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Sheng Xiao, MD

Publications

  • Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA.Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.J Clin Invest. 2014 Jun 2;124(6):2513-22.
    24812667
  • Angiari S, Donnarumma T, Rossi B, Dusi S, Pietronigro E, Zenaro E, Della Bianca V, Toffali L, Piacentino G, Budui S, Rennert P, Xiao S, Laudanna C, Casasnovas JM, Kuchroo VK, Constantin G.TIM-1 Glycoprotein Binds the Adhesion Receptor P-Selectin and Mediates T Cell Trafficking during Inflammation and Autoimmunity.Immunity. 2014 Apr 17;40(4):542-53.
    24703780
  • Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK.Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.Immunity. 2014 Apr 17;40(4):569-81.
    24745333
  • Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK.Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms.Immunity. 2014 Apr 17;40(4):477-89.
    24745332
  • Zhu B, Buttrick T, Bassil R, Zhu C, Olah M, Wu C, Xiao S, Orent W, Elyaman W, Khoury SJ.IL-4 and retinoic acid synergistically induce regulatory dendritic cells expressing Aldh1a2.J Immunol. 2013 Sep 15;191(6):3139-51.
    23960232
  • Humphreys BD, Xu F, Sabbisetti V, Grgic I, Naini SM, Wang N, Chen G, Xiao S, Patel D, Henderson JM, Ichimura T, Mou S, Soeung S, McMahon AP, Kuchroo VK, Bonventre JV.Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis.J Clin Invest. 2013 Sep 3;123(9):4023-35.
    23979159
  • Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS.Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.Nat Med. 2012 Aug(8):1248-53.
    22772464
  • Wu C, Pot C, Apetoh L, Thalhamer T, Zhu B, Murugaiyan G, Xiao S, Lee Y, Rangachari M, Yosef N, Kuchroo VK.Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation.Proc Natl Acad Sci U S A. 2013 May 7;110(19):7802-7.
    23630250
  • Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, Wu C, Karwacz K, Xiao S, Jorgolli M, Gennert D, Satija R, Shakya A, Lu DY, Trombetta JJ, Pillai MR, Ratcliffe PJ, Coleman ML, Bix M, Tantin D, Park H, Kuchroo VK, Regev A.Dynamic regulatory network controlling TH17 cell differentiation.Nature. 2013 Mar 6.
    23467089
  • Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y, Regev A, Kuchroo VK.Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.Nature. 2013 Mar 6.
    23467085
  • Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, Angin M, Wakeham A, Greenfield EA, Sobel RA, Okada H, McKinnon PJ, Mak TW, Addo MM, Anderson AC, Kuchroo VK.Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.Nat Med. 2012 Sep;18(9):1394-400.
    22863785
  • Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK.Induction and molecular signature of pathogenic TH17 cells.Nat Immunol. 2012 Oct;13(10):991-9.
    22961052
  • Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK.Aiolos promotes TH17 differentiation by directly silencing Il2 expression.Nat Immunol. 2012 Aug;13(8):770-7.
    22751139
  • Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK.Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12105-10.
    22773818
  • Xiao S, Zhu B, Jin H, Zhu C, Umetsu DT, Dekruyff RH, Kuchroo VK.Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells.Eur J Immunol. 2011 Mar 18.
    21469101
  • Wu X, Gao H, Ke W, Hager M, Xiao S, Freeman MR, Zhu Z.VentX trans-activates p53 and p16ink4a to regulate cellular senescence.J Biol Chem. 2011 Feb 16.
    21325273
  • Ligon AH, Morton CC, Bieber FR, Fletcher JA, Giersch AB, Kantarci S, Leach N, Lee C, Sandstrom M, Weremowicz S, Xiao S, Dal Cin P.Reporting of diagnostic cytogenetic results.Curr Protoc Hum Genet. 2010 Oct;Appendix 1:1D.1-23.
    20891028
  • Apetoh L, Quintana FJ, Pot C, Joller N, Xiao S, Kumar D, Burns EJ, Sherr DH, Weiner HL, Kuchroo VK.The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27.Nat Immunol. 2010 Sep;11(9):854-61.
    20676095
  • Rodriguez-Manzanet R, Sanjuan MA, Wu HY, Quintana FJ, Xiao S, Anderson AC, Weiner HL, Green DR, Kuchroo VK.T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice.Proc Natl Acad Sci U S A. 2010 May 11;107(19):8706-11.
    20368430
  • Li Y, Chang Q, Rubin BP, Fletcher CD, Morgan TW, Mentzer SJ, Sugarbaker DJ, Fletcher JA, Xiao S.Insulin receptor activation in solitary fibrous tumours.J Pathol. 2007 Apr;211(5):550-4.
    17299733
  • Xiao S, McCarthy JG, Aster JC, Fletcher JA.ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain.Blood. 2000 Jul 15;96(2):699-704.
    10887137
  • Lux ML, Rubin BP, Biase TL, Chen CJ, Maclure T, Demetri G, Xiao S, Singer S, Fletcher CD, Fletcher JA.KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors.Am J Pathol. 2000 Mar;156(3):791-5.
    10702394
  • Davison JM, Morgan TW, Hsi BL, Xiao S, Fletcher JA.Subtracted, unique-sequence, in situ hybridization: experimental and diagnostic applications.Am J Pathol. 1998 Nov;153(5):1401-9.
    9811331
  • Rubin BP, Chen CJ, Morgan TW, Xiao S, Grier HE, Kozakewich HP, Perez-Atayde AR, Fletcher JA.Congenital mesoblastic nephroma t(12;15) is associated with ETV6-NTRK3 gene fusion: cytogenetic and molecular relationship to congenital (infantile) fibrosarcoma.Am J Pathol. 1998 Nov;153(5):1451-8.
    9811336
  • Xiao S, Nalabolu SR, Aster JC, Ma J, Abruzzo L, Jaffe ES, Stone R, Weissman SM, Hudson TJ, Fletcher JA.FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome.Nat Genet. 1998 Jan;18(1):84-7.
    9425908
  • Xiao S, Lux ML, Reeves R, Hudson TJ, Fletcher JA.HMGI(Y) activation by chromosome 6p21 rearrangements in multilineage mesenchymal cells from pulmonary hamartoma.Am J Pathol. 1997 Mar;150(3):901-10.
    9060828
  • Huang SF, Xiao S, Renshaw AA, Loughlin KR, Hudson TJ, Fletcher JA.Fluorescence in situ hybridization evaluation of chromosome deletion patterns in prostate cancer.Am J Pathol. 1996 Nov;149(5):1565-73.
    8909246
  • Xiao S, Renshaw A, Cibas ES, Hudson TJ, Fletcher JA.Novel fluorescence in situ hybridization approaches in solid tumors. Characterization of frozen specimens, touch preparations, and cytological preparations.Am J Pathol. 1995 Oct;147(4):896-904.
    7573365
  • Xiao S, Li D, Corson JM, Vijg J, Fletcher JA.Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma.Cancer Res. 1995 Jul 15;55(14):2968-71.
    7606711
  • Fletcher JA, Naeem R, Xiao S, Corson JM.Chromosome aberrations in desmoid tumors. Trisomy 8 may be a predictor of recurrence.Cancer Genet Cytogenet. 1995 Feb;79(2):139-43.
    7889507
  • Lu YJ, Xiao S, Yan YS, Fu SB, Liu QZ, Li P.Direct chromosome analysis of 50 primary breast carcinomas.Cancer Genet Cytogenet. 1993 Sep;69(2):91-9.
    8402564
  • Xiao S, Feng XL, Shi YH, Liu QZ, Li P.Cytogenetic abnormalities in a squamous cell carcinoma of the penis.Cancer Genet Cytogenet. 1992 Dec;64(2):139-41.
    1486562
  • Xiao S, Wei W, Feng XL, Shi YH, Liu QZ, Li P.Direct chromosome analysis of seven primary colorectal carcinomas.Cancer Genet Cytogenet. 1992 Aug;62(1):32-9.
    1325867
  • Xiao S, Geng JS, Feng XL, Liu XQ, Liu QZ, Li P.Cytogenetic studies of eight primary gastric cancers.Cancer Genet Cytogenet. 1992 Jan;58(1):79-84.
    1728956
  • Xiao S, Feng XL, Geng JS, Yan FC, Liu QZ, Li P.Cytogenetic studies of five primary esophageal cancers.Cancer Genet Cytogenet. 1991 Sep;55(2):197-205.
    1933822