Daniel G. Tenen, MD

Publications

• Leddin M, Perrod C, Hoogenkamp M, Ghani S, Assi S, Heinz S, Wilson NK, Follows G, Schönheit J, Vockentanz L, Mosammam AM, Chen W, Tenen DG, Westhead DR, Göttgens B, Bonifer C, Rosenbauer F.Two distinct auto-regulatory loops operate at the PU.1 locus in
  21239694
• Jiang S, Alberich-Jorda M, Zagozdzon R, Parmar K, Fu Y, Mauch P, Banu N, Makriyannis A, Tenen DG, Avraham S, Groopman JE, Avraham HK.Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization.Bloo
  21063029
• Pulikkan JA, Peramangalam PS, Dengler V, Ho PA, Preudhomme C, Meshinchi S, Christopeit M, Nibourel O, Müller-Tidow C, Bohlander SK, Tenen DG, Behre G.C/EBP{alpha}-regulated microRNA-34a targets E2F3 during granulopoiesis and is downregulated in AML with
  20889924
• Yeo WL, Riely GJ, Yeap BY, Lau MW, Warner JL, Bodio K, Huberman MS, Kris MG, Tenen DG, Pao W, Kobayashi S, Costa DB.Erlotinib at a dose of 25 mg daily for non-small cell lung cancers with EGFR mutations.J Thorac Oncol. 2010 Jul;5(7):1048-53.
  20512075
• O'Brien KB, Alberich-Jordà M, Yadav N, Kocher O, Diruscio A, Ebralidze A, Levantini E, Sng NJ, Bhasin M, Caron T, Kim D, Steidl U, Huang G, Halmos B, Rodig SJ, Bedford MT, Tenen DG, Kobayashi S.CARM1 is required for proper control of proliferation a
  20530543
• Aikawa Y, Katsumoto T, Zhang P, Shima H, Shino M, Terui K, Ito E, Ohno H, Stanley ER, Singh H, Tenen DG, Kitabayashi I.PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2.Nat Med. 2010 May;16(5):580-5, 1p fo
  20418886
• Schemionek M, Elling C, Steidl U, Baumer N, Hamilton A, Spieker T, Gothert JR, Stehling M, Wagers A, Huettner CS, Tenen DG, Tickenbrock L, Berdel WE, Serve H, Holyoake TL, Muller-Tidow C, Koschmieder S.BCR-ABL enhances differentiation of long-term repopul
  20053753
• Will B, Siddiqi T, Alberich Jordà M, Shimamura T, Luptakova K, Staber PB, Costa DB, Steidl U, Tenen DG, Kobayashi S.Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells.Blood
  20160166
• Kamio N, Hirai H, Ashihara E, Tenen DG, Maekawa T, Imanishi J.Use of bicistronic vectors in combination with flow cytometry to screen for effective small interfering RNA target sequences.Biochem Biophys Res Commun. 2010 Mar 12;393(3):498-503.
  20152796
• Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Müller-Tidow C, Bohlander SK, Tenen DG, Behre G.Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia.Blood. 2010 Mar 4;115(9):1768-78
  20029046
• Guibal FC, Alberich-Jorda M, Hirai H, Ebralidze A, Levantini E, Di Ruscio A, Zhang P, Santana-Lemos BA, Neuberg D, Wagers AJ, Rego EM, Tenen DG.Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.
  19797526
• Wojiski S, Guibal FC, Kindler T, Lee BH, Jesneck JL, Fabian A, Tenen DG, Gilliland DG.PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors.Leukemia. 2009 Aug;23(8):1462-71.
  19322209
• Hoogenkamp M,Lichtinger M,Krysinska H,Lancrin C,Clarke D,Williamson A,Mazzarella L,Ingram R,Jorgensen H,Fisher A,Tenen DG,Kouskoff V,Lacaud G,Bonifer C.Early chromatin unfolding by RUNX1 - a molecular explanation for differential requirements during speci
  19339695
• Naumov GN,Nilsson MB,Cascone T,Briggs A,Straume O,Akslen LA,Lifshits E,Byers LA,Xu L,Wu HK,Janne P,Kobayashi S,Halmos B,Tenen D,Tang XM,Engelman J,Yeap B,Folkman J,Johnson BE,Heymach JV.Combined vascular endothelial growth factor receptor and epidermal gr
  19447865
• Koschmieder S,Halmos B,Levantini E,Tenen DG.Dysregulation of the C/EBPalpha differentiation pathway in human cancer.J Clin Oncol. 2009 Feb 1;27(4):619-28. Review.
  19075268
• Costa DB,Nguyen KS,Cho BC,Sequist LV,Jackman DM,Riely GJ,Yeap BY,Halmos B,Kim JH,Janne PA,Huberman MS,Pao W,Tenen DG,Kobayashi S.Effects of erlotinib in EGFR mutated non-small cell lung cancers with resistance to gefitinib.Clin Cancer Res. 2008 Nov 1;14(2
  18981003
• Ebralidze AK,Guibal FC,Steidl U,Zhang P,Lee S,Bartholdy B,Jorda MA,Petkova V,Rosenbauer F,Huang G,Dayaram T,Klupp J,O'Brien KB,Will B,Hoogenkamp M,Borden KL,Bonifer C,Tenen DG.PU.1 expression is modulated by the balance of functional sense and antise
  18676813
• Shimamura T,Li D,Ji H,Haringsma HJ,Liniker E,Borgman CL,Lowell AM,Minami Y,McNamara K,Perera SA,Zaghlul S,Thomas RK,Greulich H,Kobayashi S,Chirieac LR,Padera RF,Kubo S,Takahashi M,Tenen DG,Meyerson M,Wong KK,Shapiro GI.Hsp90 inhibition suppresses mutant E
  18632637
• Huang G,Eisenberg R,Yan M,Monti S,Lawrence E,Fu P,Walbroehl J,Lowenberg E,Golub T,Merchan J,Tenen DG,Markowitz SD,Halmos B.15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer.Cancer Re
  18593902
• Kirstetter P, Schuster MB, Bereshchenko O, Moore S, Dvinge H, Kurz E, Theilgaard-Monch K, Mansson R, Pedersen TA, Pabst T, Schrock E, Porse BT, Jacobsen SE, Bertone P, Tenen DG, Nerlov C.Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a commo
  18394553
• Costa DB, Schumer ST, Tenen DG, Kobayashi S.Differential responses to erlotinib in epidermal growth factor receptor (EGFR)-mutated lung cancers with acquired resistance to gefitinib carrying the L747S or T790M secondary mutations.J Clin Oncol. 2008 Mar 1;
  18309959
• Bruns I, Steidl U, Fischer JC, Czibere A, Kobbe G, Raschke S, Singh R, Fenk R, Rosskopf M, Pechtel S, von Haeseler A, Wernet P, Tenen DG, Haas R, Kronenwett R.Pegylated granulocyte colony-stimulating factor mobilizes CD34+ cells with different stem and pr
  18268278
• van Wageningen S, Breems-de Ridder MC, Nigten J, Nikoloski G, Erpelinck-Verschueren CA, Lowenberg B, de Witte T, Tenen DG, van der Reijden BA, Jansen JH.Gene transactivation without direct DNA binding defines a novel gain-of-function for PML-RARalpha.Bloo
  18025157
• Huang G, Zhang P, Hirai H, Elf S, Yan X, Chen Z, Koschmieder S, Okuno Y, Dayaram T, Growney JD, Shivdasani RA, Gilliland DG, Speck NA, Nimer SD, Tenen DG.PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.Nat Genet. 2008 Jan;40
  17994017
• Yu Z, Boggon TJ, Kobayashi S, Jin C, Ma PC, Dowlati A, Kern JA, Tenen DG, Halmos B.Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies.Cancer Res. 2007 Nov 1;67(21):
  17974985
• Costa DB, Halmos B, Kumar A, Schumer ST, Huberman MS, Boggon TJ, Tenen DG, Kobayashi S.BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations.PLoS Med. 2007 Oct;4(10):1669-79; discussion 1680.
  17973572
• Hoogenkamp M, Krysinska H, Ingram R, Huang G, Barlow R, Clarke D, Ebralidze A, Zhang P, Tagoh H, Cockerill PN, Tenen DG, Bonifer C.The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mech
  17785440
• Steidl U, Steidl C, Ebralidze A, Chapuy B, Han HJ, Will B, Rosenbauer F, Becker A, Wagner K, Koschmieder S, Kobayashi S, Costa DB, Schulz T, O'Brien KB, Verhaak RG, Delwel R, Haase D, Trumper L, Krauter J, Kohwi-Shigematsu T, Griesinger F, Tenen DG.A
  17694175
• Koschmieder S, D'Alo F, Radomska H, Schoneich C, Chang JS, Konopleva M, Kobayashi S, Levantini E, Suh N, Di Ruscio A, Voso MT, Watt JC, Santhanam R, Sargin B, Kantarjian H, Andreeff M, Sporn MB, Perrotti D, Berdel WE, Muller-Tidow C, Serve H, Tenen D
  17671235
• Geletu M, Balkhi MY, Peer Zada AA, Christopeit M, Pulikkan JA, Trivedi AK, Tenen DG, Behre G.Target proteins of C/EBPalphap30 in AML: C/EBPalphap30 enhances sumoylation of C/EBPalphap42 via up-regulation of Ubc9.Blood. 2007 Nov 1;110(9):3301-9.
  17671234
• Yeamans C, Wang D, Paz-Priel I, Torbett BE, Tenen DG, Friedman AD.C/EBPalpha binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment.Blood. 2007 Nov 1;110(9):3136-42.
  17671233
• Wouters BJ, Jorda MA, Keeshan K, Louwers I, Erpelinck-Verschueren CA, Tielemans D, Langerak AW, He Y, Yashiro-Ohtani Y, Zhang P, Hetherington CJ, Verhaak RG, Valk PJ, Lowenberg B, Tenen DG, Pear WS, Delwel R.Distinct gene expression profiles of acute myel
  17671232
• Costa DB, Kobayashi S, Tenen DG, Huberman MS.Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers.Lung Cancer. 2007 Oct;58(1):95-103.
  17610986
• Tatetsu H, Ueno S, Hata H, Yamada Y, Takeya M, Mitsuya H, Tenen DG, Okuno Y.Down-regulation of PU.1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth.Cancer Res. 2007 Jun 1;67(11):5328-36.
  17545613
• Costa DB, Li S, Kocher O, Feins RH, Keller SM, Schiller JH, Johnson DH, Tenen DG, Halmos B.Immunohistochemical analysis of C/EBPalpha in non-small cell lung cancer reveals frequent down-regulation in stage II and IIIA tumors: A correlative study of E3590.
  17239984
• Kobayashi S, Shimamura T, Monti S, Steidl U, Hetherington CJ, Lowell AM, Golub T, Meyerson M, Tenen DG, Shapiro GI, Halmos B.Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signal
  17145885
• Iwasaki H, Mizuno S, Arinobu Y, Ozawa H, Mori Y, Shigematsu H, Takatsu K, Tenen DG, Akashi K.The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages.Genes Dev. 2006 Nov 1;20(21):3010-21.
  17079688
• Steidl U, Rosenbauer F, Verhaak RG, Gu X, Ebralidze A, Otu HH, Klippel S, Steidl C, Bruns I, Costa DB, Wagner K, Aivado M, Kobbe G, Valk PJ, Passegué E, Libermann TA, Delwel R, Tenen DG.Essential role of Jun family transcription factors in PU.1 knockdown-
  17041602
• Zada AA, Geletu MH, Pulikkan JA, Müller-Tidow C, Reddy VA, Christopeit M, Hiddemann WD, Behre HM, Tenen DG, Behre G.Proteomic analysis of acute promyelocytic leukemia: PML-RARalpha leads to decreased phosphorylation of OP18 at serine 63.Proteomics. 2006 N
  17001604
• Kubo S, Levantini E, Kobayashi S, Kocher O, Halmos B, Tenen DG, Takahashi M.Three-dimensional magnetic resonance microscopy of pulmonary solitary tumors in transgenic mice.Magn Reson Med. 2006 Sep;56(3):698-703.
  16902979
• Lee YJ, Jones LC, Timchenko NA, Perrotti D, Tenen DG, Kogan SC.CCAAT/enhancer binding proteins alpha and epsilon cooperate with all-trans retinoic acid in therapy but differ in their antileukemic activities.Blood. 2006 Oct 1;108(7):2416-9.
  16788101
• Costa DB, Dayaram T, D'Alo F, Wouters BJ, Tenen DG, Meyerson M, Tsao MS, Halmos B.C/EBPalpha mutations in lung cancer.Lung Cancer. 2006 Aug;53(2):253-4.
  16765476
• Hirai H, Zhang P, Dayaram T, Hetherington CJ, Mizuno S, Imanishi J, Akashi K, Tenen DG.C/EBPbeta is required for 'emergency' granulopoiesis.Nat Immunol. 2006 Jul;7(7):732-9.
  16751774
• Mueller BU, Pabst T, Hauser P, Gilliland G, Neuberg D, Tenen DG.Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia.Br J Cancer. 2006 Jun 19;94(12):1918-20.
  16735999
• Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, Jänne PA, Shapiro GI, Tenen D, Johnson BE, Weissleder R, Sharpless NE, Wong KK.The impact of human EGFR kinase d
  16730237
• Pabst T, Stillner E, Neuberg D, Nimer S, Willman CL, List AF, Melo JV, Tenen DG, Mueller BU.Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia.Br J Haematol. 2006 May;133(4):400-2.
  16643447
• Wagner K, Zhang P, Rosenbauer F, Drescher B, Kobayashi S, Radomska HS, Kutok JL, Gilliland DG, Krauter J, Tenen DG.Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy.P
  16606850
• Radomska HS, Bassères DS, Zheng R, Zhang P, Dayaram T, Yamamoto Y, Sternberg DW, Lokker N, Giese NA, Bohlander SK, Schnittger S, Delmotte MH, Davis RJ, Small D, Hiddemann W, Gilliland DG, Tenen DG.Block of C/EBP alpha function by phosphorylation in acute
  16446383
• Bassères DS, Levantini E, Ji H, Monti S, Elf S, Dayaram T, Fenyus M, Kocher O, Golub T, Wong KK, Halmos B, Tenen DG.Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor
  16428462
• Mueller BU, Pabst T, Fos J, Petkovic V, Fey MF, Asou N, Buergi U, Tenen DG.ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression.Blood. 2006 Apr 15;107(8):3330-8.
  16352814
• Arinobu Y, Iwasaki H, Gurish MF, Mizuno S, Shigematsu H, Ozawa H, Tenen DG, Austen KF, Akashi K.Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis.Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18105-10.
  16330751
• Rosenbauer F, Owens BM, Yu L, Tumang JR, Steidl U, Kutok JL, Clayton LK, Wagner K, Scheller M, Iwasaki H, Liu C, Hackanson B, Akashi K, Leutz A, Rothstein TL, Plass C, Tenen DG.Lymphoid cell growth and transformation are suppressed by a key regulatory ele
  16311598
• Koschmieder S, Rosenbauer F, Steidl U, Owens BM, Tenen DG.Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.Int J Hematol. 2005 Jun;81(5):368-77.
  16158816
• Mukohara T, Engelman JA, Hanna NH, Yeap BY, Kobayashi S, Lindeman N, Halmos B, Pearlberg J, Tsuchihashi Z, Cantley LC, Tenen DG, Johnson BE, Jänne PA.Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth f
  16106023
• Iwasaki H, Somoza C, Shigematsu H, Duprez EA, Iwasaki-Arai J, Mizuno S, Arinobu Y, Geary K, Zhang P, Dayaram T, Fenyus ML, Elf S, Chan S, Kastner P, Huettner CS, Murray R, Tenen DG, Akashi K.Distinctive and indispensable roles of PU.1 in maintenance of he
  15914556
• Okuno Y, Huang G, Rosenbauer F, Evans EK, Radomska HS, Iwasaki H, Akashi K, Moreau-Gachelin F, Li Y, Zhang P, Göttgens B, Tenen DG.Potential autoregulation of transcription factor PU.1 by an upstream regulatory element.Mol Cell Biol. 2005 Apr;25(7):2832-4
  15767686
• Kobayashi S, Boggon TJ, Dayaram T, Jänne PA, Kocher O, Meyerson M, Johnson BE, Eck MJ, Tenen DG, Halmos B.EGFR mutation and resistance of non-small-cell lung cancer to gefitinib.N Engl J Med. 2005 Feb 24;352(8):786-92.
  15728811
• Cho D, Kocher O, Lee JC, Tenen DG, Meyerson ML, Janne PA, Halmos B.Unusual cases in multiple myeloma and a dramatic response in metastatic lung cancer: case 4. Mutation of the epidermal growth factor receptor in an elderly man with advanced, gefitinib-res
  15625379
• Koschmieder S, Goettgens B, Zhang P, Iwasaki-Arai J, Akashi K, Kutok JL, Dayaram T, Geary K, Green AR, Tenen DG, Huettner CS.Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogen
  15331442
• Halmos B, Bassères DS, Monti S, D'Aló F, Dayaram T, Ferenczi K, Wouters BJ, Huettner CS, Golub TR, Tenen DG.A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3 beta as a novel tumor suppr
  15205324
• Rosenbauer F, Wagner K, Zhang P, Knobeloch KP, Iwama A, Tenen DG.pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1.Blood. 2004 Jun 1;103(11):4294-301.
  14962908
• Rosenbauer F, Wagner K, Kutok JL, Iwasaki H, Le Beau MM, Okuno Y, Akashi K, Fiering S, Tenen DG.Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.Nat Genet. 2004 Jun;36(6):624-30.
  15146183
• Ross SE, Radomska HS, Wu B, Zhang P, Winnay JN, Bajnok L, Wright WS, Schaufele F, Tenen DG, MacDougald OA.Phosphorylation of C/EBPalpha inhibits granulopoiesis.Mol Cell Biol. 2004 Jan;24(2):675-86.
  14701740
• Elsässer A, Franzen M, Kohlmann A, Weisser M, Schnittger S, Schoch C, Reddy VA, Burel S, Zhang DE, Ueffing M, Tenen DG, Hiddemann W, Behre G.The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression
  12944913
• Rangatia J, Vangala RK, Singh SM, Peer Zada AA, Elsässer A, Kohlmann A, Haferlach T, Tenen DG, Hiddemann W, Behre G.Elevated c-Jun expression in acute myeloid leukemias inhibits C/EBPalpha DNA binding via leucine zipper domain interaction.Oncogene. 2003 J
  12879022
• Huettner CS, Koschmieder S, Iwasaki H, Iwasaki-Arai J, Radomska HS, Akashi K, Tenen DG.Inducible expression of BCR/ABL using human CD34 regulatory elements results in a megakaryocytic myeloproliferative syndrome.Blood. 2003 Nov 1;102(9):3363-70.
  12855552
• Zada AA, Singh SM, Reddy VA, Elsässer A, Meisel A, Haferlach T, Tenen DG, Hiddemann W, Behre G.Downregulation of c-Jun expression and cell cycle regulatory molecules in acute myeloid leukemia cells upon CD44 ligation.Oncogene. 2003 Apr 17;22(15):2296-308.
  12700665
• van Waalwijk van Doorn-Khosrovani SB, Erpelinck C, Meijer J, van Oosterhoud S, van Putten WL, Valk PJ, Berna Beverloo H, Tenen DG, Löwenberg B, Delwel R.Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in interme
  12692518
• Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG.Heterozygous PU.1 mutations are associated with acute myeloid leukemia.Blood. 2003 Mar 1;101(5):2074.
  12584148
• Rangatia J, Vangala RK, Treiber N, Zhang P, Radomska H, Tenen DG, Hiddemann W, Behre G.Downregulation of c-Jun expression by transcription factor C/EBPalpha is critical for granulocytic lineage commitment.Mol Cell Biol. 2002 Dec;22(24):8681-94.
  12446786
• Okuno Y, Huettner CS, Radomska HS, Petkova V, Iwasaki H, Akashi K, Tenen DG.Distal elements are critical for human CD34 expression in vivo.Blood. 2002 Dec 15;100(13):4420-6.
  12393741
• Truong BT, Lee YJ, Lodie TA, Park DJ, Perrotti D, Watanabe N, Koeffler HP, Nakajima H, Tenen DG, Kogan SC.CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia.Blood. 2003 Feb 1;101(3):1141-8.
  12393450
• Mayerhofer M, Valent P, Sperr WR, Griffin JD, Sillaber C.BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mam
  12393646
• Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G.The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.Blood. 2003 Jan 1;101(1):270-7.
  12393465
• Radomska HS, Gonzalez DA, Okuno Y, Iwasaki H, Nagy A, Akashi K, Tenen DG, Huettner CS.Transgenic targeting with regulatory elements of the human CD34 gene.Blood. 2002 Dec 15;100(13):4410-9.
  12393582
• Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG.Heterozygous PU.1 mutations are associated with acute myeloid leukemia.Blood. 2002 Aug 1;100(3):998-1007.
  12130514
• Welm AL, Timchenko NA, Ono Y, Sorimachi H, Radomska HS, Tenen DG, Lekstrom-Himes J, Darlington GJ.C/EBPalpha is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells.J Biol Chem. 2002 Sep 13;277(37):33848-56.
  12105198
• Reddy VA, Iwama A, Iotzova G, Schulz M, Elsasser A, Vangala RK, Tenen DG, Hiddemann W, Behre G.Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions.Blood. 2002 Jul 15;100(2):483-90.
  12091339
• Zhang P, Nelson E, Radomska HS, Iwasaki-Arai J, Akashi K, Friedman AD, Tenen DG.Induction of granulocytic differentiation by 2 pathways.Blood. 2002 Jun 15;99(12):4406-12.
  12036869
• Okuno Y, Iwasaki H, Huettner CS, Radomska HS, Gonzalez DA, Tenen DG, Akashi K.Differential regulation of the human and murine CD34 genes in hematopoietic stem cells.Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6246-51.
  11983914
• Behre G, Singh SM, Liu H, Bortolin LT, Christopeit M, Radomska HS, Rangatia J, Hiddemann W, Friedman AD, Tenen DG.Ras signaling enhances the activity of C/EBP alpha to induce granulocytic differentiation by phosphorylation of serine 248.J Biol Chem. 2002
  11978795
• Iwama A, Osawa M, Hirasawa R, Uchiyama N, Kaneko S, Onodera M, Shibuya K, Shibuya A, Vinson C, Tenen DG, Nakauchi H.Reciprocal roles for CCAAT/enhancer binding protein (C/EBP) and PU.1 transcription factors in Langerhans cell commitment.J Exp Med. 2002 Ma
  11877478
• Halmos B, Huettner CS, Kocher O, Ferenczi K, Karp DD, Tenen DG.Down-regulation and antiproliferative role of C/EBPalpha in lung cancer.Cancer Res. 2002 Jan 15;62(2):528-34.
  11809705
• Burel SA, Harakawa N, Zhou L, Pabst T, Tenen DG, Zhang DE.Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation.Mol Cell Biol. 2001 Aug;21(16):5577-90.
  11463839
• Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG.c-Myc is a critical target for c/EBPalpha in granulopoiesis.Mol Cell Biol. 2001 Jun;21(11):3789-806.
  11340171
• Pabst T, Mueller BU, Harakawa N, Schoch C, Haferlach T, Behre G, Hiddemann W, Zhang DE, Tenen DG.AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.Nat Med. 2001 Apr;7(4):444-51.
  11283671
• Pabst T, Mueller BU, Zhang P, Radomska HS, Narravula S, Schnittger S, Behre G, Hiddemann W, Tenen DG.Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia.Nat Genet. 2001 Mar;27(3):263-
  11242107
• Zhang P, Zhang X, Iwama A, Yu C, Smith KA, Mueller BU, Narravula S, Torbett BE, Orkin SH, Tenen DG.PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding.Blood. 2000 Oct 15;96(8):2641-8.
  11023493
• Rhoades KL, Hetherington CJ, Harakawa N, Yergeau DA, Zhou L, Liu LQ, Little MT, Tenen DG, Zhang DE.Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model.Blood. 2000 Sep 15;96(6):2108-15.
  10979955
• Huettner CS, Zhang P, Van Etten RA, Tenen DG.Reversibility of acute B-cell leukaemia induced by BCR-ABL1.Nat Genet. 2000 Jan;24(1):57-60.
  10615128
• Radomska HS, Huettner CS, Zhang P, Cheng T, Scadden DT, Tenen DG.CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors.Mol Cell Biol. 1998 Jul;18(7):4301-14.
  9632814
• Chen HM, Gonzalez DA, Radomska HS, Voso MT, Sun Z, Zhang P, Zhang DE, Tenen DG.Two promoters direct expression of the murine Spi-B gene, an Ets family transcription factor.Gene. 1998 Jan 30;207(2):209-18.
  9511763
• Su GH, Chen HM, Muthusamy N, Garrett-Sinha LA, Baunoch D, Tenen DG, Simon MC.Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B.EMBO J. 1997 Dec 1;16(23):7118-29.
  9384589
• Yergeau DA, Hetherington CJ, Wang Q, Zhang P, Sharpe AH, Binder M, Marín-Padilla M, Tenen DG, Speck NA, Zhang DE.Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.Nat Genet. 1997 Mar;15(3):303-6.
  9054947
• Zhang DE, Zhang P, Wang ND, Hetherington CJ, Darlington GJ, Tenen DG.Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice.Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):5
  9012825
• Cheng T, Shen H, Giokas D, Gere J, Tenen DG, Scadden DT.Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells.Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13158-63.
  8917561
• Zhang DE, Hetherington CJ, Meyers S, Rhoades KL, Larson CJ, Chen HM, Hiebert SW, Tenen DG.CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter.Mol Cell Biol. 1996
  8622667
• Zhang DE, Hohaus S, Voso MT, Chen HM, Smith LT, Hetherington CJ, Tenen DG.Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: regulation of multiple myeloid CSF receptor promoters.Curr Top Microbiol Immunol. 1996;211:137-47.
  8585944
• Chen HM, Zhang P, Voso MT, Hohaus S, Gonzalez DA, Glass CK, Zhang DE, Tenen DG.Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B.Blood. 1995 May 15;85(10):2918-28.
  7742552
• Dziennis S, Van Etten RA, Pahl HL, Morris DL, Rothstein TL, Blosch CM, Perlmutter RM, Tenen DG.The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice.Blood. 1995 Jan 15;85(2):319-29.
  7811988
• Zhang DE, Fujioka K, Hetherington CJ, Shapiro LH, Chen HM, Look AT, Tenen DG.Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (A
  7969146
• Zhang DE, Hetherington CJ, Gonzalez DA, Chen HM, Tenen DG.Regulation of CD14 expression during monocytic differentiation induced with 1 alpha,25-dihydroxyvitamin D3.J Immunol. 1994 Oct 1;153(7):3276-84.
  7522257
• Voso MT, Burn TC, Wulf G, Lim B, Leone G, Tenen DG.Inhibition of hematopoiesis by competitive binding of transcription factor PU.1.Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):7932-6.
  7520173
• Zhang DE, Hetherington CJ, Chen HM, Tenen DG.The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor.Mol Cell Biol. 1994 Jan;14(1):373-81.
  8264604
• Mastrianni DM, Tung NM, Tenen DG.Acute myelogenous leukemia: current treatment and future directions.Am J Med. 1992 Mar;92(3):286-95.
  1546728