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Sarah P. Thayer, MD, PhD

Publications

  • Faris JE, Blaszkowsky LS, McDermott S, Guimaraes AR, Szymonifka J, Huynh MA, Ferrone CR, Wargo JA, Allen JN, Dias LE, Kwak EL, Lillemoe KD, Thayer SP, Murphy JE, Zhu AX, Sahani DV, Wo JY, Clark JW, Fernandez-Del Castillo C, Ryan DP, Hong TS.FOLFIRINOX in Locally Advanced Pancreatic Cancer: The Massachusetts General Hospital Cancer Center Experience.Oncologist. 2013 May 8.
    23657686
  • Valsangkar NP, Bush DM, Michaelson JS, Ferrone CR, Wargo JA, Lillemoe KD, Fernández-del Castillo C, Warshaw AL, Thayer SP.N0/N1, PNL, or LNR? The effect of lymph node number on accurate survival prediction in pancreatic ductal adenocarcinoma.J Gastrointest Surg. 2013 Feb;17(2):257-66.
    23229885
  • Ferrone CR, Pieretti-Vanmarcke R, Bloom JP, Zheng H, Szymonifka J, Wargo JA, Thayer SP, Lauwers GY, Deshpande V, Mino-Kenudson M, Fernández-del Castillo C, Lillemoe KD, Warshaw AL.Pancreatic ductal adenocarcinoma: long-term survival does not equal cure.Surgery. 2012 Sep;152(3 Suppl 1):S43-9.
    22763261
  • Cogdill AP, Frederick DT, Cooper ZA, Garber HR, Ferrone CR, Fiedler A, Rosenberg L, Thayer SP, Warshaw AL, Wargo JA.Targeting the MAGE A3 antigen in pancreatic cancer.Surgery. 2012 Sep;152(3 Suppl 1):S13-8.
    22770803
  • Valsangkar NP, Morales-Oyarvide V, Thayer SP, Ferrone CR, Wargo JA, Warshaw AL, Fernández-del Castillo C.851 resected cystic tumors of the pancreas: a 33-year experience at the Massachusetts General Hospital.Surgery. 2012 Sep;152(3 Suppl 1):S4-12.
    22770958
  • Fernández-del Castillo C, Morales-Oyarvide V, McGrath D, Wargo JA, Ferrone CR, Thayer SP, Lillemoe KD, Warshaw AL.Evolution of the Whipple procedure at the Massachusetts General Hospital.Surgery. 2012 Sep;152(3 Suppl 1):S56-63.
    22770961
  • Nehra D, Oyarvide VM, Mino-Kenudson M, Thayer SP, Ferrone CR, Wargo JA, Muzikansky A, Finkelstein D, Warshaw AL, Castillo CF.Intraductal papillary mucinous neoplasms: does a family history of pancreatic cancer matter?.Pancreatology.;12(4):358-63.
    22898638
  • Tempero MA, Arnoletti JP, Behrman SW, Ben-Josef E, Benson AB, Casper ES, Cohen SJ, Czito B, Ellenhorn JD, Hawkins WG, Herman J, Hoffman JP, Ko A, Komanduri S, Koong A, Ma WW, Malafa MP, Merchant NB, Mulvihill SJ, Muscarella P, Nakakura EK, Obando J, Pitman MB, Sasson AR, Tally A, Thayer SP, Whiting S, Wolff RA, Wolpin BM, Freedman-Cass DA, Shead DA, .Pancreatic Adenocarcinoma, version 2.2012: featured updates to the NCCN Guidelines.J Natl Compr Canc Netw. 2012 Jun 1;10(6):703-13.
    22679115
  • Bausch D, Pausch T, Krauss T, Hopt UT, Fernandez-Del-Castillo C, Warshaw AL, Thayer SP, Keck T.Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma.Angiogenesis. 2011 Mar 26.
    21442180
  • Bausch D, Thomas S, Mino-Kenudson M, Fernández-del CC, Bauer TW, Williams M, Warshaw AL, Thayer SP, Kelly KA.Plectin-1 as a novel biomarker for pancreatic cancer.Clin Cancer Res. 2011 Jan 15;17(2):302-9.
    21098698
  • Konstantinidis IT, Dursun A, Zheng H, Wargo JA, Thayer SP, Fernandez-del Castillo C, Warshaw AL, Ferrone CR.Metastatic tumors in the pancreas in the modern era.J Am Coll Surg. 2010 Dec;211(6):749-53.
    21109158
  • Tempero MA, Arnoletti JP, Behrman S, Ben-Josef E, Benson AB, Berlin JD, Cameron JL, Casper ES, Cohen SJ, Duff M, Ellenhorn JD, Hawkins WG, Hoffman JP, Kuvshinoff BW, Malafa MP, Muscarella P, Nakakura EK, Sasson AR, Thayer SP, Tyler DS, Warren RS, Whiting S, Willett C, Wolff RA.Pancreatic adenocarcinoma.J Natl Compr Canc Netw. 2010 Oct;8(9):972-1017.
    20876541
  • Correa-Gallego C, Ferrone CR, Thayer SP, Wargo JA, Warshaw AL, Fernández-Del Castillo C.Incidental pancreatic cysts: do we really know what we are watching?.Pancreatology. 2010;10(2-3):144-50.
    20484954
  • Fritz S, Fernández-Del Castillo C, Iafrate AJ, Mino-Kenudson M, Neyhard N, Lafemina J, Stirman A, Warshaw AL, Thayer SP.Novel Xenograft and Cell Line Derived From an Invasive Intraductal Papillary Mucinous Neoplasm of the Pancreas Give New Insights Into Molecular Mechanisms.Pancreas. 2010 Apr;39(3):308-14.
    19924021
  • Strobel O, Rosow DE, Rakhlin EY, Lauwers GY, Trainor AG, Alsina J, Fernández-Del Castillo C, Warshaw AL, Thayer SP.Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia.Gastroenterology. 2010 Mar;138(3):1166-77.
    20026066
  • Iyer VR, Hahn PF, Blaszkowsky LS, Thayer SP, Halpern EF, Harisinghani MG.Added value of selected images embedded into radiology reports to referring clinicians.J Am Coll Radiol. 2010 Mar;7(3):205-10.
    20193926
  • Partelli S, Fernandez-Del Castillo C, Bassi C, Mantovani W, Thayer SP, Crippa S, Ferrone CR, Falconi M, Pederzoli P, Warshaw AL, Salvia R.Invasive intraductal papillary mucinous carcinomas of the pancreas: predictors of survival and the role of lymph node ratio.Ann Surg. 2010 Mar;251(3):477-82.
    20142730
  • Crippa S, Fernández-Del Castillo C, Salvia R, Finkelstein D, Bassi C, Domínguez I, Muzikansky A, Thayer SP, Falconi M, Mino-Kenudson M, Capelli P, Lauwers GY, Partelli S, Pederzoli P, Warshaw AL.Mucin-producing neoplasms of the pancreas: an analysis of distinguishing clinical and epidemiologic characteristics.Clin Gastroenterol Hepatol. 2010 Feb;8(2):213-9.
    19835989
  • Bausch D, Mino-Kenudson M, Fernández-Del Castillo C, Warshaw AL, Kelly KA, Thayer SP.Plectin-1 is a biomarker of malignant pancreatic intraductal papillary mucinous neoplasms.J Gastrointest Surg. 2009 Nov;13(11):1948-54; discussion 1954.
    19760374
  • Konstantinidis IT, Deshpande V, Zheng H, Wargo JA, Fernandez-del Castillo C, Thayer SP, Androutsopoulos V, Lauwers GY, Warshaw AL, Ferrone CR.Does the mechanism of lymph node invasion affect survival in patients with pancreatic ductal adenocarcinoma?.J Gastrointest Surg. 2010 Feb;14(2):261-7.
    19937477
  • Rovira M, Scott SG, Liss AS, Jensen J, Thayer SP, Leach SD.Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas.Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):75-80.
    20018761
  • Ferrone CR,Correa-Gallego C,Warshaw AL,Brugge WR,Forcione DG,Thayer SP,Fernandez-del Castillo C.Current trends in pancreatic cystic neoplasms.Arch Surg. 2009 May;144(5):448-54.
    19451487
  • LaFemina J,Roberts PA,Hung YP,Gusella JF,Sahani D,Fernandez-del Castillo C,Warshaw AL,Thayer SP.Identification of a novel kindred with familial pancreatitis and pancreatic cancer.Pancreatology. 2009;9(3):273-9.
    19407482
  • Fritz S,Fernandez-del Castillo C,Mino-Kenudson M,Crippa S,Deshpande V,Lauwers GY,Warshaw AL,Thayer SP,Iafrate AJ.Global genomic analysis of intraductal papillary mucinous neoplasms of the pancreas reveals significant molecular differences compared to ductal adenocarcinoma.Ann Surg. 2009 Mar;249(3):440-7.
    19247032
  • Fritz S,Warshaw AL,Thayer SP.Management of mucin-producing cystic neoplasms of the pancreas.Oncologist. 2009 Feb;14(2):125-36. Review.
    19211618
  • Guimaraes AR,Rakhlin E,Weissleder R,Thayer SP.Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model.Pancreas. 2008 Nov;37(4):440-4.
    18953259
  • Ferrone CR,Warshaw AL,Rattner DW,Berger D,Zheng H,Rawal B,Rodriguez R,Thayer SP,Fernandez-del Castillo C.Pancreatic fistula rates after 462 distal pancreatectomies: staplers do not decrease fistula rates.J Gastrointest Surg. 2008 Oct;12(10):1691-7; discussion 1697-8.
    18704597
  • Dominguez I, Crippa S, Thayer SP, Hung YP, Ferrone CR, Warshaw AL, Fernandez-Del Castillo C.Preoperative Platelet Count and Survival Prognosis in Resected Pancreatic Ductal Adenocarcinoma.World J Surg. 2008 Jun;32(6):1051-6.
    18224462
  • Crippa S, Salvia R, Warshaw AL, Dominguez I, Bassi C, Falconi M, Thayer SP, Zamboni G, Lauwers GY, Mino-Kenudson M, Capelli P, Pederzoli P, Castillo CF.Mucinous cystic neoplasm of the pancreas is not an aggressive entity: lessons from 163 resected patients.Ann Surg. 2008 Apr;247(4):571-9.
    18362619
  • Crippa S, Dominguez I, Rodriguez JR, Razo O, Thayer SP, Ryan DP, Warshaw AL, Fernandez-Del Castillo C.Quality of life in pancreatic cancer: analysis by stage and treatment.J Gastrointest Surg. 2008 May;12(5):783-94.
    18317851
  • Rodriguez JR, Razo AO, Targarona J, Thayer SP, Rattner DW, Warshaw AL, Fernandez-del Castillo C.Debridement and closed packing for sterile or infected necrotizing pancreatitis: insights into indications and outcomes in 167 patients.Ann Surg. 2008 Feb;247(2):294-9.
    18216536
  • Nikfarjam M, Warshaw AL, Axelrod L, Deshpande V, Thayer SP, Ferrone CR, Fernandez-del Castillo C.Improved contemporary surgical management of insulinomas: a 25-year experience at the Massachusetts General Hospital.Ann Surg. 2008 Jan;247(1):165-72.
    18156937
  • Strobel O, Dor Y, Alsina J, Stirman A, Lauwers G, Trainor A, Castillo CF, Warshaw AL, Thayer SP.In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia.Gastroenterology. 2007 Dec;133(6):1999-2009.
    18054571
  • Rodriguez JR, Salvia R, Crippa S, Warshaw AL, Bassi C, Falconi M, Thayer SP, Lauwers GY, Capelli P, Mino-Kenudson M, Razo O, McGrath D, Pederzoli P, Fernndez-Del Castillo C.Branch-duct intraductal papillary mucinous neoplasms: observations in 145 patients who underwent resection.Gastroenterology. 2007 Jul;133(1):72-9; quiz 309-10.
    17631133
  • Crippa S, Bassi C, Warshaw AL, Falconi M, Partelli S, Thayer SP, Pederzoli P, Fernandez-del Castillo C.Middle pancreatectomy: indications, short- and long-term operative outcomes.Ann Surg. 2007 Jul;246(1):69-76.
    17592293
  • Rodrguez JR, Madanat MG, Healy BC, Thayer SP, Warshaw AL, Fernndez-del Castillo C.Distal pancreatectomy with splenic preservation revisited.Surgery. 2007 May;141(5):619-25.
    17462461
  • Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP, Warshaw AL, Fernndez-Del Castillo C.Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005.Arch Surg. 2007 Apr;142(4):347-54.
    17438169
  • Strobel O, Dor Y, Stirman A, Trainor A, Fernndez-del Castillo C, Warshaw AL, Thayer SP.Beta cell transdifferentiation does not contribute to preneoplastic/metaplastic ductal lesions of the pancreas by genetic lineage tracing in vivo.Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4419-24.
    17360539
  • Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, Rowitch D, McMahon AP.A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway.Cancer Res. 2006 Oct 15;66(20):10171-8.
    17047082
  • Ferrone CR, Finkelstein DM, Thayer SP, Muzikansky A, Fernandez-delCastillo C, Warshaw AL.Perioperative CA19-9 levels can predict stage and survival in patients with resectable pancreatic adenocarcinoma.J Clin Oncol. 2006 Jun 20;24(18):2897-902.
    16782929
  • Rodrguez JR, Germes SS, Pandharipande PV, Gazelle GS, Thayer SP, Warshaw AL, Fernndez-del Castillo C.Implications and cost of pancreatic leak following distal pancreatic resection.Arch Surg. 2006 Apr;141(4):361-5; discussion 366.
    16618893
  • Sahani DV, Kadavigere R, Blake M, Fernandez-Del Castillo C, Lauwers GY, Hahn PF.Intraductal papillary mucinous neoplasm of pancreas: multi-detector row CT with 2D curved reformations--correlation with MRCP.Radiology. 2006 Feb;238(2):560-9.
    16436817
  • Rosow DE, Sahani D, Strobel O, Kalva S, Mino-Kenudson M, Holalkere NS, Alsfasser G, Saini S, Lee SI, Mueller PR, Fernndez-del Castillo C, Warshaw AL, Thayer SP.Imaging of acute mesenteric ischemia using multidetector CT and CT angiography in a porcine model.J Gastrointest Surg. 2005 Dec;9(9):1262-74; discussion 1274-.
    16332482
  • Ferrone CR, Kattan MW, Tomlinson JS, Thayer SP, Brennan MF, Warshaw AL.Validation of a postresection pancreatic adenocarcinoma nomogram for disease-specific survival.J Clin Oncol. 2005 Oct 20;23(30):7529-35.
    16234519
  • Alsfasser G, Antoniu B, Thayer SP, Warshaw AL, Fernndez-del Castillo C.Degradation and inactivation of plasma tumor necrosis factor-alpha by pancreatic proteases in experimental acute pancreatitis.Pancreatology. 2005;5(1):37-43; discussion 43.
    15775698
  • Warshaw AL, Thayer SP.Pancreaticoduodenectomy.J Gastrointest Surg. 2004 Sep-Oct;8(6):733-41.
    15358336
  • Salvia R, Fernndez-del Castillo C, Bassi C, Thayer SP, Falconi M, Mantovani W, Pederzoli P, Warshaw AL.Main-duct intraductal papillary mucinous neoplasms of the pancreas: clinical predictors of malignancy and long-term survival following resection.Ann Surg. 2004 May;239(5):678-85; discussion 685-7.
    15082972
  • Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S, Fernndez-del Castillo C, Yajnik V, Antoniu B, McMahon M, Warshaw AL, Hebrok M.Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis.Nature. 2003 Oct 23;425(6960):851-6.
    14520413
  • Fernndez-del Castillo C, Targarona J, Thayer SP, Rattner DW, Brugge WR, Warshaw AL.Incidental pancreatic cysts: clinicopathologic characteristics and comparison with symptomatic patients.Arch Surg. 2003 Apr;138(4):427-3; discussion 433-4.
    12686529
  • Thayer SP, Fernndez-del Castillo C, Balcom JH, Warshaw AL.Complete dorsal pancreatectomy with preservation of the ventral pancreas: a new surgical technique.Surgery. 2002 May;131(5):577-80.
    12019413