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Roderick T. Bronson, DVM

Publications

  • Papa A, Wan L, Bonora M, Salmena L, Song MS, Hobbs RM, Lunardi A, Webster K, Ng C, Newton RH, Knoblauch N, Guarnerio J, Ito K, Turka LA, Beck AH, Pinton P, Bronson RT, Wei W, Pandolfi PP.Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function.Cell. 2014 Apr 24;157(3):595-610.
    24766807
  • Byun AJ, Hung KE, Fleet JC, Bronson RT, Mason JB, Garcia PE, Crott JW.Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras.Cancer Lett. 2014 Jun 1;347(2):191-5.
    24632531
  • Roper J, Sinnamon MJ, Coffee EM, Belmont P, Keung L, Georgeon-Richard L, Wang WV, Faber AC, Yun J, Yilmaz OH, Bronson RT, Martin ES, Tsichlis PN, Hung KE.Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.Cancer Lett. 2014 Jun 1;347(2):204-11.
    24576621
  • Lunardi A, Webster KA, Papa A, Padmani B, Clohessy JG, Bronson RT, Pandolfi PP.Role of aberrant PI3K pathway activation in gallbladder tumorigenesis.Oncotarget. 2014 Mar 10.
    24658595
  • Yuan J, Kashiwagi S, Reeves P, Nezivar J, Yang Y, Arrifin NH, Nguyen M, Jean-Mary G, Tong X, Uppal P, Korochkina S, Forbes B, Chen T, Righi E, Bronson R, Chen H, Orsulic S, Brauns T, Leblanc P, Scholler N, Dranoff G, Gelfand J, Poznansky MC.A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma.J Hematol Oncol. 2014;7:15.
    24565018
  • Akbay EA, Moslehi J, Christensen CL, Saha S, Tchaicha JH, Ramkissoon SH, Stewart KM, Carretero J, Kikuchi E, Zhang H, Cohoon TJ, Murray S, Liu W, Uno K, Fisch S, Jones K, Gurumurthy S, Gliser C, Choe S, Keenan M, Son J, Stanley I, Losman JA, Padera R, Bronson RT, Asara JM, Abdel-Wahab O, Amrein PC, Fathi AT, Danial NN, Kimmelman AC, Kung AL, Ligon KL, Yen KE, Kaelin WG, Bardeesy N, Wong KK.D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice.Genes Dev. 2014 Mar 1;28(5):479-90.
    24589777
  • Mudbhary R, Hoshida Y, Chernyavskaya Y, Jacob V, Villanueva A, Fiel MI, Chen X, Kojima K, Thung S, Bronson RT, Lachenmayer A, Revill K, Alsinet C, Sachidanandam R, Desai A, SenBanerjee S, Ukomadu C, Llovet JM, Sadler KC.UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.Cancer Cell. 2014 Feb 10;25(2):196-209.
    24486181
  • Jun HJ, Bronson RT, Charest A.Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma.Stem Cells. 2014 Feb;32(2):338-48.
    24115218
  • Cheng H, Liu P, Zhang F, Xu E, Symonds L, Ohlson CE, Bronson RT, Maira SM, Di Tomaso E, Li J, Myers AP, Cantley LC, Mills GB, Zhao JJ.A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition.Cancer Res. 2014 Jan 1;74(1):15-23.
    24322983
  • Berger AH, Chen M, Morotti A, Janas JA, Niki M, Bronson RT, Taylor BS, Ladanyi M, Van Aelst L, Politi K, Varmus HE, Pandolfi PP.DOK2 inhibits EGFR-mutated lung adenocarcinoma.PLoS ONE. 2013;8(11):e79526.
    24255704
  • Prabhakar S, Goto J, Zhang X, Sena-Esteves M, Bronson R, Brockmann J, Gianni D, Wojtkiewicz GR, Chen JW, Stemmer-Rachamimov A, Kwiatkowski DJ, Breakefield XO.Correction: Stochastic Model of Tsc1 Lesions in Mouse Brain.PLoS ONE. 2013;8(11).
    24244248
  • Li D, Ilnytskyy Y, Kovalchuk A, Khachigian LM, Bronson RT, Wang B, Kovalchuk O.Crucial role for early growth response-1 in the transcriptional regulation of miR-20b in breast cancer.Oncotarget. 2013 Sep;4(9):1373-87.
    23945289
  • McLaughlin SK, Olsen SN, Dake B, De Raedt T, Lim E, Bronson RT, Beroukhim R, Polyak K, Brown M, Kuperwasser C, Cichowski K.The RasGAP gene, RASAL2, is a tumor and metastasis suppressor.Cancer Cell. 2013 Sep 9;24(3):365-78.
    24029233
  • Natarajan S, Li Y, Miller EE, Shih DJ, Taylor MD, Stearns TM, Bronson RT, Ackerman SL, Yoon JK, Yun K.Notch1-induced brain tumor models the sonic hedgehog subgroup of human medulloblastoma.Cancer Res. 2013 Sep 1;73(17):5381-90.
    23852537
  • Kucherlapati MH, Esfahani S, Habibollahi P, Wang J, Still ER, Bronson RT, Mahmood U, Kucherlapati RS.Genotype directed therapy in murine mismatch repair deficient tumors.PLoS ONE. 2013;8(7):e68817.
    23935891
  • Hettmer S, Teot LA, van Hummelen P, MacConaill L, Bronson RT, Dall'Osso C, Mao J, McMahon AP, Gruber PJ, Grier HE, Rodriguez-Galindo C, Fletcher CD, Wagers AJ.Mutations in Hedgehog pathway genes in fetal rhabdomyomas.J Pathol. 2013 Sep;231(1):44-52.
    23780909
  • Wang Q, Von T, Bronson R, Ruan M, Mu W, Huang A, Maira SM, Zhao JJ.Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome.Genes Dev. 2013 Jul 15;27(14):1568-80.
    23873941
  • Li CM, Chen G, Dayton TL, Kim-Kiselak C, Hoersch S, Whittaker CA, Bronson RT, Beer DG, Winslow MM, Jacks T.Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma.Genes Dev. 2013 Jul 15;27(14):1557-67.
    23873940
  • Nakaya T, Ishiguro KI, Belzil C, Rietsch AM, Yu Q, Mizuno SI, Bronson RT, Geng Y, Nguyen MD, Akashi K, Sicinski P, Nakatani Y.p600 Plays Essential Roles in Fetal Development.PLoS ONE. 2013;8(6):e66269.
    23824717
  • Bowman-Colin C, Xia B, Bunting S, Klijn C, Drost R, Bouwman P, Fineman L, Chen X, Culhane AC, Cai H, Rodig SJ, Bronson RT, Jonkers J, Nussenzweig A, Kanellopoulou C, Livingston DM.Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.Proc Natl Acad Sci U S A. 2013 May 8.
    23657012
  • Park HJ, Hong M, Bronson RT, Israel MA, Frankel WN, Yun K.Elevated id2 expression results in precocious neural stem cell depletion and abnormal brain development.Stem Cells. 2013 May;31(5):1010-21.
    23390122
  • Calvo JA, Moroski-Erkul CA, Lake A, Eichinger LW, Shah D, Jhun I, Limsirichai P, Bronson RT, Christiani DC, Meira LB, Samson LD.Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by parp1.PLoS Genet. 2013 Apr;9(4):e1003413.
    23593019
  • Coffee EM, Faber AC, Roper J, Sinnamon M, Goel G, Keung L, Wang WV, Vecchione L, Devriendt V, Weinstein BJ, Bronson RT, Tejpar S, Xavier RJ, Engelman JA, Martin ES, Hung KE.Concomitant BRAF and PI3K/mTOR Blockade is Required for Effective Treatment of BRAFV600E Colorectal Cancer.Clin Cancer Res. 2013 Apr 2.
    23549875
  • Baena E, Shao Z, Linn DE, Glass K, Hamblen MJ, Fujiwara Y, Kim J, Nguyen M, Zhang X, Godinho FJ, Bronson RT, Mucci LA, Loda M, Yuan GC, Orkin SH, Li Z.ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients.Genes Dev. 2013 Mar 15;27(6):683-98.
    23512661
  • Lee PC, Dodart JC, Aron L, Finley LW, Bronson RT, Haigis MC, Yankner BA, Harper JW.Altered Social Behavior and Neuronal Development in Mice Lacking the Uba6-Use1 Ubiquitin Transfer System.Mol Cell. 2013 Mar 12.
    23499007
  • Martin ES, Belmont PJ, Sinnamon MJ, Georgeon Richard L, Yuan J, Coffee EM, Roper J, Lee L, Heidari P, Lunt SY, Goel G, Ji C, Xie J, Xie T, Lamb J, Weinrich S, Vanarsdale TL, Bronson RT, Xavier RJ, Vander Heiden M, Kan JL, Mahmood U, Hung KE.Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation.Clin Cancer Res. 2013 Feb 12.
    23403635
  • Kasaikina MV, Turanov AA, Avanesov A, Schweizer U, Seeher S, Bronson RT, Novoselov SN, Carlson BA, Hatfield DL, Gladyshev VN.Contrasting roles of dietary selenium and selenoproteins in chemically induced hepatocarcinogenesis.Carcinogenesis. 2013 Feb 6.
    23389288
  • Maertens O, Johnson B, Hollstein P, Frederick DT, Cooper ZA, Messaien L, Bronson RT, McMahon M, Granter S, Flaherty KT, Wargo JA, Marais R, Cichowski K.Elucidating distinct roles for NF1 in melanomagenesis.Cancer Discovery. 2012 Nov 21.
    23171796
  • Dai C, Santagata S, Tang Z, Shi J, Cao J, Kwon H, Bronson RT, Whitesell L, Lindquist S.Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis.J Clin Invest. 2012 Oct 1;122(10):3742-54.
    22945628
  • Qin J, Whyte WA, Anderssen E, Apostolou E, Chen HH, Akbarian S, Bronson RT, Hochedlinger K, Ramaswamy S, Young RA, Hock H.The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.Cell Stem Cell. 2012 Sep 7;11(3):319-32.
    22770845
  • Liu J, Hettmer S, Milsom MD, Hofmann I, Hua F, Miller C, Bronson RT, Wagers AJ.Induction of histiocytic sarcoma in mouse skeletal muscle.PLoS ONE. 2012;7(8):e44044.
    22952867
  • Zhu X, Libby RT, de Vries WN, Smith RS, Wright DL, Bronson RT, Seburn KL, John SW.Mutations in a P-type ATPase gene cause axonal degeneration.PLoS Genet. 2012 Aug;8(8):e1002853.
    22912588
  • Jun HJ, Johnson H, Bronson RT, de Feraudy S, White F, Charest A.The oncogenic lung cancer fusion kinase CD74-ROS activates a novel invasiveness pathway through E-Syt1 phosphorylation.Cancer Res. 2012 Aug 1;72(15):3764-74.
    22659450
  • Lv H, Havari E, Pinto S, Gottumukkala RV, Cornivelli L, Raddassi K, Matsui T, Rosenzweig A, Bronson RT, Smith R, Fletcher AL, Turley SJ, Wucherpfennig K, Kyewski B, Lipes MA.Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans.J Clin Invest. 2011 Mar 23.
    21436590
  • Zhou XZ, Huang P, Shi R, Lee TH, Lu G, Zhang Z, Bronson R, Lu KP.The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice.J Clin Invest. 2011 Mar 23.
    21436583
  • Liu C, Bronson RT, Russell RM, Wang XD.{beta}-Cryptoxanthin supplementation prevents cigarette smoke-induced lung inflammation, oxidative damage and squamous metaplasia in ferrets.Cancer Prev Res (Phila Pa). 2011 Mar 18.
    21421799
  • Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW.Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21790-4.
    21098266
  • Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA.Telomere dysfunction induces metabolic and mitochondrial compromise.Nature. 2011 Feb 17;470(7334):359-65.
    21307849
  • Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman CE, Bronson R, Neel BG, Seidman JG, Kucherlapati R.Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.J Clin Invest. 2010 Dec 1;120(12):4353-65.
    21041952
  • Kutanzi KR, Koturbash I, Bronson RT, Pogribny IP, Kovalchuk O.Imbalance between apoptosis and cell proliferation during early stages of mammary gland carcinogenesis in ACI rats.Mutat Res. 2010 Dec 10;694(1-2):1-6.
    20659487
  • Zhu H, Woolfenden S, Bronson RT, Jaffer ZM, Barluenga S, Winssinger N, Rubenstein AE, Chen R, Charest A.The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme.Mol Cancer Ther. 2010 Sep;9(9):2618-26.
    20643786
  • Zhou Y, Cheunsuchon P, Nakayama Y, Lawlor MW, Zhong Y, Rice KA, Zhang L, Zhang X, Gordon FE, Lidov HG, Bronson RT, Klibanski A.Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene.Development. 2010 Aug;137(16):2643-52.
    20610486
  • Freitag T, Cham C, Sung HH, Beilhack GF, Durinovic-Belló I, Patel SD, Bronson RT, Schuppan D, Sønderstrup G.The human risk allele HLA-DRB1*0405 predisposes class II transgenic Ab0 NOD mice to autoimmune pancreatitis.Gastroenterology. 2010 Jul;139(1):281-91.
    20303356
  • Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Alemán JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR.The Phosphoinositide 3-Kinase Regulatory Subunit p85{alpha} Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling.Cancer Res. 2010 Jul 1;70(13):5305-15.
    20530665
  • van der Flier A, Badu-Nkansah K, Whittaker CA, Crowley D, Bronson RT, Lacy-Hulbert A, Hynes RO.Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development.Development. 2010 Jul;137(14):2439-49.
    20570943
  • Xu L, Begum S, Barry M, Crowley D, Yang L, Bronson RT, Hynes RO.GPR56 plays varying roles in endogenous cancer progression.Clin Exp Metastasis. 2010 Apr;27(4):241-9.
    20333450
  • Torres-Arzayus MI, Zhao J, Bronson R, Brown M.Estrogen-dependent and estrogen-independent mechanisms contribute to AIB1-mediated tumor formation.Cancer Res. 2010 May 15;70(10):4102-11.
    20442283
  • Duran-Struuck R, Cho PS, Teague AG, Fishman B, Fishman AS, Hanekamp JS, Moran SG, Wikiel KJ, Ferguson KK, Lo DP, Duggan M, Arn JS, Billiter B, Horner B, Houser S, Yeap BY, Westmoreland SV, Spitzer TR, McMorrow IM, Sachs DH, Bronson RT, Huang CA.Myelogenous leukemia in adult inbred MHC-defined miniature swine: A model for human myeloid leukemias.Veterinary Immunology And Immunopathology. 2010 Jun 15;135(3-4):243-56.
    20079939
  • Oliver TG, Mercer KL, Sayles LC, Burke JR, Mendus D, Lovejoy KS, Cheng MH, Subramanian A, Mu D, Powers S, Crowley D, Bronson RT, Whittaker CA, Bhutkar A, Lippard SJ, Golub T, Thomale J, Jacks T, Sweet-Cordero EA.Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer.Genes Dev. 2010 Apr 15;24(8):837-52.
    20395368
  • Wu G, Chen T, Shahsafaei A, Hu W, Bronson RT, Shi GP, Halperin JA, Aktas H, Qin X.Complement Regulator CD59 Protects Against Angiotensin II-Induced Abdominal Aortic Aneurysms in Mice.Circulation. 2010 Mar 23;121(11):1338-46.
    20212283
  • Min J, Zaslavsky A, Fedele G, McLaughlin SK, Reczek EE, De Raedt T, Guney I, Strochlic DE, Macconaill LE, Beroukhim R, Bronson RT, Ryeom S, Hahn WC, Loda M, Cichowski K.An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.Nat Med. 2010 Mar;16(3):286-94.
    20154697
  • Kucherlapati MH, Lee K, Nguyen AA, Clark AB, Hou H, Rosulek A, Li H, Yang K, Fan K, Lipkin M, Bronson RT, Jelicks L, Kunkel TA, Kucherlapati R, Edelmann W.An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.Gastroenterology. 2010 Mar;138(3):993-1002.e1.
    19931261
  • Chase TH, Lyons BL, Bronson RT, Foreman O, Donahue LR, Burzenski LM, Gott B, Lane P, Harris B, Ceglarek U, Thiery J, Wittenburg H, Thon JN, Italiano JE, Johnson KR, Shultz LD.The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia.Blood. 2010 Feb 11;115(6):1267-76.
    19846887
  • Hung KE, Maricevich MA, Richard LG, Chen WY, Richardson MP, Kunin A, Bronson RT, Mahmood U, Kucherlapati R.Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1565-70.
    20080688
  • Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, Jain RK, Jacks T.p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.Science. 2010 Jan 29;327(5965):593-6.
    20019247
  • Wang JP, Cerny A, Asher DR, Kurt-Jones EA, Bronson RT, Finberg RW.MDA5 and MAVS mediate type I interferon responses to coxsackie B virus.J Virol. 2010 Jan;84(1):254-60.
    19846534
  • Faber AC, Li D, Song Y, Liang MC, Yeap BY, Bronson RT, Lifshits E, Chen Z, Maira SM, García-Echeverría C, Wong KK, Engelman JA.Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19503-8.
    19850869
  • Minamishima YA, Moslehi J, Padera RF, Bronson RT, Liao R, Kaelin WG.A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo.Mol Cell Biol. 2009 Nov;29(21):5729-41.
    19720742
  • Abromson-Leeman S, Bronson RT, Dorf ME.Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNgamma but have a spectrum of IL-17 profiles.J Neuroimmunol. 2009 Oct 30;215(1-2):10-24.
    19692128
  • Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H.TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity.Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12453-8.
    19617548
  • Amsterdam A, Lai K, Komisarczuk AZ, Becker TS, Bronson RT, Hopkins N, Lees JA.Zebrafish Hagoromo mutants up-regulate fgf8 postembryonically and develop neuroblastoma.Mol Cancer Res. 2009 Jun;7(6):841-50.
    19531571
  • Feng Y,Valley MT,Lazar J,Yang AL,Bronson RT,Firestein S,Coetzee WA,Manley JL.SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart.Dev Cell. 2009 Apr;16(4):528-38.
    19386262
  • Bronson RT.Pathologic phenotyping of mutant mice.Methods Mol Biol. 2009;530:435-61.
    19266332
  • Araki T,Chan G,Newbigging S,Morikawa L,Bronson RT,Neel BG.Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation.Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4736-41.
    19251646
  • Cook SA,Collin GB,Bronson RT,Naggert JK,Liu DP,Akeson EC,Davisson MT.A mouse model for Meckel syndrome type 3.J Am Soc Nephrol. 2009 Apr;20(4):753-64.
    19211713
  • Reynoso ED,Elpek KG,Francisco L,Bronson R,Bellemare-Pelletier A,Sharpe AH,Freeman GJ,Turley SJ.Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade.J Immunol. 2009 Feb 15;182(4):2102-12.
    19201863
  • Zhu H,Acquaviva J,Ramachandran P,Boskovitz A,Woolfenden S,Pfannl R,Bronson RT,Chen JW,Weissleder R,Housman DE,Charest A.Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2712-6.
    19196966
  • Meira LB,Moroski-Erkul CA,Green SL,Calvo JA,Bronson RT,Shah D,Samson LD.Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice.Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):888-93.
    19139400
  • Klapacz J,Meira LB,Luchetti DG,Calvo JA,Bronson RT,Edelmann W,Samson LD.O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo.Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):576-81.
    19124772
  • Perera SA,Li D,Shimamura T,Raso MG,Ji H,Chen L,Borgman CL,Zaghlul S,Brandstetter KA,Kubo S,Takahashi M,Chirieac LR,Padera RF,Bronson RT,Shapiro GI,Greulich H,Meyerson M,Guertler U,Chesa PG,Solca F,Wistuba II,Wong KK.HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy.Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):474-9.
    19122144
  • Lai K,Amsterdam A,Farrington S,Bronson RT,Hopkins N,Lees JA.Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish.Dev Dyn. 2009 Jan;238(1):76-85.
    19097187
  • Harris MA,Yang H,Low BE,Mukherje J,Guha A,Bronson RT,Shultz LD,Israel MA,Yun K.Cancer stem cells are enriched in the side population cells in a mouse model of glioma.Cancer Res. 2008 Dec 15;68(24):10051-9.
    19074870
  • Raffel GD,Chu GC,Jesneck JL,Cullen DE,Bronson RT,Bernard OA,Gilliland DG.Ott1 (Rbm15) is essential for placental vascular branching morphogenesis and embryonic development of the heart and spleen.Mol Cell Biol. 2009 Jan;29(2):333-41.
    18981216
  • Kucherlapati MH,Yang K,Fan K,Kuraguchi M,Sonkin D,Rosulek A,Lipkin M,Bronson RT,Aronow BJ,Kucherlapati R.Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon.Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15493-8.
    18832169
  • Ince TA,Ward JM,Valli VE,Sgroi D,Nikitin AY,Loda M,Griffey SM,Crum CP,Crawford JM,Bronson RT,Cardiff RD.Do-it-yourself (DIY) pathology.Nat Biotechnol. 2008 Sep;26(9):978-9; discussion 979.
    18779800
  • Mills JR,Hippo Y,Robert F,Chen SM,Malina A,Lin CJ,Trojahn U,Wendel HG,Charest A,Bronson RT,Kogan SC,Nadon R,Housman DE,Lowe SW,Pelletier J.mTORC1 promotes survival through translational control of Mcl-1.Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10853-8.
    18664580
  • McCarty JH, Barry M, Crowley D, Bronson RT, Lacy-Hulbert A, Hynes RO.Genetic Ablation of {alpha}v Integrins in Epithelial Cells of the Eyelid Skin and Conjunctiva Leads to Squamous Cell Carcinoma.Am J Pathol. 2008 Jun;172(6):1740-7.
    18467691
  • Epardaud M, Elpek KG, Rubinstein MP, Yonekura AR, Bellemare-Pelletier A, Bronson R, Hamerman JA, Goldrath AW, Turley SJ.Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells.Cancer Res. 2008 Apr 15;68(8):2972-83.
    18413767
  • Xu X, Page JL, Surtees JA, Liu H, Lagedrost S, Lu Y, Bronson R, Alani E, Nikitin AY, Weiss RS.Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms.Cancer Res. 2008 Apr 15;68(8):2652-60.
    18413732
  • Ventura A, Young AG, Winslow MM, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JR, Jaenisch R, Sharp PA, Jacks T.Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters.Cell. 2008 Mar 7;132(5):875-86.
    18329372
  • Perera SA, Maser RS, Xia H, McNamara K, Protopopov A, Chen L, Hezel AF, Kim CF, Bronson RT, Castrillon DH, Chin L, Bardeesy N, Depinho RA, Wong KK.Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer.Carcinogenesis. 2008 Apr;29(4):747-53.
    18283039
  • Kang MS, Soni V, Bronson R, Kieff E.Epstein-Barr virus nuclear antigen 1 does not cause lymphoma in C57BL/6J mice.J Virol. 2008 Apr;82(8):4180-3.
    18256159
  • Hu W, Ferris SP, Tweten RK, Wu G, Radaeva S, Gao B, Bronson RT, Halperin JA, Qin X.Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin.Nat Med. 2008 Jan;14(1):98-103.
    18157141
  • Carroll J, Dey D, Kreisman L, Velupillai P, Dahl J, Telford S, Bronson R, Benjamin T.Receptor-binding and oncogenic properties of polyoma viruses isolated from feral mice.PLoS Pathog. 2007 Dec;3(12):e179.
    18085820
  • Li Z, Tognon CE, Godinho FJ, Yasaitis L, Hock H, Herschkowitz JI, Lannon CL, Cho E, Kim SJ, Bronson RT, Perou CM, Sorensen PH, Orkin SH.ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex.Cancer Cell. 2007 Dec;12(6):542-58.
    18068631
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  • Wong SY, Haack H, Crowley D, Barry M, Bronson RT, Hynes RO.Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis.Cancer Res. 2005 Nov 1;65(21):9789-98.
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  • Araki T, Mohi MG, Ismat FA, Bronson RT, Williams IR, Kutok JL, Yang W, Pao LI, Gilliland DG, Epstein JA, Neel BG.Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation.Nat Med. 2004 Aug;10(8):849-57.
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  • Mitsiades CS, Mitsiades NS, Bronson RT, Chauhan D, Munshi N, Treon SP, Maxwell CA, Pilarski L, Hideshima T, Hoffman RM, Anderson KC.Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications.Cancer Res. 2003 Oct 15;63(20):6689-96.
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  • Kim YM, Sachs T, Asavaroengchai W, Bronson R, Sykes M.Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720.J Clin Invest. 2003 Mar;111(5):659-69.
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    12376594
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    12048238
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