detection of DNA synthesis in vivo.Proc Natl Acad Sci U S A 2008 Feb 19;105(7):2415-20.
  18272492
• Galkin VE, Orlova A, Brieher W, Kueh HY, Mitchison TJ, Egelman EH.Coronin-1A stabilizes F-actin by bridging adjacent actin protomers and stapling opposite strands of the actin filament.J Mol Biol 2008 Feb 22;376(3):607-13.
  18177666
• Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA, Labow M, Jenkins JL, Mitchison TJ, Feng Y.Integrating high-content screening and ligand-target prediction to identify mechanism of action.Nat Chem Biol 2008 Jan;4(1):59-68.
  18066055
• Irimia D, Charras G, Agrawal N, Mitchison T, Toner M.Polar stimulation and constrained cell migration in microfluidic channels.Lab Chip 2007 Dec;7(12):1783-90.
  18030401
• Charras GT, Coughlin M, Mitchison TJ, Mahadevan L.Life and times of a cellular bleb.Biophys J 2008 Mar 1;94(5):1836-53.
  17921219
• Burbank KS, Mitchison TJ, Fisher DS.Slide-and-cluster models for spindle assembly.Curr Biol 2007 Aug 21;17(16):1373-83.
  17702580
• Vrabioiu AM, Mitchison TJ.Symmetry of septin hourglass and ring structures.J Mol Biol 2007 Sep 7;372(1):37-49.
  17628594
• Ohi R, Burbank K, Liu Q, Mitchison TJ.Nonredundant functions of Kinesin-13s during meiotic spindle assembly.Curr Biol 2007 Jun 5;17(11):953-9.
  17509883
• Eggert US, Kiger AA, Richter C, Perlman ZE, Perrimon N, Mitchison TJ, Field CM.Parallel Chemical Genetic and Genome-Wide RNAi Screens Identify Cytokinesis Inhibitors and Targets.PLoS Biol 2004 Dec;2(12):e379.
  15547975
• Venkatesh N, Feng Y, DeDecker B, Yacono P, Golan D, Mitchison T, McKeon F.Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression.Proc Natl Acad Sci U S A 2004 Jun 15;101(24):8969-74.
  15184684
• Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW.A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions.Proc Natl Acad Sci U S A 2001 Sep 11;98(19):10624-9.
  11553809
• Degterev A, Lugovskoy A, Cardone M, Mulley B, Wagner G, Mitchison T, Yuan J.Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL.Nat Cell Biol 2001 Feb;3(2):173-82.
  11175750
• Kapoor TM, Mitchison TJ.Allele-specific activators and inhibitors for kinesin.Proc Natl Acad Sci U S A 1999 Aug 3;96(16):9106-11.
  10430903
• Desai A, Verma S, Mitchison TJ, Walczak CE.Kin I kinesins are microtubule-destabilizing enzymes.Cell 1999 Jan 8;96(1):69-78.
  9989498
• Frazier JA, Wong ML, Longtine MS, Pringle JR, Mann M, Mitchison TJ, Field C.Polymerization of purified yeast septins: evidence that organized filament arrays may not be required for septin function.J Cell Biol 1998 Nov 2;143(3):737-49.
  9813094
• Desai A, Mitchison TJ.Tubulin and FtsZ structures: functional and therapeutic implications.Bioessays 1998 Jul;20(7):523-7.
  9722999
• Walczak CE, Vernos I, Mitchison TJ, Karsenti E, Heald R.A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity.Curr Biol 1998 Jul 30-Aug 13;8(16):903-13.
  9707401
• Mitchison TJ, Sawin KE, Theriot JA, Gee K, Mallavarapu A.Caged fluorescent probes.Methods Enzymol 1998;291:63-78.
  9661145
• Welch MD, Rosenblatt J, Skoble J, Portnoy DA, Mitchison TJ.Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation.Science 1998 Jul 3;281(5373):105-8.
  9651243
• Desai A, Maddox PS, Mitchison TJ, Salmon ED.Anaphase A chromosome movement and poleward spindle microtubule flux occur At similar rates in Xenopus extract spindles.J Cell Biol 1998 May 4;141(3):703-13.
  9566970
• Mitchison TJ.Towards a pharmacological genetics.Chem Biol 1994 Sep;1(1):3-6.
  9383364
• Desai A, Mitchison TJ.Microtubule polymerization dynamics.Annu Rev Cell Dev Biol 1997;13:83-117.
  9442869
• Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ.The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.J Cell Biol 1997 Jul 28;138(2):375-84.
  9230079
• Rosenblatt J, Agnew BJ, Abe H, Bamburg JR, Mitchison TJ.Xenopus actin depolymerizing factor/cofilin (XAC) is responsible for the turnover of actin filaments in Listeria monocytogenes tails.J Cell Biol 1997 Mar 24;136(6):1323-32.
  9087446
• Cramer LP, Siebert M, Mitchison TJ.Identification of novel graded polarity actin filament bundles in locomoting heart fibroblasts: implications for the generation of motile force.J Cell Biol 1997 Mar 24;136(6):1287-305.
  9087444
• Walczak CE, Verma S, Mitchison TJ.XCTK2: a kinesin-related protein that promotes mitotic spindle assembly in Xenopus laevis egg extracts.J Cell Biol 1997 Feb 24;136(4):859-70.
  9049251
• Welch MD, Mallavarapu A, Rosenblatt J, Mitchison TJ.Actin dynamics in vivo.Curr Opin Cell Biol 1997 Feb;9(1):54-61.
  9013669
• Welch MD, Iwamatsu A, Mitchison TJ.Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes.Nature 1997 Jan 16;385(6613):265-9.
  9000076
• Cramer LP, Mitchison TJ.Investigation of the mechanism of retraction of the cell margin and rearward flow of nodules during mitotic cell rounding.Mol Biol Cell 1997 Jan;8(1):109-19.
  9017599
• Field CM, al-Awar O, Rosenblatt J, Wong ML, Alberts B, Mitchison TJ.A purified Drosophila septin complex forms filaments and exhibits GTPase activity.J Cell Biol 1996 May;133(3):605-16.
  8636235
• Belmont LD, Mitchison TJ.Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules.Cell 1996 Feb 23;84(4):623-31.
  8598048
• Mitchison TJ, Cramer LP.Actin-based cell motility and cell locomotion.Cell 1996 Feb 9;84(3):371-9.
  8608590
• Walczak CE, Mitchison TJ, Desai A.XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly.Cell 1996 Jan 12;84(1):37-47.
  8548824
• Cramer LP, Mitchison TJ.Myosin is involved in postmitotic cell spreading.J Cell Biol 1995 Oct;131(1):179-89.
  7559774
• Mitchison TJ.Evolution of a dynamic cytoskeleton.Philos Trans R Soc Lond B Biol Sci 1995 Sep 29;349(1329):299-304.
  8577841
• Wordeman L, Mitchison TJ.Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis.J Cell Biol 1995 Jan;128(1-2):95-104.
  7822426
• Hirano T, Mitchison TJ.A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro.Cell 1994 Nov 4;79(3):449-58.
  7954811
• Theriot JA, Rosenblatt J, Portnoy DA, Goldschmidt-Clermont PJ, Mitchison TJ.Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts.Cell 1994 Feb 11;76(3):505-17.
  8313471
• Sawin KE, Mitchison TJ.Microtubule flux in mitosis is independent of chromosomes, centrosomes, and antiparallel microtubules.Mol Biol Cell 1994 Feb;5(2):217-26.
  8019007
• Mitchison TJ.Localization of an exchangeable GTP binding site at the plus end of microtubules.Science 1993 Aug 20;261(5124):1044-7.
  8102497
• Cramer L, Mitchison TJ.Moving and stationary actin filaments are involved in spreading of postmitotic PtK2 cells.J Cell Biol 1993 Aug;122(4):833-43.
  8349733
• Mitchison TJ, Salmon ED.Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis.J Cell Biol 1992 Nov;119(3):569-82.
  1400593
• Hyman AA, Middleton K, Centola M, Mitchison TJ, Carbon J.Microtubule-motor activity of a yeast centromere-binding protein complex.Nature 1992 Oct 8;359(6395):533-6.
  1406970
• Sawin KE, LeGuellec K, Philippe M, Mitchison TJ.Mitotic spindle organization by a plus-end-directed microtubule motor.Nature 1992 Oct 8;359(6395):540-3.
  1406972
• Theriot JA, Mitchison TJ, Tilney LG, Portnoy DA.The rate of actin-based motility of intracellular Listeria monocytogenes equals the rate of actin polymerization.Nature 1992 May 21;357(6375):257-60.
  1589024
• Mitchison TJ.Self-organization of polymer-motor systems in the cytoskeleton.Philos Trans R Soc Lond B Biol Sci 1992 Apr 29;336(1276):99-106.
  1351302
• Sawin KE, Mitchison TJ, Wordeman LG.Evidence for kinesin-related proteins in the mitotic apparatus using peptide antibodies.J Cell Sci 1992 Feb;101 ( Pt 2):303-13.
  1629247
• Hirano T, Mitchison TJ.Cell cycle control of higher-order chromatin assembly around naked DNA in vitro.J Cell Biol 1991 Dec;115(6):1479-89.
  1661728
• Symons MH, Mitchison TJ.Control of actin polymerization in live and permeabilized fibroblasts.J Cell Biol 1991 Aug;114(3):503-13.
  1860882
• Theriot JA, Mitchison TJ.Actin microfilament dynamics in locomoting cells.Nature 1991 Jul 11;352(6331):126-31.
  2067574
• Hyman AA, Mitchison TJ.Two different microtubule-based motor activities with opposite polarities in kinetochores.Nature 1991 May 16;351(6323):206-11.
  2041567
• Sawin KE, Mitchison TJ.Poleward microtubule flux mitotic spindles assembled in vitro.J Cell Biol 1991 Mar;112(5):941-54.
  1999464
• Mitchison TJ.Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence.J Cell Biol 1989 Aug;109(2):637-52.
  2760109
• Mitchison TJ.Mitosis: basic concepts.Curr Opin Cell Biol 1989 Feb;1(1):67-74.
  2698210
• Kirschner MW, Mitchison T.Microtubule dynamics.Nature 1986 Dec 18-31;324(6098):621.
  3796729
• Mitchison TJ, Kirschner MW.Properties of the kinetochore in vitro. II. Microtubule capture and ATP-dependent translocation.J Cell Biol 1985 Sep;101(3):766-77.
  4030894
• Mitchison TJ, Kirschner MW.Properties of the kinetochore in vitro. I. Microtubule nucleation and tubulin binding.J Cell Biol 1985 Sep;101(3):755-65.
  4030893