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Keith L. Ligon, MD, PhD

Publications

  • Norden AD, Lesser GJ, Drappatz J, Ligon KL, Hammond SN, Lee EQ, Reardon DR, Fadul CE, Plotkin SR, Batchelor TT, Zhu JJ, Beroukhim R, Muzikansky A, Doherty L, Lafrankie D, Smith K, Tafoya V, Lis R, Stack EC, Rosenfeld MR, Wen PY.Phase 2 study of dose-intense temozolomide in recurrent glioblastoma.Neuro Oncology. 2013 Jul;15(7):930-5.
    23553268
  • Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, Cho YJ, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KL.Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1.Proc Natl Acad Sci U S A. 2013 May 14;110(20):8188-93.
    23633565
  • Alexander BM, Ligon KL, Wen PY.Enhancing radiation therapy for patients with glioblastoma.Expert Rev Anticancer Ther. 2013 May;13(5):569-81.
    23617348
  • Phillips JJ, Aranda D, Ellison DW, Judkins AR, Croul SE, Brat DJ, Ligon KL, Horbinski C, Venneti S, Zadeh G, Santi M, Zhou S, Appin CL, Sioletic S, Sullivan LM, Martinez-Lage M, Robinson AE, Yong WH, Cloughesy T, Lai A, Phillips HS, Marshall R, Mueller S, Haas-Kogan DA, Molinaro AM, Perry A.PDGFRA Amplification is Common in Pediatric and Adult High-Grade Astrocytomas and Identifies a Poor Prognostic Group in IDH1 Mutant Glioblastoma.Brain Pathol. 2013 Feb 25.
    23438035
  • Brastianos PK, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G, Ligon KL, Palescandolo E, Van Hummelen P, Ducar MD, Raza A, Sunkavalli A, Macconaill LE, Stemmer-Rachamimov AO, Louis DN, Hahn WC, Dunn IF, Beroukhim R.Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.Nat Genet. 2013 Mar;45(3):285-9.
    23334667
  • Eberlin LS, Norton I, Orringer D, Dunn IF, Liu X, Ide JL, Jarmusch AK, Ligon KL, Jolesz FA, Golby AJ, Santagata S, Agar NY, Cooks RG.Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors.Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1611-6.
    23300285
  • Quayle SN, Lee JY, Cheung LW, Ding L, Wiedemeyer R, Dewan RW, Huang-Hobbs E, Zhuang L, Wilson RK, Ligon KL, Mills GB, Cantley LC, Chin L.Somatic Mutations of PIK3R1 Promote Gliomagenesis.PLoS ONE. 2012;7(11):e49466.
    23166678
  • Shin J, Padmanabhan A, de Groh ED, Lee JS, Haidar S, Dahlberg S, Guo F, He S, Wolman MA, Granato M, Lawson ND, Wolfe SA, Kim SH, Solnica-Krezel L, Kanki JP, Ligon KL, Epstein JA, Look AT.Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development.Dis Model Mech. 2012 Nov;5(6):881-94.
    22773753
  • Quayle SN, Chheda MG, Shukla SA, Wiedemeyer R, Tamayo P, Dewan RW, Zhuang L, Huang-Hobbs E, Haidar S, Xiao Y, Ligon KL, Hahn WC, Chin L.Integrative functional genomics identifies RINT1 as a novel GBM oncogene.Neuro Oncology. 2012 Nov;14(11):1325-31.
    23074196
  • Kieran MW, Roberts CW, Chi SN, Ligon KL, Rich BE, Macconaill LE, Garraway LA, Biegel JA.Absence of oncogenic canonical pathway mutations in aggressive pediatric rhabdoid tumors.Pediatr Blood Cancer. 2012 Dec 15;59(7):1155-7.
    22997201
  • Chi AS, Batchelor TT, Dias-Santagata D, Borger D, Stiles CD, Wang DL, Curry WT, Wen PY, Ligon KL, Ellisen L, Louis DN, Iafrate AJ.Prospective, high-throughput molecular profiling of human gliomas.J. Neurooncol. 2012 Oct;110(1):89-98.
    22821383
  • Rodriguez FJ, Ligon AH, Horkayne-Szakaly I, Rushing EJ, Ligon KL, Vena N, Garcia DI, Cameron JD, Eberhart CG.BRAF duplications and MAPK pathway activation are frequent in gliomas of the optic nerve proper.J Neuropathol Exp Neurol. 2012 Sep;71(9):789-94.
    22892521
  • Craig JM, Vena N, Ramkissoon S, Idbaih A, Fouse SD, Ozek M, Sav A, Hill DA, Margraf LR, Eberhart CG, Kieran MW, Norden AD, Wen PY, Loda M, Santagata S, Ligon KL, Ligon AH.DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues.PLoS ONE. 2012;7(6):e38881.
    22719973
  • Panageas KS, Iwamoto FM, Cloughesy TF, Aldape KD, Rivera AL, Eichler AF, Louis DN, Paleologos NA, Fisher BJ, Ashby LS, Cairncross JG, Roldán Urgoiti GB, Wen PY, Ligon KL, Schiff D, Robins HI, Rocque BG, Chamberlain MC, Mason WP, Weaver SA, Green RM, Kamar FG, Abrey LE, Deangelis LM, Jhanwar SC, Rosenblum MK, Lassman AB.Initial treatment patterns over time for anaplastic oligodendroglial tumors.Neuro Oncology. 2012 Jun;14(6):761-7.
    22661585
  • Mehta S, Huillard E, Kesari S, Maire CL, Golebiowski D, Harrington EP, Alberta JA, Kane MF, Theisen M, Ligon KL, Rowitch DH, Stiles CD.The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma.Cancer Cell. 2011 Mar 8;19(3):359-71.
    21397859
  • Maire CL, Ligon KL.Glioma Models: New GEMMs Add "Class" with Genomic and Expression Correlations.Cancer Cell. 2011 Mar 8;19(3):295-7.
    21397851
  • Agar NY, Golby AJ, Ligon KL, Norton I, Mohan V, Wiseman JM, Tannenbaum A, Jolesz FA.Development of Stereotactic Mass Spectrometry for Brain Tumor Surgery.Neurosurgery. 2010 Dec 22.
    21135749
  • Eberlin LS, Dill AL, Golby AJ, Ligon KL, Wiseman JM, Cooks RG, Agar NY.Discrimination of human astrocytoma subtypes by lipid analysis using desorption electrospray ionization imaging mass spectrometry.Angew Chem Int Ed Engl. 2010 Aug 9;49(34):5953-6.
    20602384
  • Drappatz J, Norden AD, Wong ET, Doherty LM, Lafrankie DC, Ciampa A, Kesari S, Sceppa C, Gerard M, Phan P, Schiff D, Batchelor TT, Ligon KL, Young G, Muzikansky A, Weiss SE, Wen PY.Phase I Study of Vandetanib with Radiotherapy and Temozolomide for Newly Diagnosed Glioblastoma.Int J Radiat Oncol Biol Phys. 2010 Sep 1;78(1):85-90.
    20137866
  • McIntire MG, Santagata S, Ligon K, Chirieac LR.Epidermal growth factor receptor gene amplification in atypical adenomatous hyperplasia of the lung.Am J Transl Res. 2010;2(3):309-15.
    20589169
  • Idbaih A,Criniere E,Ligon KL,Delattre O,Delattre JY.Array-Based Genomics in Glioma Research.Brain Pathol. 2010 Jan;20(1):28-38. Review.
    19298630
  • Mukasa A, Wykosky J, Ligon KL, Chin L, Cavenee WK, Furnari F.Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence.Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2616-21.
    20133782
  • Wen PY,Yung WK,Lamborn KR,Norden AD,Cloughesy TF,Abrey LE,Fine HA,Chang SM,Robins HI,Fink K,Deangelis LM,Mehta M,Di Tomaso E,Drappatz J,Kesari S,Ligon KL,Aldape K,Jain RK,Stiles CD,Egorin MJ,Prados MD.Phase II study of imatinib mesylate (Gleevec(R)) for recurrent meningiomas (North American Brain Tumor Consortium Study 01-08).Neuro-oncol. 2009 Dec;11(6):853-60.
    19293394
  • Santagata S, Maire CL, Idbaih A, Geffers L, Correll M, Holton K, Quackenbush J, Ligon KL.CRX is a diagnostic marker of retinal and pineal lineage tumors.PLoS ONE. 2009;4(11):e7932.
    19936203
  • MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Corso G, Roviello F, Shivdasani R, Kieran MW, Ligon KL, Stiles CD, Hahn WC, Meyerson ML, Garraway LA.Profiling critical cancer gene mutations in clinical tumor samples.PLoS ONE. 2009;4(11):e7887.
    19924296
  • Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, Chae SS, Zheng H, Ying H, Mahoney J, Hiller D, Jiang S, Protopopov A, Wong WH, Chin L, Ligon KL, DePinho RA.FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.Cell Stem Cell. 2009 Nov 6;5(5):540-53.
    19896444
  • Snuderl M, Eichler AF, Ligon KL, Vu QU, Silver M, Betensky RA, Ligon AH, Wen PY, Louis DN, Iafrate AJ.Polysomy for chromosomes 1 and 19 predicts earlier recurrence in anaplastic oligodendrogliomas with concurrent 1p/19q loss.Clin Cancer Res. 2009 Oct 15;15(20):6430-7.
    19808867
  • Emery B, Agalliu D, Cahoy JD, Watkins TA, Dugas JC, Mulinyawe SB, Ibrahim A, Ligon KL, Rowitch DH, Barres BA.Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination.Cell. 2009 Jul 10;138(1):172-85.
    19596243
  • Agarwalla PK,Dunn IF,Turner CD,Ligon KL,Schneider KA,Smith ER.A novel TP53 germline mutation in a family with a history of multiple malignancies: case report and review of the literature.Pediatr Neurosurg. 2008;44(6):501-8. Review.
    19127094
  • Kesari S,Schiff D,Drappatz J,LaFrankie D,Doherty L,Macklin EA,Muzikansky A,Santagata S,Ligon KL,Norden AD,Ciampa A,Bradshaw J,Levy B,Radakovic G,Ramakrishna N,Black PM,Wen PY.Phase II study of protracted daily temozolomide for low-grade gliomas in adults.Clin Cancer Res. 2009 Jan 1;15(1):330-7.
    19118062
  • Zheng H,Ying H,Yan H,Kimmelman AC,Hiller DJ,Chen AJ,Perry SR,Tonon G,Chu GC,Ding Z,Stommel JM,Dunn KL,Wiedemeyer R,You MJ,Brennan C,Wang YA,Ligon KL,Wong WH,Chin L,DePinho RA.p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.Nature. 2008 Oct 23;455(7216):1129-33.
    18948956
  • Schuller U,Heine VM,Mao J,Kho AT,Dillon AK,Han YG,Huillard E,Sun T,Ligon AH,Qian Y,Ma Q,Alvarez-Buylla A,McMahon AP,Rowitch DH,Ligon KL.Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.Cancer Cell. 2008 Aug 12;14(2):123-34.
    18691547
  • Kesari S, Schiff D, Henson JW, Muzikansky A, Gigas DC, Doherty L, Batchelor TT, Longtine JA, Ligon KL, Weaver S, Laforme A, Ramakrishna N, Black PM, Drappatz J, Ciampa A, Folkman J, Kieran M, Wen PY.Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults.Neuro-oncol. 2008 Jun;10(3):300-8.
    18403492
  • Wiedemeyer R, Brennan C, Heffernan TP, Xiao Y, Mahoney J, Protopopov A, Zheng H, Bignell G, Furnari F, Cavenee WK, Hahn WC, Ichimura K, Collins VP, Chu GC, Stratton MR, Ligon KL, Futreal PA, Chin L.Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development.Cancer Cell. 2008 Apr;13(4):355-64.
    18394558
  • Billiards SS, Haynes RL, Folkerth RD, Borenstein NS, Trachtenberg FL, Rowitch DH, Ligon KL, Volpe JJ, Kinney HC.Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia.Brain Pathol. 2008 Apr;18(2):153-63.
    18177464
  • Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK.Malignant astrocytic glioma: genetics, biology, and paths to treatment.Genes Dev. 2007 Nov 1;21(21):2683-710. Review.
    17974913
  • Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, Chin L, DePinho RA.Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.Science. 2007 Oct 12;318(5848):287-90.
    17872411
  • Monje ML, Vogel H, Masek M, Ligon KL, Fisher PG, Palmer TD.Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies.Ann Neurol. 2007 Nov;62(5):515-20.
    17786983
  • Santagata S, Ligon KL, Hornick JL.Embryonic Stem Cell Transcription Factor Signatures in the Diagnosis of Primary and Metastatic Germ Cell Tumors.Am J Surg Pathol. 2007 Jun;31(6):836-845.
    17527070
  • Ramsey MR, Krishnamurthy J, Pei XH, Torrice C, Lin W, Carrasco DR, Ligon KL, Xiong Y, Sharpless NE.Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues.Cancer Res. 2007 May 15;67(10):4732-41.
    17510401
  • Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, Anderson DJ, Stiles CD, Rowitch DH.Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.Neuron. 2007 Feb 15;53(4):503-17.
    17296553
  • Byers RJ, Di Vizio D, O'connell F, Tholouli E, Levenson RM, Gossard K, Twomey D, Yang Y, Benedettini E, Rose J, Ligon KL, Finn SP, Golub TR, Loda M.Semiautomated multiplexed quantum dot-based in situ hybridization and spectral deconvolution.J Mol Diagn. 2007 Feb;9(1):20-9.
    17251332
  • Rousseau A, Nutt CL, Betensky RA, Iafrate AJ, Han M, Ligon KL, Rowitch DH, Louis DN.Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.J Neuropathol Exp Neurol. 2006 Dec;65(12):1149-56.
    17146289
  • Santagata S, Hornick JL, Ligon KL.Comparative analysis of germ cell transcription factors in CNS germinoma reveals diagnostic utility of NANOG.Am J Surg Pathol. 2006 Dec;30(12):1613-8.
    17122519
  • Maher EA, Brennan C, Wen PY, Durso L, Ligon KL, Richardson A, Khatry D, Feng B, Sinha R, Louis DN, Quackenbush J, Black PM, Chin L, DePinho RA.Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities.Cancer Res. 2006 Dec 1;66(23):11502-13.
    17114236
  • Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, Rowitch D, McMahon AP.A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway.Cancer Res. 2006 Oct 15;66(20):10171-8.
    17047082
  • Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE.p16INK4a induces an age-dependent decline in islet regenerative potential.Nature. 2006 Sep 28;443(7110):453-7.
    16957737
  • Ligon KL, Kesari S, Kitada M, Sun T, Arnett HA, Alberta JA, Anderson DJ, Stiles CD, Rowitch DH.Development of NG2 neural progenitor cells requires Olig gene function.Proc Natl Acad Sci U S A. 2006 May 16;103(20):7853-8.
    16682644
  • Ligon KL, Fancy SP, Franklin RJ, Rowitch DH.Olig gene function in CNS development and disease.Glia. 2006 Jul;54(1):1-10. Review.
    16652341
  • Ligon KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, Louis DN, Stiles CD, Rowitch DH.The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas.J Neuropathol Exp Neurol. 2004 May;63(5):499-509.
    15198128
  • Bachoo RM, Kim RS, Ligon KL, Maher EA, Brennan C, Billings N, Chan S, Li C, Rowitch DH, Wong WH, DePinho RA.Molecular diversity of astrocytes with implications for neurological disorders.Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8384-9.
    15155908
  • Ligon KL, Echelard Y, Assimacopoulos S, Danielian PS, Kaing S, Grove EA, McMahon AP, Rowitch DH.Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia.Development. 2003 May;130(10):2275-87.
    12668639
  • Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA.Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.Cancer Cell. 2002 Apr;1(3):269-77.
    12086863
  • Black BL, Ligon KL, Zhang Y, Olson EN.Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family.J Biol Chem. 1996 Oct 25;271(43):26659-63.
    8900141
  • Burgess R, Cserjesi P, Ligon KL, Olson EN.Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites.Dev Biol. 1995 Apr;168(2):296-306.
    7729571
  • Cserjesi P, Brown D, Ligon KL, Lyons GE, Copeland NG, Gilbert DJ, Jenkins NA, Olson EN.Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis.Development. 1995 Apr;121(4):1099-110.
    7743923