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James E. Bradner, MD

Publications

  • Ichida JK, T C W J, Williams LA, Carter AC, Shi Y, Moura MT, Ziller M, Singh S, Amabile G, Bock C, Umezawa A, Rubin LL, Bradner JE, Akutsu H, Meissner A, Eggan K.Notch inhibition allows oncogene-independent generation of iPS cells.Nat Chem Biol. 2014 Jun 22.
    24952596
  • Chen C, Liu Y, Rappaport AR, Kitzing T, Schultz N, Zhao Z, Shroff AS, Dickins RA, Vakoc CR, Bradner JE, Stock W, LeBeau MM, Shannon KM, Kogan S, Zuber J, Lowe SW.MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia.Cancer Cell. 2014 May 12;25(5):652-65.
    24794707
  • Lane AA, Chapuy B, Lin CY, Tivey T, Li H, Townsend EC, van Bodegom D, Day TA, Wu SC, Liu H, Yoda A, Alexe G, Schinzel AC, Sullivan TJ, Malinge S, Taylor JE, Stegmaier K, Jaffe JD, Bustin M, Te Kronnie G, Izraeli S, Harris MH, Stevenson KE, Neuberg D, Silverman LB, Sallan SE, Bradner JE, Hahn WC, Crispino JD, Pellman D, Weinstock DM.Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation.Nat Genet. 2014 Apr 20.
    24747640
  • Gröschel S, Sanders MA, Hoogenboezem R, de Wit E, Bouwman BA, Erpelinck C, van der Velden VH, Havermans M, Avellino R, van Lom K, Rombouts EJ, van Duin M, Döhner K, Beverloo HB, Bradner JE, Döhner H, Löwenberg B, Valk PJ, Bindels EM, de Laat W, Delwel R.A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia.Cell. 2014 Apr 10;157(2):369-81.
    24703711
  • Knoechel B, Roderick JE, Williamson KE, Zhu J, Lohr JG, Cotton MJ, Gillespie SM, Fernandez D, Ku M, Wang H, Piccioni F, Silver SJ, Jain M, Pearson D, Kluk MJ, Ott CJ, Shultz LD, Brehm MA, Greiner DL, Gutierrez A, Stegmaier K, Kung AL, Root DE, Bradner JE, Aster JC, Kelliher MA, Bernstein BE.An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.Nat Genet. 2014 Apr;46(4):364-70.
    24584072
  • Lamoureux F, Baud'huin M, Rodriguez Calleja L, Jacques C, Berreur M, Rédini F, Lecanda F, Bradner JE, Heymann D, Ory B.Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle.Nat Commun. 2014;5:3511.
    24646477
  • Cho H, Herzka T, Zheng W, Qi J, Wilkinson JE, Bradner JE, Robinson BD, Castillo-Martin M, Cordon-Cardo C, Trotman LC.RapidCaP, a novel GEM model for metastatic prostate cancer analysis and therapy, reveals myc as a driver of Pten-mutant metastasis.Cancer Discovery. 2014 Mar;4(3):318-33.
    24444712
  • Federation AJ, Bradner JE, Meissner A.The use of small molecules in somatic-cell reprogramming.Trends Cell Biol. 2014 Mar;24(3):179-87.
    24183602
  • Bandopadhayay P, Bergthold G, Nguyen B, Schubert S, Gholamin S, Tang Y, Bolin S, Schumacher SE, Zeid R, Masoud S, Yu F, Vue N, Gibson WJ, Paolella BR, Mitra SS, Cheshier SH, Qi J, Liu KW, Wechsler-Reya R, Weiss WA, Swartling FJ, Kieran MW, Bradner JE, Beroukhim R, Cho YJ.BET bromodomain inhibition of MYC-amplified medulloblastoma.Clin Cancer Res. 2014 Feb 15;20(4):912-25.
    24297863
  • Roderick JE, Tesell J, Shultz LD, Brehm MA, Greiner DL, Harris MH, Silverman LB, Sallan SE, Gutierrez A, Look AT, Qi J, Bradner JE, Kelliher MA.c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.Blood. 2014 Feb 13;123(7):1040-50.
    24394663
  • Gutierrez A, Pan L, Groen RW, Baleydier F, Kentsis A, Marineau J, Grebliunaite R, Kozakewich E, Reed C, Pflumio F, Poglio S, Uzan B, Clemons P, VerPlank L, An F, Burbank J, Norton S, Tolliday N, Steen H, Weng AP, Yuan H, Bradner JE, Mitsiades C, Look AT, Aster JC.Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.J Clin Invest. 2014 Feb 3;124(2):644-55.
    24401270
  • Lwin T, Zhao X, Cheng F, Zhang X, Huang A, Shah B, Zhang Y, Moscinski LC, Choi YS, Kozikowski AP, Bradner JE, Dalton WS, Sotomayor E, Tao J.A microenvironment-mediated c-Myc/miR-548m/HDAC6 amplification loop in non-Hodgkin B cell lymphomas.J Clin Invest. 2013 Nov 1;123(11):4612-26.
    24216476
  • Fowler T, Ghatak P, Price DH, Conaway R, Conaway J, Chiang CM, Bradner JE, Shilatifard A, Roy AL.Regulation of MYC expression and differential JQ1 sensitivity in cancer cells.PLoS ONE. 2014;9(1):e87003.
    24466310
  • Lu G, Middleton RE, Sun H, Naniong M, Ott CJ, Mitsiades CS, Wong KK, Bradner JE, Kaelin WG.The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins.Science. 2014 Jan 17;343(6168):305-9.
    24292623
  • Anders L, Guenther MG, Qi J, Fan ZP, Marineau JJ, Rahl PB, Lovén J, Sigova AA, Smith WB, Lee TI, Bradner JE, Young RA.Genome-wide localization of small molecules.Nat Biotechnol. 2014 Jan;32(1):92-6.
    24336317
  • Anderson NM, Harrold I, Mansour MR, Sanda T, McKeown M, Nagykary N, Bradner JE, Lan Zhang G, Look AT, Feng H.BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines.Leukemia. 2013 Dec 17.
    24342948
  • Chapuy B, McKeown MR, Lin CY, Monti S, Roemer MG, Qi J, Rahl PB, Sun HH, Yeda KT, Doench JG, Reichert E, Kung AL, Rodig SJ, Young RA, Shipp MA, Bradner JE.Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.Cancer Cell. 2013 Dec 9;24(6):777-90.
    24332044
  • Wu X, Qi J, Bradner JE, Xiao G, Chen LF.Bromodomain and extraterminal (BET) protein inhibition suppresses human T cell leukemia virus 1 (HTLV-1) Tax protein-mediated tumorigenesis by inhibiting nuclear factor κB (NF-κB) signaling.J Biol Chem. 2013 Dec 13;288(50):36094-105.
    24189064
  • Shimamura T, Chen Z, Soucheray M, Carretero J, Kikuchi E, Tchaicha JH, Gao Y, Cheng KA, Cohoon TJ, Qi J, Akbay E, Kimmelman AC, Kung AL, Bradner JE, Wong KK.Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer.Clin Cancer Res. 2013 Nov 15;19(22):6183-92.
    24045185
  • Guerra-Bubb JM, Bowers AA, Smith WB, Paranal R, Estiu G, Wiest O, Bradner JE, Williams RM.Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs.Bioorg Med Chem Lett. 2013 Nov 1;23(21):6025-8.
    24035339
  • Chen C, Liu Y, Lu C, Cross JR, Morris JP, Shroff AS, Ward PS, Bradner JE, Thompson C, Lowe SW.Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition.Genes Dev. 2013 Sep 15;27(18):1974-85.
    24065765
  • Anand P, Brown JD, Lin CY, Qi J, Zhang R, Artero PC, Alaiti MA, Bullard J, Alazem K, Margulies KB, Cappola TP, Lemieux M, Plutzky J, Bradner JE, Haldar SM.BET bromodomains mediate transcriptional pause release in heart failure.Cell. 2013 Aug 1;154(3):569-82.
    23911322
  • Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB.The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.Nature. 2013 Jun 13;498(7453):246-50.
    23728299
  • Amin J, Puglisi A, Clarke J, Milton J, Wang M, Paranal RM, Bradner JE, Spencer J.A cyclodextrin-capped histone deacetylase inhibitor.Bioorg Med Chem Lett. 2013 Apr 2.
    23591111
  • Lovén J, Hoke HA, Lin CY, Lau A, Orlando DA, Vakoc CR, Bradner JE, Lee TI, Young RA.Selective inhibition of tumor oncogenes by disruption of super-enhancers.Cell. 2013 Apr 11;153(2):320-34.
    23582323
  • Picaud S, Da Costa D, Thanasopoulou A, Filippakopoulos P, Fish PV, Philpott M, Fedorov O, Brennan P, Bunnage ME, Owen DR, Bradner JE, Taniere P, O'Sullivan B, Muller S, Schwaller J, Stankovic T, Knapp S.PFI-1 - A highly Selective Protein Interaction Inhibitor Targeting BET bromodomains.Cancer Res. 2013 Apr 10.
    23576556
  • Puissant A, Frumm SM, Alexe G, Bassil CF, Qi J, Chanthery YH, Nekritz EA, Zeid R, Gustafson WC, Greninger P, Garnett MJ, McDermott U, Benes CH, Kung AL, Weiss WA, Bradner JE, Stegmaier K.Targeting MYCN in neuroblastoma by BET bromodomain inhibition.Cancer Discovery. 2013 Mar;3(3):308-23.
    23430699
  • Wang X, Helfer CM, Pancholi N, Bradner JE, You J.Recruitment of Brd4 to the human papillomavirus type 16 DNA replication complex is essential for replication of viral DNA.J Virol. 2013 Apr;87(7):3871-84.
    23365439
  • Herrmann H, Blatt K, Shi J, Gleixner KV, Cerny-Reiterer S, Müllauer L, Vakoc CR, Sperr WR, Horny HP, Bradner JE, Zuber J, Valent P.Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML.Oncotarget. 2012 Dec;3(12):1588-99.
    23249862
  • Gao C, Dimitrov T, Yong KJ, Tatetsu H, Jeong HW, Luo HR, Bradner JE, Tenen DG, Chai L.Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex.Blood. 2013 Feb 21;121(8):1413-21.
    23287862
  • Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, Qi J, Barsyte-Lovejoy D, Yi J, Marcellus R, Iacob RE, Engen JR, Griffin C, Aman A, Wienholds E, Li F, Pineda J, Estiu G, Shatseva T, Hajian T, Al-Awar R, Dick JE, Vedadi M, Brown PJ, Arrowsmith CH, Bradner JE, Schapira M.Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.Nat Commun. 2012;3:1288.
    23250418
  • Lockwood WW, Zejnullahu K, Bradner JE, Varmus H.Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins.Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19408-13.
    23129625
  • Deshpande AJ, Bradner J, Armstrong SA.Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.Trends Immunol. 2012 Nov;33(11):563-70.
    22867873
  • Bauer DE, Mitchell CM, Strait KM, Lathan CS, Stelow EB, Lüer SC, Muhammed S, Evans AG, Sholl LM, Rosai J, Giraldi E, Oakley RP, Rodriguez-Galindo C, London WB, Sallan SE, Bradner JE, French CA.Clinicopathologic Features and Long-term Outcomes of NUT Midline Carcinoma.Clin Cancer Res. 2012 Oct 15;18(20):5773-5779.
    22896655
  • Ott CJ, Kopp N, Bird L, Paranal RM, Qi J, Bowman T, Rodig SJ, Kung AL, Bradner JE, Weinstock DM.BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia.Blood. 2012 Oct 4;120(14):2843-52.
    22904298
  • Lin CY, Lovén J, Rahl PB, Paranal RM, Burge CB, Bradner JE, Lee TI, Young RA.Transcriptional amplification in tumor cells with elevated c-Myc.Cell. 2012 Sep 28;151(1):56-67.
    23021215
  • Matzuk MM, McKeown MR, Filippakopoulos P, Li Q, Ma L, Agno JE, Lemieux ME, Picaud S, Yu RN, Qi J, Knapp S, Bradner JE.Small-molecule inhibition of BRDT for male contraception.Cell. 2012 Aug 17;150(4):673-84.
    22901802
  • Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Goldberg L, Birger Y, Izraeli S, Gamis AS, Smith FO, Woods WG, Taub J, Scherer CA, Bradner JE, Goh BC, Mercher T, Carpenter AE, Gould RJ, Clemons PA, Carr SA, Root DE, Schreiber SL, Stern AM, Crispino JD.Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.Cell. 2012 Aug 3;150(3):575-89.
    22863010
  • Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, Kastritis E, Gilpatrick T, Paranal RM, Qi J, Chesi M, Schinzel AC, McKeown MR, Heffernan TP, Vakoc CR, Bergsagel PL, Ghobrial IM, Richardson PG, Young RA, Hahn WC, Anderson KC, Kung AL, Bradner JE, Mitsiades CS.BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc.Cell. 2011 Sep 16;146(6):904-17.
    21889194
  • Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M, Taylor MJ, Johns C, Chicas A, Mulloy JC, Kogan SC, Brown P, Valent P, Bradner JE, Lowe SW, Vakoc CR.RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.Nature. 2011 Aug 3.
    21814200
  • Schwartz BE, Hofer MD, Lemieux ME, Bauer DE, Cameron MJ, West NH, Agoston ES, Reynoird N, Khochbin S, Ince TA, Christie A, Janeway KA, Vargas SO, Perez-Atayde AR, Aster JC, Sallan SE, Kung AL, Bradner JE, French CA.Differentiation of NUT Midline Carcinoma by Epigenomic Reprogramming.Cancer Res. 2011 Apr 1;71(7):2686-96.
    21447744
  • de Zoeten EF, Wang L, Butler K, Beier UH, Akimova T, Sai H, Bradner JE, Mazitschek R, Kozikowski AP, Matthias P, Hancock WW.HDAC6 and HSP90 Control The Functions Of Foxp3+ T-Regulatory Cells.Mol Cell Biol. 2011 Mar 28.
    21444725
  • Tang W, Luo T, Greenberg EF, Bradner JE, Schreiber SL.Discovery of histone deacetylase 8 selective inhibitors.Bioorg Med Chem Lett. 2011 Feb 2.
    21334896
  • Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE.Selective inhibition of BET bromodomains.Nature. 2010 Dec 23;468(7327):1067-73.
    20871596
  • Marubayashi S, Koppikar P, Taldone T, Abdel-Wahab O, West N, Bhagwat N, Caldas-Lopes E, Ross KN, Gönen M, Gozman A, Ahn JH, Rodina A, Ouerfelli O, Yang G, Hedvat C, Bradner JE, Chiosis G, Levine RL.HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans.J Clin Invest. 2010 Oct 1;120(10):3578-93.
    20852385
  • Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, DeAngelo DJ, Carr SA, Schreiber SL, Golub TR, Ebert BL.Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12617-22.
    20616024
  • Bowers AA,Greshock TJ,West N,Estiu G,Schreiber SL,Wiest O,Williams RM,Bradner JE.Synthesis and Conformation-Activity Relationships of the Peptide Isosteres of FK228 and Largazole.J Am Chem Soc. 2009 Mar 4;131(8):2900-5.
    19193120
  • Estiu G, West N, Mazitschek R, Greenberg E, Bradner JE, Wiest O.On the inhibition of histone deacetylase 8.Bioorg Med Chem. 2010 Jun 1;18(11):4103-10.
    20472442
  • Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R.Chemical phylogenetics of histone deacetylases.Nat Chem Biol. 2010 Mar;6(3):238-243.
    20139990
  • Yoda A, Yoda Y, Chiaretti S, Bar-Natan M, Mani K, Rodig SJ, West N, Xiao Y, Brown JR, Mitsiades C, Sattler M, Kutok JL, DeAngelo DJ, Wadleigh M, Piciocchi A, Dal Cin P, Bradner JE, Griffin JD, Anderson KC, Stone RM, Ritz J, Foà R, Aster JC, Frank DA, Weinstock DM.Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):252-7.
    20018760
  • McCarroll SA, Bradner JE, Turpeinen H, Volin L, Martin PJ, Chilewski SD, Antin JH, Lee SJ, Ruutu T, Storer B, Warren EH, Zhang B, Zhao LP, Ginsburg D, Soiffer RJ, Partanen J, Hansen JA, Ritz J, Palotie A, Altshuler D.Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease.Nat Genet. 2009 Dec;41(12):1341-4.
    19935662
  • Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, Bradner JE.Direct inhibition of the NOTCH transcription factor complex.Nature. 2009 Nov 12;462(7270):182-8.
    19907488
  • Kimbrel EA, Davis TN, Bradner JE, Kung AL.In vivo pharmacodynamic imaging of proteasome inhibition.Mol Imaging.;8(3):140-7.
    19723471
  • Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, Bradner J.Direct inhibition of the Notch transcription factor complex.Nature..
  • Kawada J,Zou P,Mazitschek R,Bradner JE,Cohen JI.Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis.J Biol Chem. 2009 Jun 19;284(25):17102-9.
    19386607
  • Guan JS,Haggarty SJ,Giacometti E,Dannenberg JH,Joseph N,Gao J,Nieland TJ,Zhou Y,Wang X,Mazitschek R,Bradner JE,DePinho RA,Jaenisch R,Tsai LH.HDAC2 negatively regulates memory formation and synaptic plasticity.Nature. 2009 May 7;459(7243):55-60.
    19424149
  • Patel V,Mazitschek R,Coleman B,Nguyen C,Urgaonkar S,Cortese J,Barker RH,Greenberg E,Tang W,Bradner JE,Schreiber SL,Duraisingh MT,Wirth DF,Clardy J.Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.J Med Chem. 2009 Apr 23;52(8):2185-7.
    19317450
  • Bowers AA,West N,Newkirk TL,Troutman-Youngman AE,Schreiber SL,Wiest O,Bradner JE,Williams RM.Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold.Org Lett. 2009 Mar 19;11(6):1301-4.
    19239241
  • Bradner JE.A pulse at the heart of targeted therapy.Nat Chem Biol. 2009 Mar;5(3):144-5.
    19219016
  • Bowers A,West N,Taunton J,Schreiber SL,Bradner JE,Williams RM.Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.J Am Chem Soc. 2008 Aug 20;130(33):11219-22.
    18642817
  • Estiu G, Greenberg E, Harrison CB, Kwiatkowski NP, Mazitschek R, Bradner JE, Wiest O.Structural Origin of Selectivity in Class II-Selective Histone Deacetylase Inhibitors.J Med Chem. 2008 May 22;51(10):2898-906.
    18412327
  • Engelman JA, Zejnullahu K, Gale CM, Lifshits E, Gonzales AJ, Shimamura T, Zhao F, Vincent PW, Naumov GN, Bradner JE, Althaus IW, Gandhi L, Shapiro GI, Nelson JM, Heymach JV, Meyerson M, Wong KK, Jnne PA.PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib.Cancer Res. 2007 Dec 15;67(24):11924-32.
    18089823
  • Vegas AJ, Bradner JE, Tang W, McPherson OM, Greenberg EF, Koehler AN, Schreiber SL.Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors.Angew Chem Int Ed Engl. 2007;46(42):7960-4.
    17868168
  • Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, Chin L, DePinho RA.Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.Science. 2007 Oct 12;318(5848):287-90.
    17872411
  • Duan Z, Bradner J, Greenberg E, Mazitschek R, Foster R, Mahoney J, Seiden MV.8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells.Mol Pharmacol. 2007 Nov;72(5):1137-45.
    17675586
  • Bradner JE, McPherson OM, Koehler AN.A method for the covalent capture and screening of diverse small molecules in a microarray format.Nat Protoc. 2006;1(5):2344-52.
    17406478
  • Bradner JE, McPherson OM, Mazitschek R, Barnes-Seeman D, Shen JP, Dhaliwal J, Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P, Schreiber SL, Koehler AN.A robust small-molecule microarray platform for screening cell lysates.Chem Biol. 2006 May;13(5):493-504.
    16720270
  • Hideshima T, Bradner JE, Wong J, Chauhan D, Richardson P, Schreiber SL, Anderson KC.Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma.Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8567-72.
    15937109
  • Ansari AZ, Bradner JE, O'Halloran TV.DNA-bend modulation in a repressor-to-activator switching mechanism.Nature. 1995 Mar 23;374(6520):371-5.
    7885478