• Home
  • News
  • Calendar
  • About DF/HCC
  • Membership
  • Visitor Center

Wade Harper, PhD

Publications

  • Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC.Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.Nature. 2014 Mar 30.
    24695223
  • Mejia LA, Litterman N, Ikeuchi Y, de la Torre-Ubieta L, Bennett EJ, Zhang C, Harper JW, Bonni A.A novel Hap1-Tsc1 interaction regulates neuronal mTORC1 signaling and morphogenesis in the brain.J Neurosci. 2013 Nov 13;33(46):18015-21.
    24227713
  • Mosammaparast N, Kim H, Laurent B, Zhao Y, Lim HJ, Majid MC, Dango S, Luo Y, Hempel K, Sowa ME, Gygi SP, Steen H, Harper JW, Yankner B, Shi Y.The histone demethylase LSD1/KDM1A promotes the DNA damage response.J Cell Biol. 2013 Nov 11;203(3):457-70.
    24217620
  • Tan MK, Lim HJ, Bennett EJ, Shi Y, Harper JW.Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.Mol Cell. 2013 Oct 10;52(1):9-24.
    24035498
  • Lee PC, Dodart JC, Aron L, Finley LW, Bronson RT, Haigis MC, Yankner BA, Harper JW.Altered Social Behavior and Neuronal Development in Mice Lacking the Uba6-Use1 Ubiquitin Transfer System.Mol Cell. 2013 Mar 12.
    23499007
  • White EA, Kramer RE, Tan MJ, Hayes SD, Harper JW, Howley PM.Comprehensive analysis of host cellular interactions with human papillomavirus e6 proteins identifies new e6 binding partners and reflects viral diversity.J Virol. 2012 Dec;86(24):13174-86.
    23015706
  • Martínez-Noël G, Galligan JT, Sowa ME, Arndt V, Overton TM, Harper JW, Howley PM.Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.Mol Cell Biol. 2012 Aug;32(15):3095-106.
    22645313
  • Tan MJ, White EA, Sowa ME, Harper JW, Aster JC, Howley PM.Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling.Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):E1473-80.
    22547818
  • O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW.A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.Mol Cell. 2010 Nov 24;40(4):645-57.
    21055985
  • Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W.Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.Mol Cell. 2010 Sep 10;39(5):797-808.
    20832730
  • Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, Kaelin WG, Harper JW, Wei W.Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.Cancer Cell. 2010 Aug 9;18(2):147-59.
    20708156
  • Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME, Clark AB, Kunkel TA, Harper JW, Colaiácovo MP, Elledge SJ.A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.Mol Cell. 2010 Jul 9;39(1):36-47.
    20603073
  • Song EJ, Werner SL, Neubauer J, Stegmeier F, Aspden J, Rio D, Harper JW, Elledge SJ, Kirschner MW, Rape M.The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.Genes Dev. 2010 Jul 1;24(13):1434-47.
    20595234
  • Powell ML, Smith JA, Sowa ME, Harper JW, Iftner T, Stubenrauch F, Howley PM.NCoR1 Mediates Papillomavirus E8;E2C Transcriptional Repression.J Virol. 2010 May;84(9):4451-60.
    20181716
  • Smith JA, White EA, Sowa ME, Powell ML, Ottinger M, Harper JW, Howley PM.Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression.Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3752-7.
    20133580
  • Ciccia A, Bredemeyer AL, Sowa ME, Terret ME, Jallepalli PV, Harper JW, Elledge SJ.The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart.Genes Dev. 2009 Oct 15;23(20):2415-25.
    19793862
  • Zheng G, Schweiger MR, Martinez-Noel G, Zheng L, Smith JA, Harper JW, Howley PM.Brd4 regulation of papillomavirus protein E2 stability.J Virol. 2009 Sep;83(17):8683-92.
    19553317
  • Sowa ME, Bennett EJ, Gygi SP, Harper JW.Defining the human deubiquitinating enzyme interaction landscape.Cell. 2009 Jul 23;138(2):389-403.
    19615732
  • Svendsen JM, Smogorzewska A, Sowa ME, O'Connell BC, Gygi SP, Elledge SJ, Harper JW.Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.Cell. 2009 Jul 10;138(1):63-77.
    19596235
  • Xu L, Sowa ME, Chen J, Li X, Gygi SP, Harper JW.An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.Mol Biol Cell. 2008 Dec;19(12):5059-71.
    18799622
  • Jin J, Ang XL, Ye X, Livingstone M, Harper JW.Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase.J Biol Chem. 2008 Jul 11;283(28):19322-8.
    18480045
  • Kato N, Sakata T, Breton G, Le Roch KG, Nagle A, Andersen C, Bursulaya B, Henson K, Johnson J, Kumar KA, Marr F, Mason D, McNamara C, Plouffe D, Ramachandran V, Spooner M, Tuntland T, Zhou Y, Peters EC, Chatterjee A, Schultz PG, Ward GE, Gray N, Harper J, Winzeler EA.Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.Nat Chem Biol. 2008 Jun;4(6):347-56.
    18454143
  • Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ.SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.Nature. 2008 Mar 20;452(7185):370-4.
    18354483
  • Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, Hannon GJ, Elledge SJ.Cancer proliferation gene discovery through functional genomics.Science. 2008 Feb 1;319(5863):620-4.
    18239126
  • Bennett EJ, Harper JW.DNA damage: ubiquitin marks the spot.Nat Struct Mol Biol. 2008 Jan;15(1):20-2.
    18176551
  • Harper JW, Elledge SJ.The DNA damage response: ten years after.Mol Cell. 2007 Dec 14;28(5):739-45. Review.
    18082599
  • Huh K, Zhou X, Hayakawa H, Cho JY, Libermann TA, Jin J, Wade Harper J, Munger K.Human papillomavirus type 16 e7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor.J Virol. 2007 Sep;81(18):9737-47.
    17609271
  • Jin J, Li X, Gygi SP, Harper JW.Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.Nature. 2007 Jun 28;447(7148):1135-8.
    17597759
  • Ghule PN, Becker KA, Harper JW, Lian JB, Stein JL, van Wijnen AJ, Stein GS.Cell cycle dependent phosphorylation and subnuclear organization of the histone gene regulator p220(NPAT) in human embryonic stem cells.J Cell Physiol. 2007 Oct;213(1):9-17. Review.
    17520687
  • Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ.Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.Nature. 2007 Apr 19;446(7138):876-81.
    17443180
  • Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW, Elledge SJ.A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.Nat Cell Biol. 2007 May;9(5):556-64.
    17417629
  • Harper JW, Schulman BA.Structural complexity in ubiquitin recognition.Cell. 2006 Mar 24;124(6):1133-6. Review.
    16564007
  • Lee TH, Perrem K, Harper JW, Lu KP, Zhou XZ.The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance.J Biol Chem. 2006 Jan 13;281(2):759-68.
    16275645
  • Sundqvist A, Bengoechea-Alonso MT, Ye X, Lukiyanchuk V, Jin J, Harper JW, Ericsson J.Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).Cell Metab. 2005 Jun;1(6):379-91.
    16054087
  • Wei W, Jin J, Schlisio S, Harper JW, Kaelin WG.The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase.Cancer Cell. 2005 Jul;8(1):25-33.
    16023596
  • Miele A, Braastad CD, Holmes WF, Mitra P, Medina R, Xie R, Zaidi SK, Ye X, Wei Y, Harper JW, van Wijnen AJ, Stein JL, Stein GS.HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition.Mol Cell Biol. 2005 Jul;25(14):6140-53.
    15988025
  • Shirogane T, Jin J, Ang XL, Harper JW.SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.J Biol Chem. 2005 Jul 22;280(29):26863-72.
    15917222
  • Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW.Systematic analysis and nomenclature of mammalian F-box proteins.Genes Dev. 2004 Nov 1;18(21):2573-80.
    15520277
  • Cullinan SB, Gordan JD, Jin J, Harper JW, Diehl JA.The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase.Mol Cell Biol. 2004 Oct;24(19):8477-86.
    15367669
  • Ye X, Nalepa G, Welcker M, Kessler BM, Spooner E, Qin J, Elledge SJ, Clurman BE, Harper JW.Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.J Biol Chem. 2004 Nov 26;279(48):50110-9.
    15364936
  • Nalepa G, Harper JW.Visualization of a highly organized intranuclear network of filaments in living mammalian cells.Cell Motil Cytoskeleton. 2004 Oct;59(2):94-108.
    15362113
  • Ang XL, Harper JW.Interwoven ubiquitination oscillators and control of cell cycle transitions.Sci STKE. 2004 Jul 20;2004(242):pe31.
    15266102
  • Harper JW.Neddylating the guardian; Mdm2 catalyzed conjugation of Nedd8 to p53.Cell. 2004 Jul 9;118(1):2-4.
    15242638
  • Welcker M, Orian A, Jin J, Grim JA, Harper JW, Eisenman RN, Clurman BE.The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation.Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9085-90.
    15150404
  • Tetzlaff MT, Bai C, Finegold M, Wilson J, Harper JW, Mahon KA, Elledge SJ.Cyclin F disruption compromises placental development and affects normal cell cycle execution.Mol Cell Biol. 2004 Mar;24(6):2487-98.
    14993286
  • Tetzlaff MT, Yu W, Li M, Zhang P, Finegold M, Mahon K, Harper JW, Schwartz RJ, Elledge SJ.Inaugural Article, From The Cover: Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein.Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3338-3345.
    14766969
  • Li S, Armstrong CM, Bertin N, Ge H, Milstein S, Boxem M, Vidalain PO, Han JD, Chesneau A, Hao T, Goldberg DS, Li N, Martinez M, Rual JF, Lamesch P, Xu L, Tewari M, Wong SL, Zhang LV, Berriz GF, Jacotot L, Vaglio P, Reboul J, Hirozane-Kishikawa T, Li Q, Gabel HW, Elewa A, Baumgartner B, Rose DJ, Yu H, Bosak S, Sequerra R, Fraser A, Mango SE, Saxton WM, Strome S, Van Den Heuvel S, Piano F, Vandenhaute J, Sardet C, Gerstein M, Doucette-Stamm L, Gunsalus KC, Harper JW, Cusick ME, Roth FP, Hill DE, Vidal M.A map of the interactome network of the metazoan C. elegans.Science. 2004 Jan 23;303(5657):540-3.
    14704431
  • Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW.SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.Genes Dev. 2003 Dec 15;17(24):3062-74.
    14681206
  • Rodriguez M, Li SS, Harper JW, Songyang Z.An oriented peptide array library (OPAL) strategy to study protein-protein interactions.J Biol Chem. 2004 Mar 5;279(10):8802-7.
    14679191
  • Wang W, Ungermannova D, Jin J, Harper JW, Liu X.Negative regulation of SCFSkp2 ubiquitin ligase by TGF-beta signaling.Oncogene. 2004 Feb 5;23(5):1064-75.
    14676846
  • Ye X, Wei Y, Nalepa G, Harper JW.The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells.Mol Cell Biol. 2003 Dec;23(23):8586-600.
    14612403
  • Mitra P, Xie RL, Medina R, Hovhannisyan H, Zaidi SK, Wei Y, Harper JW, Stein JL, van Wijnen AJ, Stein GS.Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase.Mol Cell Biol. 2003 Nov;23(22):8110-23.
    14585971
  • Xu L, Wei Y, Reboul J, Vaglio P, Shin TH, Vidal M, Elledge SJ, Harper JW.BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.Nature. 2003 Sep 18;425(6955):316-21.
    13679922
  • Jin J, Harper JW.A license to kill: transcriptional activation and enhanced turnover of Myc by the SCF(kp2) ubiquitin ligase.Cancer Cell. 2003 Jun;3(6):517-8.
    12842079
  • Wu G, Xu G, Schulman BA, Jeffrey PD, Harper JW, Pavletich NP.Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.Mol Cell. 2003 Jun;11(6):1445-56.
    12820959
  • Baumgartner B, Harper JW.Deafening cycle.Nat Cell Biol. 2003 May;5(5):385-7.
    12724771
  • Wei Y, Jin J, Harper JW.The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain.Mol Cell Biol. 2003 May;23(10):3669-80.
    12724424
  • Wang Y, Shirogane T, Liu D, Harper JW, Elledge SJ.Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling.Cell. 2003 Mar 7;112(5):697-709.
    12628189
  • Passmore LA, McCormack EA, Au SW, Paul A, Willison KR, Harper JW, Barford D.Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition.EMBO J. 2003 Feb 17;22(4):786-96.
    12574115
  • Yang G, Ayala G, De Marzo A, Tian W, Frolov A, Wheeler TM, Thompson TC, Harper JW.Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.Clin Cancer Res. 2002 Nov;8(11):3419-26.
    12429629
  • Nelson DM, Ye X, Hall C, Santos H, Ma T, Kao GD, Yen TJ, Harper JW, Adams PD.Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activity.Mol Cell Biol. 2002 Nov;22(21):7459-72.
    12370293
  • Harper JW, Burton JL, Solomon MJ.The anaphase-promoting complex: it's not just for mitosis any more.Genes Dev. 2002 Sep 1;16(17):2179-206.
    12208841
  • Nalepa G, Harper JW.Efp: a ring of independence?.Nat Med. 2002 Jul;8(7):661-2.
    12091896
  • Jin J, Harper JW.RING finger specificity in SCF-driven protein destruction.Dev Cell. 2002 Jun;2(6):685-7.
    12062077
  • Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP.Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.Nature. 2002 Apr 18;416(6882):703-9.
    11961546
  • Leng X, Noble M, Adams PD, Qin J, Harper JW.Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4.Mol Cell Biol. 2002 Apr;22(7):2242-54.
    11884610
  • Au SW, Leng X, Harper JW, Barford D.Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit.J Mol Biol. 2002 Mar 1;316(4):955-68.
    11884135
  • Harper JW.A phosphorylation-driven ubiquitination switch for cell-cycle control.Trends Cell Biol. 2002 Mar;12(3):104-7.
    11859016
  • Harper JW, Adams PD.Cyclin-dependent kinases.Chem Rev. 2001 Aug;101(8):2511-26.
    11749386
  • Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ.Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.Science. 2001 Oct 5;294(5540):173-7.
    11533444
  • Harper JW.Protein destruction: adapting roles for Cks proteins.Curr Biol. 2001 Jun 5;11(11):R431-5.
    11516665
  • Ye X, Zhu C, Harper JW.A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene.Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1682-6.
    11172011
  • Goldberg AL, Elledge SJ, Harper JW.The cellular chamber of doom.Sci Am. 2001 Jan;284(1):68-73.
    11132426
  • Schulman BA, Carrano AC, Jeffrey PD, Bowen Z, Kinnucan ER, Finnin MS, Elledge SJ, Harper JW, Pagano M, Pavletich NP.Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.Nature. 2000 Nov 16;408(6810):381-6.
    11099048
  • Ma T, Van Tine BA, Wei Y, Garrett MD, Nelson D, Adams PD, Wang J, Qin J, Chow LT, Harper JW.Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription.Genes Dev. 2000 Sep 15;14(18):2298-313.
    10995387
  • Stepanova L, Finegold M, DeMayo F, Schmidt EV, Harper JW.The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissues.Mol Cell Biol. 2000 Jun;20(12):4462-73.
    10825210
  • Stepanova L, Yang G, DeMayo F, Wheeler TM, Finegold M, Thompson TC, Harper JW.Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia.Oncogene. 2000 Apr 27;19(18):2186-93.
    10822368
  • Lin BY, Ma T, Liu JS, Kuo SR, Jin G, Broker TR, Harper JW, Chow LT.HeLa cells are phenotypically limiting in cyclin E/CDK2 for efficient human papillomavirus DNA replication.J Biol Chem. 2000 Mar 3;275(9):6167-74.
    10692408
  • Shapiro GI, Harper JW.Anticancer drug targets: cell cycle and checkpoint control.J Clin Invest. 1999 Dec;104(12):1645-53.
    10606615
  • Harper JW, Elledge SJ.Skipping into the E2F1-destruction pathway.Nat Cell Biol. 1999 May;1(1):E5-7.
    10559870
  • Winston JT, Chu C, Harper JW.Culprits in the degradation of cyclin E apprehended.Genes Dev. 1999 Nov 1;13(21):2751-7.
    10557204
  • Wang Y, Penfold S, Tang X, Hattori N, Riley P, Harper JW, Cross JC, Tyers M.Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E.Curr Biol. 1999 Oct 21;9(20):1191-4.
    10531039
  • Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW.A family of mammalian F-box proteins.Curr Biol. 1999 Oct 21;9(20):1180-2.
    10531037
  • Erdamar S, Yang G, Harper JW, Lu X, Kattan MW, Thompson TC, Wheeler TM.Levels of expression of p27KIP1 protein in human prostate and prostate cancer: an immunohistochemical analysis.Mod Pathol. 1999 Aug;12(8):751-5.
    10463475
  • Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P.SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex.Mol Cell. 1999 Jul;4(1):21-33.
    10445024
  • Koepp DM, Harper JW, Elledge SJ.How the cyclin became a cyclin: regulated proteolysis in the cell cycle.Cell. 1999 May 14;97(4):431-4.
    10338207
  • Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin WG, Elledge SJ, Conaway RC, Harper JW, Conaway JW.Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.Science. 1999 Apr 23;284(5414):657-61.
    10213691
  • Skowyra D, Koepp DM, Kamura T, Conrad MN, Conaway RC, Conaway JW, Elledge SJ, Harper JW.Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.Science. 1999 Apr 23;284(5414):662-5.
    10213692
  • Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW.The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.Genes Dev. 1999 Feb 1;13(3):270-83.
    9990852
  • Zhang P, Wong C, Liu D, Finegold M, Harper JW, Elledge SJ.p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step.Genes Dev. 1999 Jan 15;13(2):213-24.
    9925645
  • Ma T, Zou N, Lin BY, Chow LT, Harper JW.Interaction between cyclin-dependent kinases and human papillomavirus replication-initiation protein E1 is required for efficient viral replication.Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):382-7.
    9892642
  • Adams PD, Li X, Sellers WR, Baker KB, Leng X, Harper JW, Taya Y, Kaelin WG.Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes.Mol Cell Biol. 1999 Feb;19(2):1068-80.
    9891042
  • Zhang P, Wong C, DePinho RA, Harper JW, Elledge SJ.Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development.Genes Dev. 1998 Oct 15;12(20):3162-7.
    9784491
  • Callahan MA, Handley MA, Lee YH, Talbot KJ, Harper JW, Panganiban AT.Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family.J Virol. 1998 Oct;72(10):8461.
    9766974