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Stephanie K. Dougan, PhD

Publications

  • Dougan SK, Dougan M, Kim J, Turner JA, Ogata S, Cho HI, Jaenisch R, Celis E, Ploegh HL.Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity.Cancer Immunol Res. 2013 Aug;1(2):99-111.
    24459675
  • Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW.In vivo discovery of immunotherapy targets in the tumour microenvironment.Nature. 2014 Feb 6;506(7486):52-7.
    24476824
  • Dougan SK, Ashour J, Karssemeijer RA, Popp MW, Avalos AM, Barisa M, Altenburg AF, Ingram JR, Cragnolini JJ, Guo C, Alt FW, Jaenisch R, Ploegh HL.Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus.Nature. 2013 Nov 21;503(7476):406-9.
    24141948
  • Dougan SK, Ogata S, Hu CC, Grotenbreg GM, Guillen E, Jaenisch R, Ploegh HL.IgG1+ ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells.Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13739-44.
    22869725
  • Zeissig S, Dougan SK, Barral DC, Junker Y, Chen Z, Kaser A, Ho M, Mandel H, McIntyre A, Kennedy SM, Painter GF, Veerapen N, Besra GS, Cerundolo V, Yue S, Beladi S, Behar SM, Chen X, Gumperz JE, Breckpot K, Raper A, Baer A, Exley MA, Hegele RA, Cuchel M, Rader DJ, Davidson NO, Blumberg RS.Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function.J Clin Invest. 2010 Aug 2;120(8):2889-99.
    20592474
  • Hu CC, Dougan SK, Winter SV, Paton AW, Paton JC, Ploegh HL.Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes.J Exp Med. 2009 Oct 26;206(11):2429-40.
    19808260
  • McGehee AM, Dougan SK, Klemm EJ, Shui G, Park B, Kim YM, Watson N, Wenk MR, Ploegh HL, Hu CC.XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis.J Immunol. 2009 Sep 15;183(6):3690-9.
    19710472
  • Hu CC, Dougan SK, McGehee AM, Love JC, Ploegh HL.XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells.EMBO J. 2009 Jun 3;28(11):1624-36.
    19407814
  • Dougan SK, Rava P, Hussain MM, Blumberg RS.MTP regulated by an alternate promoter is essential for NKT cell development.J Exp Med. 2007 Mar 19;204(3):533-45.
    17312007
  • Dougan SK, Salas A, Rava P, Agyemang A, Kaser A, Morrison J, Khurana A, Kronenberg M, Johnson C, Exley M, Hussain MM, Blumberg RS.Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells.J Exp Med. 2005 Aug 15;202(4):529-39.
    16087713