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Hava Avraham, PhD

Publications

  • Avraham HK, Jiang S, Fu Y, Nakshatri H, Ovadia H, Avraham S.Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain.J Pathol. 2014 Feb;232(3):369-81.
    24421076
  • Rodriguez PL, Jiang S, Fu Y, Avraham S, Avraham HK.The proinflammatory peptide substance P promotes blood-brain barrier breaching by breast cancer cells through changes in microvascular endothelial cell tight junctions.Int J Cancer. 2014 Mar 1;134(5):1034-44.
    23934616
  • Li H, Wood J, Whitten K, Vadival S, Seng S, Makriyannis A, Avraham S, Avraham H.Inhibition Of Fatty Acid Amide Hydrolase Activates Nrf2 Signaling And Induces Heme Oxygenase 1 Transcription In Breast Cancer Cells.Br J Pharmacol. 2013 Jan 24.
    23347118
  • Arshad F, Wang L, Sy C, Avraham S, Avraham HK.Blood-brain barrier integrity and breast cancer metastasis to the brain.Patholog Res Int. 2010;2011:920509.
    21253507
  • Jiang S, Alberich-Jorda M, Zagozdzon R, Parmar K, Fu Y, Mauch P, Banu N, Makriyannis A, Tenen DG, Avraham S, Groopman JE, Avraham HK.Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization.Blood. 2011 Jan 20;117(3):827-38.
    21063029
  • Jiang S, Zagozdzon R, Jorda MA, Parmar K, Fu Y, Williams JS, Wood JA, Makriyannis A, Banu N, Avraham S, Groopman JE, Avraham HK.ENDOCANNABINOIDS ARE EXPRESSED IN BONE MARROW STROMAL NICHES AND PLAY A ROLE IN INTERACTIONS OF HEMATOPOIETIC STEM AND PROGENITOR CELLS WITH THE BONE MARROW MICROENVIRONMENT.J Biol Chem. 2010 Nov 12;285(46):35471-8.
    20826813
  • Seng S, Avraham HK, Birrane G, Jiang S, Avraham S.Nuclear matrix protein (NRP/B) modulates the nuclear factor (erythroid-derived 2)-like 2 (NRF2)-dependent oxidative stress response.J Biol Chem. 2010 Aug 20;285(34):26190-8.
    20511222
  • Jiang S, Lee BC, Fu Y, Avraham S, Lim B, Avraham HK.Reconstitution of mammary epithelial morphogenesis by murine embryonic stem cells undergoing hematopoietic stem cell differentiation.PLoS ONE. 2010;5(3):e9707.
    20300573
  • Li H, Sekine M, Tung N, Avraham HK.Wild-Type BRCA1, but not Mutated BRCA1, Regulates the Expression of the Nuclear Form of {beta}-Catenin.Mol Cancer Res. 2010 Mar;8(3):407-20.
    20215423
  • Hinton CV,Avraham S,Avraham HK.Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain.Clin Exp Metastasis. 2010 Feb;27(2):97-105. Review.
    18814042
  • Li H, Sekine M, Seng S, Avraham S, Avraham HK.BRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responses.PLoS ONE. 2009;4(9):e7091.
    19768112
  • Hinton CV, Avraham S, Avraham HK.Contributions of Integrin-Linked Kinase to Breast Cancer Metastasis and Tumorigenesis.J Cell Mol Med.;12(5A):1517-26. Review.
    18363848
  • Lu TS,Avraham HK,Seng S,Tachado SD,Koziel H,Makriyannis A,Avraham S.Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells.J Immunol. 2008 Nov 1;181(9):6406-16.
    18941231
  • Zagozdzon R, Fu Y, Avraham HK.Csk homologous kinase inhibits CXCL12-CXCR4 signaling in neuroblastoma.Int J Oncol. 2008 Mar;32(3):619-23.
    18292939
  • Seng S, Avraham HK, Jiang S, Yang S, Sekine M, Kimelman N, Li H, Avraham S.The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells.Cancer Res. 2007 Sep 15;67(18):8596-604.
    17875699
  • Lee TH, Seng S, Sekine M, Hinton C, Fu Y, Avraham HK, Avraham S.Vascular Endothelial Growth Factor Mediates Intracrine Survival in Human Breast Carcinoma Cells through Internally Expressed VEGFR1/FLT1.PLoS Med. 2007 Jun 5;4(6):e186.
    17550303
  • Jiang S, Seng S, Avraham HK, Fu Y, Avraham S.Process Elongation of Oligodendrocytes Is Promoted by the Kelch-related Protein MRP2/KLHL1.J Biol Chem. 2007 Apr 20;282(16):12319-29.
    17324934
  • Lee TH, Seng S, Li H, Kennel SJ, Avraham HK, Avraham S.Integrin regulation by vascular endothelial growth factor in human brain microvascular endothelial cells: role of alpha6beta1 integrin in angiogenesis.J Biol Chem. 2006 Dec 29;281(52):40450-60.
    17085437
  • Seng S, Avraham HK, Jiang S, Venkatesh S, Avraham S.KLHL1/MRP2 mediates neurite outgrowth in a glycogen synthase kinase 3beta-dependent manner.Mol Cell Biol. 2006 Nov;26(22):8371-84.
    16982692
  • Tiburu EK, Karp ES, Birrane G, Struppe JO, Chu S, Lorigan GA, Avraham S, Avraham HK.31P and 2H relaxation studies of helix VII and the cytoplasmic helix of the human cannabinoid receptors utilizing solid-state NMR techniques.Biochemistry. 2006 Jun 13;45(23):7356-65.
    16752925
  • Kaminski R, Zagozdzon R, Fu Y, Mroz P, Fu W, Seng S, Avraham S, Avraham HK.Role of SRC kinases in Neu-induced tumorigenesis: challenging the paradigm using Csk homologous kinase transgenic mice.Cancer Res. 2006 Jun 1;66(11):5757-62.
    16740714
  • Park I, Avraham HK.Cell cycle-dependent DNA damage signaling induced by ICRF-193 involves ATM, ATR, CHK2, and BRCA1.Exp Cell Res. 2006 Jul 1;312(11):1996-2008.
    16630610
  • Lee BC, Avraham S, Imamoto A, Avraham HK.Identification of the nonreceptor tyrosine kinase MATK/CHK as an essential regulator of immune cells using Matk/CHK-deficient mice.Blood. 2006 Aug 1;108(3):904-7.
    16574955
  • Jiang S, Avraham HK, Kim TA, Rogers RA, Avraham S.Receptor-type PTP-NP inhibition of Dynamin-1 GTPase activity is associated with neuronal depolarization.Cell Signal. 2006 Sep;18(9):1439-46.
    16413169
  • Kim TA, Jiang S, Seng S, Cha K, Avraham HK, Avraham S.The BTB domain of the nuclear matrix protein NRP/B is required for neurite outgrowth.J Cell Sci. 2005 Dec 1;118(Pt 23):5537-48.
    16306221
  • Lee BC, Lee TH, Zagozdzon R, Avraham S, Usheva A, Avraham HK.Carboxyl-terminal Src kinase homologous kinase negatively regulates the chemokine receptor CXCR4 through YY1 and impairs CXCR4/CXCL12 (SDF-1alpha)-mediated breast cancer cell migration.Cancer Res. 2005 Apr 1;65(7):2840-5.
    15805285
  • Bu X, Avraham HK, Li X, Lim B, Jiang S, Fu Y, Pestell RG, Avraham S.Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells.Oncogene. 2005 Mar 31;24(14):2398-409.
    15735724
  • Jiang S, Avraham HK, Park SY, Kim TA, Bu X, Seng S, Avraham S.Process elongation of oligodendrocytes is promoted by the Kelch-related actin-binding protein Mayven.J Neurochem. 2005 Mar;92(5):1191-203.
    15715669
  • Liang XQ, Avraham HK, Jiang S, Avraham S.Genetic alterations of the NRP/B gene are associated with human brain tumors.Oncogene. 2004 Aug 5;23(35):5890-900.
    15208678
  • Lee BC, Lee TH, Avraham S, Avraham HK.Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells.Mol Cancer Res. 2004 Jun;2(6):327-38.
    15235108
  • Avraham HK, Lee TH, Koh Y, Kim TA, Jiang S, Sussman M, Samarel AM, Avraham S.Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase.J Biol Chem. 2003 Sep 19;278(38):36661-8.
    12844492
  • Kim TA, Avraham HK, Koh YH, Jiang S, Park IW, Avraham S.HIV-1 Tat-mediated apoptosis in human brain microvascular endothelial cells.J Immunol. 2003 Mar 1;170(5):2629-37.
    12594291
  • Miralem T, Avraham HK.Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.Mol Cell Biol. 2003 Jan;23(2):579-93.
    12509456
  • Price DJ, Avraham S, Feuerstein J, Fu Y, Avraham HK.The invasive phenotype in HMT-3522 cells requires increased EGF receptor signaling through both PI 3-kinase and ERK 1,2 pathways.Cell Commun Adhes. 2002 Mar-Apr;9(2):87-102.
    12487410
  • Lee TH, Avraham HK, Jiang S, Avraham S.Vascular endothelial growth factor modulates the transendothelial migration of MDA-MB-231 breast cancer cells through regulation of brain microvascular endothelial cell permeability.J Biol Chem. 2003 Feb 14;278(7):5277-84.
    12446667
  • Kawai H, Li H, Chun P, Avraham S, Avraham HK.Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells.Oncogene. 2002 Oct 31;21(50):7730-9.
    12400015
  • Banu N, Avraham S, Avraham HK.P-selectin, and not E-selectin, negatively regulates murine megakaryocytopoiesis.J Immunol. 2002 Oct 15;169(8):4579-85.
    12370396
  • Kim S, Zagozdzon R, Meisler A, Baleja JD, Fu Y, Avraham S, Avraham H.Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer.J Biol Chem. 2002 Sep 27;277(39):36465-70.
    12122014
  • Li H, Lee TH, Avraham H.A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer.J Biol Chem. 2002 Jun 7;277(23):20965-73.
    11916966
  • Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B.The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.Mol Cell Biol. 2002 Feb;22(4):1158-71.
    11809807
  • Lee TH, Avraham H, Lee SH, Avraham S.Vascular endothelial growth factor modulates neutrophil transendothelial migration via up-regulation of interleukin-8 in human brain microvascular endothelial cells.J Biol Chem. 2002 Mar 22;277(12):10445-51.
    11784713
  • Miralem T, Steinberg R, Price D, Avraham H.VEGF(165) requires extracellular matrix components to induce mitogenic effects and migratory response in breast cancer cells.Oncogene. 2001 Sep 6;20(39):5511-24.
    11571649
  • Bougeret C, Jiang S, Keydar I, Avraham H.Functional analysis of Csk and CHK kinases in breast cancer cells.J Biol Chem. 2001 Sep 7;276(36):33711-20.
    11445575
  • Ganju RK, Brubaker SA, Chernock RD, Avraham S, Groopman JE.Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk.J Biol Chem. 2000 Jun 9;275(23):17263-8.
    10747947
  • Altiok S, Batt D, Altiok N, Papautsky A, Downward J, Roberts TM, Avraham H.Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells.J Biol Chem. 1999 Nov 5;274(45):32274-8.
    10542266
  • Yamashita H, Avraham S, Jiang S, London R, Van Veldhoven PP, Subramani S, Rogers RA, Avraham H.Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro.J Biol Chem. 1999 Oct 15;274(42):29897-904.
    10514471
  • Banu N, Deng B, Lyman SD, Avraham H.Modulation of haematopoietic progenitor development by FLT-3 ligand.Cytokine. 1999 Sep;11(9):679-88.
    10479404
  • Taniguchi Y, London R, Schinkmann K, Jiang S, Avraham H.The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor.Blood. 1999 Jul 15;94(2):539-49.
    10397721
  • Soltysik-Espanola M, Rogers RA, Jiang S, Kim TA, Gaedigk R, White RA, Avraham H, Avraham S.Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain.Mol Biol Cell. 1999 Jul;10(7):2361-75.
    10397770
  • Price DJ, Rivnay B, Avraham H.CHK down-regulates SCF/KL-activated Lyn kinase activity in Mo7e megakaryocytic cells.Biochem Biophys Res Commun. 1999 Jun 16;259(3):611-6.
    10364466
  • Yamashita H, Avraham S, Jiang S, Dikic I, Avraham H.The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells.J Biol Chem. 1999 May 21;274(21):15059-65.
    10329710
  • Pandey P, Avraham S, Kumar S, Nakazawa A, Place A, Ghanem L, Rana A, Kumar V, Majumder PK, Avraham H, Davis RJ, Kharbanda S.Activation of p38 mitogen-activated protein kinase by PYK2/related adhesion focal tyrosine kinase-dependent mechanism.J Biol Chem. 1999 Apr 9;274(15):10140-4.
    10187797
  • Deng B, Banu N, Malloy B, Hass P, Wang JF, Cavacini L, Eaton D, Avraham H.An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis.Blood. 1998 Sep 15;92(6):1981-8.
    9731056
  • Hatch WC, Ganju RK, Hiregowdara D, Avraham S, Groopman JE.The related adhesion focal tyrosine kinase (RAFTK) is tyrosine phosphorylated and participates in colony-stimulating factor-1/macrophage colony-stimulating factor signaling in monocyte-macrophages.Blood. 1998 May 15;91(10):3967-73.
    9573036
  • Kim TA, Lim J, Ota S, Raja S, Rogers R, Rivnay B, Avraham H, Avraham S.NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation.J Cell Biol. 1998 May 4;141(3):553-66.
    9566959
  • Sato T, Fuse A, Niimi H, Fielder PJ, Avraham H.Binding and regulation of thrombopoietin to human megakaryocytes.Br J Haematol. 1998 Mar;100(4):704-11.
    9531337
  • Zrihan-Licht S, Deng B, Yarden Y, McShan G, Keydar I, Avraham H.Csk homologous kinase, a novel signaling molecule, directly associates with the activated ErbB-2 receptor in breast cancer cells and inhibits their proliferation.J Biol Chem. 1998 Feb 13;273(7):4065-72.
    9461599
  • Soltoff SP, Avraham H, Avraham S, Cantley LC.Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C.J Biol Chem. 1998 Jan 30;273(5):2653-60.
    9446569
  • Ganju RK, Dutt P, Wu L, Newman W, Avraham H, Avraham S, Groopman JE.Beta-chemokine receptor CCR5 signals via the novel tyrosine kinase RAFTK.Blood. 1998 Feb 1;91(3):791-7.
    9446638
  • Avraham S, London R, Tulloch GA, Ellis M, Fu Y, Jiang S, White RA, Painter C, Steinberger AA, Avraham H.Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells.Gene. 1997 Dec 19;204(1-2):5-16.
    9434160
  • Astier A, Maniť SN, Avraham H, Hirai H, Law SF, Zhang Y, Golemis EA, Fu Y, Druker BJ, Haghayeghi N, Freedman AS, Avraham S.The related adhesion focal tyrosine kinase differentially phosphorylates p130Cas and the Cas-like protein, p105HEF1.J Biol Chem. 1997 Aug 8;272(32):19719-24.
    9242628
  • Raja S, Avraham S, Avraham H.Tyrosine phosphorylation of the novel protein-tyrosine kinase RAFTK during an early phase of platelet activation by an integrin glycoprotein IIb-IIIa-independent mechanism.J Biol Chem. 1997 Apr 18;272(16):10941-7.
    9099753
  • Hiregowdara D, Avraham H, Fu Y, London R, Avraham S.Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin.J Biol Chem. 1997 Apr 18;272(16):10804-10.
    9099734
  • Liu ZY, Ganju RK, Wang JF, Ona MA, Hatch WC, Zheng T, Avraham S, Gill P, Groopman JE.Cytokine signaling through the novel tyrosine kinase RAFTK in Kaposi's sarcoma cells.J Clin Invest. 1997 Apr 1;99(7):1798-804.
    9120025
  • Ganju RK, Hatch WC, Avraham H, Ona MA, Druker B, Avraham S, Groopman JE.RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes.J Exp Med. 1997 Mar 17;185(6):1055-63.
    9091579
  • Price DJ, Rivnay B, Fu Y, Jiang S, Avraham S, Avraham H.Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.J Biol Chem. 1997 Feb 28;272(9):5915-20.
    9038210
  • Zrihan-Licht S, Lim J, Keydar I, Sliwkowski MX, Groopman JE, Avraham H.Association of csk-homologous kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in breast cancer cells.J Biol Chem. 1997 Jan 17;272(3):1856-63.
    8999872
  • Astier A, Avraham H, Manie SN, Groopman J, Canty T, Avraham S, Freedman AS.The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas.J Biol Chem. 1997 Jan 3;272(1):228-32.
    8995252
  • Salgia R, Avraham S, Pisick E, Li JL, Raja S, Greenfield EA, Sattler M, Avraham H, Griffin JD.The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells.J Biol Chem. 1996 Dec 6;271(49):31222-6.
    8940124
  • Li J, Avraham H, Rogers RA, Raja S, Avraham S.Characterization of RAFTK, a novel focal adhesion kinase, and its integrin-dependent phosphorylation and activation in megakaryocytes.Blood. 1996 Jul 15;88(2):417-28.
    8695788
  • Banu N, Price DJ, London R, Deng B, Mark M, Godowski PJ, Avraham H.Modulation of megakaryocytopoiesis by human macrophage-stimulating protein, the ligand for the RON receptor.J Immunol. 1996 Apr 15;156(8):2933-40.
    8609414
  • Avraham S, London R, Fu Y, Ota S, Hiregowdara D, Li J, Jiang S, Pasztor LM, White RA, Groopman JE.Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain.J Biol Chem. 1995 Nov 17;270(46):27742-51.
    7499242
  • Banu N, Wang JF, Deng B, Groopman JE, Avraham H.Modulation of megakaryocytopoiesis by thrombopoietin: the c-Mpl ligand.Blood. 1995 Aug 15;86(4):1331-8.
    7632939
  • Jhun BH, Rivnay B, Price D, Avraham H.The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit.J Biol Chem. 1995 Apr 21;270(16):9661-6.
    7536744
  • Avraham S, Jiang S, Ota S, Fu Y, Deng B, Dowler LL, White RA, Avraham H.Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product.J Biol Chem. 1995 Jan 27;270(4):1833-42.
    7530249
  • Bennett BD, Cowley S, Jiang S, London R, Deng B, Grabarek J, Groopman JE, Goeddel DV, Avraham H.Identification and characterization of a novel tyrosine kinase from megakaryocytes.J Biol Chem. 1994 Jan 14;269(2):1068-74.
    8288563
  • Avraham S, Avraham H, Austen KF, Stevens RL.Negative and positive cis-acting elements in the promoter of the mouse gene that encodes the serine/glycine-rich peptide core of secretory granule proteoglycans.J Biol Chem. 1992 Jan 5;267(1):610-7.
    1730621
  • Avraham S, Austen KF, Nicodemus CF, Gartner MC, Stevens RL.Cloning and characterization of the mouse gene that encodes the peptide core of secretory granule proteoglycans and expression of this gene in transfected rat-1 fibroblasts.J Biol Chem. 1989 Oct 5;264(28):16719-26.
    2777804
  • Avraham S, Stevens RL, Gartner MC, Austen KF, Lalley PA, Weis JH.Isolation of a cDNA that encodes the peptide core of the secretory granule proteoglycan of rat basophilic leukemia-1 cells and assessment of its homology to the human analogue.J Biol Chem. 1988 May 25;263(15):7292-6.
    3366780