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Arlene H. Sharpe, MD, PhD

Publications

  • Cooper ZA, Juneja VR, Sage PT, Frederick DT, Piris A, Mitra D, Lo JA, Hodi FS, Freeman GJ, Bosenberg MW, McMahon M, Flaherty KT, Fisher DE, Sharpe AH, Wargo JA.Response to BRAF Inhibition in Melanoma Is Enhanced When Combined with Immune Checkpoint Blockade.Cancer Immunol Res. 2014 Apr 29.
    24903021
  • Xiao Y, Yu S, Zhu B, Bedoret D, Bu X, Francisco LM, Hua P, Duke-Cohan JS, Umetsu DT, Sharpe AH, Dekruyff RH, Freeman GJ.RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance.J Exp Med. 2014 Apr 21.
    24752301
  • Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK.Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses.Immunity. 2014 Apr 17;40(4):569-81.
    24745333
  • Mott KR, Allen SJ, Zandian M, Akbari O, Hamrah P, Maazi H, Wechsler SL, Sharpe AH, Freeman GJ, Ghiasi H.Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses.PLoS ONE. 2014;9(1):e87617.
    24475315
  • Cooper ZA, Frederick DT, Juneja VR, Sullivan RJ, Lawrence DP, Piris A, Sharpe AH, Fisher DE, Flaherty KT, Wargo JA.BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes.Oncoimmunology. 2013 Oct 1;2(10):e26615.
    24251082
  • Saha A, Aoyama K, Taylor PA, Koehn BH, Veenstra RG, Panoskaltsis-Mortari A, Munn DH, Murphy WJ, Azuma M, Yagita H, Fife BT, Sayegh MH, Najafian N, Socie G, Ahmed R, Freeman GJ, Sharpe AH, Blazar BR.Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality.Blood. 2013 Oct 24;122(17):3062-73.
    24030385
  • Fuller MJ, Callendret B, Zhu B, Freeman GJ, Hasselschwert DL, Satterfield W, Sharpe AH, Dustin LB, Rice CM, Grakoui A, Ahmed R, Walker CM.Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1).Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15001-6.
    23980172
  • Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC.SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.Mol Cell. 2013 Jun 6;50(5):686-98.
    23746352
  • Maazi H, Singh AK, Speak AO, Lombardi V, Lam J, Khoo B, Inn KS, Sharpe AH, Jung JU, Akbari O.Lack of PD-L1 Expression by iNKT Cells Improves the Course of Influenza A Infection.PLoS ONE. 2013;8(3):e59599.
    23555047
  • Sage PT, Francisco LM, Carman CV, Sharpe AH.The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood.Nat Immunol. 2013 Feb;14(2):152-61.
    23242415
  • Sham CW, Chan AM, Kwong JM, Caprioli J, Nusinowitz S, Chen B, Lee JG, Gandhi NM, Francisco LM, Sharpe AH, Chen L, Braun J, Gordon LK.Neuronal programmed cell death-1 ligand expression regulates retinal ganglion cell number in neonatal and adult mice.J Neuroophthalmol. 2012 Sep;32(3):227-37.
    22635166
  • Butte MJ, Lee SJ, Jesneck J, Keir ME, Haining WN, Sharpe AH.CD28 costimulation regulates genome-wide effects on alternative splicing.PLoS ONE. 2012;7(6):e40032.
    22768209
  • Silberman D, Bucknum A, Bartlett T, Composto G, Kozlowski M, Walker A, Werda A, Cua J, Sharpe AH, Somerville JE, Riggs JE.CD28 ligation increases macrophage suppression of T-cell proliferation.Cell Mol Immunol. 2012 Jul;9(4):341-9.
    22522653
  • Hirahara K, Ghoreschi K, Yang XP, Takahashi H, Laurence A, Vahedi G, Sciumè G, Hall AO, Dupont CD, Francisco LM, Chen Q, Tanaka M, Kanno Y, Sun HW, Sharpe AH, Hunter CA, O'Shea JJ.Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1.Immunity. 2012 Jun 29;36(6):1017-30.
    22726954
  • Jin Y, Chauhan SK, Annan JE, Sage PT, Sharpe AH, Dana R.A novel function for programmed death ligand-1 regulation of angiogenesis.Am J Pathol. 2011 Apr;178(4):1922-9.
    21435468
  • Bu DX, Tarrio M, Maganto-Garcia E, Stavrakis G, Tajima G, Lederer J, Jarolim P, Freeman GJ, Sharpe AH, Lichtman AH.Impairment of the Programmed Cell Death-1 Pathway Increases Atherosclerotic Lesion Development and Inflammation.Arterioscler Thromb Vasc Biol. 2011 Mar 10.
    21393583
  • Allen SJ, Hamrah P, Gate DM, Mott KR, Mantopoulos D, Zheng L, Town T, Jones C, von Andrian UH, Freeman GJ, Sharpe AH, Benmohamed L, Ahmed R, Wechsler SL, Ghiasi H.The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus type 1.J Virol. 2011 Feb 9.
    21307196
  • Keszei M, Latchman YE, Vanguri VK, Brown DR, Detre C, Morra M, Arancibia CV, Paul E, Calpe S, Castro W, Wang N, Terhorst C, Sharpe AH.Auto-antibody production and glomerulonephritis in congenic Slamf1-/- and Slamf2-/- [B6.129] but not in Slamf1-/- and Slamf2-/- [BALB/c.129] mice.Int Immunol. 2011 Feb;23(2):149-58.
    21278219
  • Joller N, Hafler JP, Brynedal B, Kassam N, Spoerl S, Levin SD, Sharpe AH, Kuchroo VK.Cutting edge: TIGIT has T cell-intrinsic inhibitory functions.J Immunol. 2011 Feb 1;186(3):1338-42.
    21199897
  • Barber DL, Mayer-Barber KD, Feng CG, Sharpe AH, Sher A.CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition.J Immunol. 2011 Feb 1;186(3):1598-607.
    21172867
  • Zhou Q, Munger ME, Highfill SL, Tolar J, Weigel BJ, Riddle M, Sharpe AH, Vallera DA, Azuma M, Levine BL, June CH, Murphy WJ, Munn DH, Blazar BR.Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.Blood. 2010 Oct 7;116(14):2484-93.
    20570856
  • Francisco LM, Sage PT, Sharpe AH.The PD-1 pathway in tolerance and autoimmunity.Immunol Rev. 2010 Jul;236:219-42.
    20636820
  • Mueller SN, Vanguri VK, Ha SJ, West EE, Keir ME, Glickman JN, Sharpe AH, Ahmed R.PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice.J Clin Invest. 2010 Jul 1;120(7):2508-15.
    20551512
  • Brown KE, Freeman GJ, Wherry EJ, Sharpe AH.Role of PD-1 in regulating acute infections.Curr Opin Immunol. 2010 Jun;22(3):397-401. Review.
    20427170
  • El Annan J, Goyal S, Zhang Q, Freeman GJ, Sharpe AH, Dana R.Regulation of T-cell chemotaxis by programmed death-ligand 1 (PD-L1) in dry eye-associated corneal inflammation.Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3418-23.
    20019373
  • Good-Jacobson KL, Szumilas CG, Chen L, Sharpe AH, Tomayko MM, Shlomchik MJ.PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells.Nat Immunol. 2010 Jun;11(6):535-42.
    20453843
  • Ruffner MA, Kim SH, Bianco NR, Francisco LM, Sharpe AH, Robbins PD.B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function.Eur J Immunol. 2009 Nov;39(11):3084-90.
    19757438
  • Paterson AM, Sharpe AH.Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells.Nat Immunol. 2010 Feb;11(2):109-11. Review.
    20084066
  • Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH.PD-L1 regulates the development, maintenance, and function of induced regulatory T cells.J Exp Med. 2009 Dec 21;206(13):3015-29.
    20008522
  • Chen L,Sham CW,Chan AM,Francisco LM,Wu Y,Mareninov S,Sharpe AH,Freeman G,Yang XJ,Braun J,Gordon LK.Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells.Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4941-8.
    19420345
  • Pot C, Jin H, Awasthi A, Liu SM, Lai CY, Madan R, Sharpe AH, Karp CL, Miaw SC, Ho IC, Kuchroo VK.Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells.J Immunol. 2009 Jul 15;183(2):797-801.
    19570826
  • Sharpe AH.Mechanisms of costimulation.Immunol Rev. 2009 May;229(1):5-11. Review.
    19426211
  • Chen L,Pai V,Levinson R,Sharpe AH,Freeman GJ,Braun J,Gordon LK.Constitutive neuronal expression of the immune regulator, programmed death 1 (PD-1), identified during experimental autoimmune uveitis.Ocul Immunol Inflamm. 2009 Jan-Feb;17(1):47-55.
    19294574
  • Verhagen J,Gabrysova L,Minaee S,Sabatos CA,Anderson G,Sharpe AH,Wraith DC.Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease.Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3306-11.
    19218450
  • Reynoso ED,Elpek KG,Francisco L,Bronson R,Bellemare-Pelletier A,Sharpe AH,Freeman GJ,Turley SJ.Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade.J Immunol. 2009 Feb 15;182(4):2102-12.
    19201863
  • Schmidt EM,Wang CJ,Ryan GA,Clough LE,Qureshi OS,Goodall M,Abbas AK,Sharpe AH,Sansom DM,Walker LS.Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity.J Immunol. 2009 Jan 1;182(1):274-82.
    19109158
  • Bauquet AT,Jin H,Paterson AM,Mitsdoerffer M,Ho IC,Sharpe AH,Kuchroo VK.The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells.Nat Immunol. 2009 Feb;10(2):167-75.
    19098919
  • Brooks DG,Ha SJ,Elsaesser H,Sharpe AH,Freeman GJ,Oldstone MB.IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection.Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20428-33.
    19075244
  • Gotsman I,Sharpe AH,Lichtman AH.T-cell costimulation and coinhibition in atherosclerosis.Circ Res. 2008 Nov 21;103(11):1220-31. Review.
    19028921
  • Lucas JA,Menke J,Rabacal WA,Schoen FJ,Sharpe AH,Kelley VR.Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice.J Immunol. 2008 Aug 15;181(4):2513-21.
    18684942
  • Taylor PA,Ehrhardt MJ,Lees CJ,Panoskaltsis-Mortari A,Krieg AM,Sharpe AH,Murphy WJ,Serody JS,Hemmi H,Akira S,Levy RB,Blazar BR.TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection.Blood. 2008 Oct 15;112(8):3508-16.
    18614760
  • Duan B,Niu H,Xu Z,Sharpe AH,Croker BP,Sobel ES,Morel L.Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus.Lab Invest. 2008 Sep;88(9):1008-20.
    18607347
  • Butte MJ,Pena-Cruz V,Kim MJ,Freeman GJ,Sharpe AH.Interaction of human PD-L1 and B7-1.Mol Immunol. 2008 Aug;45(13):3567-72.
    18585785
  • Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH.ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival.J Immunol. 2008 Apr 15;180(8):5448-56.
    18390727
  • Ha SJ, Mueller SN, Wherry EJ, Barber DL, Aubert RD, Sharpe AH, Freeman GJ, Ahmed R.Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection.J Exp Med. 2008 Mar 17;205(3):543-55.
    18332181
  • Keir ME, Butte MJ, Freeman GJ, Sharpe AH.PD-1 and Its Ligands in Tolerance and Immunity.Annu Rev Immunol. 2008 Apr;26:677-704. Review.
    18173375
  • Kobayashi N, Karisola P, Peña-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, Umetsu DT, Dekruyff RH, Freeman GJ.TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells.Immunity. 2007 Dec;27(6):927-40.
    18082433
  • Keir ME, Freeman GJ, Sharpe AH.PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues.J Immunol. 2007 Oct 15;179(8):5064-70.
    17911591
  • Mueller SN, Matloubian M, Clemens DM, Sharpe AH, Freeman GJ, Gangappa S, Larsen CP, Ahmed R.Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection.Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15430-5.
    17878315
  • Gotsman I, Grabie N, Dacosta R, Sukhova G, Sharpe A, Lichtman AH.Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice.J Clin Invest. 2007 Oct;117(10):2974-82.
    17853943
  • Shen L, Jin Y, Freeman GJ, Sharpe AH, Dana MR.The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival.J Immunol. 2007 Sep 15;179(6):3672-9.
    17785803
  • Tai X, Van Laethem F, Sharpe AH, Singer A.Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13756-61.
    17702861
  • Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ.Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.Immunity. 2007 Jul;27(1):111-22.
    17629517
  • Love VA, Grabie N, Duramad P, Stavrakis G, Sharpe A, Lichtman A.CTLA-4 ablation and interleukin-12 driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes.Circ Res. 2007 Aug 3;101(3):248-57.
    17569889
  • Keir ME, Francisco LM, Sharpe AH.PD-1 and its ligands in T-cell immunity.Curr Opin Immunol. 2007 Jun;19(3):309-14. Review.
    17433872
  • Keir ME, Liang SC, Guleria I, Latchman YE, Qipo A, Albacker LA, Koulmanda M, Freeman GJ, Sayegh MH, Sharpe AH.Tissue expression of PD-L1 mediates peripheral T cell tolerance.J Exp Med. 2006 Apr 17;203(4):883-95.
    16606670
  • Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, Freeman GJ, Ahmed R.Restoring function in exhausted CD8 T cells during chronic viral infection.Nature. 2006 Feb 9;439(7077):682-7.
    16382236
  • Liang SC, Greenwald RJ, Latchman YE, Rosas L, Satoskar A, Freeman GJ, Sharpe AH.PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis.Eur J Immunol. 2006 Jan;36(1):58-64.
    16358363
  • Keir ME, Sharpe AH.The B7/CD28 costimulatory family in autoimmunity.Immunol Rev. 2005 Apr;204:128-43.
    15790355
  • Taylor PA, Panoskaltsis-Mortari A, Freeman GJ, Sharpe AH, Noelle RJ, Rudensky AY, Mak TW, Serody JS, Blazar BR.Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM).Blood. 2005 Apr 15;105(8):3372-80.
    15618467
  • Latchman YE, Liang SC, Wu Y, Chernova T, Sobel RA, Klemm M, Kuchroo VK, Freeman GJ, Sharpe AH.PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells.Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10691-6.
    15249675
  • Vijayakrishnan L, Slavik JM, Illés Z, Greenwald RJ, Rainbow D, Greve B, Peterson LB, Hafler DA, Freeman GJ, Sharpe AH, Wicker LS, Kuchroo VK.An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells.Immunity. 2004 May;20(5):563-75.
    15142525
  • Wang N, Satoskar A, Faubion W, Howie D, Okamoto S, Feske S, Gullo C, Clarke K, Sosa MR, Sharpe AH, Terhorst C.The cell surface receptor SLAM controls T cell and macrophage functions.J Exp Med. 2004 May 3;199(9):1255-64.
    15123745
  • Martin-Orozco N, Chen Z, Poirot L, Hyatt E, Chen A, Kanagawa O, Sharpe A, Mathis D, Benoist C.Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand.J Immunol. 2003 Dec 15;171(12):6954-60.
    14662903
  • Rodig N, Ryan T, Allen JA, Pang H, Grabie N, Chernova T, Greenfield EA, Liang SC, Sharpe AH, Lichtman AH, Freeman GJ.Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis.Eur J Immunol. 2003 Nov;33(11):3117-26.
    14579280
  • Liang SC, Latchman YE, Buhlmann JE, Tomczak MF, Horwitz BH, Freeman GJ, Sharpe AH.Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses.Eur J Immunol. 2003 Oct;33(10):2706-16.
    14515254
  • Harada H, Salama AD, Sho M, Izawa A, Sandner SE, Ito T, Akiba H, Yagita H, Sharpe AH, Freeman GJ, Sayegh MH.The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity.J Clin Invest. 2003 Jul;112(2):234-43.
    12865411
  • Ekkens MJ, Liu Z, Liu Q, Whitmire J, Xiao S, Foster A, Pesce J, VanNoy J, Sharpe AH, Urban JF, Gause WC.The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus.J Immunol. 2003 Jan 1;170(1):384-93.
    12496423
  • Schneider H, Mandelbrot DA, Greenwald RJ, Ng F, Lechler R, Sharpe AH, Rudd CE.Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice.J Immunol. 2002 Oct 1;169(7):3475-9.
    12244135
  • Jabs C, Greve B, Chang TT, Sobel RA, Sharpe AH, Kuchroo VK.Genetic background determines the requirement for B7 costimulation in induction of autoimmunity.Eur J Immunol. 2002 Sep;32(9):2687-97.
    12207354
  • Freeman GJ, Sharpe AH, Kuchroo VK.Protect the killer: CTLs need defenses against the tumor.Nat Med. 2002 Aug;8(8):787-9.
    12152031
  • Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT.Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity.Nat Med. 2002 Sep;8(9):1024-32.
    12145647
  • Brown JA, Greenwald RJ, Scott S, Schweitzer AN, Satoskar AR, Chung C, Schopf LR, van der Woude D, Sypek JP, Sharpe AH.T helper differentiation in resistant and susceptible B7-deficient mice infected with Leishmania major.Eur J Immunol. 2002 Jun;32(6):1764-72.
    12115660
  • Ekkens MJ, Liu Z, Liu Q, Foster A, Whitmire J, Pesce J, Sharpe AH, Urban JF, Gause WC.Memory Th2 effector cells can develop in the absence of B7-1/B7-2, CD28 interactions, and effector Th cells after priming with an intestinal nematode parasite.J Immunol. 2002 Jun 15;168(12):6344-51.
    12055251
  • Greenwald RJ, Latchman YE, Sharpe AH.Negative co-receptors on lymphocytes.Curr Opin Immunol. 2002 Jun;14(3):391-6.
    11973140
  • Sharpe AH, Freeman GJ.The B7-CD28 superfamily.Nat Rev Immunol. 2002 Feb;2(2):116-26.
    11910893
  • Chang TT, Kuchroo VK, Sharpe AH.Role of the B7-CD28/CTLA-4 pathway in autoimmune disease.Curr Dir Autoimmun. 2002;5:113-30.
    11826754
  • Greenwald RJ, Oosterwegel MA, van der Woude D, Kubal A, Mandelbrot DA, Boussiotis VA, Sharpe AH.CTLA-4 regulates cell cycle progression during a primary immune response.Eur J Immunol. 2002 Feb;32(2):366-73.
    11807776
  • Greenwald RJ, McAdam AJ, Van der Woude D, Satoskar AR, Sharpe AH.Cutting edge: inducible costimulator protein regulates both Th1 and Th2 responses to cutaneous leishmaniasis.J Immunol. 2002 Feb 1;168(3):991-5.
    11801630
  • Mandelbrot DA, Kishimoto K, Auchincloss H, Sharpe AH, Sayegh MH.Rejection of mouse cardiac allografts by costimulation in trans.J Immunol. 2001 Aug 1;167(3):1174-8.
    11466331
  • Witke W, Sutherland JD, Sharpe A, Arai M, Kwiatkowski DJ.Profilin I is essential for cell survival and cell division in early mouse development.Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3832-6.
    11274401
  • Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB.Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice.Mol Cell Biol. 2000 Aug;20(15):5479-89.
    10891488
  • Anderson DE, Sharpe AH, Hafler DA.The B7-CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system.Curr Opin Immunol. 1999 Dec;11(6):677-83.
    10631554
  • Chang TT, Jabs C, Sobel RA, Kuchroo VK, Sharpe AH.Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis.J Exp Med. 1999 Sep 6;190(5):733-40.
    10477557
  • Humphries DE, Wong GW, Friend DS, Gurish MF, Qiu WT, Huang C, Sharpe AH, Stevens RL.Heparin is essential for the storage of specific granule proteases in mast cells.Nature. 1999 Aug 19;400(6746):769-72.
    10466726
  • Oosterwegel MA, Mandelbrot DA, Boyd SD, Lorsbach RB, Jarrett DY, Abbas AK, Sharpe AH.The role of CTLA-4 in regulating Th2 differentiation.J Immunol. 1999 Sep 1;163(5):2634-9.
    10453003
  • Khattri R, Auger JA, Griffin MD, Sharpe AH, Bluestone JA.Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses.J Immunol. 1999 May 15;162(10):5784-91.
    10229811
  • Greenwald RJ, Urban JF, Ekkens MJ, Chen S, Nguyen D, Fang H, Finkelman FD, Sharpe AH, Gause WC.B7-2 is required for the progression but not the initiation of the type 2 immune response to a gastrointestinal nematode parasite.J Immunol. 1999 Apr 1;162(7):4133-9.
    10201938
  • Hernandez HJ, Sharpe AH, Stadecker MJ.Experimental murine schistosomiasis in the absence of B7 costimulatory molecules: reversal of elicited T cell cytokine profile and partial inhibition of egg granuloma formation.J Immunol. 1999 Mar 1;162(5):2884-9.
    10072537
  • González-Cabrero J, Wise CJ, Latchman Y, Freeman GJ, Sharpe AH, Reiser H.CD48-deficient mice have a pronounced defect in CD4(+) T cell activation.Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1019-23.
    9927686
  • Mandelbrot DA, McAdam AJ, Sharpe AH.B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).J Exp Med. 1999 Jan 18;189(2):435-40.
    9892625
  • Rauschmayr-Kopp T, Williams IR, Borriello F, Sharpe AH, Kupper TS.Distinct roles for B7 costimulation in contact hypersensitivity and humoral immune responses to epicutaneous antigen.Eur J Immunol. 1998 Dec;28(12):4221-7.
    9862359
  • La Motte RN, Sharpe AH, Bluestone JA, Mokyr MB.Importance of B7-1-expressing host antigen-presenting cells for the eradication of B7-2 transfected P815 tumor cells.J Immunol. 1998 Dec 15;161(12):6552-8.
    9862681
  • Schweitzer AN, Sharpe AH.Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production.J Immunol. 1998 Sep 15;161(6):2762-71.
    9743334
  • Van Parijs L, Sethna MP, Schweitzer AN, Borriello F, Sharpe AH, Abbas AK.Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice.J Immunol. 1997 Dec 1;159(11):5336-44.
    9548473
  • Tivol EA, Boyd SD, McKeon S, Borriello F, Nickerson P, Strom TB, Sharpe AH.CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice.J Immunol. 1997 Jun 1;158(11):5091-4.
    9164923
  • Borriello F, Sethna MP, Boyd SD, Schweitzer AN, Tivol EA, Jacoby D, Strom TB, Simpson EM, Freeman GJ, Sharpe AH.B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation.Immunity. 1997 Mar;6(3):303-13.
    9075931
  • Tivol EA, Schweitzer AN, Sharpe AH.Costimulation and autoimmunity.Curr Opin Immunol. 1996 Dec;8(6):822-30.
    8994862
  • Lynch WP, Snyder EY, Qualtiere L, Portis JL, Sharpe AH.Late virus replication events in microglia are required for neurovirulent retrovirus-induced spongiform neurodegeneration: evidence from neural progenitor-derived chimeric mouse brains.J Virol. 1996 Dec;70(12):8896-907.
    8971019
  • Blazar BR, Sharpe AH, Taylor PA, Panoskaltsis-Mortari A, Gray GS, Korngold R, Vallera DA.Infusion of anti-B7.1 (CD80) and anti-B7.2 (CD86) monoclonal antibodies inhibits murine graft-versus-host disease lethality in part via direct effects on CD4+ and CD8+ T cells.J Immunol. 1996 Oct 15;157(8):3250-9.
    8871619
  • Borriello F, Oliveros J, Freeman GJ, Nadler LM, Sharpe AH.Differential expression of alternate mB7-2 transcripts.J Immunol. 1995 Dec 15;155(12):5490-7.
    7499829
  • Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ.Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3.Science. 1995 Nov 3;270(5237):794-7.
    7481767
  • Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH.Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4.Immunity. 1995 Nov;3(5):541-7.
    7584144
  • Sharpe AH.Analysis of lymphocyte costimulation in vivo using transgenic and 'knockout' mice.Curr Opin Immunol. 1995 Jun;7(3):389-95.
    7546405
  • Prabhu Das MR, Zamvil SS, Borriello F, Weiner HL, Sharpe AH, Kuchroo VK.Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation.Eur J Immunol. 1995 Jan;25(1):207-11.
    7531145