• Home
  • News
  • Calendar
  • About DF/HCC
  • Membership
  • Visitor Center

Michael B. Brenner, MD

Publications

  • Wu M, Pedroza M, Lafyatis R, George AT, Mayes MD, Assassi S, Tan FK, Brenner MB, Agarwal SK.Identification of cadherin 11 as a mediator of dermal fibrosis and possible role in systemic sclerosis.Arthritis & Rheumatology (Hoboken, N.J.). 2014 Apr;66(4):1010-21.
    24757152
  • Bassiri H, Das R, Guan P, Barrett DM, Brennan PJ, Banerjee PP, Wiener SJ, Orange JS, Brenner MB, Grupp SA, Nichols KE.iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo.Cancer Immunol Res. 2014 Jan 1;2(1):59-69.
    24563871
  • Gu Z, Liu F, Tonkova EA, Lee SY, Tschumperlin DJ, Brenner MB.Soft matrix is a natural stimulator for cellular invasiveness.Mol Biol Cell. 2014 Feb;25(4):457-69.
    24336521
  • Tuli A, Thiery J, James AM, Michelet X, Sharma M, Garg S, Sanborn KB, Orange JS, Lieberman J, Brenner MB.Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.Mol Biol Cell. 2013 Dec;24(23):3721-35.
    24088571
  • Hu X, Kim H, Brennan PJ, Han B, Baecher-Allan CM, De Jager PL, Brenner MB, Raychaudhuri S.Application of user-guided automated cytometric data analysis to large-scale immunoprofiling of invariant natural killer T cells.Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19030-5.
    24191009
  • Wu M, Pedroza M, Lafyatis R, George AT, Mayes MD, Assassi S, Tan FK, Brenner MB, Agarwal SK.Identification of cadherin-11 as a mediator of dermal fibrosis and possible role in systemic sclerosis.Arthritis Rheum. 2013 Nov 18.
    24249394
  • Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer M, Nolan G, Kobayashi K, von Boehmer H, Mathis D, Benoist C, , Best AJ, Knell J, Goldrath A, Jojic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Rao TN, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S.The transcriptional landscape of αβ T cell differentiation.Nat Immunol. 2013 May 5.
    23644507
  • Jojic V, Shay T, Sylvia K, Zuk O, Sun X, Kang J, Regev A, Koller D, , Best AJ, Knell J, Goldrath A, Jojic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Rao TN, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S.Identification of transcriptional regulators in the mouse immune system.Nat Immunol. 2013 Apr 28.
    23624555
  • Sanderson JP, Brennan PJ, Mansour S, Matulis G, Patel O, Lissin N, Godfrey DI, Kawahara K, Zähringer U, Rossjohn J, Brenner MB, Gadola SD.CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells.Eur J Immunol. 2013 Mar;43(3):815-25.
    23280365
  • Tatituri RV, Watts GF, Bhowruth V, Barton N, Rothchild A, Hsu FF, Almeida CF, Cox LR, Eggeling L, Cardell S, Rossjohn J, Godfrey DI, Behar SM, Besra GS, Brenner MB, Brigl M.Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs.Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1827-32.
    23307809
  • Barral DC, Garg S, Casalou C, Watts GF, Sandoval JL, Ramalho JS, Hsu VW, Brenner MB.Arl13b regulates endocytic recycling traffic.Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21354-9.
    23223633
  • Cohen NR, Brennan PJ, Shay T, Watts GF, Brigl M, Kang J, Brenner MB, .Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.Nat Immunol. 2013 Jan;14(1):90-9.
    23202270
  • Veerapen N, Leadbetter EA, Brenner MB, Cox LR, Besra GS.Synthesis of a novel alpha-galactosyl ceramide haptenated-lipid antigen, a useful tool in demonstrating the involvement of iNKT cells in the production of antilipid antibodies.Bioconjug Chem. 2010 Apr 21;21(4):741-7.
    20345125
  • Odyniec AN, Barral DC, Garg S, Tatituri RV, Besra GS, Brenner MB.Regulation of CD1 antigen presenting complex stability.J Biol Chem. 2010 Apr 16;285(16):11937-47.
    20133943
  • Porcelli S, Brenner MB, Greenstein JL, Terhorst C, Balk SP, Bleicher PA.Pillars Article: Recognition of Cluster of Differentiation 1 Antigens by Human CD4-CD8- CytolyticT Lymphocyte. Nature. 1989. 341: 447-450.J Immunol. 2010 Apr 1;184(7):3306-9.
    20304831
  • Kiener HP, Watts GF, Cui Y, Wright J, Thornhill TS, Sköld M, Behar SM, Niederreiter B, Lu J, Cernadas M, Coyle AJ, Sims GP, Smolen J, Warman ML, Brenner MB, Lee DM.Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture.Arthritis Rheum. 2010 Mar;62(3):742-52.
    20131230
  • Brigl M, Brenner MB.How invariant natural killer T cells respond to infection by recognizing microbial or endogenous lipid antigens.Semin Immunol. 2010 Apr;22(2):79-86. Review.
    19948416
  • Muindi K, Cernadas M, Watts GF, Royle L, Neville DC, Dwek RA, Besra GS, Rudd PM, Butters TD, Brenner MB.Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d.Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3052-7.
    20133624
  • Cernadas M, Cavallari M, Watts G, Mori L, De Libero G, Brenner MB.Early recycling compartment trafficking of CD1a is essential for its intersection and presentation of lipid antigens.J Immunol. 2010 Feb 1;184(3):1235-41.
    20026739
  • Chiba A, Cohen N, Brigl M, Brennan PJ, Besra GS, Brenner MB.Rapid and reliable generation of invariant natural killer T-cell lines in vitro.Immunology. 2009 Nov;128(3):324-33.
    20067532
  • Felio K, Nguyen H, Dascher CC, Choi HJ, Li S, Zimmer MI, Colmone A, Moody DB, Brenner MB, Wang CR.CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice.J Exp Med. 2009 Oct 26;206(11):2497-509.
    19808251
  • Veerapen N, Brigl M, Garg S, Cerundolo V, Cox LR, Brenner MB, Besra GS.Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide.Bioorg Med Chem Lett. 2009 Aug 1;19(15):4288-91.
    19502056
  • Van Rhijn I,Young DC,De Jong A,Vazquez J,Cheng TY,Talekar R,Barral D,Leon L,Brenner MB,Katz JT,Riese R,Ruprecht RM,O'Connor PB,Costello CE,Porcelli SA,Briken V,Moody DB.CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids.J Exp Med. 2009 Jun 8;206(6):1409-22.
    19468063
  • Cohen NR,Garg S,Brenner MB.Chapter 1 Antigen Presentation by CD1 Lipids, T Cells, and NKT Cells in Microbial Immunity.Adv Immunol. 2009;102:1-94. Review.
    19477319
  • Kiener HP,Niederreiter B,Lee DM,Jimenez-Boj E,Smolen JS,Brenner MB.Cadherin 11 promotes invasive behavior of fibroblast-like synoviocytes.Arthritis Rheum. 2009 May;60(5):1305-10.
    19404963
  • Leslie DS, Dascher CC, Cembrola K, Townes MA, Hava DL, Hugendubler LC, Mueller E, Fox L, Roura-Mir C, Moody DB, Vincent MS, Gumperz JE, Illarionov PA, Besra GS, Reynolds CG, Brenner MB.Serum lipids regulate dendritic cell CD1 expression and function.Immunology. 2008 Nov;125(3):289-301.
    18445008
  • Sada-Ovalle I,Chiba A,Gonzales A,Brenner MB,Behar SM.Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria.PLoS Pathog. 2008 Dec;4(12):e1000239.
    19079582
  • Hava DL,van der Wel N,Cohen N,Dascher CC,Houben D,Leon L,Agarwal S,Sugita M,van Zon M,Kent SC,Shams H,Peters PJ,Brenner MB.Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation.Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11281-6.
    18685099
  • Kaser A,Hava DL,Dougan SK,Chen Z,Zeissig S,Brenner MB,Blumberg RS.Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules.Eur J Immunol. 2008 Aug;38(8):2351-9.
    18624350
  • Noss EH,Brenner MB.The role and therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis.Immunol Rev. 2008 Jun;223:252-70. Review.
    18613841
  • Barral DC,Cavallari M,McCormick PJ,Garg S,Magee AI,Bonifacino JS,De Libero G,Brenner MB.CD1a and MHC class I follow a similar endocytic recycling pathway.Traffic. 2008 Sep;9(9):1446-57.
    18564371
  • Leadbetter EA,Brigl M,Illarionov P,Cohen N,Luteran MC,Pillai S,Besra GS,Brenner MB.NK T cells provide lipid antigen-specific cognate help for B cells.Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8339-44.
    18550809
  • Barral DC, Brenner MB.CD1 antigen presentation: how it works.Nat Rev Immunol. 2007 Dec;7(12):929-41. Review.
    18037897
  • Milo R, Hou JH, Springer M, Brenner MP, Kirschner MW.The relationship between evolutionary and physiological variation in hemoglobin.Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16998-7003.
    17942680
  • Parisini E, Higgins JM, Liu JH, Brenner MB, Wang JH.The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism.J Mol Biol. 2007 Oct 19;373(2):401-11.
    17850815
  • Lee DM, Kiener HP, Agarwal SK, Noss EH, Watts GF, Chisaka O, Takeichi M, Brenner MB.Cadherin-11 in synovial lining formation and pathology in arthritis.Science. 2007 Feb 16;315(5814):1006-10.
    17255475
  • Kiener HP, Stipp CS, Allen PG, Higgins JM, Brenner MB.The cadherin-11 cytoplasmic juxtamembrane domain promotes alpha-catenin turnover at adherens junctions and intercellular motility.Mol Biol Cell. 2006 May;17(5):2366-76.
    16525026
  • van den Elzen P, Garg S, Len L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB.Apolipoprotein-mediated pathways of lipid antigen presentation.Nature. 2005 Oct 6;437(7060):906-10.
    16208376
  • Moody DB, Young DC, Cheng TY, Rosat JP, Roura-Mir C, O'Connor PB, Zajonc DM, Walz A, Miller MJ, Levery SB, Wilson IA, Costello CE, Brenner MB.T cell activation by lipopeptide antigens.Science. 2004 Jan 23;303(5657):527-31.
    14739458
  • Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB.Mechanism of CD1d-restricted natural killer T cell activation during microbial infection.Nat Immunol. 2003 Dec;4(12):1230-7.
    14578883
  • Vincent MS, Leslie DS, Gumperz JE, Xiong X, Grant EP, Brenner MB.CD1-dependent dendritic cell instruction.Nat Immunol. 2002 Dec;3(12):1163-8.
    12415264
  • Moody DB, Ulrichs T, Mhlecker W, Young DC, Gurcha SS, Grant E, Rosat JP, Brenner MB, Costello CE, Besra GS, Porcelli SA.CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection.Nature. 2000 Apr 20;404(6780):884-8.
    10786796
  • Sugita M, Grant EP, van Donselaar E, Hsu VW, Rogers RA, Peters PJ, Brenner MB.Separate pathways for antigen presentation by CD1 molecules.Immunity. 1999 Dec;11(6):743-52.
    10626896
  • Higgins JM, Mandlebrot DA, Shaw SK, Russell GJ, Murphy EA, Chen YT, Nelson WJ, Parker CM, Brenner MB.Direct and regulated interaction of integrin alphaEbeta7 with E-cadherin.J Cell Biol. 1998 Jan 12;140(1):197-210.
    9425167
  • Beckman EM, Porcelli SA, Morita CT, Behar SM, Furlong ST, Brenner MB.Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells.Nature. 1994 Dec 15;372(6507):691-4.
    7527500
  • Cepek KL, Shaw SK, Parker CM, Russell GJ, Morrow JS, Rimm DL, Brenner MB.Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin.Nature. 1994 Nov 10;372(6502):190-3.
    7969453