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Towia A. Libermann, PhD


  • Koulmanda M, Bhasin M, Fan Z, Hanidziar D, Goel N, Putheti P, Movahedi B, Libermann TA, Strom TB.Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival.Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15443-8.
  • Duncan K, Uwimpuhwe H, Czibere A, Sarkar D, Libermann TA, Fisher PB, Zerbini LF.NSAIDs induce apoptosis in nonproliferating ovarian cancer cells and inhibit tumor growth in vivo.IUBMB Life. 2012 Jul;64(7):636-43.
  • Kim BK, Park YJ, Libermann TA, Cho JY.PTH regulates Myleoid ELF-1-like factor (MEF)-induced MAB-21-like-1 (MAB21L1) expression through the JNK1 pathway.J Cell Biochem. 2011 Apr 4.
  • Horst D, Gu X, Bhasin M, Yang Q, Verzi M, Lin D, Joseph M, Zhang X, Chen W, Li YP, Shivdasani RA, Libermann TA.Requirement of the epithelial-specific ETS transcription factor SPDEF for mucous gland cell function in the gastric antrum.J Biol Chem. 2010 Nov 5;285(45):35047-55.
  • Kornek M, Popov Y, Libermann TA, Afdhal NH, Schuppan D.Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells.Hepatology. 2010 Sep 20.
  • Li J, Gu X, Ma Y, Calicchio ML, Kong D, Teng YD, Yu L, Crain AM, Vartanian TK, Pasqualini R, Arap W, Libermann TA, Snyder EY, Sidman RL.Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling.Neuron. 2010 Oct 6;68(1):45-60.
  • Juengel E, Bhasin M, Libermann T, Barth S, Michaelis M, Cinatl J, Jones J, Hudak L, Jonas D, Blaheta RA.Alterations of the gene expression profile in renal cell carcinoma after treatment with the histone deacetylase-inhibitor valproic acid and interferon-alpha.World J Urol. 2010 Jul 17.
  • Bhasin M, Yuan L, Keskin DB, Otu HH, Libermann TA, Oettgen P.Bioinformatic identification and characterization of human endothelial cell-restricted genes.BMC Genomics. 2010;11:342.
  • Lee JM, Libermann TA, Cho JY.The synergistic regulatory effect of Runx2 and MEF transcription factors on osteoblast differentiation markers.J Periodontal Implant Sci. 2010 Feb;40(1):39-44.
  • Konstantinopoulos PA, Fountzilas E, Goldsmith JD, Bhasin M, Pillay K, Francoeur N, Libermann TA, Gebhardt MC, Spentzos D.Analysis of multiple sarcoma expression datasets: implications for classification, oncogenic pathway activation and chemotherapy resistance.PLoS ONE. 2010;5(4):e9747.
  • Tsuchimochi K, Otero M, Dragomir CL, Plumb DA, Zerbini LF, Libermann TA, Marcu KB, Komiya S, Ijiri K, Goldring MB.GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes.J Biol Chem. 2010 Mar 12;285(11):8395-407.
  • Li Y, Liu B, Dillon ST, Fukudome EY, Kheirbek T, Sailhamer EA, Velmahos G, deMoya M, Libermann TA, Alam HB.Identification of a novel potential biomarker in a model of hemorrhagic shock and valproic acid treatment.J Surg Res. 2010 Mar;159(1):474-81.
  • Hulick P, Zimmer M, Margulis V, Skates S, Hamel M, Dahl DM, Michaelson DM, Libermann T, Signoretti S, Carney W, Wood C, Iliopoulos O.Blood Levels of Carbonic Anhydrase 9 Correlate with Clear Cell Renal Cell Carcinoma Activity.Clin. Proteomics.;5(1):37-45.
  • Arredouani MS, Lu B, Bhasin M, Eljanne M, Yue W, Mosquera JM, Bubley GJ, Li V, Rubin MA, Libermann TA, Sanda MG.Identification of the transcription factor single-minded homologue 2 as a potential biomarker and immunotherapy target in prostate cancer.Clin Cancer Res. 2009 Sep 15;15(18):5794-802.
  • Bhatt R, Wang X, Zhang L, Bhasin M, Libermann T, O’Neil A, Signoretti S, Atkins M, Mier J, Goldberg SN.Cox-2 inhibition delays resistance to sunitinib in RCC xenograft models.AACR Proceedings 2009..
  • Cho JY,Lee M,Ahn JM,Park ES,Cho JH,Lee SJ,Kim BG,Heo SH,Park HJ,Zerbini LF,Hwang D,Libermann TA.Proteomic Analysis of a PDEF Ets Transcription Factor-Interacting Protein Complex.J Proteome Res. 2009 Mar;8(3):1327-37.
  • Konstantinopoulos PA,Fountzilas E,Pillay K,Zerbini LF,Libermann TA,Cannistra SA,Spentzos D.Carboplatin-induced gene expression changes in vitro are prognostic of survival in epithelial ovarian cancer.BMC Med Genomics. 2008;1:59.
  • Koulmanda M,Bhasin M,Hoffman L,Fan Z,Qipo A,Shi H,Bonner-Weir S,Putheti P,Degauque N,Libermann TA,Auchincloss H Jr,Flier JS,Strom TB.Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16242-7.
  • Haram KM,Peltier HJ,Lu B,Bhasin M,Otu HH,Choy B,Regan M,Libermann TA,Latham GJ,Sanda MG,Arredouani MS.Gene expression profile of mouse prostate tumors reveals dysregulations in major biological processes and identifies potential murine targets for preclinical development of human prostate cancer therapy.Prostate. 2008 Oct 1;68(14):1517-30.
  • Dusek JA, Otu HH, Wohlhueter AL, Bhasin M, Zerbini LF, Joseph MG, Benson H, Libermann TA.Genomic counter-stress changes induced by the relaxation response.PLoS ONE. 2008;3(7):e2576.
  • Libermann TA, Bhasin M, Joseph MG, Signoretti S, Ernstoff MS, McDermott D, Atkins MB.Gene Expression Profiling Signatures Associated with RCC response to IL-2 Therapy.Proceedings of the 23rd ISBTC Meeting, J Immunotherapy ..
  • Ijiri K, Zerbini LF, Peng H, Otu HH, Tsuchimochi K, Otero M, Dragomir C, Walsh N, Bierbaum BE, Mattingly D, van Flandern G, Komiya S, Aigner T, Libermann TA, Goldring MB.Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes.Arthritis Rheum. 2008 Jul;58(7):2075-87.
  • Tworoger SS,Spentzos D,Grall FT,Liebermann TA,Hankinson SE.Reproducibility of proteomic profiles over 3 years in postmenopausal women not taking postmenopausal hormones.Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1480-5.
  • Signoretti S, Bratslavsky G, Waldman FM, Reuter VE, Haaga J, Merino M, Thomas GV, Pins MR, Libermann T, Gillespie J, Tomaszewski JE, Compton CC, Hruszkewycz A, Linehan WM, Atkins MB.Tissue-based research in kidney cancer: current challenges and future directions.Clin Cancer Res. 2008 Jun 15;14(12):3699-705. Review.
  • Nikolova-Krstevski V, Bhasin M, Otu HH, Libermann T, Oettgen P.Gene expression analysis of embryonic stem cells expressing VE-cadherin (CD144) during endothelial differentiation.BMC Genomics. 2008;9:240.
  • Rcker B, Almeida ME, Libermann TA, Zerbini LF, Wink MR, Sarkis JJ.E-NTPDases and ecto-5'-nucleotidase expression profile in rat heart left ventricle and the extracellular nucleotide hydrolysis by their nerve terminal endings.Life Sci. 2008 Feb 27;82(9-10):477-86.
  • Zinkin NT, Grall F, Bhaskar K, Otu HH, Spentzos D, Kalmowitz B, Wells M, Guerrero M, Asara JM, Libermann TA, Afdhal NH.Serum proteomics and biomarkers in hepatocellular carcinoma and chronic liver disease.Clin Cancer Res. 2008 Jan 15;14(2):470-7.
  • Jones J, Otu HH, Grall F, Spentzos D, Can H, Aivado M, Belldegrun AS, Pantuck AJ, Libermann TA.Proteomic identification of interleukin-2 therapy response in metastatic renal cell cancer.J Urol. 2008 Feb;179(2):730-6.
  • Marselli L, Thorne J, Ahn YB, Omer A, Sgroi DC, Libermann T, Otu HH, Sharma A, Bonner-Weir S, Weir GC.Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection.J Clin Endocrinol Metab. 2008 Mar;93(3):1046-53.
  • Peng H, Tan L, Osaki M, Zhan Y, Ijiri K, Tsuchimochi K, Otero M, Wang H, Choy BK, Grall FT, Gu X, Libermann TA, Oettgen P, Goldring MB.ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes.J Cell Physiol. 2008 May;215(2):562-73.
  • Spentzos D, Cannistra SA, Grall F, Levine DA, Pillay K, Libermann TA, Mantzoros CS.IGF axis gene expression patterns are prognostic of survival in epithelial ovarian cancer.Endocr Relat Cancer. 2007 Sep;14(3):781-90.
  • Zhang X, Zhang L, Yang H, Huang X, Otu H, Libermann TA, DeWolf WC, Khosravi-Far R, Olumi AF.c-Fos as a proapoptotic agent in TRAIL-induced apoptosis in prostate cancer cells.Cancer Res. 2007 Oct 1;67(19):9425-34.
  • Ramlawi B, Otu H, Rudolph JL, Mieno S, Kohane IS, Can H, Libermann TA, Marcantonio ER, Bianchi C, Sellke FW.Genomic expression pathways associated with brain injury after cardiopulmonary bypass.J Thorac Cardiovasc Surg. 2007 Oct;134(4):996-1005.
  • Rcker B, Almeida ME, Libermann TA, Zerbini LF, Wink MR, Sarkis JJ.Biochemical characterization of ecto-nucleotide pyrophosphatase/phosphodiesterase (E-NPP, E.C. from rat heart left ventricle.Mol Cell Biochem. 2007 Dec;306(1-2):247-54.
  • Prall WC, Czibere A, Jger M, Spentzos D, Libermann TA, Gattermann N, Haas R, Aivado M.Age-related transcription levels of KU70, MGST1 and BIK in CD34+ hematopoietic stem and progenitor cells.Mech Ageing Dev. 2007 Sep;128(9):503-10.
  • Huh K, Zhou X, Hayakawa H, Cho JY, Libermann TA, Jin J, Wade Harper J, Munger K.Human papillomavirus type 16 e7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor.J Virol. 2007 Sep;81(18):9737-47.
  • Buffon A, Wink MR, Ribeiro BV, Casali EA, Libermann TA, Zerbini LF, Robson SC, Sarkis JJ.NTPDase and 5' ecto-nucleotidase expression profiles and the pattern of extracellular ATP metabolism in the Walker 256 tumor.Biochim Biophys Acta. 2007 Aug;1770(8):1259-65.
  • Gu X, Zerbini LF, Otu HH, Bhasin M, Yang Q, Joseph MG, Grall F, Onatunde T, Correa RG, Libermann TA.Reduced PDEF Expression Increases Invasion and Expression of Mesenchymal Genes in Prostate Cancer Cells.Cancer Res. 2007 May 1;67(9):4219-26.
  • Otu HH, Can H, Spentzos D, Nelson RG, Hanson RL, Looker HC, Knowler WC, Monroy M, Libermann TA, Karumanchi SA, Thadhani R.Prediction of diabetic nephropathy using urine proteomic profiling 10 years prior to development of nephropathy.Diabetes Care. 2007 Mar;30(3):638-43.
  • Kennedy AR, Pissios P, Otu H, Xue B, Asakura K, Furukawa N, Marino FE, Liu FF, Kahn BB, Libermann TA, Maratos-Flier E, Roberson R.A high-fat, ketogenic diet induces a unique metabolic state in mice.Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1724-39.
  • Atkins MB, Ernstoff MS, Figlin RA, Flaherty KT, George DJ, Kaelin WG, Kwon ED, Libermann TA, Linehan WM, McDermott DF, Ochoa AC, Pantuck AJ, Rini BI, Rosen MA, Sosman JA, Sukhatme VP, Vieweg JW, Wood CG, King L.Innovations and challenges in renal cell carcinoma: summary statement from the second cambridge conference.Clin Cancer Res. 2007 Jan 15;13(2):667s-70s. Review.
  • Jones J, Libermann TA.Genomics of renal cell cancer: the biology behind and the therapy ahead.Clin Cancer Res. 2007 Jan 15;13(2 Pt 2):685s-692s. Review.
  • Otu HH, Naxerova K, Ho K, Can H, Nesbitt N, Libermann TA, Karp SJ.Restoration of liver mass after injury requires proliferative and not embryonic transcriptional patterns.J Biol Chem. 2007 Apr 13;282(15):11197-204.
  • Aivado M, Spentzos D, Germing U, Alterovitz G, Meng XY, Grall F, Giagounidis AA, Klement G, Steidl U, Otu HH, Czibere A, Prall WC, Iking-Konert C, Shayne M, Ramoni MF, Gattermann N, Haas R, Mitsiades CS, Fung ET, Libermann TA.Serum proteome profiling detects myelodysplastic syndromes and identifies CXC chemokine ligands 4 and 7 as markers for advanced disease.Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1307-12.
  • Gnainsky Y, Kushnirsky Z, Bilu G, Hagai Y, Genina O, Volpin H, Bruck R, Spira G, Nagler A, Kawada N, Yoshizato K, Reinhardt DP, Libermann TA, Pines M.Gene expression during chemically induced liver fibrosis: effect of halofuginone on TGF-beta signaling.Cell Tissue Res. 2007 Apr;328(1):153-66.
  • Steidl U, Rosenbauer F, Verhaak RG, Gu X, Ebralidze A, Otu HH, Klippel S, Steidl C, Bruns I, Costa DB, Wagner K, Aivado M, Kobbe G, Valk PJ, Passegu E, Libermann TA, Delwel R, Tenen DG.Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells.Nat Genet. 2006 Nov;38(11):1269-77.
  • Libermann TA, Zerbini LF.Targeting transcription factors for cancer gene therapy.Curr Gene Ther. 2006 Feb;6(1):17-33. Review.
  • Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Kung AL, Davies FE, Morgan G, Akiyama M, Shringarpure R, Munshi NC, Richardson PG, Hideshima T, Chauhan D, Gu X, Bailey C, Joseph M, Libermann TA, Rosen NS, Anderson KC.Anti-myeloma activity of heat shock protein-90 inhibition.Blood. 2006 Feb 1;107(3):1092-100.
  • Ramnarain DB, Park S, Lee DY, Hatanpaa KJ, Scoggin SO, Otu H, Libermann TA, Raisanen JM, Ashfaq R, Wong ET, Wu J, Elliott R, Habib AA.Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells.Cancer Res. 2006 Jan 15;66(2):867-74.
  • Spentzos D, Levine DA, Kolia S, Otu H, Boyd J, Libermann TA, Cannistra SA.Unique gene expression profile based on pathologic response in epithelial ovarian cancer.J Clin Oncol. 2005 Nov 1;23(31):7911-8.
  • Wada Y, Otu H, Wu S, Abid MR, Okada H, Libermann T, Kodama T, Shih SC, Minami T, Aird WC.Preconditioning of primary human endothelial cells with inflammatory mediators alters the "set point" of the cell.FASEB J. 2005 Nov;19(13):1914-6.
  • Zerbini LF, Libermann TA.GADD45 deregulation in cancer: frequently methylated tumor suppressors and potential therapeutic targets.Clin Cancer Res. 2005 Sep 15;11(18):6409-13.
  • Ijiri K, Zerbini LF, Peng H, Correa RG, Lu B, Walsh N, Zhao Y, Taniguchi N, Huang XL, Otu H, Wang H, Wang JF, Komiya S, Ducy P, Rahman MU, Flavell RA, Gravallese EM, Oettgen P, Libermann TA, Goldring MB.A Novel Role for GADD45{beta} as a Mediator of MMP-13 Gene Expression during Chondrocyte Terminal Differentiation.J Biol Chem. 2005 Nov 18;280(46):38544-55.
  • Jones J, Otu H, Spentzos D, Kolia S, Inan M, Beecken WD, Fellbaum C, Gu X, Joseph M, Pantuck AJ, Jonas D, Libermann TA.Gene signatures of progression and metastasis in renal cell cancer.Clin Cancer Res. 2005 Aug 15;11(16):5730-9.
  • Zerbini LF, Wang Y, Correa RG, Cho JY, Libermann TA.Blockage of NF-kappaB induces serine 15 phosphorylation of mutant p53 by JNK kinase in prostate cancer cells.Cell Cycle. 2005 Sep;4(9):1247-53.
  • Czibere A, Prall WC, Zerbini LF, Grall F, Craigie EC, Ulrich SD, Giagounidis AA, Haas R, Libermann TA, Aivado M.The nonsteroidal anti-inflammatory drug Exisulind selectively induces apoptosis via JNK in secondary acute myeloid leukemia after myelodysplastic syndrome.Cell Cycle. 2005 Jun;4(6):812-7.
  • Mazzocca A, Coppari R, De Franco R, Cho JY, Libermann TA, Pinzani M, Toker A.A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions.Cancer Res. 2005 Jun 1;65(11):4728-38.
  • Aivado M, Spentzos D, Alterovitz G, Otu HH, Grall F, Giagounidis AA, Wells M, Cho JY, Germing U, Czibere A, Prall WC, Porter C, Ramoni MF, Libermann TA.Optimization and evaluation of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) with reversed-phase protein arrays for protein profiling.Clin Chem Lab Med. 2005;43(2):133-40.
  • Grall FT, Prall WC, Wei W, Gu X, Cho JY, Choy BK, Zerbini LF, Inan MS, Goldring SR, Gravallese EM, Goldring MB, Oettgen P, Libermann TA.The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes.FEBS J. 2005 Apr;272(7):1676-87.
  • Zerbini LF, Libermann TA.Life and death in cancer. GADD45 alpha and gamma are critical regulators of NF-kappaB mediated escape from programmed cell death.Cell Cycle. 2005 Jan;4(1):18-20.
  • Spentzos D, Levine DA, Ramoni MF, Joseph M, Gu X, Boyd J, Libermann TA, Cannistra SA.Gene expression signature with independent prognostic significance in epithelial ovarian cancer.J Clin Oncol. 2004 Dec 1;22(23):4648-58.
  • Von Stechow D, Zurakowski D, Pettit AR, Mller R, Gronowicz G, Chorev M, Otu H, Libermann T, Alexander JM.Differential transcriptional effects of PTH and estrogen during anabolic bone formation.J Cell Biochem. 2004 Sep 15;93(3):476.
  • Voisine P, Ruel M, Khan TA, Bianchi C, Xu SH, Kohane I, Libermann TA, Otu H, Saltiel AR, Sellke FW.Differences in gene expression profiles of diabetic and nondiabetic patients undergoing cardiopulmonary bypass and cardioplegic arrest.Circulation. 2004 Sep 14;110(11 Suppl 1):II280-6.
  • Zerbini LF, Wang Y, Czibere A, Correa RG, Cho JY, Ijiri K, Wei W, Joseph M, Gu X, Grall F, Goldring MB, Zhou JR, Libermann TA.NF-{kappa}B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45{alpha} and {gamma} is essential for cancer cell survival.Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13618-13623.
  • Hong YK, Foreman K, Shin JW, Hirakawa S, Curry CL, Sage DR, Libermann T, Dezube BJ, Fingeroth JD, Detmar M.Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus.Nat Genet. 2004 Jul;36(7):683-5.
  • Zhou JR, Yu L, Zerbini LF, Libermann TA, Blackburn GL.Progression to androgen-independent LNCaP human prostate tumors: cellular and molecular alterations.Int J Cancer. 2004 Jul 20;110(6):800-6.
  • Cho JY, Akbarali Y, Zerbini LF, Gu X, Boltax J, Wang Y, Oettgen P, Zhang DE, Libermann TA.Isoforms of the Ets transcription factor NERF/ELF2 physically interact with AML1 and mediate opposing effects on AML1 mediated transcription of the B cell-specific blk gene.J Biol Chem. 2004 May 7;279(19):19512-22.
  • Wang H, Fang R, Cho JY, Libermann TA, Oettgen P.Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86.J Biol Chem. 2004 Jun 11;279(24):25241-50.
  • Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Akiyama M, Hideshima T, Chauhan D, Joseph M, Libermann TA, Garca-Echeverra C, Pearson MA, Hofmann F, Anderson KC, Kung AL.Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.Cancer Cell. 2004 Mar;5(3):221-30.
  • Brown C, Gaspar J, Pettit A, Lee R, Gu X, Wang H, Manning C, Voland C, Goldring SR, Goldring MB, Libermann TA, Gravalllese EM, Oettgen P.ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation.J Biol Chem. 2004 Mar 26;279(13):12794-803.
  • Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Hideshima T, Akiyama M, Chauhan D, Munshi N, Gu X, Bailey C, Joseph M, Libermann TA, Richon VM, Marks PA, Anderson KC.Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications.Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):540-5.
  • Ruel M, Bianchi C, Khan TA, Xu S, Liddicoat JR, Voisine P, Araujo E, Lyon H, Kohane IS, Libermann TA, Sellke FW.Gene expression profile after cardiopulmonary bypass and cardioplegic arrest.J Thorac Cardiovasc Surg. 2003 Nov;126(5):1521-30.
  • Fortunel NO, Otu HH, Ng HH, Chen J, Mu X, Chevassut T, Li X, Joseph M, Bailey C, Hatzfeld JA, Hatzfeld A, Usta F, Vega VB, Long PM, Libermann TA, Lim B.Comment on " 'Stemness': transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature".Science. 2003 Oct 17;302(5644):393; author reply 393.
  • Grall F, Gu X, Tan L, Cho JY, Inan MS, Pettit AR, Thamrongsak U, Choy BK, Manning C, Akbarali Y, Zerbini L, Rudders S, Goldring SR, Gravallese EM, Oettgen P, Goldring MB, Libermann TA.Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1.Arthritis Rheum. 2003 May;48(5):1249-60.
  • Zerbini LF, Wang Y, Cho JY, Libermann TA.Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer.Cancer Res. 2003 May 1;63(9):2206-15.
  • Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA.Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.J Clin Invest. 2003 Mar;111(5):649-58.
  • Hirakawa S, Hong YK, Harvey N, Schacht V, Matsuda K, Libermann T, Detmar M.Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells.Am J Pathol. 2003 Feb;162(2):575-86.
  • Tsien CL, Libermann TA, Gu X, Kho A, Kohane IS.CHIP TUNER: a web tool for evidence-based noise reduction in gene discovery.Proc AMIA Symp. 2002:810-4.
  • Silverman ES, Baron RM, Palmer LJ, Le L, Hallock A, Subramaniam V, Riese RJ, McKenna MD, Gu X, Libermann TA, Tugores A, Haley KJ, Shore S, Drazen JM, Weiss ST.Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung.Am J Respir Cell Mol Biol. 2002 Dec;27(6):697-704.
  • Mitsiades N, Mitsiades CS, Richardson PG, Poulaki V, Tai YT, Chauhan D, Fanourakis G, Gu X, Bailey C, Joseph M, Libermann TA, Schlossman R, Munshi NC, Hideshima T, Anderson KC.The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications.Blood. 2003 Mar 15;101(6):2377-80.
  • Kwon JH, Keates S, Simeonidis S, Grall F, Libermann TA, Keates AC.ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells.J Biol Chem. 2003 Jan 10;278(2):875-84.
  • Muotri AR, Marchetto MC, Zerbini LF, Libermann TA, Ventura AM, Sarasin A, Menck CF.Complementation of the DNA repair deficiency in human xeroderma pigmentosum group a and C cells by recombinant adenovirus-mediated gene transfer.Hum Gene Ther. 2002 Oct 10;13(15):1833-44.
  • Mitsiades N, Mitsiades CS, Poulaki V, Chauhan D, Fanourakis G, Gu X, Bailey C, Joseph M, Libermann TA, Treon SP, Munshi NC, Richardson PG, Hideshima T, Anderson KC.Molecular sequelae of proteasome inhibition in human multiple myeloma cells.Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14374-9.
  • Baron RM, Palmer LJ, Tantisira K, Gabriel S, Sonna LA, Le L, Hallock A, Libermann TA, Drazen JM, Weiss ST, Silverman ES.DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma.Am J Respir Crit Care Med. 2002 Oct 1;166(7):927-32.
  • Zerbini LF, Libermann TA, Ventura AM.Insertion of an exogenous domain in the adenovirus type 2 fiber globular region.Biochem Biophys Res Commun. 2002 Aug 30;296(4):897-903.
  • Gaspar J, Thai S, Voland C, Dube A, Libermann TA, Iruela-Arispe ML, Oettgen P.Opposing functions of the Ets factors NERF and ELF-1 during chicken blood vessel development.Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1106-12.
  • Bowen GP, Borgland SL, Lam M, Libermann TA, Wong NC, Muruve DA.Adenovirus vector-induced inflammation: capsid-dependent induction of the C-C chemokine RANTES requires NF-kappa B.Hum Gene Ther. 2002 Feb 10;13(3):367-79.
  • Dendorfer U, Oettgen P, Libermann TA.Interleukin-6 Gene Expression by Prostaglandins and Cyclic AMP Mediated by Multiple Regulatory Elements.Am J Ther. 1995 Sep;2(9):660-665.
  • D'Addario M, Libermann TA, Xu J, Ahmad A, Menezes J.Epstein-Barr Virus and its glycoprotein-350 upregulate IL-6 in human B-lymphocytes via CD21, involving activation of NF-kappaB and different signaling pathways.J Mol Biol. 2001 May 4;308(3):501-14.
  • Tsien CL, Libermann TA, Gu X, Kohane IS.On reporting fold differences.Pac Symp Biocomput. 2001:496-507.
  • Borgland SL, Bowen GP, Wong NC, Libermann TA, Muruve DA.Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB.J Virol. 2000 May;74(9):3941-7.
  • Dube A, Thai S, Gaspar J, Rudders S, Libermann TA, Iruela-Arispe L, Oettgen P.Elf-1 is a transcriptional regulator of the Tie2 gene during vascular development.Circ Res. 2001 Feb 2;88(2):237-44.
  • Gu X, Shin BH, Akbarali Y, Weiss A, Boltax J, Oettgen P, Libermann TA.Tel-2 is a novel transcriptional repressor related to the Ets factor Tel/ETV-6.J Biol Chem. 2001 Mar 23;276(12):9421-36.
  • Rudders S, Gaspar J, Madore R, Voland C, Grall F, Patel A, Pellacani A, Perrella MA, Libermann TA, Oettgen P.ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene.J Biol Chem. 2001 Feb 2;276(5):3302-9.
  • Brembeck FH, Opitz OG, Libermann TA, Rustgi AK.Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation.Oncogene. 2000 Apr 6;19(15):1941-9.
  • Kas K, Finger E, Grall F, Gu X, Akbarali Y, Boltax J, Weiss A, Oettgen P, Kapeller R, Libermann TA.ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1.J Biol Chem. 2000 Jan 28;275(4):2986-98.
  • Oettgen P, Finger E, Sun Z, Akbarali Y, Thamrongsak U, Boltax J, Grall F, Dube A, Weiss A, Brown L, Quinn G, Kas K, Endress G, Kunsch C, Libermann TA.PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression.J Biol Chem. 2000 Jan 14;275(2):1216-25.
  • Oettgen P, Kas K, Dube A, Gu X, Grall F, Thamrongsak U, Akbarali Y, Finger E, Boltax J, Endress G, Munger K, Kunsch C, Libermann TA.Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes.J Biol Chem. 1999 Oct 8;274(41):29439-52.
  • Schwaninger M, Sallmann S, Petersen N, Schneider A, Prinz S, Libermann TA, Spranger M.Bradykinin induces interleukin-6 expression in astrocytes through activation of nuclear factor-kappaB.J Neurochem. 1999 Oct;73(4):1461-6.
  • Libermann TA, Pan Z, Akbarali Y, Hetherington CJ, Boltax J, Yergeau DA, Zhang DE.AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter.J Biol Chem. 1999 Aug 27;274(35):24671-6.
  • Dube A, Akbarali Y, Sato TN, Libermann TA, Oettgen P.Role of the Ets transcription factors in the regulation of the vascular-specific Tie2 gene.Circ Res. 1999 May 28;84(10):1177-85.
  • Muruve DA, Barnes MJ, Stillman IE, Libermann TA.Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo.Hum Gene Ther. 1999 Apr 10;10(6):965-76.
  • Oettgen P, Barcinski M, Boltax J, Stolt P, Akbarali Y, Libermann TA.Genomic organization of the human ELF3 (ESE-1/ESX) gene, a member of the Ets transcription factor family, and identification of a functional promoter.Genomics. 1999 Feb 1;55(3):358-62.
  • Gupta M, Zak R, Libermann TA, Gupta MP.Tissue-restricted expression of the cardiac alpha-myosin heavy chain gene is controlled by a downstream repressor element containing a palindrome of two ets-binding sites.Mol Cell Biol. 1998 Dec;18(12):7243-58.
  • Goldman D, Sapru MK, Stewart S, Plotkin J, Libermann TA, Wasylyk B, Guan K.Cloning and characterization of GETS-1, a goldfish Ets family member that functions as a transcriptional repressor in muscle.Biochem J. 1998 Oct 15;335 ( Pt 2):267-75.
  • Sata M, Perlman H, Muruve DA, Silver M, Ikebe M, Libermann TA, Oettgen P, Walsh K.Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response.Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1213-7.
  • Oettgen P, Carter KC, Augustus M, Barcinski M, Boltax J, Kunsch C, Libermann TA.The novel epithelial-specific Ets transcription factor gene ESX maps to human chromosome 1q32.1.Genomics. 1997 Oct 15;45(2):456-7.
  • Onyia JE, Libermann TA, Bidwell J, Arnold D, Tu Y, McClelland P, Hock JM.Parathyroid hormone (1-34)-mediated interleukin-6 induction.J Cell Biochem. 1997 Nov 1;67(2):265-74.
  • Muruve DA, Manfro RC, Strom TB, Libermann TA.Ex vivo adenovirus-mediated gene delivery leads to long-term expression in pancreatic islet transplants.Transplantation. 1997 Aug 15;64(3):542-6.
  • Oettgen P, Alani RM, Barcinski MA, Brown L, Akbarali Y, Boltax J, Kunsch C, Munger K, Libermann TA.Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family.Mol Cell Biol. 1997 Aug;17(8):4419-33.
  • Muruve DA, Nicolson AG, Manfro RC, Strom TB, Sukhatme VP, Libermann TA.Adenovirus-mediated expression of Fas ligand induces hepatic apoptosis after Systemic administration and apoptosis of ex vivo-infected pancreatic islet allografts and isografts.Hum Gene Ther. 1997 May 20;8(8):955-63.
  • Akbarali Y, Oettgen P, Boltax J, Libermann TA.ELF-1 interacts with and transactivates the IgH enhancer pi site.J Biol Chem. 1996 Oct 18;271(42):26007-12.
  • Oettgen P, Akbarali Y, Boltax J, Best J, Kunsch C, Libermann TA.Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1.Mol Cell Biol. 1996 Sep;16(9):5091-106.
  • Chauhan D, Uchiyama H, Akbarali Y, Urashima M, Yamamoto K, Libermann TA, Anderson KC.Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B.Blood. 1996 Feb 1;87(3):1104-12.
  • Dendorfer U, Oettgen P, Libermann TA.Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide.Mol Cell Biol. 1994 Jul;14(7):4443-54.
  • Lopez M, Oettgen P, Akbarali Y, Dendorfer U, Libermann TA.ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development.Mol Cell Biol. 1994 May;14(5):3292-309.
  • Lichtor T, Libermann TA.Coexpression of interleukin-1 beta and interleukin-6 in human brain tumors.Neurosurgery. 1994 Apr;34(4):669-72; discussion 672-3.
  • Libermann TA, Baltimore D.Pi, a pre-B-cell-specific enhancer element in the immunoglobulin heavy-chain enhancer.Mol Cell Biol. 1993 Oct;13(10):5957-69.
  • Rong BL, Libermann TA, Kogawa K, Ghosh S, Cao LX, Pavan-Langston D, Dunkel EC.HSV-1-inducible proteins bind to NF-kappa B-like sites in the HSV-1 genome.Virology. 1992 Aug;189(2):750-6.
  • Libermann TA, Lenardo M, Baltimore D.Involvement of a second lymphoid-specific enhancer element in the regulation of immunoglobulin heavy-chain gene expression.Mol Cell Biol. 1990 Jun;10(6):3155-62.
  • Libermann TA, Baltimore D.Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.Mol Cell Biol. 1990 May;10(5):2327-34.
  • Nistr M, Libermann TA, Betsholtz C, Pettersson M, Claesson-Welsh L, Heldin CH, Schlessinger J, Westermark B.Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines.Cancer Res. 1988 Jul 15;48(14):3910-8.
  • Libermann TA, Friesel R, Jaye M, Lyall RM, Westermark B, Drohan W, Schmidt A, Maciag T, Schlessinger J.An angiogenic growth factor is expressed in human glioma cells.EMBO J. 1987 Jun;6(6):1627-32.
  • Chen E, Coussens L, Liao YC, Smith D, Yang-Feng TL, McGrath J, Van Beveren C, Verma IM, Libermann TA, Schlessinger J.Structural features of growth factor receptors with oncogenic potential.Biochem Soc Symp. 1986;52:65-82.
  • Coussens L, Yang-Feng TL, Liao YC, Chen E, Gray A, McGrath J, Seeburg PH, Libermann TA, Schlessinger J, Francke U.Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.Science. 1985 Dec 6;230(4730):1132-9.
  • Libermann TA, Nusbaum HR, Razon N, Kris R, Lax I, Soreq H, Whittle N, Waterfield MD, Ullrich A, Schlessinger J.Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin.Nature. 1985 Jan 10-18;313(5998):144-7.
  • Gooi HC, Hounsell EF, Lax I, Kris RM, Libermann TA, Schlessinger J, Sato JD, Kawamoto T, Mendelsohn J, Feizi T.The carbohydrate specificities of the monoclonal antibodies 29.1, 455 and 3C1B12 to the epidermal growth factor receptor of A431 cells.Biosci Rep. 1985 Jan;5(1):83-94.
  • Libermann TA, Nusbaum HR, Razon N, Kris R, Lax I, Soreq H, Whittle N, Waterfield MD, Ullrich A, Schlessinger J.Amplification and overexpression of the EGF receptor gene in primary human glioblastomas.J Cell Sci Suppl. 1985;3:161-72.
  • Lax I, Bar-Eli M, Yarden Y, Libermann TA, Schlessinger J.Antibodies to two defined regions of the transforming protein pp60src interact specifically with the epidermal growth factor receptor kinase system.Proc Natl Acad Sci U S A. 1984 Oct;81(19):5911-5.
  • Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tam AW, Lee J, Yarden Y, Libermann TA, Schlessinger J.Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.Nature. 1984 May 31-Jun 6;309(5967):418-25.
  • Libermann TA, Razon N, Bartal AD, Yarden Y, Schlessinger J, Soreq H.Expression of epidermal growth factor receptors in human brain tumors.Cancer Res. 1984 Feb;44(2):753-60.
  • Gooi HC, Schlessinger J, Lax I, Yarden Y, Libermann TA, Feizi T.Monoclonal antibody reactive with the human epidermal-growth-factor receptor recognizes the blood-group-A antigen.Biosci Rep. 1983 Nov;3(11):1045-52.
  • Hapgood J, Libermann TA, Lax I, Yarden Y, Schreiber AB, Naor Z, Schlessinger J.Monoclonal antibodies against epidermal growth factor receptor induce prolactin synthesis in cultured rat pituitary cells (GH3).Proc Natl Acad Sci U S A. 1983 Nov;80(21):6451-5.
  • Schreiber AB, Libermann TA, Lax I, Yarden Y, Schlessinger J.Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies.J Biol Chem. 1983 Jan 25;258(2):846-53.
  • Birchmeier W, Libermann TA, Imhof BA, Kreis TE.Intracellular and extracellular components involved in the formation of ventral surfaces of fibroblasts.Cold Spring Harb Symp Quant Biol. 1982;46 Pt 2:755-67.
  • Schlessinger J, Schreiber AB, Lax I, Yashuv-Gan Y, Libermann TA, Hillman GM, Levi A, Yarden Y.Molecular steps in the action and regulation of epidermal growth factor: a cellular mitogen.Prog Clin Biol Res. 1982;91:359-72.
  • Imhof BA, Acha-Orbea HJ, Libermann TA, Reber BF, Lanz JH, Winterhalter KH, Birchmeier W.Phosphorylation and dephosphorylation of spectrin from human erythrocyte ghosts under physiological conditions: autocatalysis rather than reaction with separate kinase and phosphatase.Proc Natl Acad Sci U S A. 1980 Jun;77(6):3264-8.