Keith L. Ligon, MD, PhD

Publications

• Mehta S, Huillard E, Kesari S, Maire CL, Golebiowski D, Harrington EP, Alberta JA, Kane MF, Theisen M, Ligon KL, Rowitch DH, Stiles CD.The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Pro
  21397859
• Maire CL, Ligon KL.Glioma Models: New GEMMs Add "Class" with Genomic and Expression Correlations.Cancer Cell. 2011 Mar 8;19(3):295-7.
  21397851
• Agar NY, Golby AJ, Ligon KL, Norton I, Mohan V, Wiseman JM, Tannenbaum A, Jolesz FA.Development of Stereotactic Mass Spectrometry for Brain Tumor Surgery.Neurosurgery. 2010 Dec 22.
  21135749
• Eberlin LS, Dill AL, Golby AJ, Ligon KL, Wiseman JM, Cooks RG, Agar NY.Discrimination of human astrocytoma subtypes by lipid analysis using desorption electrospray ionization imaging mass spectrometry.Angew Chem Int Ed Engl. 2010 Aug 9;49(34):5953-6.
  20602384
• Drappatz J, Norden AD, Wong ET, Doherty LM, Lafrankie DC, Ciampa A, Kesari S, Sceppa C, Gerard M, Phan P, Schiff D, Batchelor TT, Ligon KL, Young G, Muzikansky A, Weiss SE, Wen PY.Phase I Study of Vandetanib with Radiotherapy and Temozolomide for Newly Di
  20137866
• McIntire MG, Santagata S, Ligon K, Chirieac LR.Epidermal growth factor receptor gene amplification in atypical adenomatous hyperplasia of the lung.Am J Transl Res. 2010;2(3):309-15.
  20589169
• Idbaih A,Criniere E,Ligon KL,Delattre O,Delattre JY.Array-Based Genomics in Glioma Research.Brain Pathol. 2010 Jan;20(1):28-38. Review.
  19298630
• Mukasa A, Wykosky J, Ligon KL, Chin L, Cavenee WK, Furnari F.Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence.Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2616-21.
  20133782
• Wen PY,Yung WK,Lamborn KR,Norden AD,Cloughesy TF,Abrey LE,Fine HA,Chang SM,Robins HI,Fink K,Deangelis LM,Mehta M,Di Tomaso E,Drappatz J,Kesari S,Ligon KL,Aldape K,Jain RK,Stiles CD,Egorin MJ,Prados MD.Phase II study of imatinib mesylate (Gleevec(R)) for r
  19293394
• Santagata S, Maire CL, Idbaih A, Geffers L, Correll M, Holton K, Quackenbush J, Ligon KL.CRX is a diagnostic marker of retinal and pineal lineage tumors.PLoS ONE. 2009;4(11):e7932.
  19936203
• MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Corso G, Roviello F, Shivdasan
  19924296
• Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, Chae SS, Zheng H, Ying H, Mahoney J, Hiller D, Jiang S, Protopopov A, Wong WH, Chin L, Ligon KL, DePinho RA.FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasi
  19896444
• Snuderl M, Eichler AF, Ligon KL, Vu QU, Silver M, Betensky RA, Ligon AH, Wen PY, Louis DN, Iafrate AJ.Polysomy for chromosomes 1 and 19 predicts earlier recurrence in anaplastic oligodendrogliomas with concurrent 1p/19q loss.Clin Cancer Res. 2009 Oct 15;1
  19808867
• Emery B, Agalliu D, Cahoy JD, Watkins TA, Dugas JC, Mulinyawe SB, Ibrahim A, Ligon KL, Rowitch DH, Barres BA.Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination.Cell. 2009 Jul 10;138(1):172-85.
  19596243
• Agarwalla PK,Dunn IF,Turner CD,Ligon KL,Schneider KA,Smith ER.A novel TP53 germline mutation in a family with a history of multiple malignancies: case report and review of the literature.Pediatr Neurosurg. 2008;44(6):501-8. Review.
  19127094
• Kesari S,Schiff D,Drappatz J,LaFrankie D,Doherty L,Macklin EA,Muzikansky A,Santagata S,Ligon KL,Norden AD,Ciampa A,Bradshaw J,Levy B,Radakovic G,Ramakrishna N,Black PM,Wen PY.Phase II study of protracted daily temozolomide for low-grade gliomas in adults.
  19118062
• Zheng H,Ying H,Yan H,Kimmelman AC,Hiller DJ,Chen AJ,Perry SR,Tonon G,Chu GC,Ding Z,Stommel JM,Dunn KL,Wiedemeyer R,You MJ,Brennan C,Wang YA,Ligon KL,Wong WH,Chin L,DePinho RA.p53 and Pten control neural and glioma stem/progenitor cell renewal and differen
  18948956
• Schuller U,Heine VM,Mao J,Kho AT,Dillon AK,Han YG,Huillard E,Sun T,Ligon AH,Qian Y,Ma Q,Alvarez-Buylla A,McMahon AP,Rowitch DH,Ligon KL.Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-in
  18691547
• Kesari S, Schiff D, Henson JW, Muzikansky A, Gigas DC, Doherty L, Batchelor TT, Longtine JA, Ligon KL, Weaver S, Laforme A, Ramakrishna N, Black PM, Drappatz J, Ciampa A, Folkman J, Kieran M, Wen PY.Phase II study of temozolomide, thalidomide, and celecox
  18403492
• Wiedemeyer R, Brennan C, Heffernan TP, Xiao Y, Mahoney J, Protopopov A, Zheng H, Bignell G, Furnari F, Cavenee WK, Hahn WC, Ichimura K, Collins VP, Chu GC, Stratton MR, Ligon KL, Futreal PA, Chin L.Feedback circuit among INK4 tumor suppressors constrains
  18394558
• Billiards SS, Haynes RL, Folkerth RD, Borenstein NS, Trachtenberg FL, Rowitch DH, Ligon KL, Volpe JJ, Kinney HC.Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia.Brain Pathol. 2008 Apr;18(2):153-63.
  18177464
• Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK.Malignant astrocytic glioma: genetics, biology, and paths to treatment.Genes Dev. 2007 Nov 1;21(21):2683-710. Review.
  17974913
• Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, Chin L, DePinho RA.Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.Science. 2007 Oct
  17872411
• Monje ML, Vogel H, Masek M, Ligon KL, Fisher PG, Palmer TD.Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies.Ann Neurol. 2007 Nov;62(5):515-20.
  17786983
• Santagata S, Ligon KL, Hornick JL.Embryonic Stem Cell Transcription Factor Signatures in the Diagnosis of Primary and Metastatic Germ Cell Tumors.Am J Surg Pathol. 2007 Jun;31(6):836-845.
  17527070
• Ramsey MR, Krishnamurthy J, Pei XH, Torrice C, Lin W, Carrasco DR, Ligon KL, Xiong Y, Sharpless NE.Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues.Cancer Res. 2007 May 15;67(10):4732-41.
  17510401
• Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, Anderson DJ, Stiles CD, Rowitch DH.Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.Ne
  17296553
• Byers RJ, Di Vizio D, O'connell F, Tholouli E, Levenson RM, Gossard K, Twomey D, Yang Y, Benedettini E, Rose J, Ligon KL, Finn SP, Golub TR, Loda M.Semiautomated multiplexed quantum dot-based in situ hybridization and spectral deconvolution.J Mol Diag
  17251332
• Rousseau A, Nutt CL, Betensky RA, Iafrate AJ, Han M, Ligon KL, Rowitch DH, Louis DN.Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.J Neuropathol Exp Neurol. 2006 Dec;65(12):1149-56.
  17146289
• Santagata S, Hornick JL, Ligon KL.Comparative analysis of germ cell transcription factors in CNS germinoma reveals diagnostic utility of NANOG.Am J Surg Pathol. 2006 Dec;30(12):1613-8.
  17122519
• Maher EA, Brennan C, Wen PY, Durso L, Ligon KL, Richardson A, Khatry D, Feng B, Sinha R, Louis DN, Quackenbush J, Black PM, Chin L, DePinho RA.Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct mo
  17114236
• Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, Rowitch D, McMahon AP.A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway.Cancer Res. 2006 Oct 15;66(20):10171-8.
  17047082
• Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE.p16INK4a induces an age-dependent decline in islet regenerative potential.Nature. 2006 Sep 28;443(7110):453-7.
  16957737
• Ligon KL, Kesari S, Kitada M, Sun T, Arnett HA, Alberta JA, Anderson DJ, Stiles CD, Rowitch DH.Development of NG2 neural progenitor cells requires Olig gene function.Proc Natl Acad Sci U S A. 2006 May 16;103(20):7853-8.
  16682644
• Ligon KL, Fancy SP, Franklin RJ, Rowitch DH.Olig gene function in CNS development and disease.Glia. 2006 Jul;54(1):1-10. Review.
  16652341
• Ligon KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, Louis DN, Stiles CD, Rowitch DH.The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas.J Neuropathol Exp Neurol. 2004 May;63(5):499-509.
  15198128
• Bachoo RM, Kim RS, Ligon KL, Maher EA, Brennan C, Billings N, Chan S, Li C, Rowitch DH, Wong WH, DePinho RA.Molecular diversity of astrocytes with implications for neurological disorders.Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8384-9.
  15155908
• Ligon KL, Echelard Y, Assimacopoulos S, Danielian PS, Kaing S, Grove EA, McMahon AP, Rowitch DH.Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia.Development. 2003 May;130(10):2275-87.
  12668639
• Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA.Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transf
  12086863
• Black BL, Ligon KL, Zhang Y, Olson EN.Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family.J Biol Chem. 1996 Oct 25;271(43):26659-63.
  8900141
• Cserjesi P, Brown D, Ligon KL, Lyons GE, Copeland NG, Gilbert DJ, Jenkins NA, Olson EN.Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis.Development. 1995 Apr;121(4):1099-110.
  7743923
• Burgess R, Cserjesi P, Ligon KL, Olson EN.Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites.Dev Biol. 1995 Apr;168(2):296-306.
  7729571