DF/HCC Program Affiliation

Head and Neck Cancer, Leader
Translational Pharmacology and Early Therapeutic Trials

DF/HCC Associations

Member, Center Scientific Council

Research Abstract

Clinical and Translational Research Interests in Head and Neck Cancer: The Head and Neck Oncolgy Program is dedicated to improving the treatment and understanding of head and neck cancer. We are involved in numerous studies that include investigational therapy of squamous cell cancer, nasopharyngeal cancer, salivary gland tumors and other related cancers in the head and neck. Therapeutic interventions include chemotherapy, gene therapy, chemoradiotherapy, and chemoprevention in Phase I, II and III studies. We are investigating the molecular epidemiology of head and neck cancer by studying molecular corelates of susecptibility of different clinical grups to this disease. We are also investigating the role of CD40 in signal transduction in Squamous Cancer of the Head an Neck using in vivo and in vitro models.

Basic Laboratory Research Interests: The Human Monoclonal Antibody Laboratory uses human monoclonal antibodies to study and treat a variety of human diseases. Since many animal models do not accurately reflect human responses, this provides a unique opportunity understand the pathogenesis of human disease and develop new human therapeutic reagents. Our laboratory is studying a variety of human infectious disease and human cancers. We have amajor focus on the human immune response to HIV and are investigating the possible role of theses antinbodies in the control or progression of this disease. We are also studying antibody responses to Pseudomonas Aureginosa and Group B Streptococus infection. We are using our technology to study the antibody response to melanoma and prostate cancer in selected patients being treated with immunomodulatory therapies.

Publications

• Haddad RI, Wirth L, Posner MR.Integration of chemotherapy in the curative treatment of locally advanced head and neck cancer.Expert Rev Anticancer Ther 2003 Jun;3(3):331-8.
  12820776
• Wirth LJ, Haddad RI, Posner MR.Progress and perspectives in chemoprevention of head and neck cancer.Expert Rev Anticancer Ther 2003 Jun;3(3):339-55.
  12820777
• Haddad R, Tishler RB, Norris CM, Mahadevan A, Busse P, Wirth L, Goguen LA, Sullivan CA, Costello R, Case MA, Posner MR.Docetaxel, cisplatin, 5-fluorouracil (TPF)-based induction chemotherapy for head and neck cancer and the case for sequential, combined-m
  12604730
• Haddad R, Colevas AD, Tishler R, Busse P, Goguen L, Sullivan C, Norris CM, Lake-Willcutt B, Case MA, Costello R, Posner M.Docetaxel, cisplatin, and 5-fluorouracil-based induction chemotherapy in patients with locally advanced squamous cell carcinoma of th
  12518365
• Ringström E, Peters E, Hasegawa M, Posner M, Liu M, Kelsey KT.Human papillomavirus type 16 and squamous cell carcinoma of the head and neck.Clin Cancer Res 2002 Oct;8(10):3187-92.
  12374687
• Posner MR, Glisson B, Frenette G, Al-Sarraf M, Colevas AD, Norris CM, Seroskie JD, Shin DM, Olivares R, Garay CA.Multicenter phase I-II trial of docetaxel, cisplatin, and fluorouracil induction chemotherapy for patients with locally advanced squamous cell
  11181674
• Cavacini LA, Peterson JE, Nappi E, Duval M, Goldstein R, Mayer K, Posner MR.Minimal incidence of serum antibodies reactive with intact primary isolate virions in human immunodeficiency virus type 1-infected individuals.J Virol 1999 Nov;73(11):9638-41.
  10516076
• Posner MR, Cavacini LA, Upton MP, Tillman KC, Gornstein ER, Norris CM.Surface membrane-expressed CD40 is present on tumor cells from squamous cell cancer of the head and neck in vitro and in vivo and regulates cell growth in tumor cell lines.Clin Cancer R
  10473114
• Caglar HB, Tishler RB, Othus M, Burke E, Li Y, Goguen L, Wirth LJ, Haddad RI, Norris CM, Court LE, Aninno DJ, Posner MR, Allen AM.Dose to Larynx Predicts for Swallowing Complications After Intensity-Modulated Radiotherapy.Int J Radiat Oncol Biol Phys 2008
  18468812
• Marsit CJ, Black CC, Posner MR, Kelsey KT.A genotype-phenotype examination of cyclin D1 on risk and outcome of squamous cell carcinoma of the head and neck.Clin Cancer Res 2008 Apr 15;14(8):2371-7.
  18413827
• Duval M, Posner MR, Cavacini LA.A bispecific antibody composed of a nonneutralizing antibody to the gp41 immunodominant region and an anti-CD89 antibody directs broad human immunodeficiency virus destruction by neutrophils.J Virol 2008 May;82(9):4671-4.
  18272577
• Haddad R, Crum C, Chen Z, Krane J, Posner M, Li Y, Burk R.HPV16 transmission between a couple with HPV-related head and neck cancer.Oral Oncol 2007 Nov 29.
  18061523
• Posner MR, Haddad RI.Novel agents for the treatment of mucositis.J Support Oncol 2007 Oct;5(9 Suppl 4):33-9.
  18046996
• Wirth LJ, Posner MR.Recent advances in combined modality therapy for locally advanced head and neck cancer.Curr Cancer Drug Targets 2007 Nov;7(7):674-80.
  18045072
• Applebaum KM, Furniss CS, Zeka A, Posner MR, Smith JF, Bryan J, Eisen EA, Peters ES, McClean MD, Kelsey KT.Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer.Journal of the National Cancer Institute 2007 Dec 5;99(23):180
  18042931
• Posner MR, Hershock DM, Blajman CR, Mickiewicz E, Winquist E, Gorbounova V, Tjulandin S, Shin DM, Cullen K, Ervin TJ, Murphy BA, Raez LE, Cohen RB, Spaulding M, Tishler RB, Roth B, Viroglio Rdel C, Venkatesan V, Romanov I, Agarwala S, Harter KW, Dugan M,
  17960013
• Posner M.Evolving strategies for combined-modality therapy for locally advanced head and neck cancer.Oncologist 2007 Aug;12(8):967-74.
  17766656
• Miranda LR, Duval M, Doherty H, Seaman MS, Posner MR, Cavacini LA.The Neutralization Properties of a HIV-Specific Antibody Are Markedly Altered by Glycosylation Events Outside the Antigen-Binding Domain.J Immunol 2007 Jun 1;178(11):7132-8.
  17513762
• Chambers MS, Posner M, Jones CU, Biel MA, Hodge KM, Vitti R, Armstrong I, Yen C, Weber RS.Cevimeline for the treatment of postirradiation xerostomia in patients with head and neck cancer.Int J Radiat Oncol Biol Phys 2007 Jul 15;68(4):1102-9.
  17379432
• Furniss CS, McClean MD, Smith JF, Bryan J, Nelson HH, Peters ES, Posner MR, Clark JR, Eisen EA, Kelsey KT.Human papillomavirus 16 and head and neck squamous cell carcinoma.Int J Cancer 2007 Jun 1;120(11):2386-92.
  17315185
• Ahmed AR, Spigelman Z, Cavacini LA, Posner MR.Treatment of pemphigus vulgaris with rituximab and intravenous immune globulin.N Engl J Med 2006 Oct 26;355(17):1772-9.
  17065638
• Raut CP, Posner M, Desai J, Morgan JA, George S, Zahrieh D, Fletcher CD, Demetri GD, Bertagnolli MM.Surgical Management of Advanced Gastrointestinal Stromal Tumors After Treatment With Targeted Systemic Therapy Using Kinase Inhibitors.J Clin Oncol 2006 Ma
  16710031
• Goguen LA, Posner MR, Tishler RB, Wirth LJ, Norris CM, Annino DJ, Sullivan CA, Li Y, Haddad RI.Examining the need for neck dissection in the era of chemoradiation therapy for advanced head and neck cancer.Arch Otolaryngol Head Neck Surg 2006 May;132(5):52
  16702569
• Tishler RB, Posner MR, Norris CM, Mahadevan A, Sullivan C, Goguen L, Wirth LJ, Costello R, Case M, Stowell S, Sammartino D, Busse PM, Haddad RI.Concurrent weekly docetaxel and concomitant boost radiation therapy in the treatment of locally advanced squamo
  16682134
• Yeh SW, Cavacini LA, Bhol KC, Lin MS, Kumar M, Duval M, Posner MR, Ahmed AR.Pathogenic human monoclonal antibody against desmoglein 3.Clin Immunol 2006 Jul;120(1):68-75.
  16635589
• Kelly-Quintos C, Cavacini LA, Posner MR, Goldmann D, Pier GB.Characterization of the opsonic and protective activity against Staphylococcus aureus of fully human monoclonal antibodies specific for the bacterial surface polysaccharide poly-N-acetylglucosam
  16622211
• Mezhir JJ, Schmidt H, Yamini B, Senzer NN, Posner MC, Kufe DW, Weichselbaum RR.Chemo-inducible gene therapy.Anticancer Drugs 2005 Nov;16(10):1053-8.
  16222146
• Wilkinson RA, Piscitelli C, Teintze M, Cavacini LA, Posner MR, Lawrence CM.Structure of the Fab fragment of F105, a broadly reactive anti-human immunodeficiency virus (HIV) antibody that recognizes the CD4 binding site of HIV type 1 gp120.J Virol 2005 Oct
  16189008
• Amrein PC, Clark JR, Supko JG, Fabian RL, Wang CC, Colevas AD, Posner MR, Deschler DG, Rocco JW, Finkelstein DM, McIntyre JF.Phase I trial and pharmacokinetics of escalating doses of paclitaxel and concurrent hyperfractionated radiotherapy with or without
  16116597
• Mezhir JJ, Smith KD, Posner MC, Senzer N, Yamini B, Kufe DW, Weichselbaum RR.Ionizing radiation: a genetic switch for cancer therapy.Cancer Gene Ther 2006 Jan 1;13(1):1-6.
  16082378
• Murphy KT, Wardak A, Beckett MA, Lopez CA, Mehta N, Kimchi E, Salloum RM, Jaskowiak NT, Posner MC, Ohno T, Kufe DW, Weichselbaum RR, Mauceri HJ.Forphenicinol enhances the antitumor effects of cyclophosphamide in a model of squamous cell carcinoma.Cancer C
  15887016
• Cao W, Cavacini LA, Tillman KC, Posner MR.CD40 function in squamous cell cancer of the head and neck.Oral Oncol 2005 May;41(5):462-9.
  15878750
• Cavacini LA, Duval M, Patil A, Wood C, Mayer KH, Ruprecht RM, Posner MR.Dichotomy in cross-clade reactivity and neutralization by HIV-1 sera: Implications for active and passive immunotherapy.J Med Virol 2005 Jun;76(2):146-52.
  15834877
• Gokhale AS, Haddad RI, Cavacini LA, Wirth L, Weeks L, Hallar M, Faucher J, Posner MR.Serum concentrations of interleukin-8, vascular endothelial growth factor, and epidermal growth factor receptor in patients with squamous cell cancer of the head and neck
  15598588
• McCollum AD, Burrell SC, Haddad RI, Norris CM, Tishler RB, Case MA, Posner MR, Van den Abbeele AD.Positron emission tomography with 18F-fluorodeoxyglucose to predict pathologic response after induction chemotherapy and definitive chemoradiotherapy in head
  15390197
• Devlin PM, Kazakin J, Adak S, Li Y, Norris CM, Tishler RB, Clark JR, Busse PM, Posner MR.Prospective phase II trial of PFL-induction chemotherapy followed by definitive local treatment for advanced squamous cell carcinoma of the head and neck: 10-year fol
  15289730
• Haddad RI, Weinstein LJ, Wieczorek TJ, Bhattacharya N, Raftopoulos H, Oster MW, Zhang X, Latham VM, Costello R, Faucher J, DeRosa C, Yule M, Miller LP, Loda M, Posner MR, Shapiro GI.A phase II clinical and pharmacodynamic study of E7070 in patients with m
  15269140
• Cavacini L, Posner M.Native HIV type 1 virion surface structures: relationships between antibody binding and neutralization or lessons from the viral capture assay.AIDS Res Hum Retroviruses 2004 Apr;20(4):435-41.
  15157362
• Pignon JP, Syz N, Posner M, Olivares R, Le Lann L, Yver A, Dunant A, Lewin F, Dalley DN, Paccagnella A, Taylor SG, Domenge C, Bourhis J, Mazumdar M.Adjusting for patient selection suggests the addition of docetaxel to 5-fluorouracil-cisplatin induction th
  15057136
• Kotz T, Costello R, Li Y, Posner MR.Swallowing dysfunction after chemoradiation for advanced squamous cell carcinoma of the head and neck.Head Neck 2004 Apr;26(4):365-72.
  15054740
• Haddad RI, Tishler RB, Posner MR.Nonsurgical treatment of laryngeal cancer.N Engl J Med 2004 Mar 4;350(10):1049-53; author reply 104.
  15002117
• Glisson B, Colevas AD, Haddad R, Krane J, El-Naggar A, Kies M, Costello R, Summey C, Arquette M, Langer C, Amrein PC, Posner M.HER2 expression in salivary gland carcinomas: dependence on histological subtype.Clin Cancer Res 2004 Feb 1;10(3):944-6.
  14871971
• Haddad R, Wirth L, Costello R, Weeks L, Posner M.Phase II randomized study of concomitant chemoradiation using weekly carboplatin/paclitaxel with or without daily subcutaneous amifostine in patients with newly diagnosed locally advanced squamous cell carc
  14727246
• Haddad R, Posner M.Erythropoietin to treat anaemia in patients with head and neck cancer.Lancet 2004 Jan 3;363(9402):79-80; author reply 81-2.
  14724009
• Marsit CJ, Liu M, Nelson HH, Posner M, Suzuki M, Kelsey KT.Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival.Oncogene 2004 Jan 29;23(4):1000-4.
  14647419
• Cavacini LA, Kuhrt D, Duval M, Mayer K, Posner MR.Binding and neutralization activity of human IgG1 and IgG3 from serum of HIV-infected individuals.AIDS Res Hum Retroviruses 2003 Sep;19(9):785-92.
  14585209
• Liu F, Bergami PL, Duval M, Kuhrt D, Posner M, Cavacini L.Expression and functional activity of isotype and subclass switched human monoclonal antibody reactive with the base of the V3 loop of HIV-1 gp120.AIDS Res Hum Retroviruses 2003 Jul;19(7):597-607.
  12908937
• Haddad R, Colevas AD, Krane JF, Cooper D, Glisson B, Amrein PC, Weeks L, Costello R, Posner M.Herceptin in patients with advanced or metastatic salivary gland carcinomas. A phase II study.Oral Oncol 2003 Oct;39(7):724-7.
  12907212
• Cavacini L, Duval M, Song L, Sangster R, Xiang SH, Sodroski J, Posner M.Conformational changes in env oligomer induced by an antibody dependent on the V3 loop base.AIDS 2003 Mar 28;17(5):685-9.
  12646791
• Haddad R, Posner M.Phase II study of induction chemotherapy with paclitaxel, ifosfamide, and carboplatin (TIC) for patients with locally advanced squamous cell carcinoma of the head and neck.Cancer 2003 Mar 15;97(6):1589; author reply 1590.
  12627525
• Gupta VK, Park JO, Kurihara T, Koons A, Mauceri HJ, Jaskowiak NT, Kufe DW, Weichselbaum RR, Posner MC.Selective gene expression using a DF3/MUC1 promoter in a human esophageal adenocarcinoma model.Gene Ther 2003 Feb;10(3):206-12.
  12571627
• Posner MR, Lefebvre JL.Docetaxel induction therapy in locally advanced squamous cell carcinoma of the head and neck.Br J Cancer 2003 Jan 13;88(1):11-7.
  12556952
• Hofmann-Lehmann R, Vlasak J, Williams AL, Chenine AL, McClure HM, Anderson DC, O'Neil S, Ruprecht RM.Live attenuated, nef-deleted SIV is pathogenic in most adult macaques after prolonged observation.AIDS 2003 Jan 24;17(2):157-66.
  12545074
• Posner MR.Head and neck cancer carcinoma: new directions for treatment.MedGenMed 2002 Jun 7;4(3):15.
  12466758
• Cavacini LA, Duval M, Robinson J, Posner MR.Interactions of human antibodies, epitope exposure, antibody binding and neutralization of primary isolate HIV-1 virions.AIDS 2002 Dec 6;16(18):2409-17.
  12461414
• Tishler RB, Norris CM, Colevas AD, Lamb CC, Karp D, Busse PM, Nixon A, Frankenthaler R, Lake-Willcutt B, Costello R, Case M, Posner MR.A Phase I/II trial of concurrent docetaxel and radiation after induction chemotherapy in patients with poor prognosis sq
  12237916
• Hofmann-Lehmann R, Vlasak J, Rasmussen RA, Jiang S, Li PL, Baba TW, Montefiori DC, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Katinger H, Stiegler G, Cavacini LA, Posner MR, Ruprecht RM.Postnatal pre- and postexposure passive immunization stra
  12190851
• Park JO, Lopez CA, Gupta VK, Brown CK, Mauceri HJ, Darga TE, Manan A, Hellman S, Posner MC, Kufe DW, Weichselbaum RR.Transcriptional control of viral gene therapy by cisplatin.J Clin Invest 2002 Aug;110(3):403-10.
  12163460
• Hasegawa M, Nelson HH, Peters E, Ringstrom E, Posner M, Kelsey KT.Patterns of gene promoter methylation in squamous cell cancer of the head and neck.Oncogene 2002 Jun 20;21(27):4231-6.
  12082610
• Colevas AD, Norris CM, Tishler RB, Lamb CC, Fried MP, Goguen LA, Gopal HV, Costello R, Read R, Adak S, Posner MR.Phase I/II trial of outpatient docetaxel, cisplatin, 5-fluorouracil, leucovorin (opTPFL) as induction for squamous cell carcinoma of the head
  11943893
• Gupta VK, Jaskowiak NT, Beckett MA, Mauceri HJ, Grunstein J, Johnson RS, Calvin DA, Nodzenski E, Pejovic M, Kufe DW, Posner MC, Weichselbaum RR.Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance.Cancer J 2002 J
  11895203
• Cavacini LA, Duval M, Eder JP, Posner MR.Evidence of determinant spreading in the antibody responses to prostate cell surface antigens in patients immunized with prostate-specific antigen.Clin Cancer Res 2002 Feb;8(2):368-73.
  11839651
• Cavacini LA, Duval M, Eder JP, Kufe DW, Schlom J, Posner MR.Evidence of determinant spreading in the antibody responses to prostate cell surface antigens in patients immunized with prostate specific antigen.Clinical Cancer Research 2002 02 01;8:364-373.
• Ruprecht RM, Hofmann-Lehmann R, Smith-Franklin BA, Rasmussen RA, Liska V, Vlasak J, Xu W, Baba TW, Chenine AL, Cavacini LA, Posner MR, Katinger H, Stiegler G, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Montefiori DC, McClure HM.Protection of n
  11642027
• Colevas AD, Read R, Thornhill J, Adak S, Tishler R, Busse P, Li Y, Posner M.Hypothyroidism incidence after multimodality treatment for stage III and IV squamous cell carcinomas of the head and neck.Int J Radiat Oncol Biol Phys 2001 Nov 1;51(3):599-604.
  11597798
• Hofmann-Lehmann R, Rasmussen RA, Vlasak J, Smith BA, Baba TW, Liska V, Montefiori DC, McClure HM, Anderson DC, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Katinger H, Stiegler G, Posner MR, Cavacini LA, Chou TC, Ruprecht RM.Passive immunization
  11555137
• Colevas AD, Amrein PC, Gomolin H, Barton JJ, Read RR, Adak S, Benner S, Costello R, Posner MR.A phase II study of combined oral uracil and ftorafur with leucovorin for patients with squamous cell carcinoma of the head and neck.Cancer 2001 Jul 15;92(2):326
  11466686
• Hofmann-Lehmann R, Vlasak J, Rasmussen RA, Smith BA, Baba TW, Liska V, Ferrantelli F, Montefiori DC, McClure HM, Anderson DC, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Katinger H, Stiegler G, Cavacini LA, Posner MR, Chou TC, Andersen J, Rupre
  11462019
• Xu W, Smith-Franklin BA, Li PL, Wood C, He J, Du Q, Bhat GJ, Kankasa C, Katinger H, Cavacini LA, Posner MR, Burton DR, Chou TC, Ruprecht RM.Potent neutralization of primary human immunodeficiency virus clade C isolates with a synergistic combination of hu
  11437315
• Posner MR.Docetaxel in squamous cell cancer of the head and neck.Anticancer Drugs 2001 Feb;12 Suppl 1:S21-4.
  11340900
• Nemunaitis J, Khuri F, Ganly I, Arseneau J, Posner M, Vokes E, Kuhn J, McCarty T, Landers S, Blackburn A, Romel L, Randlev B, Kaye S, Kirn D.Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with re
  11208818
• Salloum RM, Jaskowiak NT, Mauceri HJ, Seetharam S, Beckett MA, Koons AM, Hari DM, Gupta VK, Reimer C, Kalluri R, Posner MC, Hellman S, Kufe DW, Weichselbaum RR.NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity.Cancer R
  11156396
• Malenbaum SE, Yang D, Cavacini L, Posner M, Robinson J, Cheng-Mayer C.The N-terminal V3 loop glycan modulates the interaction of clade A and B human immunodeficiency virus type 1 envelopes with CD4 and chemokine receptors.J Virol 2000 Dec;74(23):11008-16.
  11069996
• Ohyama H, Zhang X, Kohno Y, Alevizos I, Posner M, Wong DT, Todd R.Laser capture microdissection-generated target sample for high-density oligonucleotide array hybridization.Biotechniques 2000 Sep;29(3):530-6.
  10997267
• Colevas AD, Adak S, Amrein PC, Barton JJ, Costello R, Posner MR.A phase II trial of palliative docetaxel plus 5-fluorouracil for squamous-cell cancer of the head and neck.Ann Oncol 2000 May;11(5):535-9.
  10907945
• Baba TW, Liska V, Hofmann-Lehmann R, Vlasak J, Xu W, Ayehunie S, Cavacini LA, Posner MR, Katinger H, Stiegler G, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Lu Y, Wright JE, Chou TC, Ruprecht RM.Human neutralizing monoclonal antibodies of the I
  10655110
• Cavacini LA, Wisnewski A, Peterson JE, Montefiori D, Emes C, Duval M, Kingsbury G, Wang A, Scadden D, Posner MR.A human anti-HIV autoantibody enhances EBV transformation and HIV infection.Clin Immunol 1999 Dec;93(3):263-73.
  10600338
• Colevas AD, Norris CM, Tishler RB, Fried MP, Gomolin HI, Amrein P, Nixon A, Lamb C, Costello R, Barton J, Read R, Adak S, Posner MR.Phase II trial of docetaxel, cisplatin, fluorouracil, and leucovorin as induction for squamous cell carcinoma of the head a
  10550148
• Tishler RB, Busse PM, Norris CM, Rossi R, Poulin M, Thornhill L, Costello R, Peters ES, Colevas AD, Posner MR.An initial experience using concurrent paclitaxel and radiation in the treatment of head and neck malignancies.Int J Radiat Oncol Biol Phys 1999
  10192347
• Colevas AD, Posner MR.Docetaxel in head and neck cancer: a review.Am J Clin Oncol 1998 Oct;21(5):482-6.
  9781605
• Cavacini LA, Emes CL, Wisnewski AV, Power J, Lewis G, Montefiori D, Posner MR.Functional and molecular characterization of human monoclonal antibody reactive with the immunodominant region of HIV type 1 glycoprotein 41.AIDS Res Hum Retroviruses 1998 Sep 2
  9764911
• Cavacini LA, Samore MH, Gambertoglio J, Jackson B, Duval M, Wisnewski A, Hammer S, Koziel C, Trapnell C, Posner MR.Phase I study of a human monoclonal antibody directed against the CD4-binding site of HIV type 1 glycoprotein 120.AIDS Res Hum Retroviruses
  9591708
• Colevas AD, Busse PM, Norris CM, Fried M, Tishler RB, Poulin M, Fabian RL, Fitzgerald TJ, Dreyfuss A, Peters ES, Adak S, Costello R, Barton JJ, Posner MR.Induction chemotherapy with docetaxel, cisplatin, fluorouracil, and leucovorin for squamous cell carc
  9552034
• Sanz-Altamira PM, Spence LD, Huberman MS, Posner MR, Steele G, Perry LJ, Stuart KE.Selective chemoembolization in the management of hepatic metastases in refractory colorectal carcinoma: a phase II trial.Dis Colon Rectum 1997 Jul;40(7):770-5.
  9221850
• Li A, Baba TW, Sodroski J, Zolla-Pazner S, Gorny MK, Robinson J, Posner MR, Katinger H, Barbas CF, Burton DR, Chou TC, Ruprecht RM.Synergistic neutralization of a chimeric SIV/HIV type 1 virus with combinations of human anti-HIV type 1 envelope monoclonal
  9168233
• Posner MR, Colevas AD.Induction chemotherapy in the management of squamous cell cancer of the head and neck.Cancer J Sci Am 1997 Mar-Apr;3(2):73-5.
  9099455
• Pincus SH, Wehrly K, Cole R, Fang H, Lewis GK, McClure J, Conley AJ, Wahren B, Posner MR, Notkins AL, Tilley SA, Pinter A, Eiden L, Teintze M, Dorward D, Tolstikov VV.In vitro effects of anti-HIV immunotoxins directed against multiple epitopes on HIV type
  8827220
• Wolfe EJ, Cavacini LA, Samore MH, Posner MR, Kozial C, Spino C, Trapnell CB, Ketter N, Hammer S, Gambertoglio JG.Pharmacokinetics of F105, a human monoclonal antibody, in persons infected with human immunodeficiency virus type 1.Clin Pharmacol Ther 1996 J
  8681491
• Cavacini LA, Emes CL, Power J, Desharnais FD, Duval M, Montefiori D, Posner MR.Influence of heavy chain constant regions on antigen binding and HIV-1 neutralization by a human monoclonal antibody.J Immunol 1995 Oct 1;155(7):3638-44.
  7561063
• Stuart K, Posner M, Campbell K, Huberman M.Cisplatin and chronic oral etoposide as salvage therapy for advanced colorectal carcinoma.Am J Clin Oncol 1995 Aug;18(4):300-2.
  7625370
• Marchbanks K, Dudley MN, Posner MR, Darnowski J.Pharmacokinetics and pharmacodynamics of high-dose zidovudine administered as a continuous infusion in patients with cancer.Pharmacotherapy 1995 Jul-Aug;15(4):451-7.
  7479197
• Khouri YF, McIntosh K, Cavacini L, Posner M, Pagano M, Tuomala R, Marasco WA.Vertical Transmission of HIV-1. Correlation with maternal viral load and plasma levels of CD4 binding site anti-gp120 antibodies.J Clin Invest 1995 Feb;95(2):732-7.
  7860754
• Wyatt R, Sullivan N, Thali M, Repke H, Ho D, Robinson J, Posner M, Sodroski J.Functional and immunologic characterization of human immunodeficiency virus type 1 envelope glycoproteins containing deletions of the major variable regions.J Virol 1993 Aug;67(
  8331723
• Wyatt R, Thali M, Tilley S, Pinter A, Posner M, Ho D, Robinson J, Sodroski J.Relationship of the human immunodeficiency virus type 1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region.J Virol 1992 Dec;66(12):69
  1279195
• Marasco WA, Bagley J, Zani C, Posner M, Cavacini L, Haseltine WA, Sodroski J.Characterization of the cDNA of a broadly reactive neutralizing human anti-gp120 monoclonal antibody.J Clin Invest 1992 Oct;90(4):1467-78.
  1401079
• Thali M, Olshevsky U, Furman C, Gabuzda D, Posner M, Sodroski J.Characterization of a discontinuous human immunodeficiency virus type 1 gp120 epitope recognized by a broadly reactive neutralizing human monoclonal antibody.J Virol 1991 Nov;65(11):6188-93.
  1717717