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Bertal H Aktas, PhD


  • Mahalingam P, Takrouri K, Chen T, Sahoo R, Papadopoulos E, Chen L, Wagner G, Aktas BH, Halperin JA, Chorev M.Synthesis of Rigidified eIF4E/eIF4G Inhibitor-1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein-Protein Interaction.J Med Chem. 2014 Jun 4.
  • Takrouri K, Chen T, Papadopoulos E, Sahoo R, Kabha E, Chen H, Cantel S, Wagner G, Halperin JA, Aktas BH, Chorev M.Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors.Eur J Med Chem. 2014 Apr 22;77:361-77.
  • Yefidoff-Freedman R, Chen T, Sahoo R, Chen L, Wagner G, Halperin JA, Aktas BH, Chorev M.3-substituted indazoles as configurationally locked 4EGI-1 mimetics and inhibitors of the eIF4E/eIF4G interaction.Chembiochem. 2014 Mar 3;15(4):595-611.
  • Chen T, Takrouri K, Hee-Hwang S, Rana S, Yefidoff-Freedman R, Halperin J, Natarajan A, Morisseau C, Hammock B, Chorev M, Aktas BH.Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase.J Med Chem. 2013 Dec 12;56(23):9457-70.
  • Aktas BH, Qiao Y, Ozdelen E, Schubert R, Sevinc S, Harbinski F, Grubissich L, Singer S, Halperin JA.Small-Molecule targeting of translation initiation for cancer therapy.Oncotarget. 2013 Oct;4(10):1606-17.
  • Denoyelle S, Chen T, Yang H, Chen L, Zhang Y, Halperin JA, Aktas BH, Chorev M.Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors.Eur J Med Chem. 2013 Nov;69:537-53.
  • Bai H, Chen T, Ming J, Sun H, Cao P, Fusco DN, Chung RT, Chorev M, Jin Q, Aktas BH.Dual activators of protein kinase R (PKR) and protein kinase R-like kinase PERK identify common and divergent catalytic targets.Chembiochem. 2013 Jul 8;14(10):1255-62.
  • Ziegeler G, Ming J, Koseki JC, Sevinc S, Chen T, Ergun S, Qin X, Aktas BH.Embryonic lethal abnormal vision-like HuR-dependent mRNA stability regulates post-transcriptional expression of cyclin-dependent kinase inhibitor p27Kip1.J Biol Chem. 2010 May 14;285(20):15408-19.
  • Wu G, Chen T, Shahsafaei A, Hu W, Bronson RT, Shi GP, Halperin JA, Aktas H, Qin X.Complement Regulator CD59 Protects Against Angiotensin II-Induced Abdominal Aortic Aneurysms in Mice.Circulation. 2010 Mar 23;121(11):1338-46.
  • Ozel Demiralp D, Aktas H, Akar N.The effect of plasminogen activator inhibitor-1 -675 4G/5G polymorphism on PAI-1 gene expression and adipocyte differentiation.Clin. Appl. Thromb. Hemost. 2008 Oct;14(4):438-46.
  • Hyberts SG, Heffron GJ, Tarragona NG, Solanky K, Edmonds KA, Luithardt H, Fejzo J, Chorev M, Aktas H, Colson K, Falchuk KH, Halperin JA, Wagner G.Ultrahigh-resolution (1)H-(13)C HSQC spectra of metabolite mixtures using nonlinear sampling and forward maximum entropy reconstruction.J Am Chem Soc. 2007 Apr 25;129(16):5108-16.
  • Moerke NJ, Aktas H, Chen H, Cantel S, Reibarkh MY, Fahmy A, Gross JD, Degterev A, Yuan J, Chorev M, Halperin JA, Wagner G.Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G.Cell. 2007 Jan 26;128(2):257-67.
  • Gelev V, Aktas H, Marintchev A, Ito T, Frueh D, Hemond M, Rovnyak D, Debus M, Hyberts S, Usheva A, Halperin J, Wagner G.Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance.J Mol Biol. 2006 Dec 1;364(3):352-63.
  • Natarajan A, Guo Y, Harbinski F, Fan YH, Chen H, Luus L, Diercks J, Aktas H, Chorev M, Halperin JA.Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation.J Med Chem. 2004 Oct 7;47(21):4979-82.
  • Chen H, Fan YH, Natarajan A, Guo Y, Iyasere J, Harbinski F, Luus L, Christ W, Aktas H, Halperin JA.Synthesis and biological evaluation of thiazolidine-2,4-dione and 2,4-thione derivatives as inhibitors of translation initiation.Bioorg Med Chem Lett. 2004 Nov 1;14(21):5401-5.
  • Aktas H, Halperin JA.Translational regulation of gene expression by omega-3 fatty acids.J Nutr. 2004 Sep;134(9):2487S-2491S. Review.
  • Fan YH, Chen H, Natarajan A, Guo Y, Harbinski F, Iyasere J, Christ W, Aktas H, Halperin JA.Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium.Bioorg Med Chem Lett. 2004 May 17;14(10):2547-50.
  • Natarajan A, Fan YH, Chen H, Guo Y, Iyasere J, Harbinski F, Christ WJ, Aktas H, Halperin JA.3,3-diaryl-1,3-dihydroindol-2-ones as antiproliferatives mediated by translation initiation inhibition.J Med Chem. 2004 Apr 8;47(8):1882-5.
  • Aktas H, Leibfried-Rutledge ML, First NL.Meiotic state of bovine oocytes is regulated by interactions between cAMP, cumulus, and granulosa.Molecular Reproduction And Development. 2003 Jul;65(3):336-43.
  • Qin X, Krumrei N, Grubissich L, Dobarro M, Aktas H, Perez G, Halperin JA.Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility.Immunity. 2003 Feb;18(2):217-27.