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Bin Zheng, PhD


  • Yuan P, Ito K, Perez-Lorenzo R, Del Guzzo C, Lee JH, Shen CH, Bosenberg MW, McMahon M, Cantley LC, Zheng B.Phenformin enhances the therapeutic benefit of BRAFV600E inhibition in melanoma.Proc Natl Acad Sci U S A. 2013 Oct 21.
  • Shen CH, Yuan P, Perez-Lorenzo R, Zhang Y, Lee SX, Ou Y, Asara JM, Cantley LC, Zheng B.Phosphorylation of BRAF by AMPK Impairs BRAF-KSR1 Association and Cell Proliferation.Mol Cell. 2013 Oct 1.
  • Wu N, Zheng B, Shaywitz A, Dagon Y, Tower C, Bellinger G, Shen CH, Wen J, Asara J, McGraw TE, Kahn BB, Cantley LC.AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1.Mol Cell. 2013 Mar 28;49(6):1167-75.
  • Mack HI, Zheng B, Asara J, Thomas SM.AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization.Autophagy. 2012 Aug 1;8(8):1197-214.
  • Dagon Y, Hur E, Zheng B, Wellenstein K, Cantley LC, Kahn BB.p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.Cell Metab. 2012 Jul 3;16(1):104-12.
  • Tsou P, Zheng B, Hsu CH, Sasaki AT, Cantley LC.A Fluorescent Reporter of AMPK Activity and Cellular Energy Stress.Cell Metab. 2011 Apr 6;13(4):476-86.
  • Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M.AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.Cell Metab. 2011 Apr 6;13(4):376-88.
  • Zheng B,Jeong JH,Asara JM,Yuan YY,Granter SR,Chin L,Cantley LC.Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation.Mol Cell. 2009 Jan 30;33(2):237-47.