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Judy Lieberman, MD, PhD

Publications

  • Luo ML, Gong C, Chen CH, Lee DY, Hu H, Huang P, Yao Y, Guo W, Reinhardt F, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP.Prolyl Isomerase Pin1 Acts Downstream of miR200c to Promote Cancer Stem-like Cell Traits in Breast Cancer.Cancer Res. 2014 May 1.
    24786790
  • Thiery J, Lieberman J.Perforin: a key pore-forming protein for immune control of viruses and cancer.Subcell. Biochem. 2014;80:197-220.
    24798013
  • Thomas MP, Whangbo J, McCrossan G, Deutsch AJ, Martinod K, Walch M, Lieberman J.Leukocyte Protease Binding to Nucleic Acids Promotes Nuclear Localization and Cleavage of Nucleic Acid Binding Proteins.J Immunol. 2014 Apr 25.
    24771851
  • Tuli A, Thiery J, James AM, Michelet X, Sharma M, Garg S, Sanborn KB, Orange JS, Lieberman J, Brenner MB.Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.Mol Biol Cell. 2013 Dec;24(23):3721-35.
    24088571
  • Petrocca F, Altschuler G, Tan SM, Mendillo ML, Yan H, Jerry DJ, Kung AL, Hide W, Ince TA, Lieberman J.A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells.Cancer Cell. 2013 Aug 12;24(2):182-96.
    23948298
  • Lieberman J, Slack F, Pandolfi PP, Chinnaiyan A, Agami R, Mendell JT.Noncoding RNAs and cancer.Cell. 2013 Mar 28;153(1):9-10.
    23781554
  • Huang L, Jin J, Deighan P, Kiner E, McReynolds L, Lieberman J.Efficient and specific gene knockdown by small interfering RNAs produced in bacteria.Nat Biotechnol. 2013 Apr;31(4):350-6.
    23475073
  • Thomas MP, Lieberman J.Live or let die: posttranscriptional gene regulation in cell stress and cell death.Immunol Rev. 2013 May;253(1):237-52.
    23550650
  • Lieberman J, Sarnow P.Micromanaging Hepatitis C Virus.N Engl J Med. 2013 Mar 27.
    23534545
  • Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N.Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.Nat Immunol. 2013 Feb;14(2):179-85.
    23263557
  • Yan N, Lieberman J.SAMHD1 does it again, now in resting T cells.Nat Med. 2012 Nov;18(11):1611-2.
    23135508
  • Petrocca F, Lieberman J.Promise and challenge of RNA interference-based therapy for cancer.J Clin Oncol. 2011 Feb 20;29(6):747-54. Review.
    21079135
  • Thomas M, Lieberman J, Lal A.Desperately seeking microRNA targets.Nat Struct Mol Biol. 2010 Oct;17(10):1169-74.
    20924405
  • Lieberman J.Granzyme A activates another way to die.Immunol Rev. 2010 May;235(1):93-104. Review.
    20536557
  • Lieberman J.Anatomy of a murder: how cytotoxic T cells and NK cells are activated, develop, and eliminate their targets.Immunol Rev. 2010 May;235(1):5-9.
    20536551
  • Thiery J, Walch M, Jensen DK, Martinvalet D, Lieberman J.Isolation of cytotoxic T cell and NK granules and purification of their effector proteins.Curr Protoc Cell Biol. 2010 Jun;Chapter 3:Unit3.37.
    20521234
  • Navarro F, Lieberman J.Small RNAs guide hematopoietic cell differentiation and function.J Immunol. 2010 Jun 1;184(11):5939-47. Review.
    20483778
  • Thiery J, Keefe D, Saffarian S, Martinvalet D, Walch M, Boucrot E, Kirchhausen T, Lieberman J.Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis.Blood. 2010 Feb 25;115(8):1582-93.
    20038786
  • Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A.Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression.EMBO J. 2010 Feb 3;29(3):559-73.
    20019669
  • Lieberman J.Micromanaging cancer.N Engl J Med. 2009 Oct 8;361(15):1500-1.
    19812408
  • Dykxhoorn DM, Wu Y, Xie H, Yu F, Lal A, Petrocca F, Martinvalet D, Song E, Lim B, Lieberman J.miR-200 enhances mouse breast cancer cell colonization to form distant metastases.PLoS ONE. 2009;4(9):e7181.
    19787069
  • Lal A, Navarro F, Maher CA, Maliszewski LE, Yan N, O'Day E, Chowdhury D, Dykxhoorn DM, Tsai P, Hofmann O, Becker KG, Gorospe M, Hide W, Lieberman J.miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements.Mol Cell. 2009 Sep 11;35(5):610-25.
    19748357
  • Navarro F, Gutman D, Meire E, Cáceres M, Rigoutsos I, Bentwich Z, Lieberman J.miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53.Blood. 2009 Sep 3;114(10):2181-92.
    19584398
  • Petrocca F, Lieberman J.Micromanipulating cancer: microRNA-based therapeutics?.RNA Biol. 2009 Jul;6(3):335-40. Review.
    19535911
  • Zhu P, Martinvalet D, Chowdhury D, Zhang D, Schlesinger A, Lieberman J.The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1.Blood. 2009 Aug 6;114(6):1205-16.
    19506301
  • Ahmed F, Friend S, George TC, Barteneva N, Lieberman J.Numbers matter: quantitative and dynamic analysis of the formation of an immunological synapse using imaging flow cytometry.J Immunol Methods. 2009 Aug 15;347(1-2):79-86.
    19524586
  • Petrocca F,Lieberman J.Chapter 4 micromanagers of immune cell fate and function.Adv Immunol. 2009;102:227-44. Review.
    19477322
  • Lal A,Pan Y,Navarro F,Dykxhoorn DM,Moreau L,Meire E,Bentwich Z,Lieberman J,Chowdhury D.miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.Nat Struct Mol Biol. 2009 May;16(5):492-8.
    19377482
  • Yan N,Cherepanov P,Daigle JE,Engelman A,Lieberman J.The SET complex acts as a barrier to autointegration of HIV-1.PLoS Pathog. 2009 Mar;5(3):e1000327.
    19266025
  • Wu Y,Navarro F,Lal A,Basar E,Pandey RK,Manoharan M,Feng Y,Lee SJ,Lieberman J,Palliser D.Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene.Cell Host Microbe. 2009 Jan 22;5(1):84-94.
    19154990
  • Petrocca F,Lieberman J.RIG-ing an antitumor response.Nat Med. 2008 Nov;14(11):1152-3.
    18989278
  • Shun MC,Botbol Y,Li X,Di Nunzio F,Daigle JE,Yan N,Lieberman J,Lavigne M,Engelman A.Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.J Virol. 2008 Dec;82(23):11555-67.
    18799576
  • Chowdhury D, Xu X, Zhong X, Ahmed F, Zhong J, Liao J, Dykxhoorn DM, Weinstock DM, Pfeifer GP, Lieberman J.A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.Mol Cell. 2008 Jul 11;31(1):33-46.
    18614045
  • Martinvalet D,Dykxhoorn DM,Ferrini R,Lieberman J.Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.Cell. 2008 May 16;133(4):681-92.
    18485875
  • Dykxhoorn DM, Chowdhury D, Lieberman J.RNA interference and cancer: endogenous pathways and therapeutic approaches.Adv Exp Med Biol. 2008;615:299-329. Review.
    18437900
  • Chowdhury D, Lieberman J.Death by a thousand cuts: granzyme pathways of programmed cell death.Annu Rev Immunol. 2008;26:389-420. Review.
    18304003
  • Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ.Identification of host proteins required for HIV infection through a functional genomic screen.Science. 2008 Feb 15;319(5865):921-6.
    18187620
  • Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, Huang Y, Hu X, Su F, Lieberman J, Song E.let-7 regulates self renewal and tumorigenicity of breast cancer cells.Cell. 2007 Dec 14;131(6):1109-23.
    18083101
  • Jiang S, Rasmussen RA, Nolan KM, Frankel FR, Lieberman J, McClure HM, Williams KM, Babu US, Raybourne RB, Strobert E, Ruprecht RM.Live attenuated Listeria monocytogenes expressing HIV Gag: immunogenicity in rhesus monkeys.Vaccine. 2007 Oct 16;25(42):7470-9.
    17854955
  • Lee-Kirsch MA, Gong M, Chowdhury D, Senenko L, Engel K, Lee YA, de Silva U, Bailey SL, Witte T, Vyse TJ, Kere J, Pfeiffer C, Harvey S, Wong A, Koskenmies S, Hummel O, Rohde K, Schmidt RE, Dominiczak AF, Gahr M, Hollis T, Perrino FW, Lieberman J, Hubner N.Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.Nat Genet. 2007 Sep;39(9):1065-7.
    17660818
  • Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE.Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells.Leukemia. 2007 Aug;21(8):1723-32.
    17568820
  • de Fougerolles A, Vornlocher HP, Maraganore J, Lieberman J.Interfering with disease: a progress report on siRNA-based therapeutics.Nat Rev Drug Discov. 2007 Jun;6(6):443-53. Review.
    17541417
  • Pipkin ME, Lieberman J.Delivering the kiss of death: progress on understanding how perforin works.Curr Opin Immunol. 2007 Jun;19(3):301-8. Review.
    17433871
  • Chowdhury D, Beresford PJ, Zhu P, Zhang D, Sung JS, Demple B, Perrino FW, Lieberman J.The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.Mol Cell. 2006 Jul 7;23(1):133-42.
    16818237
  • Palliser D, Chowdhury D, Wang QY, Lee SJ, Bronson RT, Knipe DM, Lieberman J.An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection.Nature. 2006 Jan 5;439(7072):89-94.
    16306938
  • Keogh MC, Kim JA, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, Greenblatt JF, Krogan NJ.A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.Nature. 2006 Jan 26;439(7075):497-501.
    16299494
  • Keefe D, Shi L, Feske S, Massol R, Navarro F, Kirchhausen T, Lieberman J.Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis.Immunity. 2005 Sep;23(3):249-62.
    16169498
  • Feng H, Zhang D, Palliser D, Zhu P, Cai S, Schlesinger A, Maliszewski L, Lieberman J.Listeria-infected myeloid dendritic cells produce IFN-beta, priming T cell activation.J Immunol. 2005 Jul 1;175(1):421-32.
    15972676
  • Liu L, Xu Z, Fuhlbrigge RC, Peña-Cruz V, Lieberman J, Kupper TS.Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion.J Virol. 2005 Jun;79(12):7363-70.
    15919891
  • Song E, Zhu P, Lee SK, Chowdhury D, Kussman S, Dykxhoorn DM, Feng Y, Palliser D, Weiner DB, Shankar P, Marasco WA, Lieberman J.Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors.Nat Biotechnol. 2005 Jun;23(6):709-17.
    15908939
  • Shi L, Keefe D, Durand E, Feng H, Zhang D, Lieberman J.Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis.J Immunol. 2005 May 1;174(9):5456-61.
    15843543
  • Lee SK, Dykxhoorn DM, Kumar P, Ranjbar S, Song E, Maliszewski LE, François-Bongarçon V, Goldfeld A, Swamy NM, Lieberman J, Shankar P.Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV.Blood. 2005 Aug 1;106(3):818-26.
    15831707
  • Martinvalet D, Zhu P, Lieberman J.Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis.Immunity. 2005 Mar;22(3):355-70.
    15780992
  • Shankar P, Manjunath N, Lieberman J.The prospect of silencing disease using RNA interference.JAMA. 2005 Mar 16;293(11):1367-73.
    15769970
  • Xue Y, Johnson JS, Ornelles DA, Lieberman J, Engel DA.Adenovirus protein VII functions throughout early phase and interacts with cellular proteins SET and pp32.J Virol. 2005 Feb;79(4):2474-83.
    15681448
  • Dykxhoorn DM, Lieberman J.The silent revolution: RNA interference as basic biology, research tool, and therapeutic.Annu Rev Med. 2005;56:401-23.
    15660519
  • François-Bongarcon V, Feng Y, Lee SK, Chen G, Shankar P, Liu Y, Tao X, Shao Y, Lieberman J.Cross-Clade CD8 T-Cell Responses to HIVIIIB and Chinese B' and C/B' Viruses in North American and Chinese HIV-Seropositive Donors.J Acquir Immune Defic Syndr. 2004 Dec 1;37(4):1435-1444.
    15602120
  • Hamar P, Song E, Kökény G, Chen A, Ouyang N, Lieberman J.Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury.Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14883-8.
    15466709
  • Ince MN, Harnisch B, Xu Z, Lee SK, Lange C, Moretta L, Lederman M, Lieberman J.Increased expression of the natural killer cell inhibitory receptor CD85j/ILT2 on antigen-specific effector CD8 T cells and its impact on CD8 T-cell function.Immunology. 2004 Aug;112(4):531-42.
    15270723
  • Lieberman J.Tracking the killers: how should we measure CD8 T cells in HIV infection?.AIDS. 2004 Jul 23;18(11):1489-93.
    15238766
  • Lange CG, Xu Z, Patterson BK, Medvik K, Harnisch B, Asaad R, Valdez H, Lee SJ, Landay A, Lieberman J, Lederman MM.Proliferation responses to HIVp24 during antiretroviral therapy do not reflect improved immune phenotype or function.AIDS. 2004 Mar 5;18(4):605-13.
    15090765
  • De Groot AS, Jesdale B, Martin W, Saint Aubin C, Sbai H, Bosma A, Lieberman J, Skowron G, Mansourati F, Mayer KH.Mapping cross-clade HIV-1 vaccine epitopes using a bioinformatics approach.Vaccine. 2003 Oct 1;21(27-30):4486-504.
    14505932
  • Lieberman J, Fan Z.Nuclear war: the granzyme A-bomb.Curr Opin Immunol. 2003 Oct;15(5):553-9.
    14499264
  • Lieberman J, Song E, Lee SK, Shankar P.Interfering with disease: opportunities and roadblocks to harnessing RNA interference.Trends Mol Med. 2003 Sep;9(9):397-403.
    13129706
  • Wan J, Martinvalet D, Ji X, Lois C, Kaech SM, Von Andrian UH, Lieberman J, Ahmed R, Manjunath N.The Bcl-2 family pro-apoptotic molecule, BNIP3 regulates activation-induced cell death of effector cytotoxic T lymphocytes.Immunology. 2003 Sep;110(1):10-7.
    12941136
  • Song E, Lee SK, Dykxhoorn DM, Novina C, Zhang D, Crawford K, Cerny J, Sharp PA, Lieberman J, Manjunath N, Shankar P.Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages.J Virol. 2003 Jul;77(13):7174-81.
    12805416
  • Lieberman J.The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal.Nat Rev Immunol. 2003 May;3(5):361-70.
    12766758
  • Kushner N, Zhang D, Touzjian N, Essex M, Lieberman J, Lu Y.A fragment of anthrax lethal factor delivers proteins to the cytosol without requiring protective antigen.Proc Natl Acad Sci U S A. 2003 May 27;100(11):6652-7.
    12740437
  • Gu X, Laouar A, Wan J, Daheshia M, Lieberman J, Yokoyama WM, Katz HR, Manjunath N.The gp49B1 inhibitory receptor regulates the IFN-gamma responses of T cells and NK cells.J Immunol. 2003 Apr 15;170(8):4095-101.
    12682239
  • Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J.Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.Cell. 2003 Mar 7;112(5):659-72.
    12628186
  • Song E, Lee SK, Wang J, Ince N, Ouyang N, Min J, Chen J, Shankar P, Lieberman J.RNA interference targeting Fas protects mice from fulminant hepatitis.Nat Med. 2003 Mar;9(3):347-51.
    12579197
  • Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J.Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.Nat Immunol. 2003 Feb;4(2):145-53.
    12524539
  • Geiben-Lynn R, Kursar M, Brown NV, Addo MM, Shau H, Lieberman J, Luster AD, Walker BD.HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family.J Biol Chem. 2003 Jan 17;278(3):1569-74.
    12421812
  • Lee SK, Xu Z, Lieberman J, Shankar P.The functional CD8 T cell response to HIV becomes type-specific in progressive disease.J Clin Invest. 2002 Nov;110(9):1339-47.
    12417573
  • Zhang D, Shankar P, Xu Z, Harnisch B, Chen G, Lange C, Lee SJ, Valdez H, Lederman MM, Lieberman J.Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic.Blood. 2003 Jan 1;101(1):226-35.
    12393740
  • Lieberman J.Defying death--HIV mutation to evade cytotoxic T lymphocytes.N Engl J Med. 2002 Oct 10;347(15):1203-4.
    12374884
  • Lieberman J, Manjunath N, Shankar P.Avoiding the kiss of death: how HIV and other chronic viruses survive.Curr Opin Immunol. 2002 Aug;14(4):478-86.
    12088683
  • Novina CD, Murray MF, Dykxhoorn DM, Beresford PJ, Riess J, Lee SK, Collman RG, Lieberman J, Shankar P, Sharp PA.siRNA-directed inhibition of HIV-1 infection.Nat Med. 2002 Jul;8(7):681-6.
    12042777
  • Lieberman J, Frankel FR.Engineered Listeria monocytogenes as an AIDS vaccine.Vaccine. 2002 May 6;20(15):2007-10.
    11983264
  • Fan Z, Beresford PJ, Zhang D, Lieberman J.HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.Mol Cell Biol. 2002 Apr;22(8):2810-20.
    11909973
  • Manjunath N, Shankar P, Wan J, Weninger W, Crowley MA, Hieshima K, Springer TA, Fan X, Shen H, Lieberman J, von Andrian UH.Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes.J Clin Invest. 2001 Sep;108(6):871-8.
    11560956
  • Beresford PJ, Zhang D, Oh DY, Fan Z, Greer EL, Russo ML, Jaju M, Lieberman J.Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks.J Biol Chem. 2001 Nov 16;276(46):43285-93.
    11555662
  • Lieberman J, Shankar P, Manjunath N, Andersson J.Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection.Blood. 2001 Sep 15;98(6):1667-77.
    11535496
  • Chen G, Shankar P, Lange C, Valdez H, Skolnik PR, Wu L, Manjunath N, Lieberman J.CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection.Blood. 2001 Jul 1;98(1):156-64.
    11418475
  • Sharif-Askari E, Alam A, Rhéaume E, Beresford PJ, Scotto C, Sharma K, Lee D, DeWolf WE, Nuttall ME, Lieberman J, Sékaly RP.Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation.EMBO J. 2001 Jun 15;20(12):3101-13.
    11406587
  • Zhang D, Beresford PJ, Greenberg AH, Lieberman J.Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis.Proc Natl Acad Sci U S A. 2001 May 8;98(10):5746-51.
    11331782
  • Zhang D, Pasternack MS, Beresford PJ, Wagner L, Greenberg AH, Lieberman J.Induction of rapid histone degradation by the cytotoxic T lymphocyte protease Granzyme A.J Biol Chem. 2001 Feb 2;276(5):3683-90.
    11060286
  • Shankar P, Russo M, Harnisch B, Patterson M, Skolnik P, Lieberman J.Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection.Blood. 2000 Nov 1;96(9):3094-101.
    11049989
  • Friedman RS, Frankel FR, Xu Z, Lieberman J.Induction of human immunodeficiency virus (HIV)-specific CD8 T-cell responses by Listeria monocytogenes and a hyperattenuated Listeria strain engineered to express HIV antigens.J Virol. 2000 Nov;74(21):9987-93.
    11024127
  • Trimble LA, Kam LW, Friedman RS, Xu Z, Lieberman J.CD3zeta and CD28 down-modulation on CD8 T cells during viral infection.Blood. 2000 Aug 1;96(3):1021-9.
    10910918
  • Trimble LA, Shankar P, Patterson M, Daily JP, Lieberman J.Human immunodeficiency virus-specific circulating CD8 T lymphocytes have down-modulated CD3zeta and CD28, key signaling molecules for T-cell activation.J Virol. 2000 Aug;74(16):7320-30.
    10906185
  • Lu Y, Friedman R, Kushner N, Doling A, Thomas L, Touzjian N, Starnbach M, Lieberman J.Genetically modified anthrax lethal toxin safely delivers whole HIV protein antigens into the cytosol to induce T cell immunity.Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8027-32.
    10884430
  • Mackewicz CE, Lieberman J, Froelich C, Levy JA.HIV virions and HIV infection in vitro are unaffected by human granzymes A and B.AIDS Res Hum Retroviruses. 2000 Mar 1;16(4):367-72.
    10716374
  • Manjunath N, Shankar P, Stockton B, Dubey PD, Lieberman J, von Andrian UH.A transgenic mouse model to analyze CD8(+) effector T cell differentiation in vivo.Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13932-7.
    10570176
  • Lori F, Jessen H, Lieberman J, Finzi D, Rosenberg E, Tinelli C, Walker B, Siliciano RF, Lisziewicz J.Treatment of human immunodeficiency virus infection with hydroxyurea, didanosine, and a protease inhibitor before seroconversion is associated with normalized immune parameters and limited viral reservoir.J Infect Dis. 1999 Dec;180(6):1827-32.
    10558937
  • Shankar P, Xu Z, Lieberman J.Viral-specific cytotoxic T lymphocytes lyse human immunodeficiency virus-infected primary T lymphocytes by the granule exocytosis pathway.Blood. 1999 Nov 1;94(9):3084-93.
    10556193
  • Lori F, Rosenberg E, Lieberman J, Foli A, Maserati R, Seminari E, Alberici F, Walker B, Lisziewicz J.Hydroxyurea and didanosine long-term treatment prevents HIV breakthrough and normalizes immune parameters.AIDS Res Hum Retroviruses. 1999 Oct 10;15(15):1333-8.
    10515148
  • Andersson J, Behbahani H, Lieberman J, Connick E, Landay A, Patterson B, Sönnerborg A, Loré K, Uccini S, Fehniger TE.Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection.AIDS. 1999 Jul 30;13(11):1295-303.
    10449281
  • Lieberman J, Trimble LA, Friedman RS, Lisziewicz J, Lori F, Shankar P, Jessen H.Expansion of CD57 and CD62L-CD45RA+ CD8 T lymphocytes correlates with reduced viral plasma RNA after primary HIV infection.AIDS. 1999 May 28;13(8):891-9.
    10371169
  • Beresford PJ, Xia Z, Greenberg AH, Lieberman J.Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation.Immunity. 1999 May;10(5):585-94.
    10367904
  • Trimble LA, Xu Z, Lieberman J.Clonal expansion of antigen-specific CD8+ cytotoxic T lymphocytes is regulated by late exposure to serum to prevent apoptosis.J Immunol Methods. 1999 May 27;225(1-2):39-52.
    10365780
  • Lisziewicz J, Rosenberg E, Lieberman J, Jessen H, Lopalco L, Siliciano R, Walker B, Lori F.Control of HIV despite the discontinuation of antiretroviral therapy.N Engl J Med. 1999 May 27;340(21):1683-4.
    10348681
  • Lori F, Jessen H, Lieberman J, Clerici M, Tinelli C, Lisziewicz J.Immune restoration by combination of a cytostatic drug (hydroxyurea) and anti-HIV drugs (didanosine and indinavir).AIDS Res Hum Retroviruses. 1999 May 1;15(7):619-24.
    10331440
  • MacDonald G, Shi L, Vande Velde C, Lieberman J, Greenberg AH.Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis.J Exp Med. 1999 Jan 4;189(1):131-44.
    9874570
  • Shankar P, Sprang H, Lieberman J.Effective lysis of HIV-1-infected primary CD4+ T cells by a cytotoxic T-lymphocyte clone directed against a novel A2-restricted reverse-transcriptase epitope.J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Oct 1;19(2):111-20.
    9768618
  • Beresford PJ, Jaju M, Friedman RS, Yoon MJ, Lieberman J.A role for heat shock protein 27 in CTL-mediated cell death.J Immunol. 1998 Jul 1;161(1):161-7.
    9647220
  • Xia Z, Kam CM, Huang C, Powers JC, Mandle RJ, Stevens RL, Lieberman J.Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system.Biochem Biophys Res Commun. 1998 Feb 13;243(2):384-9.
    9480818
  • Trimble LA, Lieberman J.Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3 zeta, the signaling chain of the T-cell receptor complex.Blood. 1998 Jan 15;91(2):585-94.
    9427713
  • Lieberman J, Skolnik PR, Parkerson GR, Fabry JA, Landry B, Bethel J, Kagan J.Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients.Blood. 1997 Sep 15;90(6):2196-206.
    9310470
  • Beresford PJ, Kam CM, Powers JC, Lieberman J.Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them.Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9285-90.
    9256474
  • Lieberman J, Fabry JA, Fong DM, Parkerson GR.Recognition of a small number of diverse epitopes dominates the cytotoxic T lymphocytes response to HIV type 1 in an infected individual.AIDS Res Hum Retroviruses. 1997 Mar 20;13(5):383-92.
    9075479
  • Buchsbaum RJ, Fabry JA, Lieberman J.EBV-specific cytotoxic T lymphocytes protect against human EBV-associated lymphoma in scid mice.Immunol Lett. 1996 Sep;52(2-3):145-52.
    8905410
  • Shankar P, Fabry JA, Fong DM, Lieberman J.Three regions of HIV-1 gp160 contain clusters of immunodominant CTL epitopes.Immunol Lett. 1996 Aug;52(1):23-30.
    8877415
  • Decker LL, Shankar P, Khan G, Freeman RB, Dezube BJ, Lieberman J, Thorley-Lawson DA.The Kaposi sarcoma-associated herpesvirus (KSHV) is present as an intact latent genome in KS tissue but replicates in the peripheral blood mononuclear cells of KS patients.J Exp Med. 1996 Jul 1;184(1):283-8.
    8691144
  • Perales MA, Skolnik PR, Lieberman J.Effect of interleukin 12 on in vitro HIV type 1 replication depends on clinical stage.AIDS Res Hum Retroviruses. 1996 May 20;12(8):659-68.
    8744576
  • Roberts CG, Meister GE, Jesdale BM, Lieberman J, Berzofsky JA, De Groot AS.Prediction of HIV peptide epitopes by a novel algorithm.AIDS Res Hum Retroviruses. 1996 May 1;12(7):593-610.
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