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Kai W. Wucherpfennig, MD, PhD


  • Elpek KG, Cremasco V, Shen H, Harvey CJ, Wucherpfennig KW, Goldstein DR, Monach PA, Turley SJ.The tumor microenvironment shapes lineage, transcriptional, and functional diversity of infiltrating myeloid cells.Cancer Immunol Res. 2014 Jul(7):655-67.
  • Bettini ML, Guy C, Dash P, Vignali KM, Hamm DE, Dobbins J, Gagnon E, Thomas PG, Wucherpfennig KW, Vignali DA.Membrane Association of the CD3ε Signaling Domain Is Required for Optimal T Cell Development and Function.J Immunol. 2014 Jun 4.
  • Birnbaum ME, Mendoza JL, Sethi DK, Dong S, Glanville J, Dobbins J, Ozkan E, Davis MM, Wucherpfennig KW, Garcia KC.Deconstructing the Peptide-MHC Specificity of T Cell Recognition.Cell. 2014 May 22;157(5):1073-87.
  • Choudhuri K, Llodrá J, Roth EW, Tsai J, Gordo S, Wucherpfennig KW, Kam LC, Stokes DL, Dustin ML.Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.Nature. 2014 Mar 6;507(7490):118-23.
  • Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW.In vivo discovery of immunotherapy targets in the tumour microenvironment.Nature. 2014 Feb 6;506(7486):52-7.
  • Sethi DK, Gordo S, Schubert DA, Wucherpfennig KW.Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop.Nat Commun. 2013;4:2623.
  • Pos W, Sethi DK, Wucherpfennig KW.Mechanisms of peptide repertoire selection by HLA-DM.Trends Immunol. 2013 Oct;34(10):495-501. Review.
  • Harvey CJ, Wucherpfennig KW.Cracking the code of human T-cell immunity.Nat Biotechnol. 2013 Jul;31(7):609-10.
  • Reardon DA, Wucherpfennig KW, Freeman G, Wu CJ, Chiocca EA, Wen PY, Curry WT, Mitchell DA, Fecci PE, Sampson JH, Dranoff G.An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma.Expert Review Of Vaccines. 2013 Jun;12(6):597-615.
  • Pos W, Sethi DK, Call MJ, Schulze MS, Anders AK, Pyrdol J, Wucherpfennig KW.Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection.Cell. 2012 Dec 21;151(7):1557-68.
  • Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ.Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.Immunity. 2012 Aug 24;37(2):276-89.
  • Wucherpfennig KW, Sethi D.T cell receptor recognition of self and foreign antigens in the induction of autoimmunity.Semin Immunol. 2011 Apr;23(2):84-91.
  • Lv H, Havari E, Pinto S, Gottumukkala RV, Cornivelli L, Raddassi K, Matsui T, Rosenzweig A, Bronson RT, Smith R, Fletcher AL, Turley SJ, Wucherpfennig K, Kyewski B, Lipes MA.Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans.J Clin Invest. 2011 Mar 23.
  • Sethi DK, Schubert DA, Anders AK, Heroux A, Bonsor DA, Thomas CP, Sundberg EJ, Pyrdol J, Wucherpfennig KW.A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC.J Exp Med. 2011 Jan 17;208(1):91-102.
  • Anders AK, Call MJ, Schulze MS, Fowler KD, Schubert DA, Seth NP, Sundberg EJ, Wucherpfennig KW.HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide.Nat Immunol. 2011 Jan;12(1):54-61.
  • Wucherpfennig KW.The first structures of T cell receptors bound to peptide-MHC.J Immunol. 2010 Dec 1;185(11):6391-3.
  • Call ME, Wucherpfennig KW, Chou JJ.The structural basis for intramembrane assembly of an activating immunoreceptor complex.Nat Immunol. 2010 Nov;11(11):1023-9.
  • Wucherpfennig KW, Gagnon E, Call MJ, Huseby ES, Call ME.Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.Cold Spring Harb Perspect Biol. 2010 Apr 1;2(4):a005140. Review.
  • Wucherpfennig KW, Call MJ, Deng L, Mariuzza R.Structural alterations in peptide-MHC recognition by self-reactive T cell receptors.Curr Opin Immunol. 2009 Dec;21(6):590-5. Review.
  • Wucherpfennig KW, Gagnon E.Positively selecting peptides: their job does not end in the thymus.Nat Immunol. 2009 Nov;10(11):1143-4.
  • McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D, Ness JM, Tenembaum S, O'Connor KC, Viglietta V, Wong SJ, Tavakoli NP, de Seze J, Idrissova Z, Khoury SJ, Bar-Or A, Hafler DA, Banwell B, Wucherpfennig KW.Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis.J Immunol. 2009 Sep 15;183(6):4067-76.
  • Call MJ,Xing X,Cuny GD,Seth NP,Altmann DM,Fugger L,Krogsgaard M,Stein RL,Wucherpfennig KW.In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange.J Immunol. 2009 May 15;182(10):6342-52.
  • Xu C,Gagnon E,Call ME,Schnell JR,Schwieters CD,Carman CV,Chou JJ,Wucherpfennig KW.Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif.Cell. 2008 Nov 14;135(4):702-13.
  • Lu L, Ikizawa K, Hu D, Werneck MBF, Wucherpfennig KW, Cantor H.Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. .Immunity.;26(5):593-604.
  • Verginis P, McLaughlin KA, Wucherpfennig KW, von Boehmer H, Apostolou I.Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression.Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3479-84.
  • Nose H, Kubota R, Seth NP, Goon PK, Tanaka Y, Izumo S, Usuku K, Ohara Y, Wucherpfennig KW, Bangham CR, Osame M, Saito M.Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide.J Infect Dis. 2007 Dec 15;196(12):1761-72.
  • Grotenbreg GM, Nicholson MJ, Fowler KD, Wilbuer K, Octavio L, Yang M, Chakraborty AK, Ploegh HL, Wucherpfennig KW.Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association.J Biol Chem. 2007 Jul 20;282(29):21425-36.
  • Lu L, Ikizawa K, Hu D, Werneck MB, Wucherpfennig KW, Cantor H.Regulation of Activated CD4(+) T Cells by NK Cells via the Qa-1-NKG2A Inhibitory Pathway.Immunity. 2007 May;26(5):593-604.
  • Garibyan L, Lobito AA, Siegel RM, Call ME, Wucherpfennig KW, Geha RS.Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID).J Clin Invest. 2007 Jun;117(6):1550-7.
  • Wucherpfennig KW, Allen PM, Celada F, Cohen IR, De Boer R, Garcia KC, Goldstein B, Greenspan R, Hafler D, Hodgkin P, Huseby ES, Krakauer DC, Nemazee D, Perelson AS, Pinilla C, Strong RK, Sercarz EE.Polyspecificity of T cell and B cell receptor recognition.Semin Immunol. 2007 Aug;19(4):216-24. Review.
  • O'Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale RC, Freedman M, Steinman L, Buckle GJ, Kuchroo VK, Hafler DA, Wucherpfennig KW.Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein.Nat Med. 2007 Feb;13(2):211-7.
  • Feng J, Call ME, Wucherpfennig KW.The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site.PLoS Biol. 2006 May;4(5):e142.
  • Nicholson MJ, Moradi B, Seth NP, Xing X, Cuny GD, Stein RL, Wucherpfennig KW.Small molecules that enhance the catalytic efficiency of HLA-DM.J Immunol. 2006 Apr 1;176(7):4208-20.
  • Seth N, Kaufmann D, Lahey T, Rosenberg ES, Wucherpfennig KW.Expansion and contraction of HIV-specific CD4 T cells with short bursts of viremia, but physical loss of the majority of these cells with sustained viral replication.J Immunol. 2005 Nov 15;175(10):6948-58.
  • Reddy J, Waldner H, Zhang X, Illes Z, Wucherpfennig KW, Sobel RA, Kuchroo VK.Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis.J Immunol. 2005 Nov 1;175(9):5591-5.
  • Nicholson MJ, Hahn M, Wucherpfennig KW.Unusual features of self-peptide/MHC binding by autoimmune T cell receptors.Immunity. 2005 Oct;23(4):351-60.
  • O'Connor KC, Appel H, Bregoli L, Call ME, Catz I, Chan JA, Moore NH, Warren KG, Wong SJ, Hafler DA, Wucherpfennig KW.Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein.J Immunol. 2005 Aug 1;175(3):1974-82.
  • Call ME, Wucherpfennig KW.THE T CELL RECEPTOR: Critical Role of the Membrane Environment in Receptor Assembly and Function.Annu Rev Immunol. 2005;23:101-25.
  • Panoutsakopoulou V, Huster KM, McCarty N, Feinberg E, Wang R, Wucherpfennig KW, Cantor H.Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes.J Clin Invest. 2004 Apr;113(8):1218-24.
  • Maecker B, Sherr DH, Vonderheide RH, von Bergwelt-Baildon MS, Hirano N, Anderson KS, Xia Z, Butler MO, Wucherpfennig KW, O'Hara C, Cole G, Kwak SS, Ramstedt U, Tomlinson AJ, Chicz RM, Nadler LM, Schultze JL.The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells.Blood. 2003 Nov 1;102(9):3287-94.
  • Reddy J, Bettelli E, Nicholson L, Waldner H, Jang MH, Wucherpfennig KW, Kuchroo VK.Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers.J Immunol. 2003 Jan 15;170(2):870-7.
  • Belmares MP, Busch R, Wucherpfennig KW, McConnell HM, Mellins ED.Structural factors contributing to DM susceptibility of MHC class II/peptide complexes.J Immunol. 2002 Nov 1;169(9):5109-17.
  • von Bergwelt-Baildon MS, Vonderheide RH, Maecker B, Hirano N, Anderson KS, Butler MO, Xia Z, Zeng WY, Wucherpfennig KW, Nadler LM, Schultze JL.Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application.Blood. 2002 May 1;99(9):3319-25.
  • Vonderheide RH, Schultze JL, Anderson KS, Maecker B, Butler MO, Xia Z, Kuroda MJ, von Bergwelt-Baildon MS, Bedor MM, Hoar KM, Schnipper DR, Brooks MW, Letvin NL, Stephans KF, Wucherpfennig KW, Hahn WC, Nadler LM.Equivalent induction of telomerase-specific cytotoxic T lymphocytes from tumor-bearing patients and healthy individuals.Cancer Res. 2001 Dec 1;61(23):8366-70.
  • Wucherpfennig KW.Mechanisms for the induction of autoimmunity by infectious agents.J Clin Invest. 2001 Oct;108(8):1097-104.
  • Bourcier KD, Lim DG, Ding YH, Smith KJ, Wucherpfennig K, Hafler DA.Conserved CDR3 regions in T-cell receptor (TCR) CD8(+) T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: relationship of T-cell fine specificity and major histocompatibility complex/pepti.J Virol. 2001 Oct;75(20):9836-43.
  • Panoutsakopoulou V, Sanchirico ME, Huster KM, Jansson M, Granucci F, Shim DJ, Wucherpfennig KW, Cantor H.Analysis of the relationship between viral infection and autoimmune disease.Immunity. 2001 Jul;15(1):137-47.
  • Lee KH, Wucherpfennig KW, Wiley DC.Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes.Nat Immunol. 2001 Jun;2(6):501-7.
  • Wucherpfennig KW.Structural basis of molecular mimicry.J Autoimmun. 2001 May;16(3):293-302.
  • Appel H, Seth NP, Gauthier L, Wucherpfennig KW.Anergy induction by dimeric TCR ligands.J Immunol. 2001 Apr 15;166(8):5279-85.
  • Malherbe L, Filippi C, Julia V, Foucras G, Moro M, Appel H, Wucherpfennig K, Gury JC, Glaichenhaus N.Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major.Immunity. 2000 Dec;13(6):771-82.
  • Yu B, Gauthier L, Hausmann DH, Wucherpfennig KW.Binding of conserved islet peptides by human and murine MHC class II molecules associated with susceptibility to type I diabetes.Eur J Immunol. 2000 Sep;30(9):2497-506.
  • Krogsgaard M, Wucherpfennig KW, Cannella B, Hansen BE, Svejgaard A, Pyrdol J, Ditzel H, Raine C, Engberg J, Fugger L, Canella B.Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex.J Exp Med. 2000 Apr 17;191(8):1395-412.
  • Appel H, Gauthier L, Pyrdol J, Wucherpfennig KW.Kinetics of T-cell receptor binding by bivalent HLA-DR.Peptide complexes that activate antigen-specific human T-cells.J Biol Chem. 2000 Jan 7;275(1):312-21.
  • Hausmann DH, Yu B, Hausmann S, Wucherpfennig KW.pH-dependent peptide binding properties of the type I diabetes-associated I-Ag7 molecule: rapid release of CLIP at an endosomal pH.J Exp Med. 1999 Jun 7;189(11):1723-34.
  • Hausmann S, Biddison WE, Smith KJ, Ding YH, Garboczi DN, Utz U, Wiley DC, Wucherpfennig KW.Peptide recognition by two HLA-A2/Tax11-19-specific T cell clones in relationship to their MHC/peptide/TCR crystal structures.J Immunol. 1999 May 1;162(9):5389-97.
  • Fridkis-Hareli M, Neveu JM, Robinson RA, Lane WS, Gauthier L, Wucherpfennig KW, Sela M, Strominger JL.Binding motifs of copolymer 1 to multiple sclerosis- and rheumatoid arthritis-associated HLA-DR molecules.J Immunol. 1999 Apr 15;162(8):4697-704.
  • Hausmann S, Martin M, Gauthier L, Wucherpfennig KW.Structural features of autoreactive TCR that determine the degree of degeneracy in peptide recognition.J Immunol. 1999 Jan 1;162(1):338-44.
  • Smith KJ, Pyrdol J, Gauthier L, Wiley DC, Wucherpfennig KW.Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein.J Exp Med. 1998 Oct 19;188(8):1511-20.
  • Gauthier L, Smith KJ, Pyrdol J, Kalandadze A, Strominger JL, Wiley DC, Wucherpfennig KW.Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myelin basic protein.Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11828-33.
  • Eble JA, Wucherpfennig KW, Gauthier L, Dersch P, Krukonis E, Isberg RR, Hemler ME.Recombinant soluble human alpha 3 beta 1 integrin: purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner.Biochemistry. 1998 Aug 4;37(31):10945-55.
  • Liedtke W, Cannella B, Mazzaccaro RJ, Clements JM, Miller KM, Wucherpfennig KW, Gearing AJ, Raine CS.Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors.Ann Neurol. 1998 Jul;44(1):35-46.
  • Hausmann S, Wucherpfennig KW.Activation of autoreactive T cells by peptides from human pathogens.Curr Opin Immunol. 1997 Dec;9(6):831-8.
  • Warren KG, Catz I, Wucherpfennig KW.Tolerance induction to myelin basic protein by intravenous synthetic peptides containing epitope P85 VVHFFKNIVTP96 in chronic progressive multiple sclerosis.J Neurol Sci. 1997 Nov 6;152(1):31-8.
  • Wucherpfennig KW, Catz I, Hausmann S, Strominger JL, Steinman L, Warren KG.Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes.J Clin Invest. 1997 Sep 1;100(5):1114-22.
  • Kalandadze A, Galleno M, Foncerrada L, Strominger JL, Wucherpfennig KW.Expression of recombinant HLA-DR2 molecules. Replacement of the hydrophobic transmembrane region by a leucine zipper dimerization motif allows the assembly and secretion of soluble DR alpha beta heterodimers.J Biol Chem. 1996 Aug 16;271(33):20156-62.
  • Wucherpfennig KW, Hafler DA, Strominger JL.Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes.Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8896-900.
  • Wucherpfennig KW, Strominger JL.Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: a mechanism for MHC-linked susceptibility to human autoimmune diseases.J Exp Med. 1995 May 1;181(5):1597-601.
  • Wucherpfennig KW, Strominger JL.Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein.Cell. 1995 Mar 10;80(5):695-705.
  • Chung S, Wucherpfennig KW, Friedman SM, Hafler DA, Strominger JL.Functional three-domain single-chain T-cell receptors.Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12654-8.
  • Wucherpfennig KW.Autoimmunity in the central nervous system: mechanisms of antigen presentation and recognition.Clin Immunol Immunopathol. 1994 Sep;72(3):293-306.
  • Wucherpfennig KW, Zhang J, Witek C, Matsui M, Modabber Y, Ota K, Hafler DA.Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide.J Immunol. 1994 Jun 1;152(11):5581-92.
  • Wucherpfennig KW, Sette A, Southwood S, Oseroff C, Matsui M, Strominger JL, Hafler DA.Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.J Exp Med. 1994 Jan 1;179(1):279-90.
  • Wucherpfennig KW, Liao YJ, Prendergast M, Prendergast J, Hafler DA, Strominger JL.Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells.J Exp Med. 1993 Feb 1;177(2):425-32.
  • Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA.Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions.Proc Natl Acad Sci U S A. 1992 May 15;89(10):4588-92.
  • Hllsberg P, Wucherpfennig KW, Ausubel LJ, Calvo V, Bierer BE, Hafler DA.Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells.J Immunol. 1992 May 15;148(10):3256-63.
  • Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA.T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions.J Exp Med. 1992 Apr 1;175(4):993-1002.
  • Wucherpfennig KW, Hllsberg P, Richardson JH, Benjamin D, Hafler DA.T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones.Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2110-4.
  • Balk SP, Ebert EC, Blumenthal RL, McDermott FV, Wucherpfennig KW, Landau SB, Blumberg RS.Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes.Science. 1991 Sep 20;253(5026):1411-5.
  • Wucherpfennig KW, Weiner HL, Hafler DA.T-cell recognition of myelin basic protein.Immunol Today. 1991 Aug;12(8):277-82.
  • Lee SJ, Wucherpfennig KW, Brod SA, Benjamin D, Weiner HL, Hafler DA.Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis.Ann Neurol. 1991 Jan;29(1):33-40.
  • Wucherpfennig KW, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner HL, Hafler DA.Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein.Science. 1990 May 25;248(4958):1016-9.