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Bing Lim, MD, PhD


  • Tan HK, Toh CX, Ma D, Yang B, Liu TM, Lu J, Wong CW, Tan TK, Li H, Syn C, Tan EL, Lim B, Lim YP, Cook SA, Loh YH.Human Finger-Prick Induced Pluripotent Stem Cells Facilitate the Development of Stem Cell Banking.Stem Cells Transl Med. 2014 Mar 19.
  • Loh KM, Ang LT, Zhang J, Kumar V, Ang J, Auyeong JQ, Lee KL, Choo SH, Lim CY, Nichane M, Tan J, Noghabi MS, Azzola L, Ng ES, Durruthy-Durruthy J, Sebastiano V, Poellinger L, Elefanty AG, Stanley EG, Chen Q, Prabhakar S, Weissman IL, Lim B.Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations.Cell Stem Cell. 2014 Feb 6;14(2):237-52.
  • Loh KM, Lim B.Stem cells: Close encounters with full potential.Nature. 2013 Oct 3;502(7469):41-2.
  • Bartlett A, Buhlmann JE, Stone J, Lim B, Barrington RA.Multiple checkpoint breach of B cell tolerance in Rasgrp1-deficient mice.J Immunol. 2013 Oct 1;191(7):3605-13.
  • Tam WL, Lu H, Buikhuisen J, Soh BS, Lim E, Reinhardt F, Wu ZJ, Krall JA, Bierie B, Guo W, Chen X, Liu XS, Brown M, Lim B, Weinberg RA.Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells.Cancer Cell. 2013 Sep 9;24(3):347-64.
  • Zhang L, Prak L, Rayon-Estrada V, Thiru P, Flygare J, Lim B, Lodish HF.ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors.Nature. 2013 Jul 4;499(7456):92-6.
  • Arya SK, Lim B, Rahman AR.Enrichment, detection and clinical significance of circulating tumor cells.Lab Chip. 2013 May 7;13(11):1995-2027.
  • Orlov Y, Xu H, Afonnikov D, Lim B, Heng JC, Yuan P, Chen M, Yan J, Clarke N, Orlova N, Huss M, Gunbin K, Podkolodnyy N, Ng HH.Computer and statistical analysis of transcription factor binding and chromatin modifications by ChIP-seq data in embryonic stem cell.J Integr Bioinform. 2012;9(2):211.
  • Loh KM, Lim B.Epigenetics: Actors in the cell reprogramming drama.Nature. 2012 Aug 30;488(7413):599-600.
  • Liu TM, Ng WM, Tan HS, Vinitha D, Yang Z, Fan JB, Zou Y, Hui JH, Lee EH, Lim B.Molecular Basis of Immortalization of Human Mesenchymal Stem Cells by Combination of p53 Knockdown and Human Telomerase Reverse Transcriptase Overexpression.Stem Cells Dev. 2012 Aug 21.
  • Loh KM, Lim B.A precarious balance: pluripotency factors as lineage specifiers.Cell Stem Cell. 2011 Apr 8;8(4):363-9.
  • Zhang L, Flygare J, Wong P, Lim B, Lodish HF.miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1.Genes Dev. 2011 Jan 15;25(2):119-24.
  • Jayapal SR, Lee KL, Ji P, Kaldis P, Lim B, Lodish HF.Down-regulation of Myc is essential for terminal erythroid maturation.J Biol Chem. 2010 Dec 17;285(51):40252-65.
  • Chia NY, Chan YS, Feng B, Lu X, Orlov YL, Moreau D, Kumar P, Yang L, Jiang J, Lau MS, Huss M, Soh BS, Kraus P, Li P, Lufkin T, Lim B, Clarke ND, Bard F, Ng HH.A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.Nature. 2010 Nov 11;468(7321):316-20.
  • Wang H, Zeng X, Fan Z, Lim B.RhoH modulates pre-TCR and TCR signalling by regulating LCK.Cell Signal. 2011 Jan;23(1):249-58.
  • Loh KM, Lim B.Recreating pluripotency?.Cell Stem Cell. 2010 Aug 6;7(2):137-9.
  • Wang H, Zeng X, Fan Z, Lim B.RhoH plays distinct roles in T-cell migrations induced by different doses of SDF1alpha.Cell Signal. 2010 Jul;22(7):1022-32.
  • Jiang S, Lee BC, Fu Y, Avraham S, Lim B, Avraham HK.Reconstitution of mammary epithelial morphogenesis by murine embryonic stem cells undergoing hematopoietic stem cell differentiation.PLoS ONE. 2010;5(3):e9707.
  • Han J, Yuan P, Yang H, Zhang J, Soh BS, Li P, Lim SL, Cao S, Tay J, Orlov YL, Lufkin T, Ng HH, Tam WL, Lim B.Tbx3 improves the germ-line competency of induced pluripotent stem cells.Nature. 2010 Feb 25;463(7284):1096-100.
  • Heng JC, Feng B, Han J, Jiang J, Kraus P, Ng JH, Orlov YL, Huss M, Yang L, Lufkin T, Lim B, Ng HH.The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells.Cell Stem Cell. 2010 Feb 5;6(2):167-74.
  • Sheik Mohamed J, Gaughwin PM, Lim B, Robson P, Lipovich L.Conserved long noncoding RNAs transcriptionally regulated by Oct4 and Nanog modulate pluripotency in mouse embryonic stem cells.RNA. 2010 Feb;16(2):324-37.
  • Yuan P, Han J, Guo G, Orlov YL, Huss M, Loh YH, Yaw LP, Robson P, Lim B, Ng HH.Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells.Genes Dev. 2009 Nov 1;23(21):2507-20.
  • Dykxhoorn DM, Wu Y, Xie H, Yu F, Lal A, Petrocca F, Martinvalet D, Song E, Lim B, Lieberman J.miR-200 enhances mouse breast cancer cell colonization to form distant metastases.PLoS ONE. 2009;4(9):e7181.
  • Le MT, Xie H, Zhou B, Chia PH, Rizk P, Um M, Udolph G, Yang H, Lim B, Lodish HF.MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets.Mol Cell Biol. 2009 Oct;29(19):5290-305.
  • Liu TM,Wu YN,Guo XM,James Hoi Po H,Lee EH,Lim B.Effects of Ectopic Nanog and Oct4 Overexpression on Mesenchymal Stem Cells.Stem Cells Dev. 2009 Sep;18(7):1013-22.
  • Zhang J, Liu X, Datta A, Govindarajan K, Tam WL, Han J, George J, Wong C, Ramnarayanan K, Phua TY, Leong WY, Chan YS, Palanisamy N, Liu ET, Karuturi KM, Lim B, Miller LD.RCP is a human breast cancer-promoting gene with Ras-activating function.J Clin Invest. 2009 Aug;119(8):2171-83.
  • Le MT,Teh C,Shyh-Chang N,Xie H,Zhou B,Korzh V,Lodish HF,Lim B.MicroRNA-125b is a novel negative regulator of p53.Genes Dev. 2009 Apr 1;23(7):862-76.
  • Feng B,Jiang J,Kraus P,Ng JH,Heng JC,Chan YS,Yaw LP,Zhang W,Loh YH,Han J,Vega VB,Cacheux-Rataboul V,Lim B,Lufkin T,Ng HH.Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb.Nat Cell Biol. 2009 Feb;11(2):197-203.
  • Tay Y,Zhang J,Thomson AM,Lim B,Rigoutsos I.MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation.Nature. 2008 Oct 23;455(7216):1124-8.
  • Lim CY,Tam WL,Zhang J,Ang HS,Jia H,Lipovich L,Ng HH,Wei CL,Sung WK,Robson P,Yang H,Lim B.Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages.Cell Stem Cell. 2008 Nov 6;3(5):543-54.
  • Xiao S,Jin H,Korn T,Liu SM,Oukka M,Lim B,Kuchroo VK.Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression.J Immunol. 2008 Aug 15;181(4):2277-84.
  • Tarasov KV,Tarasova YS,Tam WL,Riordon DR,Elliott ST,Kania G,Li J,Yamanaka S,Crider DG,Testa G,Li RA,Lim B,Stewart CL,Liu Y,Van Eyk JE,Wersto RP,Wobus AM,Boheler KR.B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells.PLoS ONE. 2008;3(6):e2478.
  • Tam WL,Lim CY,Han J,Zhang J,Ang YS,Ng HH,Yang H,Lim B.T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways.Stem Cells. 2008 Aug;26(8):2019-31.
  • Song CW, Chae JJ, Choi EK, Hwang TS, Kim C, Lim BU, Park HJ.Anti-cancer effect of bio-reductive drug beta-lapachon is enhanced by activating NQO1 with heat shock.Int J Hyperthermia. 2008 Mar;24(2):161-9.
  • Tay YM, Tam WL, Ang YS, Gaughwin PM, Yang H, Wang W, Liu R, George J, Ng HH, Perera RJ, Lufkin T, Rigoutsos I, Thomson AM, Lim B.MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1.Stem Cells. 2008 Jan;26(1):17-29.
  • Choi EK, Ji IM, Lee SR, Kook YH, Griffin RJ, Lim BU, Kim JS, Lee DS, Song CW, Park HJ.Radiosensitization of tumor cells by modulation of ATM kinase.Int J Radiat Biol. 2006 Apr;82(4):277-83.
  • Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B.The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.Mol Cell Biol. 2002 Feb;22(4):1158-71.
  • Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.Essential role for Gab2 in the allergic response.Nature. 2001 Jul 12;412(6843):186-90.
  • Cuervo AM, Hu W, Lim B, Dice JF.IkappaB is a substrate for a selective pathway of lysosomal proteolysis.Mol Biol Cell. 1998 Aug;9(8):1995-2010.
  • Guillemot JC, Kruskal BA, Adra CN, Zhu S, Ko JL, Burch P, Nocka K, Seetoo K, Simons E, Lim B.Targeted disruption of guanosine diphosphate-dissociation inhibitor for Rho-related proteins, GDID4: normal hematopoietic differentiation but subtle defect in superoxide production by macrophages derived from in vitro embryonal stem cell differentiation.Blood. 1996 Oct 1;88(7):2722-31.
  • Sansilvestri P, Cardoso AA, Batard P, Panterne B, Hatzfeld A, Lim B, Lévesque JP, Monier MN, Hatzfeld J.Early CD34high cells can be separated into KIThigh cells in which transforming growth factor-beta (TGF-beta) downmodulates c-kit and KITlow cells in which anti-TGF-beta upmodulates c-kit.Blood. 1995 Sep 1;86(5):1729-35.
  • Adra CN, Kobayashi H, Rowley JD, Lim B.Assignment of the human GDID4 gene, a GDP/GTP-exchange regulator, to chromosome 12p12.3.Genomics. 1994 Nov 1;24(1):188-90.
  • Adra CN, Lelias JM, Kobayashi H, Kaghad M, Morrison P, Rowley JD, Lim B.Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions.Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):10178-52.
  • Voso MT, Burn TC, Wulf G, Lim B, Leone G, Tenen DG.Inhibition of hematopoiesis by competitive binding of transcription factor PU.1.Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):7932-6.
  • Wulf GM, Adra CN, Lim B.Inhibition of hematopoietic development from embryonic stem cells by antisense vav RNA.EMBO J. 1993 Dec 15;12(13):5065-74.
  • Adra CN, Ko J, Leonard D, Wirth LJ, Cerione RA, Lim B.Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I.Genes Chromosomes Cancer. 1993 Dec;8(4):253-61.
  • Steinberg HN, Anderson J, Lim B, Chatis PA.Cytomegalovirus infection of the BS-1 human stroma cell line: effect on murine hemopoiesis.Virology. 1993 Oct;196(2):427-32.
  • Lelias JM, Adra CN, Wulf GM, Guillemot JC, Khagad M, Caput D, Lim B.cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins.Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1479-83.
  • Scadden DT, Zeira M, Woon A, Wang Z, Schieve L, Ikeuchi K, Lim B, Groopman JE.Human immunodeficiency virus infection of human bone marrow stromal fibroblasts.Blood. 1990 Jul 15;76(2):317-22.
  • Lim B, Apperley JF, Orkin SH, Williams DA.Long-term expression of human adenosine deaminase in mice transplanted with retrovirus-infected hematopoietic stem cells.Proc Natl Acad Sci U S A. 1989 Nov;86(22):8892-6.
  • Williams DA, Lim B, Spooncer E, Longtine J, Dexter TM.Restriction of expression of an integrated recombinant retrovirus in primary but not immortalized murine hematopoietic stem cells.Blood. 1988 Jun;71(6):1738-43.
  • Tweeddale ME, Lim B, Jamal N, Robinson J, Zalcberg J, Lockwood G, Minden MD, Messner HA.The presence of clonogenic cells in high-grade malignant lymphoma: a prognostic factor.Blood. 1987 May;69(5):1307-14.
  • Williams DA, Lim B, Orkin SH.Transfer and expression of human ADA in murine hematopoietic stem cells.Prog Clin Biol Res. 1987;251:567-80.
  • Lim B, Izaguirre CA, Aye MT, Huebsch L, Drouin J, Richardson C, Minden MD, Messner HA.Characterization of reticulofibroblastoid colonies (CFU-RF) derived from bone marrow and long-term marrow culture monolayers.J Cell Physiol. 1986 Apr;127(1):45-54.
  • Denburg JA, Telizyn S, Messner H, Lim B, Jamal N, Ackerman SJ, Gleich GJ, Bienenstock J.Heterogeneity of human peripheral blood eosinophil-type colonies: evidence for a common basophil-eosinophil progenitor.Blood. 1985 Aug;66(2):312-8.
  • Denburg JA, Messner H, Lim B, Jamal N, Telizyn S, Bienenstock J.Clonal origin of human basophil/mast cells from circulating multipotent hemopoietic progenitors.Exp Hematol. 1985 Mar;13(3):185-8.
  • Lim B, Jamal N, Messner HA.Flexible association of hemopoietic differentiation programs in multilineage colonies.J Cell Physiol. 1984 Nov;121(2):291-7.
  • Lim B, Jamal N, Tritchler D, Messner HA.G6PD isoenzyme analysis of myeloid and lymphoid cells in human multilineage colonies.Blood. 1984 Jun;63(6):1481-7.