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Mel Feany, MD, PhD

Publications

  • Hegde VR, Vogel R, Feany MB.Glia are critical for the neuropathology of complex I deficiency in Drosophila.Hum Mol Genet. 2014 Apr 23.
    24760769
  • Frost B, Hemberg M, Lewis J, Feany MB.Tau promotes neurodegeneration through global chromatin relaxation.Nat Neurosci. 2014 Mar;17(3):357-66.
    24464041
  • Chen L, Periquet M, Wang X, Negro A, McLean PJ, Hyman BT, Feany MB.Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.J Clin Invest. 2009 Nov;119(11):3257-65.
    19855133
  • McFarland NR, Fan Z, Xu K, Schwarzschild MA, Feany MB, Hyman BT, McLean PJ.alpha-Synuclein S129 Phosphorylation Mutants Do Not Alter Nigrostriatal Toxicity in a Rat Model of Parkinson Disease.J Neuropathol Exp Neurol. 2009 May;68(5):515-524.
    19525899
  • Zhang S,Feany MB,Saraswati S,Littleton JT,Perrimon N.Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model.Dis Model Mech. 2009 May-Jun;2(5-6):247-66.
    19380309
  • Cullen V,Lindfors M,Ng J,Paetau A,Swinton E,Kolodziej P,Boston H,Saftig P,Woulfe J,Feany MB,Myllykangas L,Schlossmacher MG,Tyynela J.Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.Mol Brain. 2009;2(1):5.
    19203374
  • Dufty BM, Warner LR, Hou ST, Jiang SX, Gomez-Isla T, Leenhouts KM, Oxford JT, Feany MB, Masliah E, Rohn TT.Calpain-Cleavage of {alpha}-Synuclein: Connecting Proteolytic Processing to Disease-Linked Aggregation.Am J Pathol. 2007 May;170(5):1725-38.
    17456777
  • Periquet M, Fulga T, Myllykangas L, Schlossmacher MG, Feany MB.Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.J Neurosci. 2007 Mar 21;27(12):3338-46.
    17376994
  • Steinhilb ML, Dias-Santagata D, Mulkearns EE, Shulman JM, Biernat J, Mandelkow EM, Feany MB.S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila.J Neurosci Res. 2007 May 1;85(6):1271-8.
    17335084
  • Fulga TA, Elson-Schwab I, Khurana V, Steinhilb ML, Spires TL, Hyman BT, Feany MB.Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.Nat Cell Biol. 2007 Feb;9(2):139-48.
    17187063
  • Dias-Santagata D, Fulga TA, Duttaroy A, Feany MB.Oxidative stress mediates tau-induced neurodegeneration in Drosophila.J Clin Invest. 2007 Jan;117(1):236-45.
    17173140
  • Khurana V, Feany MB.Connecting cell-cycle activation to neurodegeneration in Drosophila.Biochim Biophys Acta. 2007 Apr;1772(4):446-56. Review.
    17141486
  • Gavin BA, Dolph MJ, Deleault NR, Geoghegan JC, Khurana V, Feany MB, Dolph PJ, Supattapone S.Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome.J Neurosci. 2006 Nov 29;26(48):12408-14.
    17135402
  • Kontopoulos E, Parvin JD, Feany MB.Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity.Hum Mol Genet. 2006 Oct 15;15(20):3012-23.
    16959795
  • Khurana V, Lu Y, Steinhilb ML, Oldham S, Shulman JM, Feany MB.TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.Curr Biol. 2006 Feb 7;16(3):230-41.
    16461276
  • Orso G, Martinuzzi A, Rossetto MG, Sartori E, Feany M, Daga A.Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine.J Clin Invest. 2005 Nov;115(11):3026-34.
    16276413