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Raul Mostoslavsky, MD, PhD

Publications

  • Cosentino C, Mostoslavsky R.Sirtuin to the rescue: SIRT2 extends life span of BubR1 mice.EMBO J. 2014 Jun 11.
    24920578
  • Kugel S, Mostoslavsky R.Chromatin and beyond: the multitasking roles for SIRT6.Trends Biochem Sci. 2014 Feb;39(2):72-81.
    24438746
  • Shin J, He M, Liu Y, Paredes S, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, Kapahi P, Krauss R, Mostoslavsky R, Yancopoulos GD, Alt FW, Chua KF, Chen D.SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease.Cell Rep. 2013 Nov 14;5(3):654-65.
    24210820
  • Zhong L, Martinez-Pastor B, Silberman DM, Sebastian C, Mostoslavsky R.Assaying chromatin sirtuins.Methods Mol Biol. 2013;1077:149-63.
    24014405
  • Toiber D, Erdel F, Bouazoune K, Silberman DM, Zhong L, Mulligan P, Sebastian C, Cosentino C, Martinez-Pastor B, Giacosa S, D'Urso A, Näär AM, Kingston R, Rippe K, Mostoslavsky R.SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.Mol Cell. 2013 Aug 22;51(4):454-68.
    23911928
  • Martinez-Pastor B, Cosentino C, Mostoslavsky R.A Tale of Metabolites: The Cross-Talk between Chromatin and Energy Metabolism.Cancer Discovery. 2013 May;3(5):497-501.
    23658298
  • Cosentino C, Mostoslavsky R.Metabolism, longevity and epigenetics.Cell Mol Life Sci. 2013 May;70(9):1525-41.
    23467663
  • Kugel S, Mostoslavsky R.SIRT1 Activators: The Evidence STACks up.Aging (Albany NY). 2013 Mar;5(3):142-3.
    23474671
  • Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R.The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.Cell. 2012 Dec 7;151(6):1185-99.
    23217706
  • Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, Pillai VB, Ravindra PV, Gupta M, Jeevanandam V, Cunningham JM, Deng CX, Lombard DB, Mostoslavsky R, Gupta MP.The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.Nat Med. 2012 Nov;18(11):1643-50.
    23086477
  • Sebastian C, Satterstrom KF, Haigis MC, Mostoslavsky R.From Sirtuin biology to human diseases: an update.J Biol Chem. 2012 Oct 18.
    23086954
  • Bauer I, Grozio A, Lasiglie' D, Basile G, Sturla L, Magnone M, Sociali G, Soncini D, Caffa I, Poggi A, Zoppoli G, Cea M, Feldmann G, Mostoslavsky R, Ballestrero A, Patrone F, Bruzzone S, Nencioni A.The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.J Biol Chem. 2012 Oct 18.
    23086953
  • Zhong L, Mostoslavsky R.SIRT6: A master epigenetic gatekeeper of glucose metabolism.Transcr. 2010 7;1(1):17-21.
    21327158
  • Sebastian C, Mostoslavsky R.SIRT3 in calorie restriction: can you hear me now?.Cell. 2010 Nov 24;143(5):667-8.
    21111225
  • Qin J, Van Buren D, Huang HS, Zhong L, Mostoslavsky R, Akbarian S, Hock H.Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice.J Biol Chem. 2010 Sep 3;285(36):27767-75.
    20592034
  • Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM.Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.Genes Dev. 2010 Jul 1;24(13):1403-17.
    20595232
  • Mostoslavsky R, Esteller M, Vaquero A.At the crossroad of lifespan, calorie restriction, chromatin and disease: Meeting on sirtuins.Cell Cycle. 2010 May 10;9(10).
    20458180
  • Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R.The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.Cell. 2010 Jan 22;140(2):280-93.
    20141841
  • Bruzzone S, Fruscione F, Morando S, Ferrando T, Poggi A, Garuti A, D'Urso A, Selmo M, Benvenuto F, Cea M, Zoppoli G, Moran E, Soncini D, Ballestrero A, Sordat B, Patrone F, Mostoslavsky R, Uccelli A, Nencioni A.Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.PLoS ONE. 2009;4(11):e7897.
    19936064
  • Finkel T, Deng CX, Mostoslavsky R.Recent progress in the biology and physiology of sirtuins.Nature. 2009 Jul 30;460(7255):587-91. Review.
    19641587
  • Van Gool F,Galli M,Gueydan C,Kruys V,Prevot PP,Bedalov A,Mostoslavsky R,Alt FW,De Smedt T,Leo O.Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.Nat Med. 2009 Feb;15(2):206-10.
    19151729
  • Oberdoerffer P,Michan S,McVay M,Mostoslavsky R,Vann J,Park SK,Hartlerode A,Stegmuller J,Hafner A,Loerch P,Wright SM,Mills KD,Bonni A,Yankner BA,Scully R,Prolla TA,Alt FW,Sinclair DA.SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.Cell. 2008 Nov 28;135(5):907-18.
    19041753
  • Bassing CH,Whitlow S,Mostoslovasky R,Yang-Iott K,Ranganath S,Alt FW.Vbeta cluster sequences reduce the frequency of primary Vbeta2 and Vbeta14 rearrangements.Eur J Immunol. 2008 Sep;38(9):2564-72.
    18792409
  • Kahyo T,Mostoslavsky R,Goto M,Setou M.Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein.FEBS Lett. 2008 Jul 23;582(17):2479-83.
    18588880
  • Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T.A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3374-9.
    18296641
  • Lombard DB, Schwer B, Alt FW, Mostoslavsky R.SIRT6 in DNA repair, metabolism and ageing.J Intern Med. 2008 Feb;263(2):128-41.
    18226091
  • Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, Dequiedt F, Haendeler J, Mione M, Dejana E, Alt FW, Zeiher AM, Dimmeler S.SIRT1 controls endothelial angiogenic functions during vascular growth.Genes Dev. 2007 Oct 15;21(20):2644-58.
    17938244
  • Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B.Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.Mol Cell Biol. 2007 Dec;27(24):8807-14.
    17923681
  • Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, Jung S, Alt FW, Rajewsky K, Cedar H, Bergman Y.Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus.Nat Immunol. 2007 Jul;8(7):715-22.
    17546032
  • Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE.Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells.Leukemia. 2007 Aug;21(8):1723-32.
    17568820
  • Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L.SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.Cell. 2006 Sep 8;126(5):941-54.
    16959573
  • Jung D, Giallourakis C, Mostoslavsky R, Alt FW.Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.Annu Rev Immunol. 2006;24:541-70. Review.
    16551259
  • Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW.Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.Cell. 2006 Jan 27;124(2):315-29.
    16439206
  • Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S, Kaushal D, Cheng HL, Fischer MR, Stokes N, Murphy MM, Appella E, Alt FW.Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress.Cell Metab. 2005 Jul;2(1):67-76.
    16054100
  • Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW.DNA repair, genome stability, and aging.Cell. 2005 Feb 25;120(4):497-512.
    15734682
  • Mostoslavsky R, Alt FW, Rajewsky K.The lingering enigma of the allelic exclusion mechanism.Cell. 2004 Sep 3;118(5):539-44.
    15339659
  • Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME.Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.Science. 2004 Mar 26;303(5666):2011-5.
    14976264
  • Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chua KF.Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice.Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10794-9.
    12960381
  • Mostoslavsky R, Singh N, Tenzen T, Goldmit M, Gabay C, Elizur S, Qi P, Reubinoff BE, Chess A, Cedar H, Bergman Y.Asynchronous replication and allelic exclusion in the immune system.Nature. 2001 Nov 8;414(6860):221-5.
    11700561
  • Mostoslavsky R, Singh N, Kirillov A, Pelanda R, Cedar H, Chess A, Bergman Y.Kappa chain monoallelic demethylation and the establishment of allelic exclusion.Genes Dev. 1998 Jun 15;12(12):1801-11.
    9637682