Raul Mostoslavsky, MD, PhD

Publications

• Zhong L, Mostoslavsky R.SIRT6: A master epigenetic gatekeeper of glucose metabolism.Transcr. 2010 7;1(1):17-21.
  21327158
• Sebastian C, Mostoslavsky R.SIRT3 in calorie restriction: can you hear me now?.Cell. 2010 Nov 24;143(5):667-8.
  21111225
• Qin J, Van Buren D, Huang HS, Zhong L, Mostoslavsky R, Akbarian S, Hock H.Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice.J Biol Chem. 2010 Sep 3;285(36):27767-75.
  20592034
• Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puig
  20595232
• Mostoslavsky R, Esteller M, Vaquero A.At the crossroad of lifespan, calorie restriction, chromatin and disease: Meeting on sirtuins.Cell Cycle. 2010 May 10;9(10).
  20458180
• Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R.The histon
  20141841
• Bruzzone S, Fruscione F, Morando S, Ferrando T, Poggi A, Garuti A, D'Urso A, Selmo M, Benvenuto F, Cea M, Zoppoli G, Moran E, Soncini D, Ballestrero A, Sordat B, Patrone F, Mostoslavsky R, Uccelli A, Nencioni A.Catastrophic NAD+ depletion in activated
  19936064
• Finkel T, Deng CX, Mostoslavsky R.Recent progress in the biology and physiology of sirtuins.Nature. 2009 Jul 30;460(7255):587-91. Review.
  19641587
• Van Gool F,Galli M,Gueydan C,Kruys V,Prevot PP,Bedalov A,Mostoslavsky R,Alt FW,De Smedt T,Leo O.Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.Nat Med. 2009 Feb;15(2):206-10.
  19151729
• Oberdoerffer P,Michan S,McVay M,Mostoslavsky R,Vann J,Park SK,Hartlerode A,Stegmuller J,Hafner A,Loerch P,Wright SM,Mills KD,Bonni A,Yankner BA,Scully R,Prolla TA,Alt FW,Sinclair DA.SIRT1 redistribution on chromatin promotes genomic stability but alters g
  19041753
• Bassing CH,Whitlow S,Mostoslovasky R,Yang-Iott K,Ranganath S,Alt FW.Vbeta cluster sequences reduce the frequency of primary Vbeta2 and Vbeta14 rearrangements.Eur J Immunol. 2008 Sep;38(9):2564-72.
  18792409
• Kahyo T,Mostoslavsky R,Goto M,Setou M.Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein.FEBS Lett. 2008 Jul 23;582(17):2479-83.
  18588880
• Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T.A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3374-9.
  18296641
• Lombard DB, Schwer B, Alt FW, Mostoslavsky R.SIRT6 in DNA repair, metabolism and ageing.J Intern Med. 2008 Feb;263(2):128-41.
  18226091
• Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, Dequiedt F, Haendeler J, Mione M, Dejana E, Alt FW, Zeiher AM, Dimmeler S.SIRT1 controls endothelial angiogenic functions during vascular growth.Genes Dev. 2007 Oct 15;21(20):2644-58.
  17938244
• Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B.Mammalian Sir2 homolog SIRT3 r
  17923681
• Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, Jung S, Alt FW, Rajewsky K, Cedar H, Bergman Y.Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus.Nat Immunol. 2007 Jul;8
  17546032
• Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE.Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells.Leukemia.
  17568820
• Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L.SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calori
  16959573
• Jung D, Giallourakis C, Mostoslavsky R, Alt FW.Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.Annu Rev Immunol. 2006;24:541-70. Review.
  16551259
• Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger M
  16439206
• Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S, Kaushal D, Cheng HL, Fischer MR, Stokes N, Murphy MM, Appella E, Alt FW.Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress.Cell Metab. 2005 Jul;2(1):67-76.
  16054100
• Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW.DNA repair, genome stability, and aging.Cell. 2005 Feb 25;120(4):497-512.
  15734682
• Mostoslavsky R, Alt FW, Rajewsky K.The lingering enigma of the allelic exclusion mechanism.Cell. 2004 Sep 3;118(5):539-44.
  15339659
• Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME.Stress-dependent regulation of FOXO transcription factors by the SIRT1 dea
  14976264
• Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chua KF.Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice.Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10794-9.
  12960381
• Mostoslavsky R, Singh N, Tenzen T, Goldmit M, Gabay C, Elizur S, Qi P, Reubinoff BE, Chess A, Cedar H, Bergman Y.Asynchronous replication and allelic exclusion in the immune system.Nature. 2001 Nov 8;414(6860):221-5.
  11700561
• Mostoslavsky R, Singh N, Kirillov A, Pelanda R, Cedar H, Chess A, Bergman Y.Kappa chain monoallelic demethylation and the establishment of allelic exclusion.Genes Dev. 1998 Jun 15;12(12):1801-11.
  9637682