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Andrew H. Lichtman, MD, PhD


  • Griffin GK, Lichtman AH.Two Sides to Every Pro-Inflammatory Coin: New Insights into the Role of Dendritic Cells in the Regulation of T-Cell Driven Autoimmune Myocarditis.Circulation. 2013 May 13.
  • Shah SM, Drage MG, Lichtman AH, Haddad RI.Metastatic human papillomavirus-positive nasopharyngeal carcinoma with an unusual pattern of aggressive hematogenous spread.J Clin Oncol. 2012 Nov 10;30(32):e321-3.
  • Griffin GK, Newton G, Tarrio ML, Bu DX, Maganto-Garcia E, Azcutia V, Alcaide P, Grabie N, Luscinskas FW, Croce KJ, Lichtman AH.IL-17 and TNF-α sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation.J Immunol. 2012 Jun 15;188(12):6287-99.
  • Bu DX, Tarrio M, Maganto-Garcia E, Stavrakis G, Tajima G, Lederer J, Jarolim P, Freeman GJ, Sharpe AH, Lichtman AH.Impairment of the Programmed Cell Death-1 Pathway Increases Atherosclerotic Lesion Development and Inflammation.Arterioscler Thromb Vasc Biol. 2011 Mar 10.
  • Bu DX, Tarrio M, Grabie N, Zhang Y, Yamazaki H, Stavrakis G, Maganto-Garcia E, Pepper-Cunningham Z, Jarolim P, Aikawa M, García-Cardeña G, Lichtman AH.Statin-induced kruppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses.J Clin Invest. 2010 Jun 1;120(6):1961-70.
  • Packard RR,Lichtman AH,Libby P.Innate and adaptive immunity in atherosclerosis.Semin Immunopathol. 2009 Jun;31(1):5-22. Review.
  • Gotsman I,Sharpe AH,Lichtman AH.T-cell costimulation and coinhibition in atherosclerosis.Circ Res. 2008 Nov 21;103(11):1220-31. Review.
  • Packard RR,Maganto-Garcia E,Gotsman I,Tabas I,Libby P,Lichtman AH.CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis.Circ Res. 2008 Oct 24;103(9):965-73.
  • Gotsman I, Grabie N, Dacosta R, Sukhova G, Sharpe A, Lichtman AH.Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice.J Clin Invest. 2007 Oct;117(10):2974-82.
  • Love VA, Grabie N, Duramad P, Stavrakis G, Sharpe A, Lichtman A.CTLA-4 ablation and interleukin-12 driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes.Circ Res. 2007 Aug 3;101(3):248-57.
  • Taqueti VR, Grabie N, Colvin R, Pang H, Jarolim P, Luster AD, Glimcher LH, Lichtman AH.T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity.J Immunol. 2006 Nov 1;177(9):5890-901.
  • Buono C, Binder CJ, Stavrakis G, Witztum JL, Glimcher LH, Lichtman AH.T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses.Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1596-601.
  • Rodig N, Ryan T, Allen JA, Pang H, Grabie N, Chernova T, Greenfield EA, Liang SC, Sharpe AH, Lichtman AH, Freeman GJ.Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis.Eur J Immunol. 2003 Nov;33(11):3117-26.
  • Buono C, Come CE, Stavrakis G, Maguire GF, Connelly PW, Lichtman AH.Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse.Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):454-60.
  • Buono C, Come CE, Witztum JL, Maguire GF, Connelly PW, Carroll M, Lichtman AH.Influence of C3 deficiency on atherosclerosis.Circulation. 2002 Jun 25;105(25):3025-31.
  • Cybulsky MI, Lichtman AH, Hajra L, Iiyama K.Leukocyte adhesion molecules in atherogenesis.Clin Chim Acta. 1999 Aug;286(1-2):207-18.
  • Lichtman AH, Clinton SK, Iiyama K, Connelly PW, Libby P, Cybulsky MI.Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate.Arterioscler Thromb Vasc Biol. 1999 Aug;19(8):1938-44.
  • Xie H, Lim YC, Luscinskas FW, Lichtman AH.Acquisition of selectin binding and peripheral homing properties by CD4(+) and CD8(+) T cells.J Exp Med. 1999 Jun 7;189(11):1765-76.
  • Aune TM, Mora AL, Kim S, Boothby M, Lichtman AH.Costimulation reverses the defect in IL-2 but not effector cytokine production by T cells with impaired IkappaBalpha degradation.J Immunol. 1999 May 15;162(10):5805-12.
  • Lim YC, Henault L, Wagers AJ, Kansas GS, Luscinskas FW, Lichtman AH.Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4.J Immunol. 1999 Mar 15;162(6):3193-201.
  • Kol A, Bourcier T, Lichtman AH, Libby P.Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages.J Clin Invest. 1999 Feb;103(4):571-7.
  • Perez VL, Henault L, Lichtman AH.Endothelial antigen presentation: stimulation of previously activated but not nave TCR-transgenic mouse T cells.Cell Immunol. 1998 Oct 10;189(1):31-40.
  • Kol A, Sukhova GK, Lichtman AH, Libby P.Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression.Circulation. 1998 Jul 28;98(4):300-7.
  • Kiani A, Viola JP, Lichtman AH, Rao A.Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1.Immunity. 1997 Dec;7(6):849-60.
  • Briscoe DM, Henault LE, Geehan C, Alexander SI, Lichtman AH.Human endothelial cell costimulation of T cell IFN-gamma production.J Immunol. 1997 Oct 1;159(7):3247-56.
  • Lichtman AH, Ding H, Henault L, Vachino G, Camphausen R, Cumming D, Luscinskas FW.CD45RA-RO+ (memory) but not CD45RA+RO- (naive) T cells roll efficiently on E- and P-selectin and vascular cell adhesion molecule-1 under flow.J Immunol. 1997 Apr 15;158(8):3640-50.
  • Lichtman AH, Abbas AK.T-cell subsets: recruiting the right kind of help.Curr Biol. 1997 Apr 1;7(4):R242-4.
  • Lederer JA, Perez VL, DesRoches L, Kim SM, Abbas AK, Lichtman AH.Cytokine transcriptional events during helper T cell subset differentiation.J Exp Med. 1996 Aug 1;184(2):397-406.
  • Lichtman AH, Cybulsky M, Luscinskas FW.Immunology of atherosclerosis: the promise of mouse models.Am J Pathol. 1996 Aug;149(2):351-7.
  • Briscoe DM, DesRoches LE, Kiely JM, Lederer JA, Lichtman AH.Antigen-dependent activation of T helper cell subsets by endothelium.Transplantation. 1995 Jun 15;59(11):1638-41.
  • Luscinskas FW, Ding H, Lichtman AH.P-selectin and vascular cell adhesion molecule 1 mediate rolling and arrest, respectively, of CD4+ T lymphocytes on tumor necrosis factor alpha-activated vascular endothelium under flow.J Exp Med. 1995 Mar 1;181(3):1179-86.
  • St Louis JD, Lederer JA, Lichtman AH.Costimulator deficient antigen presentation by an endothelial cell line induces a nonproliferative T cell activation response without anergy.J Exp Med. 1993 Nov 1;178(5):1597-605.
  • Todd MD, Grusby MJ, Lederer JA, Lacy E, Lichtman AH, Glimcher LH.Transcription of the interleukin 4 gene is regulated by multiple promoter elements.J Exp Med. 1993 Jun 1;177(6):1663-74.
  • Casey LS, Lichtman AH, Boothby M.IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes.J Immunol. 1992 Jun 1;148(11):3418-26.
  • Abbas AK, Williams ME, Burstein HJ, Chang TL, Bossu P, Lichtman AH.Activation and functions of CD4+ T-cell subsets.Immunol Rev. 1991 Oct;123:5-22.
  • Williams ME, Lichtman AH, Abbas AK.Anti-CD3 antibody induces unresponsiveness to IL-2 in Th1 clones but not in Th2 clones.J Immunol. 1990 Feb 15;144(4):1208-14.
  • Lichtman AH, Chin J, Schmidt JA, Abbas AK.Role of interleukin 1 in the activation of T lymphocytes.Proc Natl Acad Sci U S A. 1988 Dec;85(24):9699-703.
  • Lichtman AH, Williams ME, Ohara J, Paul WE, Faller DV, Abbas AK.Retrovirus infection alters growth factor responses of T lymphocytes.J Immunol. 1987 May 15;138(10):3276-83.
  • Lichtman AH, Tony HP, Parker DC, Abbas AK.Antigen presentation by hapten-specific B lymphocytes. IV. Comparative ability of B cells to present specific antigen and anti-immunoglobulin antibody.J Immunol. 1987 May 1;138(9):2822-5.
  • Lichtman AH, Kurt-Jones EA, Abbas AK.B-cell stimulatory factor 1 and not interleukin 2 is the autocrine growth factor for some helper T lymphocytes.Proc Natl Acad Sci U S A. 1987 Feb;84(3):824-7.
  • Lichtman AH, Segel GB, Lichtman MA.Effects of trifluoperazine and mitogenic lectins on calcium ATPase activity and calcium transport by human lymphocyte plasma membrane vesicles.J Cell Physiol. 1982 May;111(2):213-7.
  • Lichtman AH, Segel GB, Lichtman MA.Calcium transport and calcium-ATPase activity in human lymphocyte plasma membrane vesicles.J Biol Chem. 1981 Jun 25;256(12):6148-54.