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Cornelis P. Terhorst, PhD

Publications

  • De Calisto J, Wang N, Wang G, Yigit B, Engel P, Terhorst C.SAP-Dependent and -Independent Regulation of Innate T Cell Development Involving SLAMF Receptors.Frontiers In Immunology. 2014;5:186.
    24795728
  • Liao G, O'Keeffe MS, Wang G, van Driel B, de Waal Malefyt R, Reinecker HC, Herzog RW, Terhorst C.Glucocorticoid-Induced TNF Receptor Family-Related Protein Ligand is Requisite for Optimal Functioning of Regulatory CD4(+) T Cells.Frontiers In Immunology. 2014;5:35.
    24550919
  • Deng GM, Beltran J, Chen C, Terhorst C, Tsokos GC.T cell CD3ζ deficiency enables multiorgan tissue inflammation.J Immunol. 2013 Oct 1;191(7):3563-7.
    23980209
  • Detre C, Yigit B, Keszei M, Castro W, Magelky EM, Terhorst C.SAP modulates B cell functions in a genetic background-dependent manner.Immunol Lett. 2013 Jun;153(1-2):15-21.
    23806511
  • Martino AT, Basner-Tschakarjan E, Markusic DM, Finn JD, Hinderer C, Zhou S, Ostrov DA, Srivastava A, Ertl HC, Terhorst C, High KA, Mingozzi F, Herzog RW.Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells.Blood. 2013 Mar 21;121(12):2224-33.
    23325831
  • Wang X, Sherman A, Liao G, Leong KW, Daniell H, Terhorst C, Herzog RW.Mechanism of oral tolerance induction to therapeutic proteins.Adv Drug Deliv Rev. 2012 Nov 2.
    23123293
  • Chatterjee M, Hedrich CM, Rauen T, Ioannidis C, Terhorst C, Tsokos GC.CD3-T Cell Receptor Co-stimulation through SLAMF3 and SLAMF6 Receptors Enhances RORγt Recruitment to the IL17A Promoter in Human T Lymphocytes.J Biol Chem. 2012 Nov 2;287(45):38168-77.
    22989874
  • Detre C, Keszei M, Garrido-Mesa N, Kis-Toth K, Castro W, Agyemang AF, Veerapen N, Besra GS, Carroll MC, Tsokos GC, Wang N, Leadbetter EA, Terhorst C.SAP expression in invariant NKT cells is required for cognate help to support B-cell responses.Blood. 2012 Jul 5;120(1):122-9.
    22613797
  • Hoffman BE, Martino AT, Sack BK, Cao O, Liao G, Terhorst C, Herzog RW.Nonredundant Roles of IL-10 and TGF-β in Suppression of Immune Responses to Hepatic AAV-Factor IX Gene Transfer.Mol Ther. 2011 Mar 8.
    21386826
  • Keszei M, Latchman YE, Vanguri VK, Brown DR, Detre C, Morra M, Arancibia CV, Paul E, Calpe S, Castro W, Wang N, Terhorst C, Sharpe AH.Auto-antibody production and glomerulonephritis in congenic Slamf1-/- and Slamf2-/- [B6.129] but not in Slamf1-/- and Slamf2-/- [BALB/c.129] mice.Int Immunol. 2011 Feb;23(2):149-58.
    21278219
  • Wang N, Calpe S, Westcott J, Castro W, Ma C, Engel P, Schatzle JD, Terhorst C.Cutting Edge: The Adapters EAT-2A and -2B Are Positive Regulators of CD244- and CD84-Dependent NK Cell Functions in the C57BL/6 Mouse.J Immunol. 2010 Nov 15;185(10):5683-7.
    20962259
  • Sintes J, Romero X, de Salort J, Terhorst C, Engel P.Mouse CD84 is a pan-leukocyte cell-surface molecule that modulates LPS-induced cytokine secretion by macrophages.J Leukoc Biol. 2010 Oct;88(4):687-97.
    20628063
  • Walter JE, Rucci F, Patrizi L, Recher M, Regenass S, Paganini T, Keszei M, Pessach I, Lang PA, Poliani PL, Giliani S, Al-Herz W, Cowan MJ, Puck JM, Bleesing J, Niehues T, Schuetz C, Malech H, DeRavin SS, Facchetti F, Gennery AR, Andersson E, Kamani NR, Sekiguchi J, Alenezi HM, Chinen J, Dbaibo G, ElGhazali G, Fontana A, Pasic S, Detre C, Terhorst C, Alt FW, Notarangelo LD.Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency.J Exp Med. 2010 Jul 5;207(7):1541-54.
    20547827
  • Detre C, Keszei M, Romero X, Tsokos GC, Terhorst C.SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions.Semin Immunopathol. 2010 Jun;32(2):157-71. Review.
    20146065
  • Liao G, Nayak S, Regueiro JR, Berger SB, Detre C, Romero X, de Waal Malefyt R, Chatila TA, Herzog RW, Terhorst C.GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells.Int Immunol. 2010 Apr;22(4):259-70.
    20139172
  • Porcelli S, Brenner MB, Greenstein JL, Terhorst C, Balk SP, Bleicher PA.Pillars Article: Recognition of Cluster of Differentiation 1 Antigens by Human CD4-CD8- CytolyticT Lymphocyte. Nature. 1989. 341: 447-450.J Immunol. 2010 Apr 1;184(7):3306-9.
    20304831
  • Rucci F, Notarangelo LD, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley KM, Detre C, Keszei M, Walter JE, Feldman L, Cheng HL, Poliani PL, Wang JH, Balter BB, Recher M, Andersson EM, Zha S, Giliani S, Terhorst C, Alt FW, Yan CT.Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome.Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3024-9.
    20133615
  • Cooper M, Nayak S, Hoffman BE, Terhorst C, Cao O, Herzog RW.Improved Induction of Immune Tolerance to Factor IX by Hepatic AAV-8 Gene Transfer.Hum Gene Ther. 2009 Jul;20(7):767-76.
    19309290
  • Martino AT, Nayak S, Hoffman BE, Cooper M, Liao G, Markusic DM, Byrne BJ, Terhorst C, Herzog RW.Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity.PLoS ONE. 2009;4(8):e6376.
    19652717
  • Morra M, Barrington RA, Abadia-Molina AC, Okamoto S, Julien A, Gullo C, Kalsy A, Edwards MJ, Chen G, Spolski R, Leonard WJ, Huber BT, Borrow P, Biron CA, Satoskar AR, Carroll MC, Terhorst C.Defective B cell responses in the absence of SH2D1A.Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4819-23.
    15774582
  • Chung B, Aoukaty A, Dutz J, Terhorst C, Tan R.Signaling lymphocytic activation molecule-associated protein controls NKT cell functions.J Immunol. 2005 Mar 15;174(6):3153-7.
    15749842
  • Schmidt-Supprian M, Tian J, Ji H, Terhorst C, Bhan AK, Grant EP, Pasparakis M, Casola S, Coyle AJ, Rajewsky K.I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion.J Immunol. 2004 Aug 1;173(3):1612-9.
    15265889
  • Wang N, Satoskar A, Faubion W, Howie D, Okamoto S, Feske S, Gullo C, Clarke K, Sosa MR, Sharpe AH, Terhorst C.The cell surface receptor SLAM controls T cell and macrophage functions.J Exp Med. 2004 May 3;199(9):1255-64.
    15123745
  • Chan B, Lanyi A, Song HK, Griesbach J, Simarro-Grande M, Poy F, Howie D, Sumegi J, Terhorst C, Eck MJ.SAP couples Fyn to SLAM immune receptors.Nat Cell Biol. 2003 Feb;5(2):155-60.
    12545174
  • Howie D, Okamoto S, Rietdijk S, Clarke K, Wang N, Gullo C, Bruggeman JP, Manning S, Coyle AJ, Greenfield E, Kuchroo V, Terhorst C.The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production.Blood. 2002 Oct 15;100(8):2899-907.
    12351401
  • Mizoguchi E, Mizoguchi A, Takedatsu H, Cario E, de Jong YP, Ooi CJ, Xavier RJ, Terhorst C, Podolsky DK, Bhan AK.Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice.Gastroenterology. 2002 Jan;122(1):134-44.
    11781288
  • Poy F, Yaffe MB, Sayos J, Saxena K, Morra M, Sumegi J, Cantley LC, Terhorst C, Eck MJ.Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.Mol Cell. 1999 Oct;4(4):555-61.
    10549287
  • Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, van Schaik S, Notarangelo L, Geha R, Roncarolo MG, Oettgen H, De Vries JE, Aversa G, Terhorst C.The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.Nature. 1998 Oct 1;395(6701):462-9.
    9774102
  • Hollnder GA, Zuklys S, Morel C, Mizoguchi E, Mobisson K, Simpson S, Terhorst C, Wishart W, Golan DE, Bhan AK, Burakoff SJ.Monoallelic expression of the interleukin-2 locus.Science. 1998 Mar 27;279(5359):2118-21.
    9516115
  • Hollnder GA, Wang B, Nichogiannopoulou A, Platenburg PP, van Ewijk W, Burakoff SJ, Gutierrez-Ramos JC, Terhorst C.Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes.Nature. 1995 Jan 26;373(6512):350-3.
    7830770