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Vassiliki A. Boussiotis, MD, PhD


  • Nellore A, Liu B, Patsoukis N, Boussiotis VA, Li L.The cyclin dependent kinase inhibitor (R)-roscovitine mediates selective suppression of alloreactive human T cells but preserves pathogen-specific and leukemia-specific effectors.Clin Immunol.;152(1-2):48-57.
  • Patsoukis N, Li L, Sari D, Petkova V, Boussiotis VA.PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2.Mol Cell Biol. 2013 Aug;33(16):3091-8.
  • Rosenblatt J, Avivi I, Vasir B, Uhl L, Munshi NC, Katz T, Dey BR, Somaiya P, Mills H, Campigotto F, Weller E, Joyce R, Levine JD, Tzachanis D, Richardson P, Laubach J, Raje N, Boussiotis V, Yuan YE, Bisharat L, Held V, Rowe J, Anderson K, Kufe D, Avigan D.Vaccination with dendritic cell/tumor fusions following autologous stem cell transplant induces immunologic and clinical responses in multiple myeloma patients.Clin Cancer Res. 2013 Jul 1;19(13):3640-8.
  • Medraño-Fernandez I, Reyes R, Olazabal I, Rodriguez E, Sanchez-Madrid F, Boussiotis VA, Reche PA, Cabañas C, Lafuente EM.RIAM (Rap1-interacting adaptor molecule) regulates complement-dependent phagocytosis.Cell Mol Life Sci. 2013 Feb 19.
  • Ballen K, Mendizabal AM, Cutler C, Politikos I, Jamieson K, Shpall EJ, Dey BR, Attar E, McAfee S, Delaney C, McCarthy P, Ball ED, Kamble R, Avigan D, Maziarz RT, Ho VT, Koreth J, Alyea E, Soiffer R, Wingard JR, Boussiotis V, Spitzer TR, Antin JH.Phase II trial of parathyroid hormone after double umbilical cord blood transplantation.Biol Blood Marrow Transplant. 2012 Dec;18(12):1851-8.
  • Patsoukis N, Sari D, Boussiotis VA.PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A.Cell Cycle. 2012 Oct 3;11(23).
  • Wynne JP, Wu J, Su W, Mor A, Patsoukis N, Boussiotis VA, Hubbard SR, Philips MR.Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector.J Cell Biol. 2012 Oct 15;199(2):317-29.
  • Li L, Patsoukis N, Petkova V, Boussiotis VA.Runx1 and Runx3 are involved in the generation and function of highly suppressive IL-17-producing T regulatory cells.PLoS ONE. 2012;7(9):e45115.
  • Patsoukis N, Brown J, Petkova V, Liu F, Li L, Boussiotis VA.Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation.Sci Signal. 2012 Jun 26;5(230):ra46.
  • Hernandez-Varas P, Colo GP, Bartolome RA, Paterson A, Medrano-Fernandez I, Arellano-Sanchez N, Cabanas C, Sanchez-Mateos P, Lafuente EM, Boussiotis VA, Stromblad S, Teixido J.RIAM controls invasion and growth of melanoma cells.J Biol Chem. 2011 Mar 26.
  • Li L, Kim JS, Boussiotis VA.Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms.Cell Immunol. 2010;266(1):7-13.
  • Li L, Kim J, Boussiotis VA.IL-1β-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells.J Immunol. 2010 Oct 1;185(7):4148-53.
  • Rosenblatt J, Bissonnette A, Ahmad R, Wu Z, Vasir B, Stevenson K, Zarwan C, Keefe W, Glotzbecker B, Mills H, Joyce R, Levine JD, Tzachanis D, Boussiotis V, Kufe D, Avigan D.Immunomodulatory effects of vitamin D: implications for GVHD.Bone Marrow Transplant. 2010 Sep;45(9):1463-8.
  • Cutler C, Stevenson K, Kim HT, Brown J, McDonough S, Herrera M, Reynolds C, Liney D, Kao G, Ho V, Armand P, Koreth J, Alyea E, Dey BR, Attar E, Spitzer T, Boussiotis VA, Ritz J, Soiffer R, Antin JH, Ballen K.Double umbilical cord blood transplantation with reduced intensity conditioning and sirolimus-based GVHD prophylaxis.Bone Marrow Transplant. 2010 Aug 9.
  • Brown JA, Stevenson K, Kim HT, Cutler C, Ballen K, McDonough S, Reynolds C, Herrera M, Liney D, Ho V, Kao G, Armand P, Koreth J, Alyea E, McAfee S, Attar E, Dey B, Spitzer T, Soiffer R, Ritz J, Antin JH, Boussiotis VA.Clearance of CMV viremia and survival after double umbilical cord blood transplantation in adults depends on reconstitution of thymopoiesis.Blood. 2010 May 20;115(20):4111-9.
  • Rosenblatt J, Wu Z, Vasir B, Zarwan C, Stone R, Mills H, Friedman T, Konstantinopoulos PA, Spentzos D, Ghebremichael M, Stevenson K, Neuberg D, Levine JD, Joyce R, Tzachanis D, Boussiotis V, Kufe D, Avigan D.Generation of Tumor-specific T Lymphocytes Using Dendritic Cell/Tumor Fusions and Anti-CD3/CD28.J Immunother.;33(2):155-66.
  • Patsoukis N, Lafuente EM, Meraner P, Kim J, Dombkowski D, Li L, Boussiotis VA.RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells.Sci Signal. 2009;2(99):ra79.
  • Tzachanis D,Boussiotis VA.Tob, a member of the APRO family, regulates immunological quiescence and tumor suppression.Cell Cycle. 2009 Apr 1;8(7):1019-25. Review.
  • Zhou D,Medoff BD,Chen L,Li L,Zhang XF,Praskova M,Liu M,Landry A,Blumberg RS,Boussiotis VA,Xavier R,Avruch J.The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells.Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20321-6.
  • Watanabe N,Bodin L,Pandey M,Krause M,Coughlin S,Boussiotis VA,Ginsberg MH,Shattil SJ.Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3.J Cell Biol. 2008 Jun 30;181(7):1211-22.
  • Ge X, Brown J, Sykes M, Boussiotis VA.CD134-allodepletion allows selective elimination of alloreactive human T cells without loss of virus-specific and leukemia-specific effectors.Biol Blood Marrow Transplant. 2008 May;14(5):518-30.
  • Brown JA,Boussiotis VA.Umbilical cord blood transplantation: basic biology and clinical challenges to immune reconstitution.Clin Immunol. 2008 Jun;127(3):286-97. Review.
  • Barata JT, Silva A, Brandao JG, Nadler LM, Cardoso AA, Boussiotis VA.Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells.J Exp Med. 2004 Sep 6;200(5):659-69.
  • Barata JT, Boussiotis VA, Yunes JA, Ferrando AA, Moreau LA, Veiga JP, Sallan SE, Look AT, Nadler LM, Cardoso AA.IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL.Blood. 2004 Mar 1;103(5):1891-900.
  • Tzachanis D, Appleman LJ, Van Puijenbroek AA, Berezovskaya A, Nadler LM, Boussiotis VA.Differential localization and function of ADP-ribosylation factor-6 in anergic human T cells: a potential marker for their identification.J Immunol. 2003 Aug 15;171(4):1691-6.
  • Grader-Beck T, van Puijenbroek AA, Nadler LM, Boussiotis VA.cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression.Blood. 2003 Feb 1;101(3):998-1006.
  • Appleman LJ, van Puijenbroek AA, Shu KM, Nadler LM, Boussiotis VA.CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells.J Immunol. 2002 Mar 15;168(6):2729-36.
  • Tzachanis D, Berezovskaya A, Nadler LM, Boussiotis VA.Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-cell responses.Blood. 2002 Feb 15;99(4):1465-73.
  • Boussiotis VA, Tsai EY, Yunis EJ, Thim S, Delgado JC, Dascher CC, Berezovskaya A, Rousset D, Reynes JM, Goldfeld AE.IL-10-producing T cells suppress immune responses in anergic tuberculosis patients.J Clin Invest. 2000 May;105(9):1317-25.
  • Boussiotis VA, Freeman GJ, Taylor PA, Berezovskaya A, Grass I, Blazar BR, Nadler LM.p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes.Nat Med. 2000 Mar;6(3):290-7.
  • Guinan EC, Boussiotis VA, Neuberg D, Brennan LL, Hirano N, Nadler LM, Gribben JG.Transplantation of anergic histoincompatible bone marrow allografts.N Engl J Med. 1999 Jun 3;340(22):1704-14.
  • Boussiotis VA, Barber DL, Lee BJ, Gribben JG, Freeman GJ, Nadler LM.Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation.J Exp Med. 1996 Aug 1;184(2):365-76.
  • Gribben JG, Guinan EC, Boussiotis VA, Ke XY, Linsley L, Sieff C, Gray GS, Freeman GJ, Nadler LM.Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft-versus-host disease and extend the donor pool.Blood. 1996 Jun 1;87(11):4887-93.
  • Freeman GJ, Boussiotis VA, Anumanthan A, Bernstein GM, Ke XY, Rennert PD, Gray GS, Gribben JG, Nadler LM.B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4.Immunity. 1995 May;2(5):523-32.
  • Boussiotis VA, Barber DL, Nakarai T, Freeman GJ, Gribben JG, Bernstein GM, D'Andrea AD, Ritz J, Nadler LM.Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor.Science. 1994 Nov 11;266(5187):1039-42.
  • Boussiotis VA, Freeman GJ, Griffin JD, Gray GS, Gribben JG, Nadler LM.CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy.J Exp Med. 1994 Nov 1;180(5):1665-73.
  • Freeman GJ, Gribben JG, Boussiotis VA, Ng JW, Restivo VA, Lombard LA, Gray GS, Nadler LM.Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation.Science. 1993 Nov 5;262(5135):909-11.
  • Boussiotis VA, Freeman GJ, Gray G, Gribben J, Nadler LM.B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance.J Exp Med. 1993 Nov 1;178(5):1753-63.